Can freezing tumors control prostate cancer recurrence?
NCT ID NCT01727284
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether MR-guided cryoablation—a procedure that freezes tumors—can effectively treat prostate cancer that has come back in the prostate bed. Researchers are enrolling 107 patients whose tumors are small and not suitable for surgery or radiation. The goal is to see if the frozen tumors are controlled over three years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MR-guided cryoablation (a procedure that uses extreme cold to freeze and destroy tumor tissue, guided by MRI)
- What this could lead to
- If successful, this could offer a non-surgical option to control prostate cancer recurrences in the prostate bed, potentially delaying or avoiding more aggressive treatments.
- What could go wrong
- This is a single-arm study without a comparison group, so it's unclear if cryoablation is better than other options. The procedure may not fully eliminate the tumor, and there are risks like damage to nearby structures (rectum, urethra).
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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107 people
The number who actually took part.
- Started
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Dec 2012
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 100 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with "biopsy proven" soft tissue tumor recurrences of prostate fossa * Surgery is not a desirable alternative therapy at the time of enrollment * Radiation therapy has failed or not indicated or can be safely postponed * Tumor size is \< 5 cm at its largest diameter * Tumor does not encompass the rectal wall or external urethral sphincter * Patient is able to undergo MRI Exclusion Criteria: * N/A
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States