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Cannabis users may need different sedation for wisdom teeth surgery

NCT ID NCT07423195

Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compares cannabis users and non-users during wisdom tooth removal under IV sedation. Researchers will measure how much sedative medication is needed and track vital signs like heart rate and blood pressure. The goal is to understand if cannabis use changes how people respond to sedation, which could help doctors personalize care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cannabis (recreational marijuana/THC)
What this could lead to
If successful, this study could help dentists and anesthesiologists adjust sedation doses for patients who use cannabis, improving safety and comfort during wisdom tooth removal.
What could go wrong
This is an observational study, not a treatment trial. It only looks at differences between users and non-users, so it won't prove cause and effect. Results may not apply to other surgeries or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 242 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population is patients who are scheduled for third molar extraction surgery under IV sedation.

Ages

16 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provide a signed and dated informed consent form. * Willing to comply with all study procedures and be available for the duration of the study. * Aged ≥ 16 years old. * Presence at least one mandibular 3rd molar * American Society of Anesthesiologists (ASA) physical status class I or II Exclusion Criteria: * Pathology (cyst or tumor) associated with the third molar tooth; * Health comorbidities (BMI 40 and above, and severe cardiovascular disease); * Pregnancy or lactation * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis use Marijuana usage Sedation and analgesia Wisdom tooth

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Michigan School of Dentistry/ Oral and Maxillofacial Surgery

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

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