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Fit gut: study links exercise to healthier microbiome

NCT ID NCT07276464

Knowledge-focused Sponsor: University of Rennes 2 Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how being physically fit changes the bacteria in your gut. Researchers will compare the gut microbes of 30 healthy men, from inactive to elite athletes, by testing their exercise capacity and analyzing stool samples. The goal is to find connections between fitness levels and gut health, which could help understand how exercise supports a healthy digestive system.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal how exercise shapes gut bacteria, pointing toward ways to improve intestinal health through fitness.
What could go wrong
This is a small, early observational study with only 30 healthy men, so results may not apply to women, older people, or those with health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

30 people

The number who actually took part.

Started

Nov 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Populations located in a continuum from inactive people to top-level athletes with high and very high exercise capacity.

Ages

18 to 30 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male participant * Aged between 18 and 30 years (inclusive) * Body Mass Index (BMI) between 18 and 25 kg/m² (inclusive) * No history of gastrointestinal disease, including inflammatory bowel disease * Be a non-smoker. * Have a regular bowel transit (1-2 bowel movements per day or every other day) without recurrent episodes of diarrhea or constipation * Having provided free, informed, and written consent to participate in the study * Training status : * Low to moderate active subjects : Perform 2 to 4 hours per week of moderate to vigorous physical activity (VO₂max between 40 and 50 mL·min-¹·kg-¹). * Trained subjects : Perform 5 to 7 hours per week of regular endurance training for at least one year (VO₂max between 50 and 65 mL·min-¹·kg-¹). Highly trained subjects : Perform at least 10 hours per week of structured endurance training, with daily or twice-daily sessions (VO₂max greater than 65 mL·min-¹·kg-¹). Exclusion Criteria: * History of cardiovascular disease. * Presence of a metabolic disorder (e.g., diabetes). * Use of antibiotics, antifungal, or antiparasitic agents within the past 3 months, or planned use during participation in the study. * Use of prebiotic and/or probiotic supplements within the 7 days preceding the study, providing ≥10⁸ CFU or organisms per day. * Current use of medication for chronic pain management, including paracetamol, vasodilators, homeopathic treatments, or aspirin at doses \>500 mg/day. * Simultaneous participation in another clinical study involving human subjects, or recent participation in a previous study for which the exclusion period has not yet expired.

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Conditions

The condition(s) this trial relates to.

colitis Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • University Rennes 2 - Laboratory "Movement, Sport and health Sciences"

    Bruz, Britanny, 35170, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.