Mayo Clinic

Researchers at Mayo Clinic are studying a remote monitoring program called SHIELD for cancer patients who are starting systemic therapy. Participants use a smartphone app to report symptoms and wear a small temperature sensor. The app and sensor send data to the medical record, w…

This study compares two drugs, sodium bicarbonate and THAM, for treating metabolic acidosis in patients after heart surgery. About 250 adults who develop acidosis after using a heart-lung machine will be randomly assigned to receive one of the two drugs. The main goal is to see i…

This trial investigates whether using a device called a Cell Saver to recycle a patient's own blood during spinal deformity surgery is safe and reduces the need for donor blood transfusions. About 146 adults undergoing major spinal surgery will be randomly assigned to receive eit…

This study tests whether the drug Bimzelx (bimekizumab) can improve skin symptoms in adults with pityriasis rubra pilaris, a rare condition causing red, scaly patches. Researchers will enroll 12 participants and measure how many achieve at least 75% improvement in skin severity a…

This trial tests whether an automated insulin delivery system, the DEKA TWIIST pump with Tidepool Loop software, can safely manage glucose levels in pregnant people with type 1 diabetes. The system adjusts insulin automatically and can be set to pregnancy-specific glucose targets…

This study tests two common methods for calculating mealtime insulin doses in hospitalized adults with type 2 diabetes. One method, carbohydrate counting, adjusts the insulin dose based on the grams of carbs a patient actually eats. The other uses a fixed dose that changes only w…

This trial compares two common medications, phenylephrine and norepinephrine, used to treat low blood pressure during complex spine surgery. The goal is to see which drug better maintains blood flow to organs during the operation and leads to fewer complications and a smoother re…

This phase II trial is testing whether adding a special type of radiation therapy to the immunotherapy drug pembrolizumab before surgery can help shrink oral cavity tumors. The study compares two radiation techniques: proton spatially fractionated radiotherapy (SFRT), which deliv…

This trial tests whether adding semaglutide to structured lifestyle counseling improves heart and blood vessel health in postmenopausal breast cancer survivors with obesity who are taking an aromatase inhibitor. Participants will receive either semaglutide or a placebo, along wit…

This trial tests whether a virtual world-based cardiac rehabilitation program can improve heart health and participation compared to standard in-person rehab. The program, called Destination Cardiac Rehab, is a 3D interactive telehealth option that patients can use from home. Res…

This study tests a new drug called ABBV-383 in 38 people with Waldenström macroglobulinemia that has come back or not responded to treatment. The drug is a monoclonal antibody designed to block cancer growth. The trial has two parts: first finding a safe dose, then checking how w…

This study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…

This trial tests a drug called HRX215 in 80 adults with colorectal cancer that has spread to the liver. Before surgery to remove liver tumors, patients often get a procedure (PVE) that blocks blood flow to the tumor area to encourage the healthy part of the liver to grow. HRX215 …

This study tests the safety of using a patient's own stem cells (taken from fat) to prevent bile duct complications after a living donor liver transplant. About 20 adults with end-stage liver disease will receive these cells during surgery. The goal is to see if this approach red…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

Researchers at Mayo Clinic are testing an investigational radioactive tracer called 68Ga-FAPI-46 to see how it distributes in the lungs of people with interstitial lung disease. About 10 participants with a clinical diagnosis of ILD and lung abnormalities on a recent CT scan rece…

Researchers at Mayo Clinic are testing whether people who have a type 2 heart attack, without major blockages in the large heart arteries, are more likely to have disease in the tiny blood vessels of the heart. The study uses a special X-ray procedure called coronary reactivity t…

This study at Mayo Clinic will enroll 100 adults with atrial fibrillation who are taking the drug dofetilide. Researchers will compare a non-invasive magnetic heart scan (magnetocardiography, or MCG) with the standard ECG to see which better predicts safe drug dosing and heart co…

This study will test whether a combination of an AI-powered risk tool, a simple 'sponge on a string' test, and nurse navigation can improve screening for Barrett's esophagus and esophageal cancer. Over 1,000 adults at higher risk will be enrolled. The goal is to see if these less…

This study looks for protein markers in urine and blood that could help identify different types of kidney cancer without needing a biopsy. Researchers will analyze stored urine samples from 300 people and collect blood before and after kidney removal surgery. The goal is to deve…

This study will test a new iPhone app called FaceScan that uses LiDAR and voice recognition to measure visual acuity. Researchers at Mayo Clinic will compare the app's results to standard eye exams in 150 adult patients. The goal is to see if the app is accurate enough for home o…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This study tests whether taking low-dose aspirin can lower inflammation in the womb lining and help prevent endometrial cancer. It involves 25 postmenopausal women who have non-atrophic endometrial changes and pain. Participants will be randomly assigned to take aspirin or not, a…

This pilot study aims to see if offering self-collection kits for cervical cancer screening and HPV vaccination in emergency departments can reach women who have limited healthcare access. Researchers will enroll 100 women aged 18-65 and track how many participate and complete th…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

This study uses magnetic resonance elastography (MRE), a special MRI technique, to measure stiffness in the lower back muscles of people with chronic low back pain before and after a single session of device-assisted massage therapy. The goal is to see if MRE can detect physical …

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function. Researchers will measure blood pressure, heart rate, and nerve activity in 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see if cannabis can help man…

Researchers at Mayo Clinic are running a pilot study to see whether clearing a blocked pancreatic duct improves how the pancreas makes insulin in people with chronic pancreatitis. Participants are adults with minimally symptomatic chronic pancreatitis and a duct blockage. The stu…

This pilot trial tests whether a program of virtual ukulele lessons, called STRUM, can help teenagers preserve cognitive function and emotional resilience while undergoing radiation therapy for cancer. The study enrolls adolescents aged 12 to 17 who are receiving initial radiatio…

This study tests whether THC (with or without CBD) can improve sleep in people with solid organ cancer who have insomnia. About 69 participants will receive either THC, a THC/CBD mix, or a placebo as a liquid under the tongue. The goal is to see if these cannabis-based compounds …

This phase II trial tests whether rimegepant, a drug used for migraines, can reduce pelvic pain in women with endometriosis. The study enrolls 132 women aged 18 to 45 with surgically confirmed endometriosis and moderate-to-severe pain. Participants take either rimegepant or a pla…

This trial tests whether briefly raising the arm during a propofol injection can reduce the burning pain some people feel. It compares this technique to the standard lidocaine pretreatment, and to a combination of both. About 45 adults scheduled for propofol anesthesia will parti…

This study tests whether a 6-week mindfulness meditation app can reduce pain intensity and improve mood in people with spinal cord injury who have chronic pain. Participants are randomly assigned to either use the mindfulness app or a health education app. The goal is to see if t…

This study tests whether a seven-session, telehealth-based therapy called Meaning-Centered Psychotherapy is practical and helpful for stem cell transplant survivors and their main caregivers. The program aims to help dyads stay connected to meaning, cope with difficult experience…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This pilot study will test whether bright light therapy can help reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers plan to enroll 70 adults on inpatient units at Mayo Clinic. Participants will receive 60-minute sessions of light ther…

This study compares a physical activity program to a health education program for improving memory and attention in Hispanic women aged 50 and older who have been treated for early-stage breast cancer. Researchers want to see if aerobic exercise can help with cognitive problems l…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study tests whether weekly virtual reality sessions can help manage menopause symptoms like hot flashes and night sweats. Women aged 45 to 60 who have at least 28 hot flashes per week will use a VR headset at home for 8 weeks. Researchers will track changes in hot flash freq…

This study tests a virtual reality assistant called ViRA designed to provide emotional support and help with daily needs like food and transportation for Black men recently diagnosed with prostate cancer. About 200 participants will use the ViRA app and researchers will measure h…

This study at Mayo Clinic will test if dry needling with electrical stimulation can improve sleep and reduce symptoms in people with restless legs syndrome. Twenty adults aged 18-75 with a clinical diagnosis will receive two weekly sessions targeting leg muscles. Researchers will…

This study will give 200 plastic surgery patients access to an artificial intelligence virtual assistant called AIVA. The assistant answers questions about their upcoming surgery. Researchers want to see if this reduces phone calls to clinic staff and improves patient and provide…

This study tests whether adding a neutral shoe insert to standard physical therapy helps people with long-term hip pain (greater trochanteric pain syndrome). About 36 adults with unilateral hip pain for over three months will be assigned to physical therapy plus a shoe insert on …

This study compares two approaches to notify relatives of people diagnosed with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. One method lets patients share information themselves; the other has the study team contact relatives directly. R…

This Mayo Clinic study will test whether a special ultrasound technique, called shear wave elastography, can measure how stiff brain tumors are compared to healthy brain tissue during surgery. Researchers will enroll 30 adults with newly diagnosed or recurrent brain tumors. The g…

Researchers at Mayo Clinic are studying whether an implantable Doppler monitor can record the sound of blood flowing through a free flap and convert it into a visual signal. The trial enrolls 100 adults scheduled for free flap surgery, a procedure that moves tissue to rebuild par…

This study aims to understand how symptoms of indolent systemic mastocytosis relate to biological signals in the body. Researchers will collect samples and data from 25 participants over 12 weeks to see how different treatments affect these signals. The goal is to improve underst…

This study explores how nurses and family members describe and practice family engagement in emergency departments. Researchers will interview nurses and family members to understand what helps or hinders family involvement during emergency care. The goal is to gain insights that…

This early study at Mayo Clinic tests a new implantable device called the Brain Interchange System in up to 8 people with drug-resistant epilepsy. The device records high-speed brain signals and can deliver targeted electrical stimulation to prevent seizures. Unlike current syste…

This study surveys people with lung tumors before and after a procedure called percutaneous ablation, which uses heat or cold to destroy cancer cells. Participants will rate symptoms like pain, fatigue, and shortness of breath on a simple scale. The goal is to understand how pati…

This study creates a biospecimen and data repository at Mayo Clinic to help evaluate patients with rare or undiagnosed genetic conditions. Participants, who have already had standard genetic testing without a diagnosis, will provide samples and medical data. A multidisciplinary t…

This study uses a special PET scan to look for signs of inflammation in the brains of people with Post-COVID syndrome. Researchers want to learn more about why some people have long-lasting symptoms after a COVID-19 infection. Ten Mayo Clinic patients who had COVID-19 and are exp…

This study tests whether adding special air quality sensors and software to hospital ventilation systems can lower the number of respiratory infections among healthcare workers. About 850 Mayo Clinic staff will report symptoms and provide self-swabs when sick. The goal is to see …

This study looks at how long the drug calaspargase pegol stays at effective levels in the blood of children and young adults with acute lymphoblastic leukemia or lymphoma. Researchers will measure drug activity and check for links to side effects. The goal is to better understand…

This early study tests whether a small device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the device placed temporarily during their operation. The goal is to see if the device works and is safe, not to treat t…

This study will check how well pulse oximeters measure oxygen levels when blood flow to the hand is increased or decreased. Twenty healthy adults will breathe lower-oxygen air while researchers compare oximeter readings to blood samples. The goal is to see if changes in hand bloo…

This study looks at how a common genetic change (the T allele at rs7903146) affects the pancreas's own production of GLP-1, a hormone that helps control blood sugar. Researchers will give 80 healthy adults a drug that blocks GLP-1 receptors to see how their insulin and glucagon l…

This study observes 100 patients having elective brain surgery to clip an aneurysm. Some take daily low-dose aspirin, others do not. Researchers track bleeding during surgery and on CT scans afterward to understand the risks. The goal is to help doctors decide whether to stop or …

This study aims to understand how resistance exercise (like weight lifting) helps muscles use insulin better to control blood sugar. Researchers at Mayo Clinic will study 16 sedentary adults who are weight-stable. Participants will undergo exercise training, and scientists will m…