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Could a whiff of xenon replace the Pre-Surgery chill pill?

NCT ID NCT06080100

NEW Symptom relief Sponsor: The S.N. Fyodorov Eye Microsurgery State Institution Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are testing whether inhaling a low dose of xenon gas can ease anxiety before laser vision correction. The trial enrolls 140 people who score high on stress and anxiety tests and are scheduled for ReLEx SMILE eye surgery. Participants receive either xenon or a standard anti-anxiety pill, and the team tracks stress markers like cortisol, blood sugar, and heart rhythm to compare the two approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inhaled xenon gas at a low, non-sleep-inducing dose
What this could lead to
If xenon works, it could offer a fast, non-pill way to calm patients before eye surgery and possibly other brief procedures.
What could go wrong
This is an early-stage trial with 140 people, so any benefit may be small or not hold up in larger studies. Xenon is a scarce, costly gas, and inhaling it carries its own risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

140 people

The number who actually took part.

Started

Nov 2023

Finished

Sep 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * upcoming operation ReLEx® SMILE; * high anxiety and stress instability (Spielberger-Khanin test of 46 points or more); * signed informed consent to participate in the study. Exclusion Criteria: \- concomitant somatic diseases in the decompensation stage.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Anxiety Psychological stress XENON

Contacts and locations

Locations

  • s. Fyodorov Eye Microsurgery Federal State Inctitution

    Krasnodar, 350012, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.