AI-Powered heart check could spot silent disease in minutes
NCT ID NCT06891222
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining an AI-enhanced electrocardiogram (ECG) with a focused heart ultrasound can better detect structural heart disease in people without symptoms. About 2,705 adults with no known heart problems will get an AI-ECG, and if it flags a concern, they'll also get a quick ultrasound. The goal is to see if this approach catches more cases of hidden heart conditions like weak heart muscle or narrowed valves.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AI-ECG and focused cardiac ultrasound
- What this could lead to
- If successful, this could make heart disease screening faster and easier, catching problems early with just an ECG and a quick ultrasound.
- What could go wrong
- This is an early-stage screening study, not a treatment trial. The AI may not be accurate enough, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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2,705 people
The number who actually took part.
- Started
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Apr 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All subjects aged 18 or older without known congenital or acquired SHD scheduled to undergo an elective outpatient electrocardiogram
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients (\>18 years of age) * Echocardiogram is not clinically indicated Exclusion Criteria: * Prior history of congenital or acquired SHD, as defined by the following 1. Aortic Stenosis: 2. Heart Failure 3. Left Ventricular Dysfunction 4. Cardiac Amyloidosis 5. Hypertrophic Cardiomyopathy (HCM) 6. Rheumatic Heart Disease 7. Congenital Heart Disease * Recent (within last 12 months) echocardiogram * Scheduled clinically indicated future echocardiogram * Inability to provide informed consent to participate in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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