HEALTHY

This study tests a new quadrivalent seasonal influenza vaccine in healthy infants aged 6 months to under 3 years. The goal is to see if the vaccine is safe and produces a strong immune response. Around 245 infants will receive either the new vaccine or an existing one, and their …

This study tests a new vaccine called H107e/CAF®10b to prevent tuberculosis (TB). It is the first time this vaccine is given to people, so the main goal is to check its safety and how well it triggers the immune system. The trial involves 140 healthy adults aged 18 to 45. The vac…

This early-stage study tests a new vaccine called V540D in 72 healthy adults. The vaccine is designed to protect against the same nine HPV types as the current GARDASIL®9 vaccine, plus additional HPV types that can cause cancer. The main goal is to check if the vaccine is safe an…

This study tests a new 'accordian' gum graft method against the standard free gingival graft for people with less than 2 mm of attached gum tissue. The goal is to see which technique better increases gum width and reduces discomfort. 36 adults with missing teeth and thin gums wil…

This study tests whether using a person's own extracted tooth as a bone graft can better preserve the socket (the hole left after tooth removal) compared to letting it heal naturally. Twenty healthy adults will be randomly assigned to either receive the tooth graft or no graft. R…

This early-stage study tests the safety of an experimental drug called LY3537031 in 302 people who are overweight, obese, or healthy. Researchers will monitor side effects, measure how the drug moves through the body, and track weight changes over about 49 weeks. The goal is to s…

This study aims to create detailed brain charts for the Chinese population by collecting MRI scans from over 10,000 healthy people of different ages. These charts will show what a normal brain looks like at each age, helping doctors detect diseases like multiple sclerosis, Alzhei…

This study checks if a new device can screen for type 2 diabetes by measuring sugar levels in fingernails instead of using a blood test. About 100 adults with and without diabetes will have their fingernails scanned and compare results to a standard finger-prick blood test. The g…

This study tests a new ultrasound method that uses a contrast agent to create detailed images of blood vessels in the kidneys. Researchers want to see if this can help diagnose chronic kidney disease more accurately. The study includes both healthy volunteers and people with kidn…

This study tests whether an educational program for parents and healthcare providers can increase HPV vaccination rates among girls aged 9 to 17 in Ohio Appalachia. About 624 parents and providers are involved. The goal is to see if learning more about the vaccine leads to more g…

This study looks at whether cranberry juice can prevent urinary tract infections (UTIs) in healthy women who are prone to them. Researchers will measure how well participants' urine blocks bacteria after drinking cranberry juice. The goal is to find out who might benefit most fro…

This study tests whether a device that gently stimulates a nerve in the ear (called TaVNS) can reduce anxiety and distress in healthcare workers. About 90 participants will use the device and have their brain activity measured with MRI scans. The goal is to see if this simple, no…

This study looks at whether different types of exercise training can help people with Pulmonary Arterial Hypertension (PAH) feel better and have a better quality of life. Researchers are comparing whole-body aerobic training with leg-only weight training in 45 participants. The g…

This study tests whether a yeast cell wall extract (mannooligosaccharides and beta-glucans) can improve gut symptoms and gut bacteria in healthy adults aged 50-99. About 40 participants will rate their digestive symptoms daily. The goal is to see if this supplement can ease commo…

This pilot study looks at whether an 8-week nutritional supplement can reduce actinic purpura (age-related bruising) in older adults. Thirty healthy volunteers aged 55 and older will take either the supplement or vitamin C alone. Researchers will check skin changes using photos a…

This study tests whether Aquamin, a natural mineral from red algae, can reduce bad breath. Fifteen adults with self-reported halitosis took the supplement for 90 days. Researchers measured improvement using a questionnaire about how bad breath affects daily life.

This study aimed to see if taking a prebiotic supplement for six weeks could reduce morning cortisol levels in healthy young adults aged 18-25 with mild to moderate stress. Participants would have provided saliva, stool, urine, and blood samples. However, the study was withdrawn …

This study looked at whether taking magnesium citrate (400 mg daily for 90 days) could improve sleep quality and thinking skills in healthy Saudi adults who had poor sleep. Researchers compared 41 adults who took the supplement to a group that took nothing. The goal was to see if…

This study looks at whether a fermented papaya supplement can help older adults (ages 70-80) make fewer mistakes while driving. Participants take three doses of the supplement in one day and then complete a driving simulator test. The goal is to see if the supplement improves att…

This study tests whether CoQ10, a natural supplement, can reduce fatigue in people with Crohn's disease. About 60 participants will take one of two doses of CoQ10 for 8 weeks, and healthy volunteers will take it for 2 weeks. The goal is to see if fatigue improves enough to justif…

This study tests whether menthol vapor applied near the eye can trigger tear production in 30 healthy adults. Dry eyes happen when not enough tears are made, causing soreness. If menthol safely stimulates tears, it may lead to new options beyond eye drops.

This study tests whether a special social and activity program helps seniors living in nursing homes feel happier, less anxious, and behave less agitatedly. About 200 older adults (over 62) will take part. Researchers will compare those in the program to those receiving usual car…

This study tests whether vibrating the tendons, combined with robotic arm training, can improve arm and hand function in people who had a stroke at least 6 months ago. 40 participants will receive the therapy, and researchers will measure changes in movement and sensation. The go…

This study looks at how amino acids change the release of glucagon and insulin compared to glucose alone. Researchers will test 30 people who are healthy, have type 2 diabetes, or are obese. The goal is to better understand hormone regulation in these conditions.

This study looks at how being overweight during pregnancy might affect a baby's brain development. Researchers will compare brain scans and developmental tests of babies born to normal-weight and obese mothers. The goal is to understand if inflammation from obesity plays a role. …

This study aimed to see if insulin given as a nasal spray reaches the brain and spinal fluid in healthy adults aged 36 to 55. Participants would have received one dose of low-dose insulin, high-dose insulin, or a placebo, then provided fluid samples over 40 minutes. The study was…

This early-stage study is testing a single dose of the drug remternetug in 24 healthy Chinese adults to see if it is safe and how the body processes it. Participants receive the drug as an injection under the skin and are monitored for about 25 weeks. The study does not aim to tr…

This study tests a new electric bandage that creates hydrogen peroxide to help clean wounds and prevent infection. Researchers at Mayo Clinic are putting the bandage on the healthy skin of 40 volunteers to see if it causes any discomfort, redness, swelling, or allergic reactions.…

This study examines tear proteins in 20 children who used orthokeratology (ortho-k) lenses for at least 6 months. Researchers want to find out why some kids have better myopia control than others. By comparing protein levels between good and poor responders, they hope to improve …

This study looks at whether HIV disrupts the body's internal clock (circadian rhythm), which could lead to health problems like diabetes and heart disease. Researchers will measure gene activity at different times of day in 80 people with and without HIV. The goal is to understan…

This early-stage study looks at how a single dose of an experimental medicine (PF-08653944) is absorbed when injected into the abdomen, thigh, or upper arm. It involves 54 overweight or obese adults who are otherwise healthy. The goal is to understand safety and how the body proc…

This study looks at how ketamine affects brain signals in 120 healthy adults. Participants receive either a study drug or placebo for 4 days and undergo brain scans before and after. The goal is to better understand brain changes linked to psychosis, not to treat any disease.

This study looks at whether taking melatonin can change how your heart and blood vessels respond to a cold stress test, both at rest and while exercising. Researchers will measure blood pressure, heart rate, and oxygen levels in muscles and the brain. The study involves 100 healt…

This study aims to improve MRI imaging by testing new software and hardware techniques in healthy adults aged 18 and older. Researchers will compare standard images with new research images to see if the new methods provide clearer or more useful information. Participants undergo…

This study compares two types of urine samples—expressed prostatic secretion (EPS) and post massage urine (PMU)—to see which one more accurately predicts whether a prostate biopsy will find cancer. About 243 men scheduled for a prostate biopsy will provide both samples. The goal …

This study looks at whether giving a probiotic (Bifidobacterium longum subsp. infantis) to healthy, breastfed infants for 21 days can increase the amount of helpful bacteria in their stool. About 120 babies born by C-section or vaginal delivery are participating. Researchers will…

This study uses a special radioactive tracer and PET/MRI scans to track white blood cells entering the brain in people with fibromyalgia, chronic fatigue syndrome, or multiple sclerosis, as well as healthy volunteers. The goal is to better understand brain inflammation in these c…

This early-stage study is testing a single dose of a new drug called ALXN2030 in 48 healthy adults. The main goal is to see if it is safe and what side effects it may cause. Researchers will also measure how the drug behaves in the body and how the immune system responds. This is…

This study tests an experimental drug called LY3981314 in healthy volunteers to see if it is safe and how the body handles it. About 76 participants will receive a single injection under the skin and be monitored for up to 25 weeks. This is an early-stage trial, so there is no di…

This study looks at how much flavanols (natural compounds found in foods like apples, berries, and tea) people consume in their daily diet. Researchers will collect urine samples from 200 healthy adults aged 25-75 to measure specific breakdown products. The goal is to better unde…

This early-stage study tests the safety and how the body processes three different forms of an experimental drug called idazoxan in 150 healthy adults. Participants take a single dose and are monitored for side effects and drug levels in the blood. The goal is to gather safety da…

This study looks at how visible light and UVA1 affect skin redness and tanning in people with different skin types. Researchers will test 14 healthy volunteers to better understand these reactions and improve how light sensitivity is measured. The goal is to gather knowledge, not…

This study tests how well two different forms of the drug aramchol are absorbed by the body. Sixteen healthy adults aged 18 to 45 will take both a granule suspension and a tablet, then have their blood levels measured. The goal is to see which form delivers the drug more effectiv…

This study aimed to check if a device called LabClasp can accurately estimate blood lactate levels without needing a blood draw. It planned to include healthy adults doing exercise and ICU patients. However, the study was withdrawn before any participants were enrolled.

This study looks at whether certain brain wave patterns (called gamma oscillations) can predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity before and during ketamine treatment in 100 adults. The goal is …

This study looks at whether giving extra parenting support to families with very young children in Flint, Michigan can help kids' development and mental health after the water crisis. About 486 families with babies up to 3 months old took part. Researchers measured parenting stre…

This study looks at whether mothers who have obesity during pregnancy may have babies with differences in brain development. Researchers will use MRI scans of the baby's brain at about 2 weeks old to check for any effects. The study includes healthy pregnant women with either a n…

This study enrolls 66 healthy adults to provide comparison data for the Mayo Clinic Adult Congenital Heart Disease Registry. Participants must have no heart disease, normal blood pressure, and a BMI of 30 or less. Researchers will measure oxygen use and heart function to better u…

This study looks at whether daily breathing exercises (called inspiratory muscle training) can improve mental and physical well-being in healthy adults. About 150 participants will be split into three groups: one does stronger breathing exercises, one does very light exercises, a…

This study aims to improve magnetic resonance spectroscopy (MRS), a technique that measures brain chemicals without surgery. Researchers will test new methods using stronger MRI magnets (3 to 7 Tesla) in 30 healthy adults. The goal is to get clearer and more detailed images of br…

This study looks at how low doses of ketamine change brain activity in 35 healthy adults. Participants will have two brain scans at least a week apart while receiving ketamine. The goal is to find the smallest dose that still produces a measurable brain response, helping research…

This early-stage study tests whether Nezavist is safe for people and how the body processes it. Thirty-two healthy adults will receive either the drug or a placebo. The results will guide future research on using Nezavist to help people drink less alcohol.

This study aims to find better ways to collect and analyze breath samples from 1,000 people, including those with and without lung disease. The goal is to improve methods for future research, not to test a treatment. Participants will simply provide breath samples for analysis.

This study looks for better ways to measure fats and energy use in blood samples. Twenty-four healthy, non-smoking adults will give blood through a standard vein draw and finger pricks, both at the clinic and at home using a mail-in kit. The goal is to see if at-home finger-prick…

This study looks at how a ketone drink changes the way muscles take up sugar after a meal. Researchers will measure sugar levels in the forearm of 14 healthy adults aged 18-40. The goal is to learn more about how ketones help control blood sugar, which could lead to new treatment…

This study looks at whether two types of olive oil can change risk factors for heart disease, such as cholesterol levels, inflammation, and gene activity. Researchers will test blood samples from 44 healthy adults of different body weights after they consume the oils. The goal is…

This study was designed to test the safety and tolerability of a new drug called LEO 142397 in healthy volunteers. It was planned in two parts: a single dose and daily doses for 14 days. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study looks at how well the body absorbs omega-3 fatty acids (EPA and DHA) from two different algae sources compared to fish oil and a placebo. Healthy adults aged 18-64 take 600 mg of omega-3 daily for 6 weeks. The goal is to see if algae-based omega-3 is as good as fish oi…

This study aimed to see if people aged 65 and older could understand the science behind pain and change their beliefs about it. Participants would have completed questionnaires about pain knowledge and attitudes. However, the study was withdrawn before any participants were enrol…

This study tests a new, pill-sized camera on a string (OFDI capsule) that people swallow while awake to take detailed pictures of the upper small intestine. Researchers want to see if it's comfortable and works well in 108 volunteers, including healthy adults and people with celi…

This study looks at how natural compounds in strawberries and raspberries (polyphenols) interact with gut bacteria to reduce inflammation. Overweight adults with mild inflammation will eat berry-based foods or a control diet for 4 weeks. Researchers will measure changes in blood …

This study looks at how exercise changes fat (adipose) tissue and how those changes might improve health as we age or if we have obesity. Researchers will measure immune cells and inflammatory markers in fat tissue samples from 56 healthy adults before and after exercise. The goa…

This study was designed to see if two different physical therapy techniques—postural reconstruction and muscle stretching—could change brain activity in healthy young adults. Researchers planned to use brain scans to compare the effects. However, the study was withdrawn before an…

This study looks at how breastfeeding influences the immune system and gut bacteria in Filipino infants. Researchers will track 60 healthy babies from birth to 12 months, with an optional 2-year follow-up. They will test blood and stool samples to understand immune markers and gu…

This study looks at the best ways to teach cooking and food skills to adults. Researchers want to see if cooking classes can help lower stress, improve diet, and reduce food waste. About 180 adults aged 18 and older who can attend in-person classes will take part. Participants wi…

This study aims to build a large online registry of adults interested in brain research. Participants complete questionnaires and cognitive tests from home to help scientists understand brain aging and diseases like Alzheimer's. Anyone over 18 can join by visiting the study websi…

This pilot study uses special PET scans to see where and how opioids attach to receptors in the brain and body. Researchers will study up to 60 adults, including some with opioid use disorder and some healthy volunteers. The goal is to better understand opioid binding, not to tes…

This study looks at whether a non-invasive device that temporarily changes brain activity (called rTMS) can affect how healthy adults make decisions. It involves two 2-3 hour visits and uses questionnaires to measure impulsiveness. The study is not a treatment—it aims to gather k…

This study looks at whether manual therapy (like massage or joint mobilization) can improve physical performance in healthy people who exercise regularly. Sixty participants will do sports tests before and after therapy to measure changes in strength, flexibility, and body respon…

This study tests if two different ways of giving survodutide—a pre-filled syringe and a pre-filled pen—deliver the drug into the body in the same way. About 56 healthy or overweight adults will receive a single dose of each method and have their blood levels measured. The goal is…

This study looks at whether taking creatine for a week helps trained breath-hold divers cycle longer and harder while holding their breath. Twenty-six healthy divers will either get creatine or a placebo, then do a breath-hold cycling test. The goal is to see if creatine improves…

This study looks at whether a 12-week after-school sports program can help girls ages 8-10 in rural California become more physically active. About 30 girls will take part in the program, which introduces different sports and builds physical skills. Researchers will check if the …

This study looks at how a new medicine called LY3537031 enters the blood and leaves the body when given as a shot under the skin in different spots or into a vein. It involves 46 healthy adults. The goal is to understand the drug's behavior and check for safety, not to treat any …

This study looks at 100 healthy 8-year-olds to see if being fed breast milk, milk-based formula, or soy-based formula during their first year affects their language skills and brain function. Researchers use brain scans and language tests to compare the three groups. The goal is …

This study looks at how the body processes a drug called LY4064809. Eight healthy adults will receive the drug by mouth and by IV to see what percentage enters the bloodstream. Participants stay at the research center for 14 days, and the study lasts about 21 days. There is no tr…

This study looks at whether shining a special UV flashlight—often used to find pet urine or saliva—on human skin changes levels of nitric oxide, a gas important for health. Researchers will measure nitric oxide from the ear, hand, or forehead of 150 healthy volunteers before and …

This study looks at how short bursts of low oxygen (acute intermittent hypoxia) affect hand strength in healthy adults. Researchers want to understand how this treatment changes the spinal cord and nerves. The study involves 32 healthy people aged 18-70 who will have their grip s…

This study looks at how what a child eats in the morning influences their thinking and brain function. Researchers will test 151 children aged 9-10, including those with obesity, using psychological assessments and brain scans. The goal is to understand the link between morning n…

This study looks at how the kidneys process a substance called glycolate into oxalate, which can form kidney stones. Fifteen healthy adults follow a special low-oxalate diet and receive a safe, labeled form of glycolate to track its conversion. The goal is to better understand no…

This study looks at why ballet dancers get ankle injuries by measuring their muscle strength, balance, and flexibility. Researchers will compare injured and uninjured dancers, plus non-dancers, to find key risk factors. The goal is to create better rehab programs and help dancers…

This study looks at why cranberry juice helps prevent urinary tract infections (UTIs) in some women but not others. Researchers think the answer lies in the gut microbiome—the bacteria living in our intestines. 160 healthy women who are prone to UTIs will drink cranberry juice or…

This study looks at how blood moves in the gut after eating in people with postprandial hypotension (a drop in blood pressure after meals). Researchers will use MRI scans and a hormone-blocking drug to understand the role of a hormone called GIP. The goal is to learn more about w…

This study looks at how aspirin works when given as a shot compared to a pill in 40 healthy adults aged 18 to 55. Researchers will measure safety, drug levels in the blood, and effects on blood clotting. The goal is to understand the differences between the two forms of aspirin.

This study looks at whether common balance tests can help doctors figure out the exact reason someone feels unsteady or dizzy. Researchers will test 330 people, including healthy volunteers and those with conditions like stroke, vision problems, inner ear issues, or spine problem…

This study looks at whether giving parents special recipes and advice can improve the diets of healthy toddlers aged 2 to 3.5 years. About 80 children will either get personalized meal plans with meat and vegetables or standard healthy eating tips. Researchers will measure change…

This early-stage study tests a single dose of the experimental drug SPY003-207 in 59 healthy adults to check its safety and how the body processes it. Participants are randomly assigned to receive either the drug or a placebo, and neither they nor the researchers know who gets wh…

This study looks at how a personalized, calorie-restricted diet affects metabolism in overweight or obese Chinese adults. Researchers will measure how the body uses energy and burns fat and carbs before and after a 12-week diet plan. The goal is to understand why people respond d…

This early-stage study tested whether a common antibiotic (ceftriaxone) given as a rectal suppository or tablet works as well as the standard intravenous (IV) injection. 37 healthy Thai adults received all three forms in random order, with a washout period between doses. The goal…

This study was designed to test how easy and safe a new watch-like device (Watch-TEA) is to use. It was planned for healthy adults to wear the device for a few days and report any skin irritation or discomfort. The goal was to gather information that could help develop the device…

This study looks at how different tablet versions of the drug enlicitide are absorbed and processed in the bodies of 30 healthy adults. Researchers will measure drug levels in the blood over time and monitor for any side effects. The goal is to find out which tablet form works be…

This study aims to find biological markers in urine and blood that can detect altitude exposure and use of recombinant human erythropoietin (rHuEPO), a substance sometimes misused in sports. Forty healthy, non-competing athletes will spend time at high altitude and at sea level, …

This observational study looks at why about 43% of people with multiple sclerosis (MS) feel their walking gets worse the longer they walk. Researchers will measure changes in walking patterns and brain activity in 70 MS patients and 30 healthy volunteers during short and long wal…

This early-stage study is testing a new drug called LH-001 in 56 healthy adults aged 18 to 60. The main goal is to see if the drug is safe and what side effects it might cause. Researchers will also measure how the drug moves through the body. This study is currently on hold.

This study looks at how fish oil and red wine change certain markers in the blood and urine that are linked to inflammation and cell stress. It involves 40 healthy adults who take different combinations of fish oil, red wine, or alcohol. The goal is to better understand how these…

This study looks at whether a combination of brain stimulation and brain imaging can predict if depression will return in people who are currently in remission. Researchers will use a mild magnetic pulse to the forehead and measure brain activity changes. The goal is to find a wa…

This study in 24 healthy adults compares how much metronidazole enters the blood when a gel or cream is applied to skin treated with a micropatch. The goal is to see if the micropatch changes drug absorption. Participants will have blood samples and skin color measurements taken …

This study looks at how the brain changes old movement habits, like a bad golf swing or piano technique. Researchers will use EEG to measure brain activity and apply gentle electrical stimulation to see if it helps people learn a new movement. The study involves 30 healthy adults…

This study looks at how a common heart medication, diltiazem, changes the amount of the experimental cancer drug nemtabrutinib in the body. About 26 healthy adults will take nemtabrutinib with and without diltiazem, and researchers will measure drug levels in their blood. The goa…

This early-stage study is testing a new drug, LY4005130, in 118 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, given as a shot under the skin or into a vein. The study tracks side effects and drug levels in th…

This study involves 60 healthy adults to see if a single tablet containing two medicines (enlicitide and rosuvastatin) works the same as taking them separately. Researchers measure drug levels in the blood over time. The goal is to understand absorption, not to treat any disease.

This study aims to figure out the best schedule for follow-up visits for people who wear contact lenses. Researchers will track 300 healthy adults, both new and experienced lens wearers, to see how many visits are needed to keep eyes safe and healthy. The goal is to create clear …

This early-stage study tests a single injection of letrozole (a hormone-blocking drug) in 90 healthy post-menopausal women. The goal is to see how the body processes the drug and if it is safe. No treatment is being given for any disease.

This study looks at two ways of training the brain to focus on internal body signals, like heartbeat. Sixty healthy adults will use real-time brain scans to try to control a key brain region involved in emotions and body awareness. The goal is to see which strategy works better, …

This study observes how the sugars, fats, and proteins in breast milk differ among mothers and change over time. It also looks at how these components, along with the mother's diet and health, affect the development of the baby's gut bacteria. About 395 pregnant women who plan to…

This study was designed to test whether tartrazine, a common food dye, could temporarily make skin transparent in healthy volunteers. Researchers planned to apply different doses to the skin and take pictures to see if it improved visibility of structures beneath the skin. The st…

This study looks at how exercising in the morning versus the evening, and on an empty stomach versus after eating, changes the way your body burns energy. Researchers will measure energy use and fat burning in 20 healthy adults with overweight or obesity during treadmill workouts…

This study looks at how children absorb iron from special nutrient supplements. Researchers will give 30 children (aged 1-3) in Kenya a supplement with a safe iron tracer, then measure how much iron gets into their blood. The goal is to learn more about iron absorption in healthy…

This early-stage study tests a new medicine called PF-07999415 in 32 healthy adults aged 18 to 65. Participants receive a single shot and stay in a clinic for 2 weeks to monitor for side effects. The goal is to check safety and how the body processes the drug, not to treat any di…

This study involves 1,000 adults who use special smell cards at home to measure their sense of smell. The goal is to see if these tests can reliably detect smell changes caused by COVID-19 and track recovery over time. Participants include people with known smell loss, those with…

This study tests a new version of the medicine survodutide, which is being developed for obesity and liver conditions. About 100 healthy adults aged 18 to 65 with a BMI between 27 and 40 will receive weekly injections of either the current or new formulation for 28 weeks. Researc…

This study looks at how the cerebellum, a part of the brain, helps us learn and adjust our speech over time and in the moment. Researchers will study people with cerebellar ataxia (a condition that affects coordination) and healthy volunteers. They will use speaking tasks, brain …

This early-stage study tests a new medicine called PF-08049820, being developed for moderate to severe eczema (atopic dermatitis). The study involves 71 healthy adults aged 18 to 65 to check the drug's safety, how the body processes it, and whether food affects its absorption. Pa…

This study looks at how insulin in the brain changes blood flow and nerve activity in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, and nerve signals to muscles. No treatment is given—this is an observation-only study to better understand h…

This study looks at how certain fats in the blood change over 24 hours in people with night eating syndrome compared to healthy volunteers. Researchers want to see if unusual eating patterns disrupt the natural rhythm of these fats. The study involves 12 participants and is curre…

This early-stage study is testing two different versions of MK-1167, an experimental medicine being developed for Alzheimer's disease, in 16 healthy adults. The main goal is to see how the drug moves through the body and to check its safety before testing it in people with Alzhei…

This study looks at how the tightening of blood vessels (called sympathetic vasoconstriction) may reduce the ability of insulin to widen blood vessels and take up sugar. Researchers will test this by temporarily blocking the tightening signal in the forearm of 36 adults with obes…

This study looks at how air pollution and the body's internal clock (circadian rhythm) interact in people with asthma. Researchers will measure tiny molecules called microRNAs in sputum samples from 20 adults with and without asthma, collected at different times over 48 hours. Th…

This study tests whether measuring tiny electrical signals from the skin can detect how much pain a person feels. Thirty-seven healthy volunteers will have their hand in cold water while their skin activity is recorded. The goal is to develop an algorithm that spots pain-related …

This early-phase study is testing a new radioactive tracer called [18F]FTP in 29 healthy adults. The goal is to see how the tracer moves through the body and brain using PET/CT scans, and to check its safety. This research helps develop better tools for brain imaging, but does no…

This study was designed to see how well compounds from a standardized ashwagandha supplement are absorbed in healthy adults aged 65 and older. Researchers planned to measure levels of active ingredients in the blood after taking the supplement. However, the study was withdrawn be…

This study looks at how anti-inflammatory drugs change fats in the blood. Healthy adults donate blood, which is then treated with drugs in a lab. Researchers measure many different fats to find new effects or side effects of these drugs. The goal is to better understand how these…

This study aimed to see if people can feel a virtual hand as their own when it is controlled by their real hand. Researchers planned to test 30 right-handed adults with simple and complex hand movements in virtual reality. The study was withdrawn before any participants were enro…

This study looks at how grapefruit juice changes the way the blood thinner edoxaban works in the body. It involves 14 healthy adults aged 19 to 50. Researchers will measure drug levels and blood clotting to see if grapefruit juice has an effect. The results will help understand p…

This study looks at whether a digital platform called mindline.sg can help adults in Singapore better understand mental health, feel better emotionally, and improve their quality of life. About 300 participants with mild to moderate mental health symptoms will either use the plat…

This study looks at how your body's daily rhythms (chronobiome) change with age and sex. Researchers will analyze blood samples from 48 healthy adults—young (18-30) and older (55-75)—to find differences in proteins. No treatment is given; the goal is simply to learn more about ho…

This study looks at how different types of cannabis oil (high or low CBD-to-THC ratio) affect stress and self-control in healthy adults aged 19-35 who use cannabis occasionally. Participants will undergo brain scans and provide saliva samples to measure stress markers. The goal i…

This study aims to develop better lab tests to diagnose and monitor two rare kidney diseases: aHUS and C3G. Researchers will analyze blood, cells, and kidney tissue from 180 patients and healthy volunteers. The goal is to find markers that help doctors choose the right treatment …

This study tests a research PET scanner that can take pictures of most of the body at once, unlike current machines that only scan small sections. About 268 healthy adults and people with cognitive issues will be scanned to see how well the machine works. The goal is to gather in…

This study uses a special MRI technique to measure brain stiffness in people with Alzheimer's, mild cognitive impairment, and healthy volunteers. Researchers want to see if brain stiffness can serve as a new marker to detect Alzheimer's disease. The study involves 450 participant…

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the blood versus deep in the lymphatic system. In MS participants, researchers will also look at how these cells change after treatment with the approved drug ofatu…

This study aims to see if how the small intestine absorbs sugar can predict how much weight people lose after bariatric surgery. Researchers will compare obese patients scheduled for surgery with lean individuals. They will also check for gene changes that might affect sugar abso…

This study looks at how working night shifts changes the bacteria in your gut, which might increase the risk of certain diseases. Researchers will compare the gut bacteria of 12 healthy male night shift workers and day workers over time. The goal is to understand how sleep and wo…

This study looks at how a common inhaled steroid (fluticasone propionate) changes gene activity and cell types in the lungs of 30 healthy adults. Participants will take the steroid for 4 weeks and undergo a bronchoscopy to collect airway samples. The goal is to understand the dru…