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Childhood trauma may rewire the brain in opioid addiction

NCT ID NCT06355778

Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disorder on buprenorphine, and healthy volunteers. The goal is to understand brain differences that could lead to better treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 185 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for all groups: * Fluent in English * Able to give informed consent * Normal/corrected-to-normal vision and hearing Inclusion Criteria for Opioid Use Disorder (OUD) group: * Diagnosis of OUD * Be actively receiving buprenorphine (BUP) for opioid agonist therapy * Be free from illicit substance use for at least 2 weeks * The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol) Inclusion Criteria for the BUP control group: * Taking BUP for chronic pain * No Substance Use Disorder (including OUD) * The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol) Inclusion Criteria for Healthy participant group: * Not taking BUP * Free of any psychiatric or major medical conditions Exclusion Criteria for all groups: * Pregnancy * Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis) * Actively suicidal * Contraindication for MRI * Inability to tolerate small, enclosed spaces without anxiety or unable to fit comfortably in the MRI scanner * Life history of schizophrenia, learning disability, attention deficit disorder, or pervasive developmental disorder * Use of substances or prescription medications that could interfere with measures of interest (per protocol) * Unable to provide informed consent * Participants who have completed other studies in our lab involving learning and memory assessments with the same/similar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due to possible learning/practice effects

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Conditions

The condition(s) this trial relates to.

opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Opioid use disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

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