Nerve block before bypass may stop post-surgery heart flutter
NCT ID NCT07570940
First seen Jun 26, 2026 · Last updated Sep 10, 2026 · Updated 3 times
Summary
This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will be randomly assigned to receive either the numbing drug (liposomal bupivacaine) or a placebo (salt water) injection. Their heart rhythms will be monitored continuously with a wearable ECG device.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- liposomal bupivacaine
- What this could lead to
- If it works, this could provide a simple, non-drug way to prevent a common and serious heart rhythm problem after bypass surgery.
- What could go wrong
- This is a single, early-phase 4 trial at one center. The nerve block may not reduce AFib risk, and there are risks from the injection itself, such as bleeding or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 450 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged ≥40 years scheduled to undergo isolated coronary artery bypass grafting will be eligible. * Cases will also remain eligible if, after the initial surgical listing, additional procedures-such as valvular interventions or septal myectomy-are performed, OR if coronary artery bypass grafting (CABG) is listed as the primary intervention with other procedures noted as possible additional interventions. * Cases will also remain eligible if additional procedures-such as left atrial appendage ligation, MAZE procedure, cryotherapy, or pulmonary vein isolation-are concomitantly listed with the CABG. Exclusion criteria: * Permanent atrial fibrillation * Mechanical circulatory support implant or explant * Procedures not requiring cardiopulmonary bypass * Heart and/or lung transplant patients * Active infection/sepsis * Pre-operative anti-arrhythmic use (aside from beta-blockers). * Participant has a known allergy to adhesives or hydrogels. * Participant has a visible skin injury or broken skin at the location for study device placement. * Participant does not have the competency to wear the device for the prescribed patching period. * Participant has a neuro-stimulator, as it may disrupt the quality of ECG data. * Participants who are pregnant. In accordance with Mayo Clinic's standard cardiac surgery protocol, all women of childbearing potential undergo routine preoperative pregnancy testing. Pregnancy status will therefore be confirmed prior to enrollment. Any participant with a positive pregnancy test will be deemed ineligible and will not be enrolled in the study. * Participants who lack the capacity to provide informed consent will not be approached or enrolled in this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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