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Could a simple ultrasound replace kidney biopsies?

NCT ID NCT05764642

First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 28 times

Summary

This study tests a new ultrasound technique that uses tiny bubbles to create detailed images of blood vessels in the kidney. Researchers hope this can help diagnose chronic kidney disease without an invasive biopsy. The study involves 186 healthy volunteers and kidney disease patients at Mayo Clinic.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Mayo Clinic Florida

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic Minnesota

    Rochester, Minnesota, 55905, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Definity (ultrasound contrast agent)

What this could lead to

If successful, this could provide a non-invasive way to diagnose and monitor chronic kidney disease, reducing the need for biopsies.

What could go wrong

This is an early-phase study with only 186 participants, so results may not apply to everyone. The imaging technique is still experimental and may not be accurate enough for routine use.

Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.