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Massive dengue vaccine trial for kids launches – could it stop the virus?

NCT ID NCT07013487

Vaccine Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 9 times

Summary

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a strong immune response, and reduces cases of dengue fever caused by any of the four dengue virus types. Participants will receive either the vaccine or a placebo, and researchers will monitor for side effects and confirmed dengue infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 12,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Oct 2031

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The key Inclusion Criteria include but are not limited to: * Is generally healthy based on medical history and physical examination. The key Exclusion Criteria include but are not limited to: * Has a known or suspected impairment of immunological function. * Has a history of congenital or acquired immunodeficiency. * Has a documented human immunodeficiency virus (HIV) infection or is breastfeeding from a mother with documented HIV infection. * Has a documented history of hepatitis B or C infection. * Has a bleeding disorder contraindicating subcutaneous vaccination or repeated venipuncture. * Has a serious or progressive disease, including but not limited to cancer, uncontrolled diabetes, severe cardiac, renal or hepatic insufficiency, or systemic autoimmune or neurologic disorders. * Has a known neurologic or cognitive behavioral disorder, including encephalitis/myelitis, acute disseminating encephalomyelitis, pervasive development disorder, and related disorders. * Previous receipt of a dengue vaccine or plans to receive any dengue vaccine (investigational or approved) for the duration of the study (other than the study vaccine). * Received systemic corticosteroids \<30 days before receipt of study intervention or is expected to require systemic corticosteroids ≤28 days after receipt of study intervention. * Has received a blood transfusion or blood products, including immunoglobulins, ≤6 months before receipt of study intervention or plans to receive a blood transfusion or blood products (including immunoglobulins) ≤28 days after receipt of study intervention. * Has received immunosuppressive therapies, including chemotherapeutic agents used to treat cancer or other conditions, treatments associated with organ or bone marrow transplantation, or autoimmune disease, ≤6 months before receipt of study intervention or plans to receive immunosuppressive therapies ≤28 days after receipt of study intervention.

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Conditions

The condition(s) this trial relates to.

dengue disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    5 sites in 3 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Cai Lay Regional General Hospital ( Site 0093)

    ACTIVE_NOT_RECRUITING

    Cai Lậy, Tien Giang, 860 000, Vietnam

  • Chong Hua Hospital ( Site 0051)

    ACTIVE_NOT_RECRUITING

    Cebu City, Cebu, 6000, Philippines

  • Chulalongkorn University-Pediatrics ( Site 0063)

    RECRUITING

    Bangkok, Bangkok, 10330, Thailand

  • Cipayung Primary Health Center ( Site 0105)

    ACTIVE_NOT_RECRUITING

    East Jakarta, Jakarta Special Capital Region, 13840, Indonesia

  • Clinical Research Investigator Group ( Site 0110)

    ACTIVE_NOT_RECRUITING

    Bayamón, 00960, Puerto Rico

  • Dong Thap General Hospital ( Site 0092)

    ACTIVE_NOT_RECRUITING

    Dong Thập, 810000, Vietnam

  • Dr Cipto Mangunkusumo Hospital-Pediatrics ( Site 0101)

    RECRUITING

    Jakarta, Jakarta Special Capital Region, 10430, Indonesia

  • Faculty of Medicine - Khon Kaen University-Pediatrics ( Site 0064)

    ACTIVE_NOT_RECRUITING

    Amphoe Mueang, Changwat Khon Kaen, 40002, Thailand

  • Faculty of Medicine Siriraj Hospital-Pediatric Infectious Diseases ( Site 0065)

    ACTIVE_NOT_RECRUITING

    Bangkok, Bangkok, 10700, Thailand

  • Faculty of Tropical Medicine, Mahidol University ( Site 0062)

    ACTIVE_NOT_RECRUITING

    Bangkok, Bangkok, 10400, Thailand

  • Faculty of Tropical Medicine, Mahidol University - Vaccine Trial Centre ( Site 0067)

    ACTIVE_NOT_RECRUITING

    Ratchathewi, Bangkok, 10400, Thailand

  • Health Index Multispecialty And Lying-In Clinic ( Site 0042)

    ACTIVE_NOT_RECRUITING

    Bacoor, Cavite, 4102, Philippines

  • Hospital Al-Sultan Abdullah - Universiti Teknologi MARA ( Site 0029)

    COMPLETED

    Bandar Puncak Alam, Selangor, 42300, Malaysia

  • Hospital Ampang ( Site 0028)

    ACTIVE_NOT_RECRUITING

    Ampang, Selangor, 68000, Malaysia

  • Hospital Pakar Kanak - Kanak UKM (HPKK) ( Site 0024)

    COMPLETED

    Cheras, Kuala Lumpur, 56000, Malaysia

  • Hospital Sibu ( Site 0021)

    ACTIVE_NOT_RECRUITING

    Sibu, Sarawak, 96000, Malaysia

  • Hospital Tunku Azizah-Paediatric ( Site 0022)

    ACTIVE_NOT_RECRUITING

    Kuala Lumpur, 50300, Malaysia

  • Jatinegara Primary Health Center ( Site 0102)

    ACTIVE_NOT_RECRUITING

    East Jakarta, Jakarta Special Capital Region, 13310, Indonesia

  • KK Women's and Children's Hospital ( Site 0002)

    ACTIVE_NOT_RECRUITING

    Singapore, Central Singapore, 229899, Singapore

  • Kamphaeng Phet-AFRIMS Virology Research Unit KAVRU ( Site 0070)

    ACTIVE_NOT_RECRUITING

    Muang, Changwat Kamphaeng Phet, 62000, Thailand

  • Kelapa Gading Primary Health Center ( Site 0104)

    ACTIVE_NOT_RECRUITING

    North Jakarta, Jakarta Special Capital Region, 14240, Indonesia

  • Kien Giang Women's and Children hospital ( Site 0091)

    RECRUITING

    Rach Gia, An Giang, 920 000, Vietnam

  • Latin Clinical Trial Center ( Site 0113)

    ACTIVE_NOT_RECRUITING

    San Juan, 00909, Puerto Rico

  • Maharaj Nakorn Chiang Mai Hospital ( Site 0066)

    ACTIVE_NOT_RECRUITING

    Muang, Chiang Mai, 50200, Thailand

  • National University Hospital-Paediatrics ( Site 0001)

    ACTIVE_NOT_RECRUITING

    Singapore, Central Singapore, 119074, Singapore

  • Norzel Medical and Diagnostic Clinic Foundation Corp ( Site 0044)

    ACTIVE_NOT_RECRUITING

    Cebu City, Central Visayas (Region VII), 6000, Philippines

  • Pasar Minggu Primary Health Center ( Site 0103)

    ACTIVE_NOT_RECRUITING

    South Jakarta, Jakarta Special Capital Region, 12620, Indonesia

  • Pasteur Institute in Ho Chi Minh city ( Site 0089)

    RECRUITING

    Ho Chi Minh City, 70000, Vietnam

  • Philippine General Hospital ( Site 0041)

    ACTIVE_NOT_RECRUITING

    Manila, National Capital Region, 1000, Philippines

  • Ponce Medical School Foundation Inc./CAIMED Center ( Site 0112)

    ACTIVE_NOT_RECRUITING

    Ponce, 00716, Puerto Rico

  • Quang Nam Hospital for Women and Children ( Site 0094)

    ACTIVE_NOT_RECRUITING

    Da Nang, 550000, Vietnam

  • Queen Sirikit National Institute of Child Health-Pediatric Infectious Disease ( Site 0071)

    RECRUITING

    Bangkok, Bangkok, 10400, Thailand

  • San Juan Bautista School of Medicine - Clinical Research Unit ( Site 0114)

    ACTIVE_NOT_RECRUITING

    Caguas, 00726, Puerto Rico

  • Songklanagarind hospital-Department of Pediatrics ( Site 0061)

    ACTIVE_NOT_RECRUITING

    Hat Yai, Changwat Songkhla, 90110, Thailand

  • Sunway Medical Centre ( Site 0027)

    ACTIVE_NOT_RECRUITING

    Petaling Jaya, Selangor, 47500, Malaysia

  • Tan Tock Seng Hospital ( Site 0003)

    ACTIVE_NOT_RECRUITING

    Singapore, Central Singapore, 308433, Singapore

  • Thammasat University Hospital-Department of Pediatrics ( Site 0068)

    ACTIVE_NOT_RECRUITING

    Khong Luang, Changwat Pathum Thani, 12120, Thailand

  • University Malaya Medical Centre-Department of Paediatrics ( Site 0025)

    ACTIVE_NOT_RECRUITING

    Lembah Pantai, Kuala Lumpur, 59100, Malaysia

  • University of the Philippines Manila ( Site 0047)

    ACTIVE_NOT_RECRUITING

    Metro Manila, National Capital Region, 1000, Philippines

  • Wellness clinical Research Vega Baja ( Site 0116)

    ACTIVE_NOT_RECRUITING

    Vega Baja, 00693, Puerto Rico

  • West Visayas State University Medical Center ( Site 0045)

    ACTIVE_NOT_RECRUITING

    Iloilo City, Iloilo, 5000, Philippines

More trials for these conditions

Other studies related to the condition(s) this trial covers.