University Of Michigan

This study is testing a 9-week online family program designed to help caregivers of LGBTQ+ youth of color become more supportive and accepting. The goal is to see if improving family relationships can reduce the youth's depression, anxiety, substance use, and other risks linked t…

This study aims to find the best length of time to cool children who survive a cardiac arrest outside the hospital. Researchers want to see if cooling for a longer period helps protect the brain and leads to better recovery one year later. The trial will enroll 900 children who a…

This study is testing whether adding non-weight bearing leg exercises to standard wound care helps diabetic foot ulcers heal faster. Researchers will compare 40 participants doing supervised exercises three times a week for six weeks against those receiving only standard care. Th…

This study is testing if a medication called dapagliflozin, often used for diabetes, can help reduce future heart risks in women who had high blood pressure during pregnancy. Researchers will enroll 200 women who recently gave birth and had conditions like pre-eclampsia. Particip…

This study is testing whether technology-based virtual care programs can help people better manage their alcohol use and overall well-being. Researchers are enrolling 400 adults with alcohol use disorder to try different online approaches that focus on goal-setting, skill-buildin…

This pilot study is testing a new device designed to help adults with moderate to severe obstructive sleep apnea (OSA) who cannot use or do not like standard CPAP machines. The study will see if the device is comfortable, easy to use, and can reduce the number of times a person s…

This study is testing a smartphone app designed to help people who are in treatment for both opioid and alcohol addiction. It aims to see if the app is easy to use and helpful for 50 adults on Michigan Medicaid. The app uses a reward system to encourage people to stay on track wi…

This program provides continued access to metreleptin, a hormone replacement therapy, for patients with partial lipodystrophy who previously benefited from treatment in a clinical study. The program is for patients who showed improvement in diabetes control, triglyceride levels, …

This study is testing a custom-made, 3D-printed splint designed to hold open the collapsing windpipes of young children with a severe condition called tracheobronchomalacia. The splint is 'bioresorbable,' meaning it dissolves in the body over about five years. Researchers aim to …

This study is testing a new program designed to help doctors safely reduce or stop thyroid medication in adults aged 65 and older who may be taking too much. The program provides education for both patients and doctors. The goal is to reduce potential harm from overtreatment and …

This study is testing whether patients recover better after kidney stone surgery if doctors leave out a small internal tube called a stent. About 800 patients having this surgery will be randomly assigned to get a stent or not. Researchers will compare pain levels and unplanned t…

This study is testing if adding guided exercise to a standard talk therapy program helps Black men with type 2 diabetes better control their blood sugar and feel better mentally. It will involve 80 men over 7 months, with sessions held online. The goal is to see if this combined …

This study aims to improve how doctors program sacral nerve stimulators, which are like pacemakers for the bladder. Researchers will test if measuring the body's electrical responses during programming leads to better symptom control for people with overactive bladder. The study …

This study is testing a new brain training technique for people with depression. While lying in an MRI scanner, participants see real-time feedback about their brain activity and try to learn to control it. Researchers hope this training can help people better manage their depres…

This study is gathering more information about an already-approved medical stitch called STRATAFIX. Researchers want to see how well it works and how safe it is for closing wounds after brain or spine surgeries over the long term. They will track wound healing, check for infectio…

This study is testing a smartphone app called HeartSteps to see if it helps people with heart disease stay physically active after finishing a cardiac rehab program. For 3 months, 60 participants will use the app, which sends encouraging messages and helps with activity planning,…

This study aims to understand how a hormone-suppressing medication called Relugolix Combination Therapy affects pelvic pain in women with moderate-to-severe endometriosis. Researchers will measure changes in pain levels, inflammation, and brain activity using MRI scans and blood …

This study is testing whether simple, non-motorized exercise equipment combined with muscle stimulation can help people recover arm function after a stroke. Researchers want to see if this affordable approach is practical and effective for use in a home setting. The goal is to de…

This study is testing personalized support programs to help people scheduled for elective surgery reduce their alcohol use. It aims to improve surgical recovery and promote long-term wellness. The program adapts its approach based on how participants are responding.

This study is checking how well a nasal airway device works for controlling sleep apnea over a full year. It follows 20 people who already used the device in a previous study and want to keep using it. Researchers will stay in touch with participants and check their sleep quality…

This study is testing a new cardiac rehabilitation program designed specifically for women. Researchers want to see if women who join this women-only program attend more sessions and see better improvements in their heart health and mood compared to women in the usual mixed-gende…

This study compares two timing approaches for bone graft surgery to treat infections around dental implants. Researchers are testing whether performing the bone graft immediately after cleaning the infected area works as well as waiting several weeks between cleaning and grafting…

This study compares two standard ICU monitoring approaches for patients with severe traumatic brain injury. Researchers want to know if adding brain oxygen monitoring to standard pressure monitoring helps patients recover better. About 1,100 patients will be randomly assigned to …

This study is testing a mobile health program designed to help young African American adults (ages 18-30) with uncontrolled asthma. The program uses a combination of a smartphone app, video meetings with a nurse, text messages, and activity tracking. Researchers want to see if th…

This study is testing whether gentle electrical brain stimulation can help improve vision and thinking problems in people with posterior cortical atrophy, a rare form of dementia that primarily affects vision. Fifty participants will receive either real or fake stimulation sessio…

This study is testing if a medication called Tirzepatide, already used for diabetes, can help adults with a rare condition called partial lipodystrophy. People with this disorder lose fat tissue abnormally, which often leads to poorly controlled diabetes and high blood fats. Rese…

This study is testing a program called HealthyLifetime, which uses nurse coaches to help older adults build healthy habits and self-care skills. The goal is to help participants maintain their health and ability to live independently in their own homes as they age. The program wo…

This study is testing whether a telemedicine approach can detect serious eye diseases as effectively as traditional in-person eye exams. Researchers will compare detection rates for glaucoma, diabetic retinopathy, and cataracts in 900 patients at community health centers. The goa…

This study aims to find out if a prostate MRI scan is better than a combination of blood and urine tests at detecting aggressive prostate cancer in men who need their first biopsy. Researchers will enroll 950 men who are scheduled for a biopsy but haven't been diagnosed yet. The …

This study is testing a new computer system called PICTURE that uses artificial intelligence to analyze data from hospitalized children. It checks information like vital signs every 15 minutes to predict if a child's health might be getting worse, so doctors can act sooner. The m…

This study is testing a new, non-invasive imaging technology called photoacoustic tomography (PAT) to see if it can help detect and monitor rheumatoid arthritis. The scan combines laser light and ultrasound to create detailed pictures of joints. Researchers are enrolling adults w…

This study is testing whether ultrasound imaging can be used to check how well a bone graft is healing after a tooth is pulled. Researchers will compare ultrasound images to standard methods in 140 adults who need a tooth extraction, bone graft, and later a dental implant. The go…

This study is testing a special after-school program called YES-IDEAS, designed to prevent youth violence. It aims to empower middle school students by having them design and lead community improvement projects, with the goal of reducing fights and bullying while promoting positi…

This study is testing a combined approach to help prevent suicide in Black teenagers. It pairs a specific type of therapy with a team of supportive adults nominated by the teen. The goal is to see if this combined method is practical and shows early signs of helping teens who hav…

This study is testing if a concentrated grape powder, taken before heart surgery, can prevent a common complication called postoperative atrial fibrillation (POAF), which is an irregular heartbeat. Researchers believe natural compounds in grapes might reduce inflammation that can…

This study is testing a school-based program designed to prevent the commercial sexual exploitation of children and reduce teen dating violence. Over 3,200 high school students will participate, with some receiving the educational curriculum and others serving as a comparison gro…

This study aims to find the most effective way for people to safely dispose of unused prescription opioid pain medications after outpatient surgery. Researchers will compare two methods: a mail-back kit versus in-home disposal products. The goal is to prevent leftover pills from …

This study is testing whether personalized text messages can help young adults who don't get enough exercise become more active and slow weight gain. Researchers will compare three groups: one gets messages tailored by a smart algorithm, one gets random messages, and one gets no …

This study is testing a new digital system that uses fingerprint identification to help more children in Ghana complete their full set of vaccines. The system tracks children's vaccination records and alerts health workers when a child is behind schedule, while also sending voice…

This study is testing a new program designed to help rural families with children store their firearms more safely. Researchers want to see if the program leads to more guns being locked and unloaded at home. They are enrolling 600 families from Michigan's Upper Peninsula who own…

This study is testing whether delivering healthy groceries to the homes of low-income pregnant women helps them gain a healthy amount of weight and eat better during pregnancy. Researchers will compare three groups: one receiving standard food assistance, one getting that food de…

This study tests if involving family members in a proven hospital care program is better at preventing delirium (sudden, severe confusion) in older patients. It will compare the standard Hospital Elder Life Program (HELP) with a new version that trains and includes family caregiv…

This study is testing whether a simple, 4-week strength training program is practical and helpful for new mothers who recently had pregnancy complications like preeclampsia or gestational diabetes. These conditions increase a woman's future risk of heart disease and diabetes. Res…

This study is testing two technology-based programs designed to prevent or reduce alcohol misuse among teenagers. About 1,400 youth aged 12-19 who have drunk alcohol in the past year will either use a brief web-based program or that same program plus eight weeks of supportive tex…

This study is testing a community-led program to help families in Nigeria get and use chlorine to make their drinking water safe. It involves 30 communities and focuses on pregnant women and mothers with young children. The goal is to see if this approach effectively increases ch…

This study is testing whether adding an extra dose of an approved antibiotic during appendix removal surgery works better than the current standard single dose. Researchers will compare the two approaches in 46 adults having surgery for appendicitis. They'll measure antibiotic le…

This study is testing whether a community and faith-based support program can help more Black Americans at high risk for glaucoma get to eye doctor appointments. Researchers want to see if providing extra resources and education makes people more likely to get the preventive care…

This study is testing whether a single dose of calcium gluconate given through an IV can safely reduce blood loss during cesarean delivery for pregnant patients at high risk for serious bleeding. It will involve 140 participants who will be randomly assigned to receive either the…

This study is testing if taking sodium nitrate pills can prevent kidney injury in high-risk patients who need medical scans using contrast dye. It will enroll 100 patients with reduced kidney function who are scheduled for a heart angiogram or CT scan. The main goal of this pilot…

This study is testing whether a home-based electrical stimulation therapy (TEA) can reduce abdominal pain in people with irritable bowel syndrome with constipation (IBS-C). Researchers will compare the TEA device against a common medication (escitalopram/Lexapro) and a sham (fake…

This study aims to develop smarter control systems for powered prosthetic legs using machine learning. Researchers will test new software that helps prosthetic knees and ankles adapt more naturally to different activities like walking, climbing stairs, and standing up. The study …

This is a small, early-stage study to see if a special treadmill training program can help improve how people walk and load their knee after ACL reconstruction surgery. The program uses a 'split-belt' treadmill where each leg walks at a slightly different speed. Researchers will …

This study is testing a soft, self-supporting nasal tube (ssNPA) to see if it can help children with weak throat muscles breathe better during sleep. Researchers will measure if the device reduces sleep apnea events and is comfortable for kids to use. The goal is to improve sleep…

This small pilot study is testing whether a 6-week remote occupational therapy program is practical and helpful for seniors living in affordable housing. The program combines one-on-one and group video sessions to help participants build habits and skills to be more active and ma…

This study is testing whether a low sulfur diet can help reduce persistent symptoms like pain and diarrhea in people with Crohn's disease who are in remission. Twenty participants will be randomly assigned to follow either the special diet or their usual diet for eight weeks, wit…

This study is testing whether a small, wearable electrical stimulation device can help reduce chronic pain and depression symptoms in people with cirrhosis. Participants will use the device at home for 10 weeks to see if it's a practical and acceptable treatment option. The main …

This study is testing whether a combination of thinking exercises and a gentle, non-invasive form of brain stimulation can help improve memory, attention, and problem-solving in adults aged 50 and older. The goal is to see if these methods, used alone or together, can help people…

This study is testing whether a non-invasive brain stimulation technique can reduce chronic pain in people with fibromyalgia. Researchers will compare brain activity in people with fibromyalgia to healthy volunteers, then test if targeted stimulation can change this activity and …

This study is testing whether a non-invasive brain stimulation treatment can reduce migraine pain. Researchers will give 60 chronic migraine patients either real or fake stimulation for 20 days to see if it decreases their headache days and pain intensity. The goal is to find a n…

This study is testing whether a tablet app called the 'Epilepsy Visit Planner' helps patients with drug-resistant epilepsy communicate better with their doctors during clinic visits. About 150 adult patients at the University of Michigan will either use the app in the waiting roo…

This study is testing whether sending supportive text messages to parents can help them better care for their teenagers who are at risk for suicide after an emergency room visit. It will involve 420 teens (ages 13-17) and their parents. The main goals are to see if this text supp…

This study aims to find out which of two common surgical procedures works better to relieve symptoms of ulnar neuropathy at the elbow, a condition that causes pain, numbness, and weakness in the hand. Researchers will compare the surgeries in 378 adults who have not improved with…

This study is testing a special online therapy program called Empower@Home, designed for older adults who have trouble leaving home due to mobility issues and are feeling depressed. The program uses videos and interactive exercises to teach coping skills, with weekly support call…

This study is testing whether a mild, painless electrical stimulation applied to the scalp can improve speech fluency in adults who stutter. Researchers will measure changes in brain activity and count stuttered syllables before and after stimulation sessions. The goal is to see …

This study is testing whether applying a silver fluoride solution to certain sensitive teeth before a dental procedure helps the numbing injection work better. Researchers want to see if this reduces pain for children who have a specific condition that makes their molars very sen…

This small pilot study is testing whether women can safely use a home nerve stimulation device to improve sexual arousal symptoms. Researchers want to see if the treatment helps with lubrication, arousal, and orgasm difficulties. Some participants will also try a smart vibrator f…

This study is testing a special treadmill training method to improve how people walk and load their knee after ACL reconstruction surgery. Researchers want to see if walking on a treadmill with belts moving at different speeds can help retrain proper knee movement patterns. The s…

This study is testing whether a short, online behavioral therapy program delivered via Zoom can help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to teach participants strategies to reduce their pain intensity, decrease pain-related …

This study is testing a new group therapy delivered over Zoom to help adults who have both chronic pain and opioid use disorder. The therapy focuses on understanding and expressing emotions to reduce pain, disability, and opioid-related problems. Researchers want to see if this a…

This study is testing a new program called SCOOP, which uses weekly coaching sessions and videos to teach older adults in rural areas how to better manage chronic pain and increase social connections. Researchers want to see if the program helps reduce how much pain interferes wi…

This study is testing a new physical therapy program designed to help people with multiple sclerosis (MS) become more physically active. Researchers want to see if regular consultations with a physical therapist are a practical and helpful way to encourage exercise. The goal is t…

This study is testing whether combining standard low vision rehabilitation with emotional regulation therapy helps people with inherited retinal diseases who are experiencing significant anxiety about their vision loss. Researchers want to see if this combined approach improves d…

This study is testing whether specific diets can help reduce severe bloating, abdominal pain, and other gut symptoms in people with systemic sclerosis (scleroderma). Researchers will compare three different dietary approaches in 60 participants to see which works best. The goal i…

This study is testing whether four virtual coaching sessions can help veterans with chronic pain use their own cannabis products more effectively. The research aims to see if this coaching improves pain management, sleep, anxiety, and overall quality of life. The study will enrol…

This study aims to find the best way to manage children's pain after they go home from common surgeries like tonsil or gallbladder removal. Researchers will compare two standard medication approaches: one using common pain relievers (NSAIDs plus acetaminophen) and another adding …

This study is testing whether a personalized website called PainGuide can help people better manage their chronic lower back pain. Researchers want to see if using this online tool to change daily behaviors reduces how much pain interferes with life. The study is enrolling 550 ad…

This study aims to find the best and safest way to manage pain after common surgeries like gallbladder removal, hernia repair, and breast lump removal. It will compare two standard medication plans: one using common pain relievers like ibuprofen and acetaminophen, and another usi…

This study is testing if having a friendly, trained therapy dog nearby helps children feel less anxious and behave more calmly when they get a numbing shot at the dentist. Researchers will compare children's reactions and heart rates during the shot with and without a dog present…

This study is testing which of two extra treatments works better for women with chronic pelvic floor muscle tightness and pain. All participants will receive standard pelvic floor physical therapy. Researchers will compare adding a daily muscle relaxant pill (cyclobenzaprine) to …

This study is testing if using virtual reality (VR) to experience peaceful nature scenes can help reduce depression, anxiety, and stress in people who are in intensive treatment for alcohol use disorder. Researchers will enroll 50 adults with moderate depression who are starting …

This study is testing if offering hospitalized patients a menu of wellness items—like music, art, spiritual care, or nutrition support—improves their satisfaction with their hospital stay. About 300 patients at the University of Michigan hospital will be asked to choose items the…

This study is testing a special online therapy program called Empower@Home, designed to help homebound older adults who are feeling depressed. The program uses interactive lessons based on cognitive-behavioral therapy (CBT) and is supported by weekly check-in calls from trained c…

This study is developing and testing a culturally adapted family support program for Lakota LGBTQ2S+ youth and their caregivers. The 8-week group program aims to reduce family rejection, improve mental health, and decrease risks like depression and substance use. Researchers are …

This study is testing whether using virtual reality (VR) to experience nature walks at home can help reduce depression in people with progressive multiple sclerosis (MS). Researchers will give 40 participants a VR headset to use for short sessions several times a week over 8 week…

This study is testing whether patients recover better without a temporary internal tube (stent) after a common kidney stone procedure. Researchers will compare pain levels, daily life impact, and healthcare visits over 30 days between patients who get a stent and those who do not…

This study is testing whether a virtual reality (VR) program that teaches mind-body techniques can help hospitalized patients with inflammatory bowel disease (IBD) manage their pain. Researchers want to see if patients find the VR therapy practical and acceptable to use while in …

This study is testing a short, online therapy program designed to help veterans manage chronic low back pain. Researchers want to see if this Zoom-based program is safe, practical, and acceptable to participants. The goal is to see if this type of behavioral intervention can help…

This study aims to understand how the brain works under anesthesia and whether gentle ultrasound stimulation can help people wake up faster. Researchers will give healthy volunteers common anesthesia drugs and use focused ultrasound pulses on specific brain areas while taking bra…

This study aims to understand how brain function related to learning and memory differs in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on medication, people taking the same medication …

This study aims to learn if the CT scans people get for lung cancer screening can also be used to spot Chronic Obstructive Pulmonary Disease (COPD). Researchers will look at the scans of 200 current and former smokers to see if signs of COPD are present and then confirm the findi…

This study aims to understand how a slow-release version of a diabetes drug (glipizide) breaks down and gets absorbed in the human digestive system. Healthy volunteers will have a thin tube passed into their stomach and intestines to collect fluid samples, along with giving blood…

This study aims to understand the long-term health journey of people with rare genetic or acquired lipodystrophy syndromes, where the body lacks normal fat tissue. Researchers will follow about 500 participants for 5 to 7 years to track how many develop serious conditions like di…

This study aims to understand if certain genes make people more likely to develop painful rotator cuff tears in their shoulder. Researchers will analyze the DNA of thousands of adults who either have a confirmed tear or a healthy shoulder, using MRI scans to verify their status. …

This study aims to understand if and why the eczema medication dupilumab works differently in Caucasian, Asian, and African American patients. Researchers will enroll 30 adults with moderate-to-severe eczema to measure changes in their skin's immune response after starting the dr…

This study is testing an educational tool designed to help adults newly diagnosed with eosinophilic esophagitis (EoE) understand their treatment options. Researchers want to see if this tool is easy to use and helpful for patients when making decisions about managing their condit…

This study aims to discover which personal traits—like genetics, metabolism, or health markers—best predict who will succeed at losing weight and maintaining that loss long-term. It will enroll 3,200 adults, both with and without obesity, to collect detailed health data. The goal…

This early research study aims to see if a medication called sotagliflozin, which is used for diabetes, might also help reduce blood clotting. Researchers will compare its effects on blood platelets to those of several FDA-approved antiplatelet drugs like aspirin. The study invol…

This study tests a new system that helps match kidney disease patients with clinical trials that might be right for them. It works by analyzing patient information to find trials targeting their specific type of kidney condition. The study also measures how well patients understa…

This study is testing whether doctors find a new disposable activity monitor, called the VERABAND™, useful for managing patients with chronic low back pain. About 340 patients will wear the monitor while starting a new pain treatment, and their doctors will receive reports on the…

This study aims to understand how a gentle, non-invasive form of electrical brain stimulation affects brain activity and memory. Researchers will enroll 80 older adults, some with mild memory concerns and some without, to see how their brains respond during memory tasks. The goal…

This University of Michigan study aims to understand how different personality traits and brain patterns relate to substance use behaviors in young adults. Researchers will use brain scans and behavioral tests to examine 294 participants aged 18-20. The study focuses on observing…

This study aims to understand how a mother and baby's emotional connection and feeding behaviors in the first year relate to the child's future risk of obesity. Researchers will observe 300 mother-infant pairs over several years, measuring growth, feeding interactions, and emotio…

This study aims to understand how a mother and baby's emotional connection and eating behaviors develop together from infancy. Researchers will observe 150 toddlers to see how their feelings and bond with their mother relate to their food choices and weight. The goal is to gather…

This study aims to understand the long-term recovery of children who receive ECMO, a form of life support for severe breathing failure. It will compare outcomes between children who receive ECMO as usual care and those managed with a strict ventilator protocol that uses ECMO only…

This study aims to understand how stuttering relates to rhythm perception and brain activity in children. Researchers will compare 500 children who stutter with those who don't through rhythm tests and brain scans over three years. The goal is to gather knowledge about the brain …

This study aims to find biological markers in blood, wound fluid, and tissue that can predict whether a diabetic foot ulcer will heal or not. It will enroll 5000 adults with an open foot ulcer from diabetes to collect samples and track their healing over 78 weeks. The goal is to …

This study aims to understand how the emotional connection between a mother and her baby, combined with early feeding experiences, shapes the child's future eating behaviors and weight. Researchers will observe 150 children from an existing long-term study at ages 18 and 36 month…

This study aims to understand why people with prediabetes and type 2 diabetes tire more quickly during exercise. Researchers will test a special 8-week leg exercise program that temporarily restricts blood flow to see if it improves muscle fatigue and blood vessel function. The g…

This study aims to understand how regular cannabis use affects sedation during wisdom tooth surgery. Researchers will compare two groups—cannabis users and non-users—measuring how much anesthesia medication they need and how their bodies respond during the procedure. The goal is …

This study aims to understand how eczema (atopic dermatitis) and food allergies might be connected biologically. Researchers will collect blood and skin samples from 200 people with different combinations of these conditions and healthy volunteers. The goal is to create a 'molecu…

This study aims to understand how swelling affects the daily lives of children and adults with Nephrotic Syndrome, a serious kidney disease. Researchers will conduct interviews with patients and parents to learn about their experiences. The information gathered will be used to cr…

This study aims to understand how a mother and baby's emotional connection and feeding behaviors develop together over time. Researchers will observe 150 mother-child pairs to see how this relationship affects the child's eating habits, food intake, and weight. The goal is to gat…

This study aims to understand how non-invasive brain stimulation can improve hand movement control in healthy older adults. Researchers will compare standard stimulation with personalized, targeted stimulation to see which works better for tasks like pegboard tests and precision …