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Gut check: 4,000-Person study links diet, genes, and stomach troubles

NCT ID NCT06657001

Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick and others don't, which could lead to better diet advice in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 4,001 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults who have consented to the Mayo Clinic Biobank with gastrointestinal disease.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age greater than or equal to 18 years * Gastrointestinal patients with or without genomic sequencing results available for the following cohorts: * Inflammatory Bowel Disease (IBD) * Irritable Bowel Syndrome (IBS) * Crohn's Disease * Celiac Disease * Diarrhea * Constipation * Healthy age and sex matched controls with or without genomic sequencing results available o Control is defined as patients without gastrointestinal disease or no symptoms at time of sampling * Able to provide written, informed consent * Participant has a smartphone device with access to internet connection Exclusion Criteria: * Patients with cognitive impairment * Active use of antibiotics at the time of stool collection

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Conditions

The condition(s) this trial relates to.

celiac disease constipation disorder Crohn disease diarrheal disease Digestive System Diseases dyspepsia functional gastric disease inflammatory bowel disease irritable bowel syndrome microscopic colitis ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Celiac disease Constipation Crohn's disease Diarrhea Functional dyspepsia Inflammatory bowel disease (IBD) Irritable bowel syndrome (IBS) Microbiome Microscopic colitis Uc - ulcerative colitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.