CONSTIPATION

This Phase 2 trial tested whether the antibody drug isatuximab could help control AL amyloidosis in patients whose disease had returned or didn't respond to prior treatments. The study enrolled 43 adults with confirmed organ damage from this rare protein disorder. Participants re…

This study compared two different surgical methods, called Swenson and Soave, for treating children with Hirschsprung's disease, a condition where part of the bowel lacks the nerves needed to move stool. The main goal was to see if one technique took less time to perform. Researc…

This study aimed to improve how doctors diagnose chronic constipation and fecal incontinence (bowel control problems). Researchers tested new devices, including a simulated feces device called Fecobionics, on 130 patients with these conditions and 101 healthy volunteers. The goal…

This study tested whether a simple ear massage could help prevent or reduce constipation in patients recovering from leg surgery. Researchers enrolled 40 patients to see if massaging specific points on the ear could stimulate bowel activity. The goal was to find a safe, non-drug …

This study tested whether a specific probiotic supplement could help relieve chronic constipation. Researchers enrolled 90 adults with long-term constipation and gave them either the probiotic or a placebo pill. The goal was to see if the probiotic improved bowel movements and st…

This study tested whether a simple abdominal massage could help relieve constipation in people receiving kidney dialysis. Researchers gave 24 patients a 15-minute massage twice a week during their dialysis sessions for six weeks, while 25 others received their usual care. They me…

This study tested whether a single session of abdominal massage could provide immediate benefits for people with chronic constipation. Researchers compared 30 adults who received the real massage to a group that simply waited, measuring effects on blood vessel stiffness, muscle o…

This study tested whether a guided exercise and education program delivered through video calls (telerehabilitation) could help relieve constipation symptoms and improve quality of life. Researchers enrolled 32 adults with chronic constipation to participate in the remote program…

This early study tested a new wireless skin patch designed to deliver medication without needles. The goal is to help people with spinal cord injuries who suffer from severe constipation and bowel incontinence. Researchers checked if the patch was safe and if the body absorbed th…

This study tested if a gentle electrical stimulation to a nerve near the ankle could help children with severe constipation caused by uncoordinated pelvic floor muscles. Researchers compared the real stimulation to a fake (sham) treatment in 40 children aged 8-18. The goal was to…

This study tested whether starting a laxative before pelvic organ prolapse surgery helps reduce discomfort with bowel movements after the operation. Researchers compared women who took the laxative both before and after surgery to those who only took it afterward. The goal was to…

This study tested whether a special insole, designed using reflexology principles, could help manage constipation in people receiving palliative care. For four weeks, one group of patients walked for 20 minutes a day wearing the insoles, while another group walked without them. R…

This study tested whether daily probiotic supplements could help children with cerebral palsy who suffer from chronic constipation. For 28 days, children took either a Lactobacillus reuteri supplement, a Lactobacillus rhamnosus supplement with a prebiotic, or received standard ca…

This study tested a new, faster care pathway for people with chronic constipation at the University of Michigan. Researchers wanted to see if using this specific plan made doctors more likely to order the recommended tests and physical therapy. They tracked 109 patients to measur…

This small pilot study tested whether treating constipation in people with chronic kidney disease might improve their kidney health. Researchers gave 14 patients with both conditions a constipation treatment and checked if it was practical to deliver. They measured changes in kid…

This early study tested how two drugs used for bowel problems in people with spinal cord injuries get into the body. Researchers compared giving the drugs through a standard IV to delivering them through a special skin patch. The goal was to see if the patch method could be a fut…