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Could a simple blood test improve heart surgery outcomes?

NCT ID NCT06895213

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study at Mayo Clinic looks at how renin, a protein in the blood, changes when patients are on the heart-lung machine during open heart surgery. Researchers want to see if renin levels can help guide treatments for low blood pressure. The study will enroll 100 adults having elective heart surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors use renin levels to better manage blood pressure during heart surgery, potentially reducing complications.
What could go wrong
This is an early observational study with only 100 participants. It is not testing a treatment, so it may not lead to any direct changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult persons 18 years of age or greater (female and male).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult persons 18 years of age or greater. * Scheduled for an elective cardiac surgical procedure involving the use of cardiopulmonary bypass. Exclusion Criteria: * Surgery involving heart or lung transplantation or implant of a durable left ventricular assist device. * Emergency cardiac surgery. * Established diagnosis of any congenital heart disease. * End-stage kidney disease receiving kidney replacement therapy before surgery.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery with cardiopulmonary bypass

Contacts and locations

Locations

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.