Experimental antibody shows promise for rare amyloid disease

NCT ID NCT03499808

Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase II trial tested the drug isatuximab in 43 patients with AL amyloidosis that had come back or stopped responding to treatment. Isatuximab is a monoclonal antibody that may help stop abnormal protein buildup. The study measured how well the drug reduced disease markers and monitored side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: isatuximab (a monoclonal antibody given intravenously)
What this could lead to: If successful, isatuximab could offer a new treatment option for patients with AL amyloidosis that has returned or not responded to prior therapy.
What could go wrong: This is a small, early-phase trial (43 participants) with no control group. Results may not confirm benefit, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

43 people

The number who actually took part.

Started

Jun 2018

Finished

Sep 2023

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have relapsed or refractory primary systemic AL amyloidosis, histologically-confirmed by positive Congo red stain with green by birefringence on polarized light microscopy, OR characteristic appearance by electron microscopy AND confirmatory AL amyloid typing (mass spectrometry-based proteomic analysis or immunofluorescence) * Patient must have measurable disease within 28 days prior to registration; serum beta2 microglobulin, serum quantitative immunoglobulins (immunoglobulin \[Ig\]G, IgA, and IgM), serum free kappa and lambda, and serum protein electrophoresis (SPEP) with M-protein quantification must be obtained within 14 days prior to registration * Patient must demonstrate a difference in the involved serum free light chains (kappa or lambda) versus the uninvolved serum free light chain of \>= 4.5 mg/dL within 14 days prior to registration * Patient must have objective organ involvement defined by ONE (or more) of the following; all disease for involved organs must be assessed and documented on the AL baseline tumor assessment form * Kidney: albuminuria greater than or equal to 500 mg per day on a 24-hour urine specimen within 35 days prior to registration, OR prior kidney biopsy (at time of diagnosis) showing amyloid deposition * Heart: mean left ventricular wall thickness on echocardiogram greater than or equal to 12 mm in the absence of hypertension or valvular heart disease, OR N-terminal fragment brain natriuretic protein (NT-pro) brain natriuretic peptide (BNP) greater than 332 ng/mL provided that patient does not have impaired renal function (as defined by calculated creatinine clearance less than 25 mL/min) within 14 days prior to registration, OR prior cardiac biopsy (at time of diagnosis) showing amyloid deposition with past documented or presently noted clinical symptoms and signs supportive of a diagnosis of heart failure in the absence of an alternative explanation for heart failure * Liver: hepatomegaly (total liver span \> 15 cm) as demonstrated by computed tomography (CT) or magnetic resonance imaging (MRI) within 35 days prior to registration OR elevated alkaline phosphatase (ALP) greater than 1.5 times the upper limit of normal within 14 days prior to registration, OR prior liver biopsy (at time of diagnosis) showing amyloid deposition * Gastrointestinal tract: prior biopsy showing amyloid deposition AND symptoms such as GI bleeding or persistent diarrhea (\> 4 loose stools/day on most days over a consecutive 28-day period) * Autonomic or peripheral nervous system: orthostatic blood pressure, symptoms of nausea, early satiety, diarrhea or constipation, abnormal sensory and/or motor findings on neurologic exam, or gastric atony by gastric emptying scan; Note: pulse and blood pressure must be recorded with the patient supine (lying down), and then again after at least 1 minute, but less than 3 minutes of standing; this assessment must be repeated on 2 separate occasions (at least 1 day apart; e.g. day -3 and day -1) within a 28-day screening period * Soft tissue: macroglossia, or soft tissue deposits (including lymphadenopathy, recurrent peri-orbital purpura, peri-articular, skin or other soft tissue) requiring therapy * Patients must not have active symptomatic multiple myeloma, as defined by 2015 International Myeloma Working Group (IMWG) criteria (hypercalcemia, renal failure, anemia, and bone \[CRAB\] criteria; bone marrow plasmacytosis \> 60%); kappa: lambda ratio \> 100 is acceptable only if the clinical symptoms and sign are attributable only to amyloidosis and not multiple myeloma (hemoglobin \[Hgb\] \< 8 g/dL) * Patient must be relapsed or refractory to at least one prior line of therapy (such as: transplant, radiation, or chemotherapy) * Patients must have completed other systemic therapy \>= 14 days or investigational drug \>= 28 days prior to registration, surgery (other than biopsies) \>= 21 days prior to registration, and any autologous stem cell transplant (ASCT) \>= 100 days prior to registration * Patients must not have received any or supplements which have been known to have some anti-amyloidogenic effect (such as: doxycycline; curcumin; prednisone; dexamethasone; epigallocatechin gallate \[EGCG\]) within 14 days prior to registration * Patients must not have any known allergies to isatuximab or other monoclonal antibody therapies * Patients must not have received daratumumab within 56 days prior to registration nor have been refractory to daratumumab * Patients must not be eligible for autologous stem cell transplantation * Patients must have a complete medical history and physical exam within 14 days prior to registration * Within 14 days prior to registration: Total bilirubin =\< 2.0 x IULN (institutional upper limit of the norm) AND * Within 14 days prior to registration: Serum glutamic-oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST) and serum glutamate pyruvate transaminase (SGPT)/alanine aminotransferase (ALT) =\< 4.0 x IULN * Creatinine clearance (CrCl) \>= 25 mL/min, as measured by a 24-hour urine collection or as estimated by the Cockcroft and Gault formula; the serum creatinine value used in the calculation must have been obtained within 35 days prior to registration * Patients must have bone marrow aspirate, including fluorescence in situ hybridization (FISH) (including: del 17p; t11;14; t4;14, t14;16; and del 13q) and cytogenetic testing (normal ? XY; and all abnormalities) within 35 days prior to registration; central pathology analysis will not be required, however the local pathology report and FISH/cytogenetic data must be submitted in Medidata RAVE * Within 14 days prior to registration: Absolute neutrophil count (ANC) \>= 1,000 cells/mcl without growth factor support, AND * Within 14 days prior to registration: Platelets \>= 75,000 cells/mcl * Patients must have hemoglobin \>= 8 g/dL within 14 days prior to registration; patients may have received transfusion if greater than 7 days prior to registration * New York Heart Association (NYHA) \< class IV heart failure * Left ventricular ejection fraction (LVEF) by echocardiogram (ECHO) \>= 35% within 35 days prior to registration; and * NT-proBNP =\< 8500 ng/L within 14 days prior to registration * Patients must have a Zubrod performance status =\< 2 * Patients must not have any clinically significant uncontrolled systemic illness, including but not limited to uncontrolled, active infection requiring intravenous antibiotics, unstable angina pectoris, myocardial infarction within the past 6 months, uncontrolled cardiac arrhythmias, uncontrolled hypertension, or uncontrolled diabetes mellitus * Uncontrolled diabetes: patients who have a diagnosis of diabetes must have an glycosylated hemoglobin (HbA1C) \< 7% within 14 days prior to registration; the same criterion will be used in patients with confirmed diagnosis of diabetes mellitus who have been on a stable dietary or therapeutic regimen for this condition in the last three months * Uncontrolled blood pressure and hypertension: all blood pressure measurements within the 14 days prior to registration must be systolic blood pressure (SBP) =\< 160 and diastolic blood pressure (DBP) =\< 100; an exception can be made by a healthcare provider for a patient with a single blood pressure elevation who upon rechecking has a normal blood pressure * Females of childbearing potential must have a negative baseline pregnancy test within 14 days prior to registration; this may be either a serum or urine pregnancy test, with a sensitivity of at least 50 mIU/mL; females of childbearing potential (FCBP) must also agree: (1) to have a pregnancy test prior to the start of each treatment cycle and (2) to either commit to continued abstinence from heterosexual intercourse or to use effective contraception while receiving study drug and for at least 12 weeks after receiving the last dose of study drug; females are considered to be of ?childbearing potential? if they have had menses at any time in the preceding 24 consecutive months; in addition to routine contraceptive methods, ?effective contraception? also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, she is responsible for beginning contraceptive measures * Patients with evidence of hepatitis B virus (HBV) are eligible provided there is minimal hepatic injury and the patient has undetectable HBV on suppressive HBV therapy; patient must be willing to maintain adherence to HBV therapy; patients with previously treated and eradicated hepatitis C virus (HCV) who have minimal hepatic injury are eligible * Patients who are known to be human immunodeficiency virus (HIV)-positive at registration are eligible if at time of registration they meet all other protocol eligibility criteria in addition to the following: * Patient has undetectable HIV viral load by standard polymerase chain reaction (PCR) clinical assay * Patient is willing to maintain adherence to combination antiretroviral therapy * Patient has no history of acquired immunodeficiency syndrome (AIDS) defining condition (other than CD4 cell count \< 200 mm\^3) * Patient is otherwise likely to have a near normal lifespan if not for the presence of relapsed/refractory amyloid * No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for at least two years

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Conditions

The condition(s) this trial relates to.

AL amyloidosis constipation disorder diarrheal disease Gastrointestinal Hemorrhage Hepatomegaly Immunoglobulin Light-chain Amyloidosis Lymphadenopathy lymphatic system disorder macroglossia Nausea primary systemic amyloidosis purpura soft tissue amyloid neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amorphous, eosinophilic, and acellular deposit Constipation Diarrhea Early satiety Gastrointestinal hemorrhage Hepatomegaly Lymphadenopathy Macroglossia Nausea Primary systemic amyloidosis Purpura Recurrent primary amyloidosis Refractory primary amyloidosis

Contacts and locations

Locations

21st Century Oncology-Pontiac

Pontiac, Michigan, 48341, United States
Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Academic Hematology Oncology Specialists

Grosse Pointe Woods, Michigan, 48236, United States
Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States
Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Ascension Saint John Hospital

Detroit, Michigan, 48236, United States
Ascension Saint Joseph Hospital

Tawas City, Michigan, 48764, United States
Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Boulder Community Hospital

Boulder, Colorado, 80301, United States
Bozeman Deaconess Hospital

Bozeman, Montana, 59715, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
CHI Health Saint Francis

Grand Island, Nebraska, 68803, United States
CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Camden Clark Medical Center

Parkersburg, West Virginia, 26101, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Care Specialists of Illinois-Swansea

Swansea, Illinois, 62226, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Capital Region Southwest Campus

Jefferson City, Missouri, 65109, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle on Vermilion

Danville, Illinois, 61832, United States
Caro Cancer Center

Caro, Michigan, 48723, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Centerpoint Medical Center LLC

Independence, Missouri, 64057, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic-Weston

Weston, Florida, 33331, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Hospital

Missoula, Montana, 59804, United States
Comprehensive Cancer Care and Research Institute of Colorado LLC

Englewood, Colorado, 80113, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Denver Health Medical Center

Denver, Colorado, 80204, United States
East Carolina University

Greenville, North Carolina, 27834, United States
Eastern Maine Medical Center

Bangor, Maine, 04401, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Maple Grove Medical Center

Maple Grove, Minnesota, 55369, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview-Southdale Hospital

Edina, Minnesota, 55435, United States
Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States
Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States
Fremont - Rideout Cancer Center

Marysville, California, 95901, United States
Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, 48503, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Good Samaritan Medical Center

Lafayette, Colorado, 80026, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Great Lakes Cancer Management Specialists-Doctors Park

East China Township, Michigan, 48054, United States
Great Lakes Cancer Management Specialists-Macomb Medical Campus

Macomb, Michigan, 48044, United States
Great Lakes Cancer Management Specialists-Macomb Professional Building

Warren, Michigan, 48093, United States
Great Lakes Cancer Management Specialists-Rochester Hills

Rochester Hills, Michigan, 48309, United States
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center

Grosse Pointe Woods, Michigan, 48236, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Harold Alfond Center for Cancer Care

Augusta, Maine, 04330, United States
Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, Washington, 98310, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Harrison Medical Center

Bremerton, Washington, 98310, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
Heartland Hematology and Oncology

Kearney, Nebraska, 68845, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64507, United States
Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States
Hematology and Oncology Consultants PC

Omaha, Nebraska, 68122, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Hope Cancer Center

Pontiac, Michigan, 48341, United States
Hope Cancer Clinic

Livonia, Michigan, 48154, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States
IHA Hematology Oncology Consultants-Ann Arbor

Ypsilanti, Michigan, 48197, United States
IHA Hematology Oncology Consultants-Brighton

Brighton, Michigan, 48114, United States
IHA Hematology Oncology Consultants-Canton

Canton, Michigan, 48188, United States
IHA Hematology Oncology Consultants-Chelsea

Chelsea, Michigan, 48118, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Jewish Hospital Medical Center Northeast

Louisville, Kentucky, 40245, United States
Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Northwest

Portland, Oregon, 97227, United States
Kaiser Permanente Washington

Seattle, Washington, 98112, United States
Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States
Kansas Institute of Medicine Cancer and Blood Center

Lenexa, Kansas, 66219, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Kootenai Cancer Center

Post Falls, Idaho, 83854, United States
Kootenai Cancer Clinic

Sandpoint, Idaho, 83864, United States
Kootenai Medical Center

Coeur d'Alene, Idaho, 83814, United States
Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States
Littleton Adventist Hospital

Littleton, Colorado, 80122, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford

Biddeford, Maine, 04005, United States
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

Sanford, Maine, 04073, United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, Illinois, 60160, United States
Marshfield Clinic - Weston Center

Weston, Wisconsin, 54476, United States
Marshfield Clinic Stevens Point Center

Stevens Point, Wisconsin, 54482, United States
Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
McKee Medical Center

Loveland, Colorado, 80539, United States
Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States
Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States
Memorial GYN Plus

Ooltewah, Tennessee, 37363, United States
Memorial Hospital

Chattanooga, Tennessee, 37404, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Menorah Medical Center

Overland Park, Kansas, 66209, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
Mercy Medical Center

Springfield, Massachusetts, 01104, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Michigan Breast Specialists-Grosse Pointe Woods

Grosse Pointe Woods, Michigan, 48236, United States
Michigan Breast Specialists-Macomb Township

Macomb, Michigan, 48044, United States
Michigan Breast Specialists-Warren

Warren, Michigan, 48093, United States
Midlands Community Hospital

Papillion, Nebraska, 68046, United States
Minimally Invasive Surgery Hospital

Lenexa, Kansas, 66219, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, 63127, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Mountain Blue Cancer Care Center

Golden, Colorado, 80401, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
National Jewish Health-Main Campus

Denver, Colorado, 80206, United States
National Jewish Health-Northern Hematology Oncology

Thornton, Colorado, 80260, United States
National Jewish Health-Western Hematology Oncology

Golden, Colorado, 80401, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States
North Colorado Medical Center

Greeley, Colorado, 80631, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States
Onslow Memorial Hospital

Jacksonville, North Carolina, 28546, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parker Adventist Hospital

Parker, Colorado, 80138, United States
Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
Porter Adventist Hospital

Denver, Colorado, 80210, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Oncology and Hematology Care Southeast

Clackamas, Oregon, 97015, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Pulmonary Medicine Center of Chattanooga-Hixson

Hixson, Tennessee, 37343, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Research Medical Center

Kansas City, Missouri, 64132, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Rocky Mountain Cancer Centers - Pueblo

Pueblo, Colorado, 81008, United States
Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States
Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States
Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers-Parker

Parker, Colorado, 80138, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Rush - Copley Medical Center

Aurora, Illinois, 60504, United States
Rush-Copley Healthcare Center

Yorkville, Illinois, 60560, United States
SCL Health Lutheran Medical Center

Wheat Ridge, Colorado, 80033, United States
SCL Health Saint Joseph Hospital

Denver, Colorado, 80218, United States
SIH Cancer Institute

Carterville, Illinois, 62918, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Medical Center-Baker City

Baker City, Oregon, 97814, United States
Saint Alphonsus Medical Center-Nampa

Nampa, Idaho, 83686, United States
Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, 97914, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint John Macomb-Oakland Hospital

Warren, Michigan, 48093, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph London

London, Kentucky, 40741, United States
Saint Joseph Mercy Brighton

Brighton, Michigan, 48114, United States
Saint Joseph Mercy Canton

Canton, Michigan, 48188, United States
Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118, United States
Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106, United States
Saint Joseph Mercy Oakland

Pontiac, Michigan, 48341, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Saint Luke's Mountain States Tumor Institute

Boise, Idaho, 83712, United States
Saint Luke's Mountain States Tumor Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Mountain States Tumor Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Mountain States Tumor Institute - Nampa

Nampa, Idaho, 83686, United States
Saint Luke's Mountain States Tumor Institute-Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's South Hospital

Overland Park, Kansas, 66213, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary Mercy Hospital

Livonia, Michigan, 48154, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States
Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States
Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital-Orange Care Center

Orange, Connecticut, 06477, United States
Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital-Waterbury Care Center

Waterbury, Connecticut, 06708, United States
Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States
Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States
Southwest Oncology PC

Durango, Colorado, 81301, United States
Sparrow Hospital

Lansing, Michigan, 48912, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Stephens Memorial Hospital

Norway, Maine, 04268, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122-4307, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Women's Imaging Center

Denver, Colorado, 80209, United States
TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States
TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
United Hospital Center

Bridgeport, West Virginia, 26330, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Colorado Hospital

Aurora, Colorado, 80045, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
WVUH-Berkely Medical Center

Martinsburg, West Virginia, 25401, United States
Waldo County General Hospital

Belfast, Maine, 04915, United States
Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Western Surgical Care

Denver, Colorado, 80220, United States
Yale University

New Haven, Connecticut, 06520, United States
Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473, United States

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