New brain scan method could shed light on depression and Alzheimer's
NCT ID NCT06874205
First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 27 times
Summary
This study tests a new radioactive tracer called 11C-JMJ-129 to see how well it can highlight a protein called PDE4D in the brain and body of healthy volunteers. PDE4D is linked to thinking and mood, and may play a role in disorders like Alzheimer's and depression. Researchers will also test if a medication called disulfiram can improve the quality of the brain images. Up to 40 healthy adults aged 18 and older will have PET and MRI scans to help develop better tools for future studies of brain disorders.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
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Contact
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Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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