Brain-Body combo training tested for stroke and moyamoya recovery
NCT ID NCT07144930
First seen Jun 25, 2026 · Last updated Aug 28, 2026 · Updated 2 times
Summary
This study explores whether a training program that mixes cognitive tasks (like memory and attention exercises) with physical therapy can improve recovery in people with post-stroke cognitive impairment or Moyamoya disease. Researchers will also use brain imaging to see how thinking and movement are linked. The trial involves 210 participants and compares the combined training to motor training alone over 4 weeks, with follow-ups up to a year.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cognitive-motor incorporated training (MCIT) program
- What this could lead to
- If successful, this could point toward a more effective rehabilitation approach for people with stroke or Moyamoya disease, potentially improving both thinking and movement.
- What could go wrong
- This is an early-stage study with a small number of participants. The training is short (4 weeks), and results may not apply to all patients. There is no guarantee the combined training will outperform standard motor training alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 210 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Part 1: Inclusion Criteria: * For aged-matched healthy controls: 1. being 20 years of age or older 2. the ability to stand for more than 30 seconds 3. a MoCA score of higher than 26. * For PSCI participants: 1. Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase) 2. Being 20 years of age or older 3. The ability to stand for more than 30 seconds 4. a MoCA score of less than 26 * For the MMD group: 1. a confirmed diagnosis of Moyamoya disease or Moyamoya syndrome through CT scan or angiography 2. If stroke occurred, being in the subacute phase (one week post-stroke) 3. being 20 years of age or older 4. the ability to stand for more than 30 seconds 5. a MoCA score of less than 26 Exclusion Criteria: 1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded 2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions 3. the presence of other neurological disorders or unstable vital signs may interfere with the experiment 4. currently hospitalized in the intensive care unit (ICU) 5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation Part 2: Inclusion Criteria: 1. Diagnosis of stroke confirmed by brain CT or MRI, with symptom onset more than 7 days prior (subacute or chronic phase) 2. Being 20 years of age or older 3. The ability to stand for more than 30 seconds 4. a MoCA score of less than 26 Exclusion Criteria: 1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded 2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions 3. the presence of other neurological disorders or unstable vital signs may interfere with the experiment 4. currently hospitalized in the intensive care unit (ICU) 5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation Part 3: Inclusion Criteria: 1. Moyamoya disease/syndrome confirmed through CT scan or angiography 2. being in the subacute phase, defined as one week after stroke onset 3. being 20 years of age or older 4. the ability to stand for more than 30 seconds 5. a Montreal Cognitive Assessment (MoCA) score of less than 26. Exclusion Criteria: 1. unstable or uncontrolled vital signs, including a resting heart rate \>100 or \<40 BPM, a respiratory rate \>20 or \<12 breaths per minute, an SpO2 \< 95%, a central arterial pressure (CAP) \<80 mmHg, and individuals requiring ICP monitoring will also be excluded 2. requiring invasive mechanical ventilation or being deemed unsuitable by the attending physician due to unstable medical conditions 3. the presence of other neurological disorders or unstable vital signs that could interfere with the experiment 4. currently hospitalized in the intensive care unit (ICU) 5. Severe visual or hearing impairments, or communication and comprehension difficulties that interfere with study participation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National Taiwan University
RECRUITINGTaipei, Taiwan
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