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Researchers track Long-Term effects of carotid artery procedures

NCT ID NCT05465122

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows up with people who took part in the CREST-2 trial to see how well treatments for carotid artery narrowing work over the long term. It includes about 2,480 participants who had either surgery, stenting, or intensive medical management. The main goal is to track strokes and other outcomes years after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,480 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2022

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with asymptomatic carotid stenosis previously randomized in the CREST-2 trial.

Ages

35 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Currently active or graduated participants in the CREST-2 randomized trial * Able to provide written informed consent by self * Fluent in English or Spanish Exclusion Criteria: * Unable to provide written informed consent * Inability to follow study procedures

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Conditions

The condition(s) this trial relates to.

carotid stenosis stroke disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stenoses, carotid

Contacts and locations

Locations

  • Banner University Medical Center

    Tucson, Arizona, 85724, United States

  • Baptist Health

    Lexington, Kentucky, 40503, United States

  • Berks Cardiologists

    Wyomissing, Pennsylvania, 19610, United States

  • Cardiovascular Institute NW Florida

    Panama City, Florida, 32405, United States

  • Central Arkansas VA

    Little Rock, Arkansas, 72143, United States

  • Crouse Hospital

    Syracuse, New York, 13210, United States

  • Deaconess Heart Group

    Newburgh, Indiana, 47630, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Endeavor Health/NorthShore University

    Evanston, Illinois, 60201, United States

  • Gundersen Clinic, Ltd.

    La Crosse, Wisconsin, 54601, United States

  • Hartford Hospital

    Hartford, Connecticut, 06102, United States

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • Hospital Clinic of Barcelona

    Barcelona, 08036, Spain

  • Hospital of University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Inova Fairfax Hospital

    Falls Church, Virginia, 22042, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21224, United States

  • Kaiser Permanente Divsion of Research

    San Francisco, California, 94115, United States

  • Kaiser Permanente Los Angeles

    Los Angeles, California, 90027, United States

  • Kaiser Permanente San Francisco

    San Francisco, California, 94115, United States

  • Lyerly Neurosurgery/Baptist Health

    Jacksonville, Florida, 32207, United States

  • Maine Medical Center

    Portland, Maine, 04102, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Jacksonville

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic Pheonix

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Mercy Health St. Vincent

    Toledo, Ohio, 43608, United States

  • Mercy Hospital

    St Louis, Missouri, 63141, United States

  • Miami Cardiac and Vascular Institute

    Miami, Florida, 33176, United States

  • Michigan Heart

    Ypsilanti, Michigan, 48197, United States

  • Michigan Vascular Center

    Flint, Michigan, 48532, United States

  • Mission Cardiovascular Research Institute

    Fremont, California, 94538, United States

  • Morton Plant Mease Healthcare

    Clearwater, Florida, 33756, United States

  • North Memorial Medical Center

    Golden Valley, Minnesota, 55422, United States

  • Nova Scotia Health Authority

    Halifax, Nova Scotia, B3H 3A7, Canada

  • Ochsner Health System

    New Orleans, Louisiana, 70121, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Pinnacle Health

    Harrisburg, Pennsylvania, 17043, United States

  • Prairie Heart/St. John's Hospital

    Springfield, Illinois, 62701, United States

  • SUNY Buffalo

    Buffalo, New York, 14203, United States

  • Seton Medical Center

    Austin, Texas, 78705, United States

  • Sparrow Clinical Research Institute

    Lansing, Michigan, 48912, United States

  • St. Elizabeth's Medical Center

    Boston, Massachusetts, 02135, United States

  • St. Joseph's Medical Center

    Stockton, California, 95204, United States

  • Tennova Healthcare

    Knoxville, Tennessee, 37934, United States

  • The Miriam Hospital

    Providence, Rhode Island, 02906, United States

  • USC/Keck Medical Center

    Los Angeles, California, 90033, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of California Los Angeles

    Los Angeles, California, 90095, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Florida Health at Shands

    Gainesville, Florida, 32610, United States

  • University of Florida Jacksonville

    Jacksonville, Florida, 32209, United States

  • University of Iowa Hospitals & Clinics

    Iowa City, Iowa, 52242, United States

  • University of Utah Hospitals & Clinics

    Salt Lake City, Utah, 84132, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • VA Ann Arbor

    Ann Arbor, Michigan, 48105, United States

  • VA Medical Center

    Baltimore, Maryland, 21201, United States

  • VA Pittsburgh

    Pittsburgh, Pennsylvania, 15240, United States

  • VA Puget Sound

    Seattle, Washington, 98108, United States

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Wake Forest Baptist Health

    Winston-Salem, North Carolina, 27157, United States

  • Weill Cornell Medical College

    New York, New York, 10065, United States

  • Wellmont CVA Heart Institute

    Kingsport, Tennessee, 37660, United States

  • White Oak Medical Center

    Silver Spring, Maryland, 20904, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 16520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.