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Could a daily probiotic boost energy and ease bloating?

NCT ID NCT07362251

Symptom relief Sponsor: University of Thessaly Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 02, 2026 · Updated 3 times

Summary

This pilot study is testing whether a multi-strain probiotic supplement called Smile Probio 45B is easy for healthy adults to take and whether it helps with digestion, fatigue, and quality of life. Forty healthy adults will take the probiotic daily for 30 days, starting with one capsule and increasing to three. They will track their bowel habits, symptoms, and energy levels, and complete questionnaires about their well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
multi-strain probiotic (Smile Probio 45B)
What this could lead to
If it works, this could point toward a simple daily supplement to ease bloating, improve energy, and support overall well-being in healthy people.
What could go wrong
This is a very small, early pilot study with only 40 healthy adults and no placebo group. Results may not apply to the general population, and any benefits might be due to chance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

May 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged over 18 years * Body Mass Index (BMI) \>18 kg/m² and \<30 kg/m² * No use of antibiotics in the past month * Willingness to provide informed consent Exclusion Criteria: * Pregnancy or breastfeeding * Age under 18 years * Diagnosis of a chronic autoimmune disease (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriasis) * Diagnosis of type I or II diabetes * Current use of immunosuppressive medications * Current use of antibiotics or use of antibiotics within the past month * Current use of other supplements such as probiotics, prebiotics, or synbiotics * Kidney or liver disease * Self-reported allergy to any component of the probiotic * Psychological conditions affecting the ability to provide informed consent (e.g., dementia, psychosis, substance use) * Gastrointestinal surgery within the last 6 months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • School of Physical Education, Sport Science and Dietetics

    Trikala, Thessaly, 42132, Greece

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