HEALTHY

This study tests a new nasal spray COVID-19 booster vaccine (LVT-001) in healthy adults who have already received at least three mRNA COVID-19 shots. The goal is to see if the nasal spray is safe and boosts immunity better than a standard mRNA booster. The trial involves 238 part…

This study tests a new vaccine called V118E, designed to protect against Streptococcus pneumoniae bacteria, which can cause serious infections like pneumonia. Researchers want to see if it is safe and well-tolerated in healthy adults. About 126 participants will receive either th…

This early-stage study is testing two new vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus, such as infectious mononucleosis and certain cancers. About 250 healthy adults and teens will receive either the vaccine or a placebo to check for s…

This large study is testing a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a good immune response, and reduces cases of dengue fever caused by any of the four dengue virus types. Participants will rece…

This study tests a vaccine given to pregnant women to help protect their babies from group B streptococcus (GBS), a bacteria that can cause serious illness in newborns. About 6,000 healthy pregnant women will receive either the vaccine or a placebo (saltwater shot). Researchers w…

This early-stage study tests a new drug called LY3938577 in healthy volunteers and people with type 1 diabetes. The main goals are to check safety, how the drug moves through the body, and how well it controls blood sugar compared to a standard insulin. The study has four parts a…

This early-phase study tests a new drug called LY4064912 in 144 healthy adults and people with overweight or obesity. The main goal is to check if the drug is safe and what side effects it may cause. Participants will receive the drug as a shot under the skin or through an IV, an…

This study looks at whether a weekly low-dose rapamycin pill (everolimus), resistance training (like lifting weights), or both can improve bone formation and muscle function in women aged 60-75 who have lower bone density but not osteoporosis. About 148 women will be randomly ass…

This early-stage study tests a new drug called LY4213663 in healthy volunteers and people with rheumatoid arthritis (RA). The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug. The study lasts…

This early-stage study tests a new drug called LY4006895 in healthy people and those with early Alzheimer's. The main goal is to check if the drug is safe and how the body processes it. The study has two parts: a single dose in healthy volunteers and multiple doses in Alzheimer's…

This early-stage study tests a new drug called XmAb657 in 60 people, including healthy volunteers and those with autoimmune diseases like scleroderma or Sjögren's. The main goal is to check if the drug is safe and tolerable when given as an injection under the skin. Researchers w…

This study tests whether adding lactase drops to milk helps premature babies (born 28-34 weeks) gain weight better. Many preemies lack enough lactase to digest lactose, which may slow growth. The trial will compare weight gain in 100 newborns who get lactase-fortified milk versus…

This study checks if two versions of the drug survodutide work the same way in the body. It involves 80 healthy adults who are overweight or have obesity. Participants will receive both formulations at different times to compare how the drug is absorbed and processed.

This study is testing whether transferring healthy gut bacteria (via fecal transplant) can improve both stomach issues and autism-related behaviors in 60 people aged 7-30 with autism and gastrointestinal problems. Researchers will measure changes in gut symptoms, social skills, a…

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. About 63 participants will be followed for up to a year. This is not a cure; it ai…

This early-stage study tests a new drug called IBI3013. First, healthy adults receive a single dose to check safety and how the body processes it. Then, people with active vitiligo (white patches on skin) or severe alopecia areata (patchy hair loss) receive multiple doses. The go…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests two light-based techniques (diffuse reflectance spectroscopy and photoacoustic imaging) to see if they can tell the difference between healthy, benign, and malignant breast tissue. About 90 adults with a breast tumor larger than 1 cm will be scanned, and the resu…

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without sedation. About 30 adults who are healthy or have Lynch syndrome, Crohn disease, or inflammatory bowel disease will try it. The goal is to see if the capsule can get clear imag…

This study is testing a device called Inflammacheck that measures certain chemicals in a person's breath to see if it can help tell if someone has lung cancer. The goal is to create a simple, non-invasive tool that could be used in clinics to quickly decide who needs further test…

This study is testing a new automated MRI method to see if it can produce clearer images of the liver. It involves 200 participants, including healthy adults and people with known or suspected liver disease or iron overload. Participants will have one MRI scan, and the goal is to…

This study tests a new injection called [18F]LY4214835 to see if it is safe and how it spreads in the body. It includes both healthy volunteers and people with cancer. The goal is to improve cancer imaging, not to treat the disease. Participation lasts about 35 days.

This early-stage study tests a new imaging agent called NeuCaVis in 12 healthy volunteers. Unlike standard PET scans that can be hard to read in the brain and heart, NeuCaVis targets a sugar only used by inflamed tissues, potentially making disease easier to see. The goal is to c…

This study explores a new blood test that may detect active heart inflammation in people with sarcoidosis, a disease that can cause serious heart problems. Researchers will measure DNA fragments released from damaged heart cells in 120 participants, including healthy volunteers a…

This study looks at whether it's better to give the RSV and Tdap vaccines together at one visit or separately at different visits during pregnancy. Researchers want to see if a larger trial is possible and will check safety and immune responses. About 60 healthy pregnant individu…

This study looks at whether adding technology (a website and virtual coaching) to basic education and goal-setting can help older adults who live alone, have mild memory concerns, and are not very active to increase their physical activity. The goal is to see if more activity, al…

This study aims to create and test a home safety program for Latinx families with children ages 15 months to 5 years. Researchers will work with community centers to adapt an existing program, then test it with 100 caregivers. The goal is to see if the program helps parents super…

This study tests a 9-month program called NE+ for American Indian youth ages 12-18. The program includes educational modules, cultural teachings, and caregiver involvement to promote healthy relationships, prevent substance use, and improve mental health. Researchers will compare…

This study looks at whether moving around during labor can improve birth outcomes for first-time mothers with low-risk pregnancies. About 714 women will either receive standard care or use a special mobility system. The main goal is to see if the system reduces unplanned cesarean…

This early-stage study tests an experimental drug called SP-624 in 36 adults—some healthy and some with major depression. Participants take the drug or a placebo daily for two weeks. Researchers use EEG brain scans and AI to see if SP-624 changes brain activity or improves memory…

This early-stage study tests a new medicine called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. The study will also measure how the drug moves through the body and its ef…

This study looks at whether eating grapes can help improve muscle strength and thinking skills in healthy women aged 65 and older. Participants will come to campus for four sessions to do strength tests, thinking tests, and blood draws. The goal is to see if a simple dietary chan…

This study tests a new inhaled medication called Optate for people with mild COVID-19. About 40 adults will receive either Optate or a placebo spray. Researchers will measure virus levels in the nose and track symptom changes using a quality-of-life survey. The goal is to see if …

This study looks at whether giving children a small incentive (like a prize) after a medical procedure can lower their anxiety. About 187 children aged 6 to 17 who are having a procedure and are supported by a child life specialist will take part. Their anxiety will be measured b…

This study tests whether a multi-strain probiotic supplement called Smile Probio 45B is easy for healthy adults to take and whether it helps with digestion, energy levels, and overall well-being. Forty healthy adults will take the probiotic daily for 30 days, record their bowel h…

This early-stage study tests a new pill called BGM0504 in healthy and overweight or obese adults who do not have diabetes. The main goal is to check the drug's safety and how the body handles it. Researchers will also measure weight changes over 8 weeks. The study involves 75 par…

This study tests whether a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both lasers on small skin areas and report their pain levels. Researchers will also take photos and use imaging t…

This early-stage study tests an experimental injection called LY3971297 in healthy volunteers and people with obesity and high blood pressure. The main goal is to check for side effects and see how the drug moves through the body. About 225 participants will be involved, with stu…

This early-stage study tests a new medicine called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in different parts of the study …

This study tests whether a supplement called citicoline can improve mood in healthy adults who have moderate mood issues. About 90 people will take either citicoline or a placebo daily for several weeks. Researchers will measure mood, sleep quality, stress, and certain blood mark…

This study tests whether a krill oil supplement called Lysoveta can improve memory in healthy adults aged 50 to 75 who feel their memory isn't as sharp as it used to be. Participants will take either Lysoveta or a placebo pill daily for about 4 months and complete computer-based …

This early-stage study is testing a new weight loss medicine called MK-4082, taken as a pill rather than an injection. Researchers want to see if it is safe and how the body handles different doses. The study involves 120 healthy adults with a body mass index (BMI) between 25 and…

This study looks at whether Bragg apple cider vinegar can help control blood sugar after a meal in healthy adults aged 20-50. Participants will drink either vinegar or water with a carbohydrate-rich meal, then have their blood sugar measured. The goal is to see if vinegar reduces…

This study tests a new virtual reality system that combines mirror therapy with fun games to help stroke patients improve arm movement. Researchers will check how comfortable and easy the system is to use in 172 healthy volunteers and stroke survivors. The goal is to see if this …

This study tests if a special vacuum dressing (closed incision negative pressure therapy) helps wounds heal better after breast reduction surgery compared to a standard bandage. About 92 women will each have one breast treated with the special dressing and the other with a standa…

This study looks at whether drinking an olive extract (OliPhenolia®) for 8 days helps healthy, active adults burn more fat during cycling. It also checks if having caffeine before exercise makes the effect stronger. About 40 volunteers will take part. The goal is to see if this n…

This study looks back at medical records and brain MRI scans from up to 2000 children (healthy and with developmental delays) to create computer models that link brain images with genetic information. The goal is to better understand and predict developmental disorders, but no ne…

This study looks at whether eating grapes rich in natural compounds called flavonoids can protect brain function, blood vessel health, and mood during mental stress in healthy young adults. Researchers will give 44 participants either high-flavonoid grape powder or a low-flavonoi…

This study looks at how the drug olomorasib enters the bloodstream and how long it takes the body to clear it. About 120 healthy adults will take the drug by mouth and stay overnight at a research center for 10 nights over 7 weeks. The goal is to gather information, not to treat …

This study looks at whether training the muscles you use to breathe in can help amateur CrossFit athletes perform better and feel less tired. About 94 healthy adults aged 18-60 who do CrossFit will be split into two groups: one does breathing exercises with a special device, the …

This study looks at how your gut and brain work together to control hunger and fullness. Researchers will give 15 healthy adults different food-related sensations (like stomach stretching or tasting food) and use brain scans to see which areas light up. The goal is to better unde…

This study watches how social behaviors and brain networks grow in 100 infants and toddlers who have a higher or lower chance of developing autism. Researchers will use safe brain scans (MRI and EEG) during natural sleep, along with developmental tests, to spot early differences.…

This study looks at how HIV affects the brain even when the virus is controlled by medication. Researchers will use special PET and MRI scans to measure brain connections and inflammation in 70 adults, including those with HIV and healthy volunteers. The goal is to better underst…

This study follows 204 people with depression to see if brain activity and genetic tests can predict who can safely stop taking antidepressants without relapsing. Participants will have brain wave tests, sleep recordings, and blood draws during treatment. The goal is to find biol…

This study tests whether a single dose of vicadrostat affects the heart's electrical activity in 45 healthy adults aged 18 to 50. Participants receive vicadrostat, placebo, or moxifloxacin in a crossover design. The goal is to compare heart rhythm changes, ensuring the drug is sa…

This study checks how well a new algorithm can spot irregular heartbeats using sensors on the finger and wrist. It involves 120 healthy adults aged 18 to 80. The goal is to see if the sensors work as well as a standard ECG, not to treat or prevent any disease.

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans, brain wave tests, and thinking assessments to learn more about these disorders. The go…

This study takes small tissue samples from the rectum of people with IBS and healthy volunteers to measure how nerves in the gut behave. The goal is to develop a new method to record nerve activity and understand what goes wrong in IBS. No treatments are tested; the focus is pure…

This early-stage study tests whether the experimental drug HB0056 is safe and tolerable in healthy adults. About 46 volunteers aged 18 to 55 will receive a single dose and be monitored for side effects. The goal is to gather safety data, not to treat any disease.

This early-stage study is testing a new drug, HY8931, in 60 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo and be followed for up to 90 days.

This study looks at how quickly and how long gut bacteria change when healthy adults take a fiber called chicory inulin. Over 13 weeks, 52 participants will take either inulin or a placebo and provide stool and blood samples. The goal is to understand individual differences in gu…

This study is testing a new portable breathing device designed to help people with sudden breathing failure before they get to the hospital. The device delivers continuous air pressure to keep the airways open. Researchers will check how easy it is to use and how well it works in…

This study is testing a new wireless capsule that you swallow to measure temperature inside your digestive tract. The goal is to see if it can help doctors find diseases like Crohn's disease. Ten healthy adults will take part to check if the capsule works correctly.

This study looks at how stroke changes the way people move their arms when walking. Researchers will measure brain activity and muscle patterns in 84 people (stroke survivors and healthy volunteers) to understand why arm swing is different after a stroke. The goal is to use these…

This study tests whether a computer-animated character that explains medical illustrations helps people understand them better and feel less anxious. About 300 healthy adults will compare learning from the character on a screen, in virtual reality, or on their own. The goal is to…

This early-stage study tests a new medicine called PF-07985631, which may one day treat a kidney disease called IgA nephropathy. About 76 healthy adults aged 18 to 55 will receive either the drug or a placebo as a small injection. The main goal is to check safety and how the body…

This study looks at how the experimental drug PF-07328948 is absorbed and removed from the body. It involves 8 healthy men aged 18-64 who will take the drug by mouth and by injection. The goal is to learn about the drug's behavior, not to treat any disease.

This study aims to better understand how many calories a person needs to eat to stay in energy balance—where weight stays steady. Researchers will use a special room called a whole-room calorimeter to measure energy burned and compare it to standard formulas. 34 healthy adults wi…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study collects heart pressure and blood flow data from 50 healthy adults to create a comparison group for a larger registry of people with congenital heart disease. Participants must have no heart conditions, not take heart medications, and meet health criteria. The goal is …

This study tests whether a low-dose fisetin supplement (100 mg daily for 7 weeks) is safe and can reduce signs of inflammation and aging in healthy adults aged 50 and older. Researchers will compare changes in blood markers and side effects between the supplement and placebo grou…

This study looks at whether salbutamol, a common asthma medication, can improve exercise performance in non-asthmatic endurance athletes. Researchers will test if a select group of athletes with breathing limitations might benefit from the drug. The study involves 64 healthy, hig…

This early-stage study is testing a new drug, HY6725, in 74 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo, and are followed for up to 150 days. This research does not ai…

This study at the University of Oxford looks at how a drug called pimavanserin, which blocks a specific serotonin receptor in the brain, affects memory, emotions, and decision-making. Researchers will compare the drug to a placebo in 80 healthy adults aged 18-45. The goal is to b…

This study tests new MRI software to see if it can make image-guided ablation procedures safer and more precise. Researchers will compare the new technology to standard MRI in 100 healthy volunteers and patients. The goal is to improve targeting of tumors and assessment of treatm…

This study gives healthy volunteers psilocybin (the active compound in magic mushrooms) or a placebo, then uses brain scans and thinking tasks to see how the drug alters thoughts and brain patterns. About 30 adults aged 18-75 will participate. The goal is to understand the drug's…

This study looks at how a new medicine called PF-07328948 moves through the body and how safe it is in people with normal or reduced kidney function. About 28 adults aged 18 to 80 will take a single dose by mouth and stay at a research unit for 6 days. The results will help docto…

This observational study looks at how gut bacteria relate to brain changes in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will collect stool and blood samples, perform brain scans, and run memory tests on 200 participants. T…

This early-stage study tests whether BLKR201 is safe in 128 healthy adults aged 18 to 55. Participants take the drug or a placebo by mouth and stay at a research unit for monitoring. Researchers also measure how the drug moves through the body and whether food affects its absorpt…

This early-stage study tests whether ZT003 is safe and how it moves through the body in healthy adults and those who are overweight. About 76 participants will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels, not to treat any di…

This study looks at how natural changes in the female hormone estradiol affect the spinal cord's ability to adapt. Researchers will use mild electrical stimulation to test spinal responses in 50 healthy young adults. The goal is to understand basic biology, not to treat any disea…

This early-phase study tests the safety and tolerability of a new drug called SYNT-101 in healthy adults and those who are overweight or have obesity. About 64 participants will receive either the drug or a placebo to monitor side effects and how the drug moves through the body. …

This study tests a community workshop called I CAN that teaches people how to work together to reduce cancer in their area. About 200 healthy adults in Western New York will take part. The goal is to see if the program is practical and well-liked, not to directly treat or prevent…

This study looks at whether current protein recommendations for children ages 8-10 are too low, especially for those who are very active and fit. Researchers will measure how the body uses protein in 30 normal-weight kids with different activity levels. The goal is to better unde…

This study looks for brain signals that can predict how chronic low back pain changes over time. Researchers will use EEG, a non-invasive brain scan, to track brain activity in 130 adults with and without chronic back pain. The goal is to find patterns that could lead to better, …

This early-stage study tests a new drug, CM383, in 30 healthy men to see how the body absorbs and processes it, and to check for any side effects. Participants receive a single dose either through an IV or an injection. This study does not aim to treat any disease.

This study tests whether a home-based mobile app can help 3-4 year olds who currently meet few movement guidelines improve their physical activity, sleep, and screen time. About 80 children and their parents will use the app for 12 weeks, with researchers tracking changes using a…

This study compares a 9-week group cycling program to a single training session to see which gets more adults cycling regularly. Participants are healthy adults who rarely ride a bike. The goal is to find an effective and cost-efficient way to increase cycling for better health a…

This study aims to find out if children with primary ciliary dyskinesia (PCD) also have a condition called bronchial hyperresponsiveness, where airways tighten too easily. Researchers will measure lung function in 40 participants (30 with PCD and 10 healthy) using breathing tests…

This study tests a new brain-training method to reduce the return of fear in healthy adults. Participants learn to control a brain connection linked to memory while inside an MRI scanner. The goal is to see if this training can weaken the spontaneous return of fear after it has b…

This early-stage study is the first time the experimental drug CAY001 is given to humans. It will involve 24 healthy volunteers aged 18-50 to check the drug's safety, how the body processes it, and what side effects may occur. Participants receive a single dose by IV and are moni…

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults to help researchers better understand conditions like lupus, celiac disease, and kidney disease. The goal is to find new biomarkers and improve future tests and treatments.…

This study looks at whether taking the blood pressure drug losartan changes how the body processes the antibiotic cephalexin. Researchers want to know if taking them together or three hours apart makes a difference. The study involves 12 healthy adults aged 18-40. It aims to help…

This study compares two ways of giving people real-time feedback on their brain activity using fMRI. 90 healthy adults will learn to control a brain region called the anterior insula, which is linked to emotions and body awareness. The goal is to see which feedback method works b…

This study looks at how eating berries, like cloudberries and lingonberries, affects tiny particles called extracellular vesicles that help cells communicate. Researchers will study 60 healthy adults to see if berries change these signals and gut bacteria. The goal is to learn mo…

This study looks at how a gentle, noninvasive nerve stimulation on the ear affects the brain and stomach. Researchers will use brain scans and stomach imaging to measure changes in activity. The goal is to understand how this stimulation works in healthy people and those with sto…

This study checks how well the Owlet OSS 3.0-M1 sensor measures pulse rate and blood oxygen levels in toddlers and preschoolers aged 19 months to 5 years. About 90 healthy children will wear the sensor, and its readings will be compared to a standard medical device. The goal is t…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can change how the brain processes information. Healthy adults aged 20-40 and 60-80 will do computer tasks while receiving either real or placebo stimulation, and their brain activity will be me…

This early-stage study tests whether a new drug called IMP761 is safe in healthy adults aged 18 to 55. Participants receive either the drug or a placebo and are monitored for side effects and how the drug moves through the body. The study does not aim to treat any disease, but to…

This study tests a 21-day self-guided digital program designed to prepare healthy adults for a supervised psychedelic session with psilocybin. Forty volunteers will be randomly assigned to either a daily meditation or music-listening routine before taking a 25 mg dose of psilocyb…

This study looks at how common skin creams—like antifungals, mild steroids, and moisturizers—change the community of tiny organisms living on your skin. Researchers will test these creams on healthy adults to see if they alter the types and amounts of bacteria present. The goal i…

This study looks at how different types of strength training—using a steady beat, a variable beat, or no beat at all—affect the brain and muscles. Researchers will measure changes in brain signals and muscle strength in 60 healthy adults over 4 weeks. The goal is to see if adding…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain oscillations. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective…

This study looks at how healthy bone marrow plasma cells use a nutrient called glutamine. Researchers will give a special labeled form of glutamine to 20 healthy adults aged 18-60, then take a small bone marrow sample to measure how it's processed. The goal is to test if this met…

This study looks at how past childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will compare three groups: people with opioid use disorder on buprenorphine, people without the disorder on buprenorphine, and healthy adults.…

This early-stage study tests the safety and how the body handles a new drug, AZD1613, in healthy adults, including those of Japanese and Chinese descent. About 136 participants will receive either the drug or a placebo. The goal is to gather information on side effects and drug l…

This study looks at how well physiotherapy students learn important people skills like teamwork, leadership, and communication through simulated practice. About 100 second-year students and their teachers will rate these skills after each of nine simulation sessions. The goal is …

This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can highlight a protein called PDE4D in the brain and body. PDE4D is linked to thinking and mood, and may play a role in conditions like Alzheimer's and depression. Healthy adults aged 18 and older wi…

This early-stage study tests a new drug, LTG-001, in 204 healthy adults aged 18 to 55. The goal is to check the drug's safety, side effects, and how the body processes it when taken by mouth or through a vein. Participants receive either the drug or a placebo, and no direct healt…

This study looks at how the body's immune cells react to a new type of cancer vaccine called a neoantigen vaccine. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune responses. The goal is to learn how to better grow and …

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will measure changes in urine levels after giving potassium citrate to 24 adults, some with a history of kidney stones and some without. The go…

This study looks at whether a specific type of acupuncture (electroacupuncture) can increase bowel activity in 30 healthy adults. Participants will have their bowel sounds recorded before, during, and after a 20-minute acupuncture session. The goal is to see if this approach coul…

This study follows healthy women who are trying to get pregnant, as well as women who are not, to collect samples and data during the first two weeks after fertilization. The goal is to learn about the molecular signals between mother and embryo that lead to a successful pregnanc…

This early-stage study tests the safety and how the body handles an inhaled drug called CPD704. It involves 90 healthy Chinese adults aged 18-55. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at sleep issues in healthy Somali Americans and how they might affect blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to find hidden sleep problems that could raise hypertension risk.

This study looks at how lepodisiran enters the blood and leaves the body in people with mild, moderate, or severe liver issues compared to those with healthy livers. About 33 adults will receive a single injection under the skin and be monitored for up to 9 weeks. The goal is to …

This study looks at how an experimental medicine, PF-08653944, is processed by the body in adults with normal liver function and those with mild to severe liver impairment. Participants receive a single injection and are monitored with blood tests and check-ups. The study does no…

This study is creating a large collection of human biological samples and health information, called a biobank. Researchers will use these materials to study the causes of diseases like cancer, heart disease, and diabetes. Up to 10,000 participants will provide samples and data t…

This early-stage study in 16 healthy adults aims to compare how a new tablet form of the experimental drug PF-07799933 is absorbed versus the current version. It also checks if a high-fat meal or an acid-reducing drug changes absorption. No treatment benefit is expected; the goal…

This study looks at how paying attention in different ways during calf-strength training affects walking in healthy older adults. Researchers will compare two types of external focus with an internal focus to see which leads to smoother, more automatic movement. Participants will…

This study aims to develop better ways to perform MRI scans by testing new imaging techniques in healthy volunteers and current NIH participants. Up to 1,000 adults aged 18 and older will have one or more MRI scans, each lasting 20 minutes to 2 hours, with some requiring contrast…

This study tests the long-term safety of a supplement called palmitoylethanolamide (PEA) in 200 healthy adults aged 18 and older. Participants take either PEA or a placebo daily for 12 months and attend check-ups to monitor side effects, vital signs, and blood work. The goal is s…

This study looks at how the body processes a drug called MK-1084 when the liver is not working normally. Researchers will give a single dose to people with liver impairment and to healthy volunteers, then measure drug levels in the blood over time. The goal is to understand if li…

This study tests whether a brain stimulation cap can help healthy adults quickly reach a deep meditative state, normally achieved only after years of practice. 48 participants will wear an EEG cap and receive stimulation while doing a guided meditation task. The goal is to see if…

This study looks at whether brain activity can predict when someone will make a mistake during a typing task, up to 1 second before it happens. Researchers will use brain scans (MRI and MEG) to measure brain signals in 40 healthy, right-handed adults aged 18-35. The goal is to un…

This study looks at how the Q-Collar, a device worn around the neck, changes the way blood flows to the brain during rest and exercise. Twenty healthy adults aged 18-30 will complete two sessions—one with the collar and one without—while doing standing tests, breathing exercises,…

This early-stage study enrolls 32 healthy volunteers to measure how much aramchol gets into the blood from two different single doses of a new tablet form. The goal is to compare the drug levels and choose the best dose for future studies. Participants are healthy adults aged 18-…

This early-stage study tests a new drug called LY4515100 in 40 healthy adults to see if it is safe and how the body processes it. Participants take the drug or a placebo and stay overnight for monitoring. There is no expected treatment benefit, as the goal is simply to gather saf…

This study looks at how specific brain regions track both emotions and time during emotional events to help guide decisions. Researchers will scan 50 healthy adults using fMRI while they view emotional images and report which emotion lasted longer. They will also use magnetic sti…

This early-stage study tests the safety and how the body handles a new drug called BI 3821001. It involves 72 healthy men aged 18 to 55. Participants receive either a single dose of the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blo…

This study looks at how different levels of breathing exercises change oxygen levels in the chest muscles of healthy people. Researchers will measure muscle oxygen before, during, and after training sessions. The goal is to understand the body's response to breathing workouts, no…

This study looks at how young adults (ages 18-22) differ in their attention, impulse control, and brain responses to rewards. Researchers want to see if these differences are linked to cannabis use. Participants will complete tasks and brain scans to help understand these pattern…

This study looks at how caffeinated drinks affect how people feel and their body's responses. It involves 150 healthy adults who already drink caffeine regularly. Participants will try different caffeinated beverages and report their feelings using simple rating scales, while als…

This study looks at 260 young adults from a larger lung health study. They will get a special MRI scan that uses a harmless gas to take detailed pictures of their lungs. The goal is to find early signs of lung problems before they turn into serious disease. No treatment is given—…

This study looks at whether giving a mild electrical pulse to a nerve in the ear (called taVNS) after taking psilocybin can help people remember the deep thoughts and feelings they had during the experience. The idea is that the nerve zap might boost brain flexibility and memory …

This study looks at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions or locations, compared to healthy volunteers. Researchers want to see if TLE patients forget spatial details faster over several weeks. The goal is to better understand …

This study tests whether a 16-week ideomotor group exercise program can improve thinking, movement, and overall well-being in healthy adults aged 50 and older. Participants will exercise twice a week in a community gym and be compared to a group doing cognitive training. The goal…

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical muscle stimulation. Researchers will check blood and spinal fluid for biomarkers to decide whether to start the program r…

This study looks at how the heart pumps blood and uses energy in healthy adults of different ages. Researchers will measure heart pressures and blood samples at rest and during exercise. The goal is to better understand normal heart function, not to test a treatment. About 80 hea…

This study looks at how a gentle electrical current applied to the scalp can change brain activity in people who had a stroke over 6 months ago. Researchers will test two different stimulation frequencies and a placebo in 45 participants, including healthy volunteers. Using brain…

This study tests whether a new tablet form of tafamidis works the same as the current capsule in healthy adults. About 24 participants will take each version once under fed conditions. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks at whether training the muscles you use to breathe can also make your tongue stronger and more enduring. Researchers will measure tongue strength and endurance in 60 healthy adults before and after a breathing muscle training program. The goal is to understand if…

This study aims to develop a new way to stimulate the brain using focused ultrasound, guided by brain wave recordings (EEG). Researchers will test this approach in 80 healthy adults aged 18-64 to find the best settings for future treatments. The goal is to create a system that ca…

This study looks at whether a training program that mixes mental tasks with physical exercises can improve thinking and movement in people who have had a stroke or have Moyamoya disease. Researchers will measure brain activity during these tasks using a special headband. The goal…

This study looks at whether a teacher-led program called the Early Childhood Friendship Project can help preschoolers be less aggressive and more social. About 600 children from diverse backgrounds will take part, and researchers will track their behavior, thinking skills, and ev…

This study looks at whether carbon fiber insoles can help healthy, active men jump higher and sprint faster. About 38 men aged 18-30 will do jump and sprint tests with and without the insoles. The goal is to measure any performance changes, not to treat or cure any disease.

This study looks for shared genetic and chemical clues between eczema (atopic dermatitis) and food allergies. Researchers will collect blood and skin samples from 200 people, including those with food allergies, eczema, or neither. The goal is to create a molecular map that could…

This study is testing whether wearable devices like smartwatches can accurately measure movement problems in people with Huntington's disease. About 100 participants, including those with Huntington's and healthy volunteers, will wear devices and answer surveys over several virtu…

This study looks at how a single dose of the experimental drug BI 1291583 enters the blood in people with and without liver problems. The drug is being developed for bronchiectasis, a chronic lung disease. About 32 adults aged 18–80 will take one tablet and be monitored for about…

This study is testing new wearable sensors made in a lab to see if they are comfortable and safe to wear. About 22 healthy adults will wear the sensors, and researchers will compare their readings of heart rate, breathing, and blood flow to approved medical devices. The goal is t…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand movement in healthy older adults. Researchers will compare a standard dose with a personalized dose tailored to each person's brain network. The goal is to understand how the brain…

This study tests a new radioactive tracer called [18F]-fluoromannitol in 10 healthy adults to see if it is safe and how it spreads in the body. The tracer is used with PET scans and may one day help doctors find infections in people with sickle cell disease, cancer, or joint impl…

This study creates and tests a training program for Care Food Specialists—workers who focus on food preparation and oral health in long-term care. About 150 healthy students in Taiwan will take the course and be assessed on their knowledge, attitudes, and behaviors before and aft…

This study looks at how a new drug called ulonivirine affects the way the body processes two common medications: atorvastatin (for cholesterol) and metformin (for diabetes). It involves 12 healthy adults who will take these drugs with and without ulonivirine to compare drug level…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This study is testing a new portable ultrasound device that measures bone density in the lower leg without using radiation. Researchers will compare its results to the standard X-ray method (DXA) in 350 healthy adults aged 21 to 55. The goal is to see if the ultrasound device can…

This study looks at whether blood flow in fat tissue differs between healthy younger adults (18-35) and older adults (65-80). Participants will have their fat tissue blood flow measured, provide two small fat samples from the belly, and drink a sugary drink. The goal is to unders…

This study looks at how much harmful chemicals from fire smoke get into firefighters' bodies. Researchers will collect urine and cheek cell samples from 60 firefighters before and after they fight a real structural fire. The goal is to measure changes in toxin levels to better un…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to identify biological markers that predict disease progression and help create personalized prevention and treatment plans. Part…

This study is an early test of a new drug called LY4066708 in 104 healthy adults. The main goal is to check for side effects and see how the drug moves through the body and brain. Participants will be followed for up to 24 weeks. This study does not aim to treat any disease.

This early-stage trial tests a new medicine called BI 3804379 in healthy adults aged 18 to 65. The goal is to check if it is safe and how the body processes it. Participants receive either the drug or a placebo as a shot under the skin, with doses given once or multiple times. Th…

This study looks at how growth hormone affects beta-cells, which make insulin and control blood sugar, in people with a family history of type 2 diabetes. Researchers will compare two groups of 30 obese adults—those with and without a family history of diabetes—to understand why …

This study looks at how the brain's memory and thinking areas change as we grow. Healthy teens (13-18) and adults (19-25) will do memory tasks during brain scans. Researchers hope to understand how we form and connect memories at different ages. There is no treatment or cure invo…

This study looks at how kidney blood flow changes during exercise in healthy young African American adults compared to White adults. Researchers want to understand why African Americans face higher rates of heart and kidney problems. Participants will do cycling, cold hand tests,…

This study looks at how different caffeinated drinks change your mood and body functions. Researchers will ask 75 healthy adults who already drink caffeine to try a test beverage and rate their feelings. The goal is to understand the effects of various caffeine drinks, not to tre…

This study tests whether taking the probiotic Lactobacillus rhamnosus GG (LGG) can prevent or reduce changes in gut bacteria caused by common acid reflux medications (PPIs). Researchers will compare stool samples from 30 healthy adults taking a PPI plus either LGG or a placebo. T…

This study tests a new imaging device called Electrical Impedance Tomography (EIT) that uses electrodes to create lung pictures without radiation. Researchers will compare EIT images to standard tests in children with chronic lung disease, neuromuscular disease, and healthy contr…

This early-stage study is testing a new drug, M5542, in healthy adults to see if it is safe and how the body processes it. About 49 participants will receive either a single dose of M5542 or a placebo by injection. The goal is to check for side effects and measure drug levels in …

This study looks at whether a person's natural thinking abilities can predict how well they learn to control a specific brain region using real-time fMRI. Forty healthy adults will practice regulating their brain activity while being scanned. The goal is to understand the link be…

This study looks at whether a single injection of the drug mirikizumab works as well as two injections in healthy people. Researchers will check safety and how the body handles the drug. About 450 healthy adults will take part, and the study lasts about 15 weeks per person.

This study collects small tissue samples from the abdominal lining of children and adults undergoing peritoneal dialysis. Researchers will study these samples to see how the lining changes over time and how different dialysis fluids affect it. The goal is to better understand the…

This study looks at how growth hormone, alone or combined with liraglutide, changes appetite signals, energy use, and blood sugar in healthy adults and people with growth hormone deficiency. Participants will receive each treatment for 21 days in random order. The goal is to unde…

This study is looking for 2000 healthy adults who have a close family member with a blood cancer called myeloma or related conditions. The goal is to find early warning signs by collecting blood samples and health data over time. Researchers hope this will lead to better ways to …

This study explores whether a brain-computer interface (BCI) can help people with motor disorders, like spinal cord injury or stroke, control assistive devices just by thinking about moving. Researchers will use electrical stimulation to train the brain and improve BCI accuracy. …

This study is gathering detailed eye scans from 180 people, including those with healthy eyes and those with retinal disease, glaucoma, or corneal conditions. The goal is to collect data that may help researchers better understand these eye diseases. Participants will have their …

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a combination of brain stimulation and EEG can measure brain complexity during sedation without…

This study from Stanford University looks at why different people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood sugar af…

This early-stage study tests the safety and tolerability of a new drug called DF5112 in 48 healthy adults aged 18 to 55. Participants receive either the drug or a placebo by injection and are monitored for about a week in a clinic, with follow-up visits up to 29 days. The goal is…

This study looks at how the brain processes optimistic and pessimistic reward signals in healthy people and those with Parkinson's disease. Researchers will use MRI scans while participants play a game to see if these signals are different in Parkinson's. The goal is to better un…

This study looks at how beta-cells (which make insulin) respond to growth hormone in women who had gestational diabetes. Researchers want to understand why some women develop high blood sugar during pregnancy. The study involves 30 women and uses tests to measure insulin producti…

This study uses a gentle electrical current (tDCS) on the scalp to see how it changes brain activity during thinking tasks. Researchers will measure attention, memory, and brain waves in 75 healthy adults and people with schizophrenia. The goal is to understand how different brai…

This study tests whether stimulating the vagus nerve with a small device placed behind the ear can affect insulin, C-peptide, and blood sugar levels. Researchers will measure these changes in 30 healthy adults aged 18-70. The goal is to learn how the vagus nerve controls insulin,…

This study is testing whether a mobile app called Flourish can improve well-being in college students. Researchers will randomly assign 2,500 students to either use the app, use it with a buddy, or continue with their usual resources. Over six weeks, participants will complete su…

This study looks at how a medicine called BI 3000202 behaves in the body of people with and without liver problems. About 44 adults aged 18 to 80 will take one tablet and have their blood tested over a month. The goal is to understand if liver impairment changes how the drug work…

This early-stage study is testing a new antibiotic called BAL2420 in healthy adults to see if it is safe and how the body processes it. The drug is being developed to fight serious bacterial infections that are hard to treat. About 136 volunteers will receive either the drug or a…

This early-stage study checks if a new experimental HIV medicine, MK-4646, changes the levels of standard HIV drugs (BIC/FTC/TAF and dolutegravir) in the blood. It involves 16 healthy adults and focuses on safety and how the body processes these drugs together. The results will h…

This study looks at how kidney blood flow changes during exercise and stress in healthy older African American adults compared to White adults. Researchers want to understand why African Americans face higher rates of heart and kidney problems. Participants will exercise lying do…

This study tests whether a temporary, non-invasive brain stimulation technique called TMS can change how healthy people respond to stress. About 55 participants will complete tasks during MRI scans, then receive both real and sham TMS on different days to compare effects. The goa…

This early-stage study is testing a new drug called LY3867070 in 196 healthy people to see if it is safe and how the body handles it. Participants take the drug by mouth and have blood tests to measure side effects and drug levels. The goal is to gather safety information, not to…

This study uses a special brain scan (PET) with a new tracer called [11C]APP311 to measure synaptic density—the connections between brain cells—in people with psychotic disorders or cannabis use disorder, compared to healthy volunteers. Researchers want to understand how these br…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers aged 50 and older, including healthy individuals. The goal is to better understand …

This study looks at whether intermittent fasting helps healthy adults lose body fat and improve their quality of life. Researchers will measure body fat percentage and visceral fat in 70 participants. The goal is to see if this eating pattern is a practical way to manage weight.

This early-stage study tests a new drug called LY4088044 in healthy adults to see if it is safe and how the body handles it. About 104 participants will receive the drug or a placebo, either as a shot under the skin or into a vein. The study lasts up to 92 weeks and focuses on si…

This study looks at how a new drug, MK-2828, interacts with two other medicines in healthy adults. In one part, participants take MK-2828 with itraconazole to see if levels change. In another part, they take MK-2828 multiple times before a single dose of midazolam. The goal is to…

This study tests whether healthy adults can learn to control a part of their brain linked to worry using real-time brain scans (fMRI). Sixty participants will receive either real or fake feedback as they try to reduce their anxiety about upcoming events. The goal is to see if thi…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just sitting still. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rat…

This study tests a new imaging tool that gives surgeons a live, 3D view inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or diabetic retinopathy, as well as healthy volunteers. The goal is to see if this t…

This study looks at whether using video calls (telemedicine) is a good way to educate and counsel people who are thinking about donating a kidney while they are still alive. Researchers want to see if this approach helps donors make better decisions and stay engaged in the proces…

This early-stage study tests an experimental drug called FZ008-145 in 190 healthy adults. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure pain tolerance using a cold water test. This study does not aim to treat any disease.

This study is testing a new minitablet version of the drug obefazimod in 44 healthy adults aged 18 to 55. The goal is to see how the body processes the minitablet compared to the current capsule and whether the minitablet tastes acceptable. This is an early-stage study that does …

This study follows 120 college freshmen for one year to see how vegan, vegetarian, or omnivore diets affect body weight, fat, and the bacteria in their gut and mouth. Participants provide saliva, stool, urine, and blood samples to track changes. The goal is to understand how diff…

This study tests a drink containing caprylic acid and omega-3 fatty acids to see if it helps muscles recover strength and reduce fatigue after intense exercise. Researchers will compare the drink to a placebo in 28 healthy, active young men. The goal is to learn whether these nut…

This study aims to understand what keeps the brain healthy as we age. It will follow up to 100,000 generally healthy adults over time, using online tests and surveys twice a year. Participants also get access to brain training and coaching. The goal is to learn how thinking, life…

This study follows 10,000 healthy adults for up to 20 years to find ways to detect cancer earlier. Participants give blood samples and answer questionnaires about lifestyle and medications. The goal is to identify changes in proteins, RNA, and DNA that signal cancer before sympto…

This study looks at how genetic differences affect the way healthy adults process the blood thinner warfarin. Researchers will give participants single doses of warfarin and other drugs to measure metabolism and compare it to their DNA. The goal is to better understand why warfar…

This study looks at how fast the body turns EPA (an omega-3 fat) into DHA (another omega-3) in healthy people. Researchers want to know if a person's sex and a specific gene affect this process. 64 healthy adults will take EPA supplements for 12 weeks and give blood samples. The …

This study looks at tongue strength and endurance in 300 healthy adults aged 18 and older. Using a special device, researchers will measure how well participants can push and lift their tongues. The goal is to understand normal tongue function and see how it relates to handgrip a…

This study watches how babies aged 6 to 24 months chew infant cereals with different textures. Researchers want to see if certain textures help develop chewing skills at different ages. About 153 healthy children will be video-recorded while eating. This is an observation study, …

This study looks at how small changes in your genes might affect the body's natural ability to control inflammation. Inflammation is a normal response to injury or illness, but when it goes unchecked, it can lead to diseases like rheumatoid arthritis and heart problems. Researche…

This study follows 800 pregnant people and their babies to see how the mother's sitting, physical activity, and sleep during pregnancy relate to the child's growth and heart health up to age 2. Researchers will track children's weight, waist size, and body fat. The goal is to lea…

This study tests two different injector pens that deliver the same medicine (Genotropin) under the skin. Researchers want to see if both pens work the same way in healthy adults aged 18 to 60. Participants will receive one dose with each pen and have blood samples taken to measur…

This study tests a new neck-strengthening device called TopSpin360 in 60 junior hockey players. Researchers want to see if using the device can increase neck strength and improve measures of brain function, like reaction time and brain wave activity. The goal is to learn more abo…

This study looks at how certain dietary supplements might change the immune system in healthy adults aged 18 to 45. Participants will take supplements or a placebo and give blood samples to measure immune proteins. The goal is to understand how these supplements affect the body's…

This study looks at how blind people use a white cane not just to move around, but to sense the world. Researchers will measure where people feel a touch on the cane and track brain activity with EEG and MRI. The goal is to understand how the cane becomes an extension of the body…

This study looks at adults who carry the gene for phenylketonuria (PKU) but don't have the disease. Researchers want to see if their brains handle phenylalanine differently and if it affects thinking or brain activity. Participants will take phenylalanine or a placebo, then have …

This study is testing a new method called RNA-Seq to find genetic causes of rare diseases in people who have not been diagnosed with standard genetic tests. Researchers will take skin samples from about 105 participants, including healthy volunteers and patients with known or sus…

This study looks at how different parts of the brain talk to each other in healthy adults. Researchers will use safe, non-invasive methods like magnetic stimulation and brain wave recordings to measure these connections. The goal is to better understand normal brain function, not…

This study looks at how cooling the thigh muscles changes the way nerves control them. Researchers will use special sensors to measure muscle signals in 24 healthy adults aged 18-35. The goal is to see if this method works well and to gather information for larger studies.

This study looks at people with a change in the GBA1 gene, which raises their risk for Parkinson's disease. Researchers will use simple, non-invasive tests to find early signs of Parkinson's that can appear up to 20 years before symptoms start. They will compare GBA1 carriers, pe…

This study looks at whether it's easier and more effective for healthy young adults to eat more potassium-rich foods instead of cutting back on salt to improve blood vessel health. 32 participants will get diet coaching on either a high-potassium or low-sodium diet. Researchers w…

This early-stage study is testing a new drug called BI 3776528 in healthy male volunteers to see if it is safe and how the body handles it. About 142 men aged 18 to 50 will receive either the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This study looks at how being overweight or obese changes blood pressure responses during different breathing exercises and aerobic tests. Researchers will measure blood pressure in 80 healthy adults at rest and during exercise. The goal is to better understand the link between o…

This study looks at whether brain cell connections in the memory center improve after people with cannabis use disorder stop using cannabis for at least 4 weeks. Researchers will compare these changes to healthy volunteers and test memory performance. The goal is to understand ho…

This study looks at how people who speak two languages (like Mandarin and English) or a spoken language and sign language control which language they use. Researchers will have participants do language tasks and measure accuracy and speed. The goal is to better understand languag…

This study translates and tests a questionnaire (CCSTQ) in Turkish to measure social and psychological factors that affect women's decisions to get screened for cervical cancer. About 215 Turkish women aged 21-65 who are sexually active will participate. The goal is to better und…

This study looks at how eating white potatoes at breakfast versus dinner changes blood sugar, hunger, and how many calories people eat later. Researchers want to see if potatoes can help control appetite better than other carbs. The study involves 30 healthy adults aged 18-65 wit…

This study tests how a new prostate cancer medicine, opevesostat, behaves in the body when taken with or without itraconazole, a common antifungal drug. Fourteen healthy adult men will receive both drugs in a fixed order, and researchers will measure drug levels in their blood. T…

This study looks at whether adding polyphenol-rich foods like beans and lentils to your daily diet can improve skin health. Researchers will study 50 women aged 45-65 over 12 weeks, measuring skin redness, moisture, and other factors. The goal is to see if these foods change the …

This study looks at how certain drinks change amino acid levels and appetite-related hormones in healthy adults aged 20 to 50. About 24 participants will try different beverages and have their blood tested after each drink. The goal is to understand how these drinks affect the bo…

This study looks at whether drinking beetroot juice (which contains nitrate) before sleep can change how well you sleep and how your blood vessels and nerves work at night. It involves 60 healthy adults in two age groups (18-35 and 65-80). The goal is to understand the body's nig…

This study aims to see if special force sensors can reliably measure how tight a carbon-fiber leg brace (ankle-foot orthosis) presses against the leg. Researchers will test 60 people: healthy volunteers, regular brace users without nerve damage, and regular brace users with perip…

This early-stage study is testing whether an inhaled drug called RB042 is safe and how the body processes it. About 90 healthy adults and healthy smokers will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the body, not to t…

This early-stage study is testing a new drug, SRK-439, in 76 healthy adults aged 18 to 55. The goal is to check if the drug is safe and how the body processes it. Participants will receive either one or multiple doses of the drug or a placebo. This study does not aim to treat any…

This study aims to measure how much energy healthy Chinese people use each day using a precise method called doubly labelled water. Researchers will collect data from 240 healthy children and adults across China, along with body measurements, blood tests, and activity levels. The…

This early-stage study tests the safety and how the body processes a single dose of IBI3032 in 32 healthy adults. Participants are randomly assigned to receive either the drug or a placebo. The goal is only to gather safety information, not to treat any disease.

This study checks if people can use a home kit to measure levels of urolithin A in their blood after taking Mitopure. About 250 healthy adults aged 18 to 80 will collect a small blood sample at home and send it in. The goal is to see if the kit works reliably and is easy to use.

This study looks at how much protein male cyclists aged 65 and older need after a cycling workout. Researchers will use a safe, non-invasive method to measure protein requirements. The goal is to improve dietary guidelines for active older adults. Eight healthy, experienced cycli…

This early-stage study tests an experimental oral drug called AS-S603, designed to break down protein clumps linked to Alzheimer's disease. The trial involves 88 healthy adults and elderly volunteers in Korea and Caucasian participants to check the drug's safety and how the body …

This early-stage study is testing a natural compound called fisetin in 60 healthy younger adults and older patients with multiple chronic conditions. Participants take fisetin or a placebo for two days and are followed for up to three months. The goal is to see if fisetin is safe…

This study explores whether using an AI chatbot (like ChatGPT) can improve the clinical reasoning skills of physical therapy students. Researchers will compare students who practice with the AI to those who follow the usual curriculum. The goal is to see if AI can help students b…

This early-stage study tests whether a new topical drug called JW0061 is safe for healthy adults. About 104 Korean and Caucasian volunteers will receive either the drug or a placebo cream. The goal is to check for side effects and how the body processes the drug, not to treat any…

This study looks at whether the phase of your menstrual cycle (follicular vs. luteal) changes how your body responds to sprint interval training. Researchers will measure endurance performance and muscle changes in 24 healthy women over 2 weeks. The goal is to understand if timin…

This study looks at how the drug LY3537031 is processed by the body in people with mild, moderate, or severe liver problems compared to healthy volunteers. About 32 adults will receive a single injection under the skin. The goal is to measure drug levels in the blood and check fo…

This study looks at a part of the brain called the reticulospinal system, which helps control movement like walking and reaching. Researchers will use loud sounds and motion tracking to measure how this system works in healthy people and in those with spinal cord injuries. The go…

This early-stage study tests a new medicine, PF-07985631, in healthy adults to see if it is safe and how the body handles it. The medicine is being developed for a kidney disease called IgA nephropathy. Participants receive either the drug or a placebo as an injection or IV, and …

This study looks at how one session of moderate or high-intensity exercise changes blood vessel function in healthy people and those with slightly high blood pressure (prehypertension). Researchers will measure artery stiffness and blood flow before and after exercise in 45 adult…

This study is testing whether a supplement called 7-keto lithocholic acid (7-KLCA) can change the types of bacteria living in the gut and improve health markers like blood sugar and cholesterol. Researchers will give the supplement to 40 healthy adults for 12 weeks and measure ch…

This study aims to collect normal measurements of tongue strength and movement in 300 healthy children aged 4 to 17. Researchers will use a simple device to measure tongue pressure and check for tongue-tie restrictions. The goal is to establish standard values that can help diagn…

This study looks at how the liver processes a new medicine called PF-07328948. Researchers want to see if people with different levels of liver function handle the drug differently. About 26 adults, some with liver problems and some healthy, will take a single tablet and stay at …

This study compares a new cuff-less wrist wearable (ViTrack) to standard blood pressure cuffs in 91 healthy adults with normal or high blood pressure. The goal is to see if the wrist device measures blood pressure accurately. Researchers will also check for skin irritation from t…

This study looks at how a 30-minute exercise session changes appetite and hunger-related hormones when healthy men are on a low-calorie diet. Researchers will compare three groups: one with no diet changes, one on a strict diet, and one on a strict diet plus exercise. The goal is…

This study tests whether brain stimulation can help healthy adults quickly reach a deep meditative state, normally achieved only after years of training. Twelve participants will wear a special cap, receive brain stimulation, and perform meditation tasks while researchers measure…

This early-stage study is testing a new drug, NSHO-101, in 24 healthy adults. The main goal is to see how the body handles the drug and whether it is safe. Participants must be in good health and willing to follow study rules. This research does not aim to treat any disease.

This early-stage study is testing a new drug called BI 3031185 in 60 healthy men aged 18 to 50. The goal is to see if the drug is safe and how the body processes it when taken by mouth multiple times. Participants will be randomly assigned to receive either the drug or a placebo,…

This study looks at whether a nasal spray with oxytocin (the 'love hormone') can help people better control a specific brain region during a brain-scanning task. Healthy adults will receive either oxytocin or a placebo and then practice using their thoughts to change brain activi…

This study looks at whether a diet low in methionine (an amino acid) can change the bacteria in your gut and lower inflammation. Forty healthy adults will follow the diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure gut ba…

This study enrolls 330 healthy adults to see if two different autoinjectors deliver the same amount of the drug tulisokibart into the body. Researchers will measure drug levels in the blood and watch for any side effects. The goal is to make sure both devices work the same way be…

This study tests whether a single dose of oxytocin nasal spray changes how healthy adults react to threats in a virtual predator-prey game. Researchers measure escape success, brain activity, and anxiety levels. The goal is to understand how oxytocin influences defensive behavior…

This study looks at how short (10 minutes) and longer (30 minutes) exercise sessions affect hunger, appetite-related hormones, and how much men eat after a meal. Fourteen healthy men will have their blood tested and appetite tracked. The goal is to understand when and how exercis…

This study translates and tests health questionnaires about pain, movement, and daily life for Albanian-speaking people. About 300 adults with muscle or joint pain, back pain, or other musculoskeletal issues will fill out the translated forms. The goal is to make sure these tools…

This study aims to learn how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 volunteers, including healthy individuals and those at higher risk for type 2 diabetes. Partici…

This study looks at how doing the "Xuong tan lac than" exercise for 12 weeks changes joint flexibility and muscle endurance in healthy adults. About 34 volunteers will practice the exercise daily and get tested every few weeks. The goal is to learn if this traditional exercise ca…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children aged 9 to 14. Researchers will test kids' attention, memory, and mood after they consume different dairy products. The goal is to understand how dairy might help the brain throu…

This early-stage study tests the safety and tolerability of BT01001 eye drops in 32 healthy adults aged 18 to 50. Participants receive either the active eye drop or a placebo, and researchers monitor for side effects. The goal is to gather safety information, not to treat any dis…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or healthy vision will pa…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study collects blood samples from 400 healthy adults aged 18 to 65 to learn how platelets work and cause inflammation and blood clots in diseases. Participants give blood at the Cleveland Clinic. No treatment or medication is given. The goal is to build a biorepository for f…

This study looks at how the drug mirdametinib is absorbed and removed from the body in people with moderate or severe liver problems compared to those with healthy livers. It involves 32 adults aged 18 to 80. The goal is to gather information, not to treat any condition.

This early-stage study in 39 healthy adults checks if a new heart failure medicine called MK-2828 affects how the body handles two common drugs: rosuvastatin and furosemide. The goal is to gather safety and interaction data, not to treat any disease. Participants must be in good …

This study looks at how social media addiction and compulsive exercise are connected in healthy university students aged 18-24. Researchers will use surveys to measure social media use and exercise patterns. The goal is to understand the relationship between these behaviors, not …

This study aims to learn more about the natural bacteria (microbiome) living in the vagina and mouth of healthy women. Researchers will collect swab samples from 520 participants visiting gynecology or dermatology clinics in Finland. No treatments or medications are involved—only…

This study aims to develop a simple decision tool for physical therapists to know when they should check vital signs like heart rate and blood pressure during outpatient therapy. Researchers will survey 100 experienced physical therapists over three rounds to agree on which signs…

This study looks at whether listening to music while running changes the forces your feet apply to the treadmill and your overall running form. Researchers will measure things like impact and how your body moves. The goal is to understand if music can affect injury risk or perfor…

This study looks at whether taking a daily carotenoid supplement (like those found in carrots) can improve eye health in healthy adults aged 18-75. Over 3 months, researchers will measure changes in the retina's protective pigment, blood flow, and vision sharpness. Participants w…

This study looks at how the brain works during tasks involving emotions, attention, and memory in both healthy volunteers and people with depression. Researchers use brain scans and gentle brain stimulation to measure activity. The goal is to gather information that could lead to…

This study will measure how fast 360 healthy young people (ages 6-20) need to walk to get health benefits. Researchers will track steps per minute and heart rate to create simple, personalized walking guidelines. The goal is to replace vague advice like 'walk briskly' with clear …

This study looks at how taking sialic acid by mouth changes the types and amounts of bacteria in the gut, especially harmful ones like E. coli. It involves 42 healthy adults aged 18 to 75. No treatment or cure is being tested—the goal is simply to learn more about how sialic acid…

This study looks at how physical fitness changes the bacteria in your gut. Researchers will compare gut microbes from inactive people to elite athletes to see if exercise boosts gut health. The goal is to understand which bacteria are linked to better fitness and create a sample …

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study aims to improve how we see inflammation in the brains of people with Alzheimer's disease. Current scans can't tell which brain cells are inflamed, but this new method uses two different tracers and math to separately track microglia and astrocytes. Researchers will sca…

This study aims to find the best way to record electrical signals from the stomach using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings and locations in healthy adults to see what tri…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy. Researchers will test 30 adults—some with nerve problems from chemo and some healthy—using a special device called ToeScale. Participants will also answer quest…