Healthy

This phase 2 trial tests V540A, an experimental vaccine designed to protect against 9 HPV types already covered by Gardasil 9, plus additional unique types. About 525 healthy women aged 16-26 will receive either V540A or Gardasil 9 to compare safety and immune response. The goal …

This early-stage trial tests a new vaccine called V540D, designed to protect against more types of human papillomavirus (HPV) than the current Gardasil 9 vaccine. The study involves 72 healthy adults and will compare the safety and immune response of V540D to Gardasil 9. The main…

This study tests a new vaccine called H107e/CAF®10b to prevent tuberculosis (TB). It is the first time this vaccine is given to people. The trial involves 140 healthy adults aged 18 to 45 and checks for side effects and how well the vaccine triggers the immune system. The goal is…

This study is testing whether two different versions of the drug survodutide are equally effective in the body. It involves 80 healthy overweight or obese adults who will receive both formulations in a crossover design. The goal is to see if the new formulation matches the origin…

This study tests whether a mobile app called Geego Kids can improve motor skills in first-grade children. Over 12 weeks, teachers lead short movement breaks in class, and children do weekly homework activities with family support. The goal is to see if the app helps kids become m…

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

This study compares two ways of delivering meals to homebound adults aged 66 and older who are on Meals on Wheels waiting lists. One group gets a hot meal delivered daily, five days a week; the other receives a box of 10 frozen meals every two weeks. Researchers track how many da…

This early-stage study tests MK-4082, a new weight loss pill, in 120 healthy overweight or obese adults. Unlike current injectable weight loss drugs, this medicine is taken as a pill. The main goal is to check safety and how the body processes different doses, not yet to measure …

This phase 2 trial tests a nasal spray called Optate in 24 adults with mild COVID-19. The spray aims to lower virus levels in the nose and improve symptoms like congestion. Participants receive either Optate or a placebo, and researchers measure changes in virus levels and sympto…

This study tests whether using a person's own extracted tooth (processed into a graft) can better preserve the shape of the socket after tooth removal compared to letting it heal naturally. Twenty healthy adults will be randomly assigned to receive either the tooth graft or no gr…

This early-stage study tests a new drug called LY3537031 in overweight, obese, and healthy volunteers. The main goal is to check safety and how the body handles the drug. Researchers will also measure weight changes and blood sugar levels. The study involves about 300 people and …

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This study tests a new ultrasound technique called super-resolution ultrasound imaging (SRUI) to see tiny blood vessels in the kidneys. Researchers will give an FDA-approved contrast agent called Definity to healthy volunteers and people with chronic kidney disease (CKD) who need…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study compares two types of urine samples—expressed prostatic secretion (EPS) and post-massage urine (PMU)—to see which one better predicts whether a prostate biopsy will find cancer. About 243 men scheduled for a prostate biopsy will provide both samples, and researchers wi…

This study aimed to test a device called LabClasp that estimates blood lactate levels without a needle, using fluid from the skin. It was designed for healthy people during exercise and for ICU patients. However, the trial was withdrawn before any volunteers were enrolled, so no …

This study tests a simple, at-home smell test to see if it can detect COVID-19 infection and track how smell recovers over time. About 1000 adults, including those with known smell loss and healthy volunteers, will use smell cards to rate odor intensity, identification, and discr…

Researchers at Mayo Clinic are testing whether measuring brain stiffness with a special MRI scan (magnetic resonance elastography) can serve as a new biomarker for Alzheimer's disease. The study will enroll 450 adults, including healthy volunteers, people with mild cognitive impa…

This study tests whether a program called FIT FIRST, which involves intense exercise three times a week for 18 weeks, can improve bone health in Danish adolescents. Researchers will compare bone density and blood markers between students in schools that use the program and those …

This study tested whether an educational program for parents and healthcare providers could increase HPV vaccination rates among girls aged 9 to 17 in Ohio Appalachia. Over 600 parents and providers took part. The goal was to see if teaching about the vaccine leads to more girls …

This trial tests whether a six-week aquatic program based on the 'back school' approach can reduce pain and disability in adults with non-specific low back pain. Participants are randomly assigned to either attend the program (twice weekly, 45-minute sessions) or to a control gro…

This study looks at whether astaxanthin, a natural supplement, can reduce fatigue and improve performance in badminton players. Fourteen healthy athletes will take either astaxanthin or a placebo for four weeks. Researchers will measure endurance, grip strength, and jump power to…

This study tests a communication intervention designed to help oncology providers—like doctors, nurses, and social workers—discuss treatment costs with cancer patients. The goal is to reduce financial toxicity, the stress and hardship caused by medical expenses. Participants will…

This study tests whether whole-body aerobic training (like brisk walking) or isolated leg training (with weights) better improves symptoms and quality of life in people with pulmonary arterial hypertension (PAH). About 45 participants with PAH will be assigned to one of the two e…

This study looks at whether taking beta-alanine, a common supplement, can help wrestlers perform better and feel less muscle fatigue during two days of simulated matches. Sixteen healthy wrestlers aged 12 to 25 will take the supplement and then do wrestling drills to measure thei…

This early-phase study tests whether taking CoQ10 supplements for 8 weeks can ease fatigue in people with Crohn's disease. About 60 adults with stable Crohn's will receive one of two doses, and researchers will track changes in fatigue and quality of life. The goal is to see if a…

This study from UCLA is testing whether daily breathing exercises using a special device (called inspiratory muscle training) can improve mental and physical well-being. 150 healthy adults will be split into three groups: one using high-resistance breathing, one using low-resista…

This study planned to test whether taking a prebiotic supplement for six weeks could reduce morning cortisol levels in healthy young adults aged 18-25 with mild to moderate stress. Participants would have provided saliva, stool, urine, and blood samples. However, the trial was wi…

This study is testing a 5-week program of fun activities—like laughter therapy, reminiscing about the past, and brain games—for seniors living in care facilities. Researchers want to see if it helps improve emotional well-being, reduce anxiety, and calm agitated behavior. The pro…

This study tests whether vibrating the tendons, combined with robotic arm training, can improve arm and hand movement in people who had a stroke at least 6 months ago. 40 participants will receive the therapy, and researchers will measure changes in motor function and body awaren…

This study tests whether an 8-week nutritional supplement can reduce actinic purpura (age-related bruising) in 30 healthy adults aged 55 and older. Participants will be randomly assigned to receive either the supplement or vitamin C alone. Researchers will track changes in bruise…

This study is testing whether a daily supplement made from baker's yeast can improve digestion and reduce gut symptoms in healthy adults aged 50 to 99. Participants take 15 grams of the supplement each day and report any changes in how their stomach feels. The goal is to see if t…

This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. Participants wear special earbuds that send gentle vibrations to stimulate the vagus nerve. Researchers will also use brain sca…

This study tests whether applying menthol solution to the cheek can release vapors that stimulate cold sensors on the eye, triggering natural tear production. Thirty healthy adults will receive either menthol or a placebo on one cheek, and researchers will measure if tears overfl…

This study looks at how your gut and brain work together to control appetite. Researchers will place a temporary balloon in the stomach and give participants tasteless and tasty meals while scanning their brains with MRI. The goal is to understand the signals that make us feel fu…

This early-stage study will test how eltrekibart, an experimental drug, is absorbed when injected under the skin compared to when given through a vein. Sixty healthy adults will receive a single dose and be monitored for about 17 weeks. The goal is to gather safety and absorption…

This early-stage study is testing an experimental oral drug called LY3867070 in 196 healthy volunteers. The main goal is to see if the drug is safe and what side effects it might cause. Researchers will also measure how the body processes the drug. This is a first step to see if …

This trial is testing how well different versions of the experimental drug enlicitide are absorbed by the body. Healthy adults will take the drug in various tablet forms, both on an empty stomach and after a high-fat meal, to see which formulation leads to the highest drug levels…

This early-stage trial studies how different tablet forms of MK-1403, a drug designed for heart and blood vessel disease, are absorbed and tolerated in healthy adults. Researchers will measure the drug levels in the blood and monitor for any side effects. The results will help de…

Researchers at Ohio State University are studying how background noise affects speech understanding in adults with normal hearing. About 200 native English speakers aged 18 to 70 will listen to filtered speech in different frequency ranges while noise is added at various levels. …

This study explores how the brain changes old movement memories, like a bad golf swing or piano technique. Researchers will use EEG to measure brain activity and apply gentle electrical stimulation to see if they can help people learn a new movement. The goal is to understand the…

This trial investigates whether pramipexole tablets produced at two different manufacturing sites are processed identically by the body. Healthy volunteers aged 18 to 55 take both versions in a crossover design, and researchers compare drug levels in the blood. The goal is to con…

This study looks at flavanols, natural compounds found in foods like apples, berries, and tea. Researchers will collect urine samples from 200 healthy adults to measure flavanol metabolites and estimate how much flavanols people typically consume. The goal is to better understand…

This study tests a 12-week sports program called Girls PLAY designed to help rural girls aged 8-10 become more physically active. The program includes in-person sessions and take-home activities led by Boys & Girls Club staff. Researchers want to see if the program is feasible an…

This study looks at how the immune system and gut bacteria develop in 60 healthy Filipino infants who are breastfed from birth to 12 months old. Researchers will collect blood and stool samples to measure immune markers and gut health. An optional follow-up of about 2 years may p…

This study is checking if taking a supplement called palmitoylethanolamide (PEA) every day for a year is safe for healthy adults. About 200 volunteers aged 18 and older will take either PEA or a placebo pill. Researchers will track side effects, vital signs, and blood tests over …

This study will test whether using essential oils (by smelling, applying to skin, or swallowing capsules) can improve immune health in healthy adults aged 18 to 45. Forty participants will use either the oils or a placebo for 30 days. Researchers will measure changes in blood, sa…

Researchers are testing an experimental oral drug called LY3526318 in healthy Japanese men to see if it is safe and well tolerated. The study also measures how the drug affects the kidneys and liver by checking how the body handles other medications like metformin and simvastatin…

This early-phase study tests how the experimental drug MK-8527 behaves in the body when taken with food or with other medicines like probenecid and itraconazole. It involves 44 healthy adults and measures drug levels in the blood. The goal is to gather safety and drug-interaction…

This study tests a special education program for first-time mothers that combines hypnosis techniques with breastfeeding information. The goal is to see if it helps mothers feel more confident and motivated to breastfeed. About 80 healthy pregnant women will take part, and resear…

This study looks at whether the body stores salt in the skin and muscles, and if that stored salt is linked to higher blood pressure. Researchers will compare healthy people with those who have hypertension, using MRI scans to measure salt content. They will also check if people …

Researchers are testing how well the body absorbs vitamin D, calcium, potassium, and magnesium from almond, soy, and oat milks compared with cow's milk. Healthy adults will avoid dairy and vitamin D-fortified foods for three weeks, then drink one type of milk daily for a week. Bl…

This study tests a prototype device that measures electrolytes like sodium and potassium in urine. Healthy adults aged 18 to 60 will provide urine samples after eating different standardized meals (such as high-fruit or nut diets) and during their normal daily life. The goal is t…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just resting. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rate, str…

This study looks at how the kidneys turn a substance called glycolate into oxalate, which can form kidney stones. Fifteen healthy adults will eat a special low-oxalate diet and receive a harmless tracer to track this process. The goal is to better understand how oxalate is made i…

This early-phase study tests a new radioactive tracer called [18F]-fluoromannitol in 10 healthy adults. The tracer is designed to light up infections on PET scans. Researchers will check its safety and how it spreads through the body. If all goes well, it may later be tested in p…

This study looks at how cooling the thigh muscle changes the way nerves control it. Researchers will use special sensors to measure muscle signals in 24 healthy adults aged 18-35. The goal is to see if this method works well, so they can plan larger studies later. No treatment is…

This trial asks healthy adults to donate small blood samples—via finger prick or vein—to help test a new blood analyser. The device's results will be compared against standard laboratory equipment to see if it can accurately count blood cells. Participants won't receive their blo…

This early-stage trial investigates the safety and tolerability of a new drug called BI 3031185 in healthy Japanese men, given as single or multiple doses. It also examines whether multiple doses of BI 3031185 affect how the body processes a common oral contraceptive (YAZ®) in he…

This study investigates whether performing the same visual search task repeatedly in a block changes how people search compared to when tasks are randomly mixed. Healthy adults with normal color vision will complete four search tasks where the target stays the same but distractor…

This study looks at how eating a high-fat or low-fat meal changes the way the body absorbs the drug tersolisib. Healthy volunteers receive two doses of tersolisib—one on an empty stomach and one with a meal—and have blood tests to measure drug levels. The goal is to understand wh…

This early-stage study is testing a new drug called BI 3031185 in 100 healthy adults to see if it is safe and how the body handles it. Participants will take multiple doses of the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This trial asks whether a standardized 12-minute osteopathic lymphatic massage can enhance immune readiness in healthy adults. Thirty participants will each receive the massage, a sham light touch, and a 15-minute exercise session in random order across three visits. Blood draws …

This early-phase trial is testing a new drug called BI 3821001 in 72 healthy men to see if it is safe and how the body processes it. Participants receive either a single rising dose of the drug or a placebo. The study focuses on side effects and drug levels in the blood, not on t…

This study is testing new ways to perform MRI scans to see if they can produce better images than current methods. About 662 healthy volunteers and patients will undergo MRI scans using both standard and experimental techniques. The goal is to find out whether these new methods i…

This study explores whether using disinfectants containing quaternary ammonium compounds (QACs) affects health compared to alcohol-based products. Healthy university students will use these products for a month, then switch after a break, while researchers measure exposure throug…

This study investigates whether mental activity—called covert consciousness—can occur during sedation with dexmedetomidine or ketamine. Healthy volunteers will undergo fMRI scans while performing mental imagery tasks (like imagining playing tennis) at different sedation depths. T…

This study is testing a new, non-invasive way to measure the body's sympathetic nervous system — the part that controls the 'fight-or-flight' response. Researchers will record nerve activity from the skin of about 1,000 people, including healthy volunteers and those with conditio…

This early-stage study will give 30 healthy volunteers single doses of two experimental drugs, MK-7262 and enlicitide, to see how they affect each other's levels in the blood. The goal is purely to understand how the drugs interact, not to treat any disease. Results will guide fu…

This pilot study looks at how well young children absorb iron from special nutrient supplements. Researchers will give 30 children in Kenya (ages 1-3) a supplement with a harmless iron tracer, then measure iron levels in their blood two weeks later. Half the children are healthy,…

This study investigates whether people of different racial and ethnic backgrounds process calcium and sodium differently when eating high versus low amounts of salt. Healthy adults who are Black, White, Hispanic, or Asian will follow controlled diets with either typical Western s…

This study looks at two shoulder tests—the modified closed kinetic chain upper extremity stability test and the posterior shoulder endurance test—in healthy young adults aged 18 to 25. Researchers want to see how these tests relate to each other and whether they work as well in s…

This study investigates whether specific breathing patterns and a gentle nerve stimulation technique can influence the brain's glymphatic system — its natural waste-clearing process. Healthy adults aged 18 to 70 will undergo MRI scans while performing breathing tasks and receivin…

This early-stage study tests a new medicine called PF-07999415 in healthy adults aged 18 to 65. Participants receive a single shot and stay in a clinic for 2 weeks for monitoring. The goal is to check safety and how the body processes the drug, not to treat any disease. Results w…

This study examines protein differences in the tears of nearsighted children who use special overnight contact lenses (orthokeratology) to slow down worsening vision. Researchers want to understand why some children get better control of their myopia than others. The study involv…

This study looks at how eating a high-fat or low-fat meal changes the way the body absorbs a drug called FWD1802. It involves 18 healthy Chinese adults who will take the drug once under different meal conditions. The goal is to understand food effects, not to treat any disease.

This study aims to see if healthy older African American adults have a larger drop in kidney blood flow during exercise compared to White adults. Twelve participants will do cycling, a cold hand test, and mental math while researchers measure kidney blood flow. The goal is to und…

This study looks at how ketamine changes brain activity in 35 healthy volunteers. Participants will have two brain scans after receiving different doses of ketamine. The goal is to understand the brain processes linked to psychosis, not to treat any disease. The study is currentl…

This study tests a method to measure diaphragm muscle function using rapid magnetic stimulation of the phrenic nerves in the neck. Researchers will check how repeatable the measurements are and how adding weights to the chest affects breathing. Sixteen healthy, non-smoking adults…

This study investigates how natural variations in brain anatomy affect the brain's ability to regulate blood flow. Healthy adults undergo an MRI while performing two breathing tests—one with increased carbon dioxide and one with low oxygen—to measure changes in brain blood flow. …

This early-stage study is testing a single dose of remternetug in 24 healthy Chinese adults to see if it is safe and how the body processes it. Participants will have blood tests and be monitored for side effects over about 25 weeks. The study does not aim to treat any disease, b…

This study tests whether a simple breathing test can reliably measure blood flow in the lining of the windpipe and large airways. Healthy adults breathe a harmless gas called dimethyl ether, and the amount they breathe out reveals how much blood is flowing through the airway tiss…

This study in 24 healthy adults tests whether using a micropatch before applying metronidazole gel or cream improves how much drug gets into the bloodstream. Participants receive both formulations at different times, and researchers measure drug levels and skin changes. The goal …

This early-stage study is testing a new drug, LTG-001, in 204 healthy adults aged 18 to 55. The goal is to check how safe the drug is, how well people tolerate it, and how it moves through the body. Participants will receive either the drug or a placebo by mouth or through a vein…

This study looks at how the drug tulisokibart enters the body when given through two different autoinjectors. About 330 healthy adults will receive a single injection, and researchers will measure drug levels in the blood and check for side effects. The goal is to see if both dev…

This study looked at how well 3D-printed custom insoles work for healthy adults and those with flat feet. About 100 people wore the insoles for 3 weeks, at least 3 hours each day. Researchers measured foot pressure, walking patterns, and how satisfied people were with the insoles…

This study looks at how two different versions of gecacitinib hydrochloride tablets are absorbed and processed by the body in healthy adults. About 64 participants aged 18 to 45 will take a single dose of each version under fasting conditions. The goal is to compare the drug leve…

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This early-stage trial tests the safety and metabolism of an experimental oral drug called DF-003 in 96 healthy volunteers. The drug aims to reduce inflammation and kidney scarring, potentially offering a new treatment for chronic kidney disease. Participants receive either a sin…

This study tests a new wearable patch called the Medicsen Smartpatch, which uses ultrasound to push medicine through the skin without needles. Thirty healthy volunteers will receive a drug both by patch and by standard injection, then compare safety, comfort, and how well the dru…

This study tests a new drug called LY3981314 in healthy people to see if it is safe and how the body handles it. About 76 participants will receive a single injection under the skin and be monitored for up to 25 weeks. The goal is to gather safety information, not to treat any di…

This study tests whether a ketone drink can increase how much sugar muscles take up after a meal. Researchers will give 14 healthy adults either a ketone supplement or a placebo before a mixed meal, then measure sugar balance in the forearm. The goal is to better understand how k…

This study was designed to see if a single group lesson about how pain works could help older adults understand pain better and change their beliefs about it. The researchers planned to enroll people aged 65 and older who could speak and read Spanish. However, the study was withd…

This Mayo Clinic study looks at how a single session of exercise affects fat tissue in healthy adults of different ages and weights. Researchers will take small fat samples from the belly before, right after, and three hours after a 30-minute bike workout. They want to see how ex…

This study looks at whether taking melatonin can change how your heart and blood vessels respond to a cold stress test, both at rest and during exercise. Researchers will measure things like blood pressure, heart rate, and oxygen levels in muscles and the brain. The study involve…

This study looks for biological markers in the blood and urine of athletes that can tell if someone has been at high altitude or used a drug called erythropoietin (EPO). Forty healthy runners will spend time at altitude and also receive either EPO or a placebo. The goal is to imp…

This was an early-stage study designed to check the safety and tolerability of a new drug called LEO 142397 in healthy people. The study was planned in two parts: one group would get a single dose, and another would take it daily for two weeks. However, the study was withdrawn be…

This study looks at how visible light (and some UVA1) affects the skin of 14 healthy adults with different skin tones. Researchers will measure redness and tanning right after exposure and check skin samples for longer-term changes. The goal is to make light testing more accurate…

This study looks at whether weekly cooking classes can help adults eat better, waste less food, and feel less stressed. About 180 adults will attend in-person classes with cooking and tasting activities. Researchers will measure food waste and other changes over 10 weeks.

This early-stage study tests the safety of a new drug called ALXN2030 in 48 healthy adults. Participants receive a single injection of the drug or a placebo, and researchers monitor for side effects, how the drug moves through the body, and its effect on the immune system. The go…

This pilot study will use special PET scans to measure opioid receptor binding in the brain, spinal cord, and other organs in up to 60 adults, including healthy volunteers and people with opioid use disorder. The goal is to better understand how opioids affect the whole body, not…

This study aims to improve how breath samples are collected and analyzed to find better ways to measure lung health. Researchers will collect breath from up to 1,000 people, including healthy volunteers and those with respiratory or inflammatory conditions. No treatments or medic…

This study looks at how natural compounds in strawberries and raspberries (polyphenols) affect inflammation and gut bacteria in overweight adults with mild inflammation. About 105 participants will eat berry products or a control diet for 4 weeks. Researchers will measure blood a…

This study aims to develop better lab tests to diagnose and monitor two rare kidney diseases: atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). Researchers will analyze blood, cells, and kidney tissue from 180 patients and healthy volunteers to find markers t…

This early-stage trial tests the safety of a single dose of SPY003-207 in 59 healthy adults. Participants are randomly assigned to receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to gather initial…

This study looks at how a single session of short, mild low-oxygen breathing (acute intermittent hypoxia) changes hand strength in healthy adults. Researchers want to understand how this technique affects the brain and spinal cord. The results will help design future therapies fo…

This study aims to improve magnetic resonance spectroscopy (MRS), a type of brain scan that measures up to 18 different brain chemicals. Researchers are testing new methods at higher magnetic fields (3 to 7 Tesla) to get clearer and more detailed images. The study involves 30 hea…

This early-stage study tests the safety and how the body processes three different forms of the drug idazoxan in 150 healthy adults. Participants take a single dose and are monitored for side effects and drug levels in the blood. The goal is to gather safety data, not to treat an…

This study tests whether measuring sweat gland activity on the skin can detect pain. Thirty-seven healthy volunteers will dip their hand in ice-cold water while wearing a skin sensor. Some will also do a stressful color-naming task. The goal is to see if the sensor can tell mild,…

This study is looking for healthy adults to serve as a comparison group for a larger registry of people with adult congenital heart disease. Researchers will measure how well the heart and lungs work during exercise. The goal is to better understand the differences between health…

This pilot study from Tufts University aims to understand how combining touch and sight in virtual reality (VR) can create a feeling of owning a virtual hand. Researchers will have 30 right-handed adults perform tasks while seeing their virtual hand touched and feeling the same p…

This study looks at how a common asthma inhaler (fluticasone propionate) changes gene activity and cell types in the lungs of 30 healthy adults. Participants will take the inhaler for 4 weeks and have a bronchoscopy (a camera down the airway) to collect samples. The goal is to un…

This study looks at how different types of cannabis oil (high or low CBD-to-THC ratio) affect stress and self-control in healthy adults aged 19-35 who use cannabis occasionally. Participants will undergo brain scans and stress tests to measure changes in brain activity, stress ho…

This early-phase study at Vanderbilt University Medical Center is looking at how certain nerve signals (called sympathetic vasoconstriction) might interfere with insulin's ability to widen blood vessels and take up sugar. The researchers will give a drug called phentolamine into …

This study looks at how age, sex, and eating a fatty meal affect the body's internal daily rhythms, known as the chronobiome. Researchers will compare blood samples from 48 healthy adults, half aged 18-30 and half aged 55-75, to see differences in proteins. The goal is to better …

This study looks at how fish oil and red wine change certain markers in the blood and urine that are linked to inflammation and cell stress. Forty healthy adults will take high doses of fish oil or a placebo, along with red wine or alcohol, to see how these substances affect the …

This study looks at how HIV might disrupt the body's internal clock, which could lead to health problems like diabetes and heart disease. Researchers will track gene activity at different times of day in 80 people with and without HIV. The goal is to understand why these issues a…

This study compares two ways of training the brain to better sense internal body signals, like heartbeat. Sixty healthy adults will use real-time brain scans to learn either a simple or a more complex strategy. Researchers want to see which method better activates a key brain reg…

This study looks at how amino acids (building blocks of protein) affect the release of glucagon and insulin compared to sugar alone. Researchers will test 30 adults who are healthy, have type 2 diabetes, or are obese. The goal is to better understand these hormone responses, not …

This study tests a new type of PET scanner that can take pictures of most of the body at once, instead of just a small section. Researchers want to see how well this scanner works in healthy adults and people with memory problems. The goal is to gather information to improve futu…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study looks at how a personalized, calorie-restricted diet affects metabolism in overweight or obese Chinese adults. Researchers will measure how the body uses energy before and after a 12-week diet plan. The goal is to understand why people respond differently to the same d…

This study tests whether shining a UV flashlight on the skin changes nitric oxide levels, as part of developing a new, noninvasive way to measure certain molecules in the body. Researchers will recruit 150 healthy adults and children, expose their ear lobes, hands, or foreheads t…

This study uses MRI scans to measure blood flow in the gut after drinking sugar water in people with postprandial hypotension (a drop in blood pressure after meals) and healthy volunteers. Researchers will test whether blocking a hormone called GIP changes blood flow patterns. Th…

This study looks at whether the natural compounds in olive oil, called polyphenols, can improve heart health markers like cholesterol, inflammation, and gene activity. Researchers will give two types of olive oil to healthy, overweight, and obese adults aged 20-45. The goal is to…

This study aims to figure out the best schedule for follow-up visits for people who wear contact lenses. Researchers will track 300 healthy adults aged 18 to 40 who are new or experienced lens wearers. The goal is to see if fewer visits can still keep eyes safe and comfortable.

This study tests a new electric bandage that creates small amounts of hydrogen peroxide to help heal wounds and prevent infections. Researchers at Mayo Clinic are putting the bandage on the healthy skin of 40 volunteers to see if it causes any discomfort, redness, swelling, or al…

This study looks at how working night shifts changes the bacteria in your gut and how your body handles sugar. Researchers will compare 12 healthy men who work night shifts with those who work during the day. They will track gut bacteria and blood sugar levels at different times …

This study looks at how anti-inflammatory drugs change fat molecules in human blood. Researchers will test blood samples from 30 healthy adults in a lab to measure many different fats. The goal is to find new effects or side effects of these drugs, which could lead to better trea…

This study looks at how air pollution and the body's internal clock (circadian rhythm) interact to worsen asthma, especially at night. Researchers will measure tiny molecules called microRNAs in the sputum of 20 adults with and without asthma over 48 hours. The goal is to underst…

This study compares the 24-hour rhythm of blood fats in people with night eating syndrome versus healthy volunteers. Researchers aim to see if unusual eating habits disrupt these rhythms. Only 12 participants are enrolled, and the study is currently suspended.

This study looks at whether manual therapy (like massage or joint mobilization) can improve physical and sports performance in healthy, active adults. Researchers will measure strength, flexibility, and other body responses before and after a therapy session. The goal is to see i…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the lymph system versus blood. In MS participants, fluid is also collected before and after treatment with the drug ofatumumab. The goal is to understand how the im…

This study will collect brain scans from over 10,000 healthy people in China to create standard brain charts. These charts will show what a normal brain looks like at different ages. Doctors can then compare a patient's brain scan to these charts to help diagnose diseases like mu…

This early-stage study tests whether a common antibiotic (ceftriaxone) can be given as a rectal suppository instead of an injection. 37 healthy Thai adults will try both forms to compare how well the drug is absorbed and any side effects. The goal is to find a needle-free option …

This observational study examines walking fatigue in people with multiple sclerosis (MS) and healthy volunteers. Researchers will measure gait patterns and brain activity using wearable sensors and a brain imaging technique called fNIRS during walking tests. The goal is to unders…

This study looks at how insulin in the brain changes blood flow and nerve signals in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, as well as nerve activity. The goal is to understand basic body functions, not to treat any disease.

This study looks at how exercising in the morning versus the evening, and on an empty versus full stomach, changes the way your body burns energy and fat. Researchers will measure these effects in 20 adults with overweight or obesity who are already active. The goal is to better …

This study looks at how a mother's weight during pregnancy might affect her baby's brain development. Researchers will follow 260 pregnant women (some with normal weight, some with obesity) and scan their babies' brains with MRI at 2 weeks, 1 year, and 2 years old. They will also…

This study looks at how the sugars, fats, and proteins in breast milk change from mother to mother and over time. Researchers want to see how these differences, along with the mother's diet and health, affect the development of the baby's gut bacteria. About 395 pregnant women wh…

This study was designed to see how well compounds from a standardized ashwagandha supplement are absorbed in healthy adults aged 65 and older. Researchers planned to measure levels of active ingredients in the blood after taking the supplement. The study was withdrawn before enro…

This study involves 24 healthy, non-smoking adults who will give blood samples through a standard blood draw and finger sticks (some done at home and mailed in). Researchers want to improve how they measure fatty acids and energy use in blood cells. The goal is to make remote blo…

This study looks at whether giving a probiotic called B. infantis to healthy, breastfed infants for 21 days can increase the amount of good bacteria in their stool. Researchers will measure bacteria levels and track any stomach issues or other health changes. The study involves 1…

This study looks at whether offering parenting support to all families with very young children in Flint, Michigan can help kids' development and mental health after the water crisis. About 486 families with babies up to 3 months old took part. Researchers measured parenting stre…

This study measures muscle strength, balance, and flexibility in 45 ballet dancers to find out what makes them more likely to hurt their ankles. Researchers compare dancers who had ankle injuries in the past year with those who didn't, plus a group of non-dancers. The goal is to …

This study aimed to see if insulin, given as a nasal spray, reaches the fluid around the brain and spinal cord. Researchers planned to give a single dose of low or high insulin (or a placebo) to 18 healthy adults aged 36–55, then collect samples via spinal tap at several time poi…

This study looks at whether taking creatine for a week can help trained breath-hold divers perform better on a stationary bike while holding their breath. 26 healthy divers will take either creatine or a placebo, then do a breath-hold cycling test. Researchers will measure how fa…

This study aimed to see if tartrazine, a common food dye, could make skin temporarily transparent in healthy adults. Researchers planned to apply different doses to the back, stomach, and forearm and take photos every 5 minutes. However, the study was withdrawn before any partici…

This study looks at how the cerebellum, a part of the brain, helps us learn and adjust our speech. Researchers will use brain scans, magnetic stimulation, and speaking tasks in people with cerebellar ataxia (a movement disorder) and healthy volunteers. The goal is to better under…

This study tests a new, tethered capsule that takes detailed images of the upper small intestine (duodenum) as you swallow it. Researchers want to see if the procedure is comfortable and works well in 108 people, including healthy volunteers and those with celiac disease. The goa…

This study looks at how different breakfasts affect thinking and brain activity in 9-10 year old children. Researchers will give kids either a high protein or high carbohydrate shake and then test their memory, attention, and brain function using tests and brain scans. The goal i…

This study looks at 100 healthy 8-year-olds who were fed breast milk, milk-based formula, or soy-based formula during their first year. Researchers use brain scans and language tests to see if the type of infant diet affects brain function and language skills later in childhood.

This study looks at whether a mother's obesity during pregnancy can affect her baby's brain development. Researchers will use MRI scans on newborns at 2 weeks old to check for any differences. The study includes 13 healthy mothers with either a normal weight or obesity, but witho…

This study was withdrawn before enrolling any participants. It planned to use brain scans (SPECT) to see if two rehabilitation techniques—postural reconstruction and muscle stretching—change brain activity during a simple ankle movement in healthy adults aged 18 to 35. The goal w…

This phase 1 trial in 14 healthy adults tests whether grapefruit juice changes how the body absorbs and processes the blood thinner edoxaban. Participants take edoxaban alone and then with grapefruit juice to compare drug levels and clotting measures. The goal is to see if grapef…

This study tests whether a brain stimulation technique, called theta-burst stimulation, can help predict if depression will come back in people who are currently in remission. Researchers will measure brain activity changes during stimulation using a special imaging cap. The goal…

This study tests a wearable device that delivers mild electrical stimulation to the wrist (called transcutaneous electrical acustimulation, or TEA) in healthy adults. Participants wear the device for three days and use it for 60 minutes daily. The goal is to see if the device is …

This study looks at whether the way your gut absorbs sugar can predict how much weight you lose after bariatric surgery. Researchers will take small tissue samples from the intestine before and one year after surgery in 52 obese patients. They will check for changes in sugar abso…

This study was designed to see if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could temporarily alter how healthy people make rational decisions. Participants would have undergone two sessions of either real or sham stimul…

This study investigates why cranberry juice prevents urinary tract infections (UTIs) in some women but not others. Researchers will have 160 healthy women who are prone to UTIs drink cranberry juice or a placebo (apple juice) daily for three weeks. They will measure how well the …