Earbuds that zap nerves could ease healthcare worker burnout
NCT ID NCT05132881
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. Participants wear special earbuds that send gentle vibrations to stimulate the vagus nerve. Researchers will also use brain scans to see how the device affects brain activity. The goal is to find a non-drug way to help stressed healthcare professionals feel better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS) earbuds
- What this could lead to
- If it works, this could point toward a drug-free way to ease anxiety and burnout in healthcare workers.
- What could go wrong
- This is a small, early-stage study with no placebo control, so results may not be conclusive or apply to the general public.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2021
- Expected to finish
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Nov 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy male and female persons who work in health care and health care workers (all races and ethnicity) \>21 years of age 2. All subjects must have a smartphone device that can be used in conjunction the Neuvana 2.0 3. Drug-free from medications that may affect brain physiology such that the imaging results will not be useful as determined by the PI. 4. Able to understand and provide signed informed consent. Available and willing to be followed -up according to study protocol 5. Female subjects of childbearing potential have a negative pregnancy test 6. Subjects have no significant medical neurological or psychological disorders 7. Stable health problems that should have no substantial effect on cerebral blood flow will be allowed (i.e. controlled hypertension, medication controlled diabetes). 8. Current medications and supplements will be reviewed by the Principal Investigator or a designated physician or health practitioner. Subjects may take medications or supplements but should be on a stable dose regimen for at least 3 months. For those receiving TaVNS program, it is preferable that subjects remain on that dose for the full TaVNS program period (with the exception of having an adverse reaction in which the medication or supplement must be stopped). 9. PI will evaluate each subject for any potential medical issues that might be a problem and will consult with the subject's primary care provider if there are any questions about it. Additional Inclusion Criteria for the TaVNS program for Distressed Workers 1. Distress scored as at least a 6 or greater on the SUDS distress level from 1 to 10. 2. Distressing recollection(s) that causes physiological reactivity (i.e., increased heart rate and/or increased skin conductance level - SCL), as described above. Healthy control with no distress or other exclusion criteria Exclusion Criteria: 1. Any medical conditions that may interfere with cerebral blood flow as determined by the PI. 2. Currently taking medication that might affect cerebral blood flow as per the P.I. (i.e. antidepressants, antipsychotics, anxiolytics, benzodiazepines, sedatives, anti-seizure medications, but with the exception of those described above) 3. Subject is unable or unwilling to lie still in the scanner (i.e. due to claustrophobia or weight) 4. Subject has metal in their body or other reason that they cannot undergo magnetic resonance imaging. 5. Previous brain surgery or intracranial abnormalities they may complicate interpretation of the brain scans (e.g., stroke, tumor, vascular abnormality). 6. Pregnancy or breastfeeding 7. Concurrent participation in another research protocol that might affect the outcome of this study. 8. Use of a defibrillator or pacemaker or other implanted or metallic electronic device. Doing so could cause electric shock, burns, electrical interference, or death. 9. Epilepsy 10. History of Seizures 11. Temporomandibular Joint Disorder, Bell's Palsy, impaired cranial nerve function, or facial pain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Thomas Jefferson University, Marcus Institute of Integrative Health Centers
Philadelphia, Pennsylvania, 19107, United States
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