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Common drug combo under scrutiny: losartan and cephalexin interaction tested

NCT ID NCT07300670

Knowledge-focused Sponsor: Aleksi Tornio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether taking the blood pressure drug losartan changes how the antibiotic cephalexin works in the body. Twelve healthy volunteers will take both drugs at the same time, three hours apart, or cephalexin alone. Researchers will measure drug levels in blood and urine to see if timing matters.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
losartan and cephalexin
What this could lead to
If successful, this could help doctors understand how to time these two drugs to avoid unwanted interactions, making treatments safer.
What could go wrong
This is a very small, early-phase study in healthy people, not patients. The results may not apply to real-world medical situations or reveal any significant interaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * written informed consent * 18-40 years of age * good health * systolic blood pressure of at least 115 mmHg * all screening laboratory results (P-Krea, Pt-GFReEPI, P-Na, P-K, P-ALAT, P-AFOS, P-GT, B-PVK+T) acceptable; minor deviations from reference ranges are acceptable at the discretion of a physician-scientist with the exceptions of Pt-GFReEPI which must be at or above the reference limit and P-K which must be at or below the higher reference limit (Reference limits: Tyks Laboratories, Turku University Hospital) * regarding female subjects, a negative pregnancy test (S-HCG-O) before the study, and the use of a highly effective contraceptive method (e.g. copper intrauterine device, bilateral tubal occlusion, vasectomised partner, or abstinence from heterosexual intercourse), according to CTFG Recommendations related to contraception and pregnancy testing in clinical trials, are required Exclusion Criteria: * inability to provide written informed consent in Finnish * remarkable illness * confirmed or reasonably suspected allergy to cephalexin, amoxicillin, benzylpenicillin, phenoxymethylpenicillin, piperacillin, cefaclor, or cefamandole * confirmed or reasonably suspected severe delayed allergic reaction to any beta-lactam antibiotic * underweight (BMI less than 18.5 kg/m2) * obesity (BMI greater than 30 kg/m2) * smoking * regular medication, including hormonal contraception in the form of pills, intrauterine device, subdermal implant etc. * current or planned pregnancy, and breastfeeding * less than three months elapsed since a prior clinical trial * less than three months elapsed since donating blood

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Possible interaction between losartan and cephalexin

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Unit of Clinical Pharmacology, Turku University Hospital

    RECRUITING

    Turku, Southwest Finland, FI-20520, Finland

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