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Could a common painkiller replace opioids for bowel blockages?

NCT ID NCT05878015

Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if giving IV acetaminophen (like Tylenol) can control pain as well as opioids in people hospitalized with a small bowel obstruction. About 18 adults will be randomly assigned to receive either IV acetaminophen or usual opioid pain care. Researchers will measure pain scores, how quickly the blockage resolves, and hospital stay length.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Small bowel obstruction diagnosed by radiographic study; and * Abdominal pain on admission. * Nothing per mouth diet. * The ability to give appropriate consent or have an appropriate representative available to do so. Exclusion Criteria: * Known liver failure or cirrhosis. * Acetaminophen toxicity on admission. * Known acetaminophen allergy. * Alcohol intoxication on admission. * History of substance abuse. * Creatinine clearance \< 30 (or Creatinine level \> 2). * Liver transplant recipients. * Ileus on admission. * Admitted for surgical intervention for SBO. * Admitted for venting Gastric tube placement. * On chronic opioid therapy (defined as use of opioid on daily or near daily basis within previous 45 days (both long acting and short acting). * Presentation without abdominal pain on admission. * Already hospitalized for other reasons and develop SBO while at the hospital. * Pregnant women. * Unable to provide informed consent.

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Conditions

The condition(s) this trial relates to.

intestinal obstruction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Small bowel obstruction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mayo Clinic Florida

    Jacksonville, Florida, 32224, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.