CONSTIPATION

This study looks at two different ways to help women have their first bowel movement after vaginal surgery for pelvic organ prolapse. About 88 women will be randomly assigned to take either an oral senna or a rectal bisacodyl suppository. The goal is to see which option leads to …

This study tests whether a probiotic called Lactobacillus plantarum can safely improve bowel habits in adults with chronic constipation. About 80 participants will take either the probiotic or a placebo daily. The main goal is to see if stool becomes softer and more regular.

This study tests whether pyridostigmine, a drug that boosts nerve signals, can help with constipation in people with Parkinson disease. Constipation is a common and bothersome symptom that often starts years before movement problems. Sixteen adults with Parkinson disease will tak…

This study tests a liquid probiotic with multiple bacterial strains in 20 adults who have constipation. Participants will take the probiotic for several weeks to see if it improves bowel symptoms and quality of life. The goal is to find a better, drug-free option for people unhap…

This study is testing whether a fermented milk drink containing a specific probiotic (Lacticaseibacillus paracasei strain Shirota) can help relieve constipation in Filipino adults. Researchers will enroll 60 adults aged 18-59 who have hard or lumpy stools at least 25% of the time…

This study from Mayo Clinic looks at how to improve biofeedback treatments for people with a type of constipation called dyssynergic defecation. Researchers will measure changes in rectal and anal pressure, balloon expulsion time, and emptying rates. The goal is to better underst…

This study tests tenapanor, a drug already approved for irritable bowel syndrome, as a treatment for constipation in people with cystic fibrosis. About 25 adults will take one 50 mg tablet twice daily for 4 weeks. Researchers will track bowel movements and use questionnaires to s…

This study tests an experimental drug called brenipatide for adults with irritable bowel syndrome with constipation (IBS-C). About 342 participants will receive either the drug or a placebo injection under the skin for several weeks. The goal is to see if the drug safely improves…

This study tests whether a daily probiotic drop (BioAmicus Complete) can ease tummy issues like colic, constipation, and diarrhea, as well as skin symptoms of food allergy (eczema) in infants. About 140 babies will receive either the probiotic or a placebo for 25 days. The goal i…

This study tests whether an herbal formula called MZRW can help cancer survivors who have constipation. About 70 adults who have finished cancer treatment at least a month ago will take either MZRW or a placebo pill for 2 weeks. Researchers will check if bowel movements improve a…

This study looks at whether a natural dietary supplement called Inno Cleanse can help reduce bloating in healthy people who often feel bloated. Researchers will give 30 participants either the supplement or a placebo for two weeks and track changes in bloating, weight, and other …

This study tests whether taking a daily probiotic called Weizmannia (Bacillus) coagulans JBI-YZ6.3 can ease constipation and improve overall gut health in healthy, physically active adults aged 18 to 50. About 30 participants will receive both the probiotic and a placebo at diffe…

This study tests a new, high-resolution probe to measure colon muscle activity in people with severe constipation that doesn't get better with standard laxatives. Researchers will compare results from 76 patients and healthy volunteers to see if the probe can better identify colo…

This study tests a new device called Fecobionics that measures how the rectum and anus work during bowel movements. Researchers want to see if it can help predict how well biofeedback therapy works for people with a type of constipation called dyssynergia. About 24 adults aged 21…