New imaging tool could shed light on brain disorders

NCT ID NCT06874205

Recruiting now Knowledge-focused Sponsor: National Institute of Mental Health (NIMH) Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 29 times

Summary

This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can highlight a protein called PDE4D in the brain and body. PDE4D is linked to thinking and mood, and may play a role in conditions like Alzheimer's and depression. Healthy adults aged 18 and older will receive the tracer and undergo PET and MRI scans, with some also taking a medication called disulfiram to improve image quality. The goal is to improve brain imaging methods for future studies of brain disorders.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

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Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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HEALTHY