Constipation

This trial tests whether taking a daily probiotic supplement for 8 weeks can relieve constipation in adults. Participants are randomly assigned to receive either the probiotic or a placebo, and researchers track changes in bowel habits, gut symptoms, and overall well-being throug…

This study tests whether transplanting healthy gut bacteria can relieve constipation and bloating in people with systemic sclerosis, an autoimmune disease that often affects the digestive tract. Participants will receive the bacteria either as capsules or as a retention enema. Th…

This study looks at whether a new, high-resolution probe can better diagnose severe constipation that doesn't get better with standard laxatives. Researchers will compare results from healthy volunteers and patients with suspected colonic inertia. The goal is to improve diagnosis…

This study tests an injected drug called brenipatide in 342 adults with irritable bowel syndrome with constipation (IBS-C). Participants will receive either the drug or a placebo for about 35 weeks. The goal is to see if brenipatide safely reduces abdominal pain and improves bowe…

This study tests whether a probiotic called Akk09 can improve bowel movements and ease constipation symptoms in adults. About 70 participants will take either the probiotic or a placebo daily for 4 weeks. Researchers will track changes in stool consistency and overall gut health.

This study tests whether a dietary supplement can improve constipation and related symptoms like gas and bloating. About 550 adults with constipation will take either the active supplement or a placebo for 4 weeks. Researchers will measure changes in constipation severity and dig…

This study tests whether a probiotic supplement can safely relieve constipation in adults. About 105 people with chronic constipation will receive either the probiotic or a placebo. Researchers will track changes in stool consistency using the Bristol Stool Scale to see if the pr…

This study tests whether a traditional herbal formula called MZRW can help cancer survivors who suffer from constipation. Researchers will give 70 participants either MZRW or a placebo for two weeks and track bowel movements and gut bacteria changes. The goal is to see if MZRW is…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This study is testing whether a fermented milk drink containing a specific probiotic (Lacticaseibacillus paracasei strain Shirota) can help relieve constipation symptoms in Filipino adults. Researchers will measure changes in stool consistency, bowel movement frequency, and how l…

This trial studies 88 women undergoing vaginal surgery for pelvic organ prolapse. Half will take senna pills and half will use bisacodyl suppositories after surgery. Researchers will measure how quickly each group has their first bowel movement and how satisfied they are with the…

This study tests whether pyridostigmine, a drug that stimulates the gut, can safely relieve chronic constipation in people with Parkinson's disease. Constipation is a common and bothersome symptom that often appears years before movement problems. Sixteen adults with Parkinson's …

This study tests whether a daily probiotic supplement (Weizmannia coagulans) can reduce constipation and improve gut health in healthy, physically active adults aged 18 to 50. About 30 participants will take the probiotic or a placebo for 4 weeks each, with a break in between, an…

This pilot study is testing a multi-strain liquid probiotic in 20 adults who report having constipation. Participants take 70 ml of the probiotic daily for 28-35 days. The goal is to see if it improves constipation symptoms and quality of life, offering a possible alternative for…

This study at Mayo Clinic tests whether biofeedback therapy and inspiratory muscle training can help people with dyssynergic defecation—a condition where pelvic floor muscles don't relax properly during bowel movements. Two hundred adults aged 18 to 80 with chronic constipation w…

This study explores whether methane gas produced by gut microbes is linked to the progression of Parkinson's disease and related conditions like dementia. Researchers will measure breath methane levels in 200 adults—including those with Parkinson's, those at high risk (REM sleep …

This study aims to understand why constipation occurs and improve diagnostic tests. Researchers will use specialized tools like a rectal balloon and pressure sensors to measure how the rectum and anus work during bowel movements. The study includes healthy volunteers and people w…

This study looks at whether a bowel flush regimen, using either MiraLAX or GoLytely, changes the types of bacteria in the gut of children with severe chronic constipation. Researchers will collect stool samples before and after a surgical procedure called an antegrade continence …

This study tests whether inflating a small balloon during biofeedback therapy helps people with chronic constipation coordinate their muscles better. Biofeedback therapy teaches patients how to relax and tighten the right muscles to have a bowel movement. The study compares the s…

This study is looking at whether test anxiety during final exams is linked to bowel problems and constipation in university students. About 200 students will fill out questionnaires about their anxiety and digestive health. The goal is to better understand how mental stress might…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study tests a new device called Fecobionics that measures how the rectum and anus work during bowel movements. Researchers want to see if it can predict which patients with a type of constipation called dyssynergia will benefit from biofeedback therapy. About 24 adults will …