CORONARY ARTERY DISEASE

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with heart failure and severe blockages in multiple heart arteries. The goal is to see which approach better prevents death, stroke, heart attacks, and hospital readmissions ove…

This study tests a special balloon coated with medicine to open completely blocked heart arteries. 30 adults with chest pain or heart disease will get this treatment. Doctors will use ultrasound and pressure tests right after and again at 6 months to see if the artery stays open.…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (low pumping function) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and improved q…

This study is testing a long stent (a small mesh tube) to treat long blockages in the heart's arteries. The goal is to see if using one long stent is safe and works well for these difficult blockages. About 1,039 adults with coronary artery disease will take part. The main focus …

This study is testing a new, longer drug-coated stent (Orsiro Mission) for people with long blockages in their heart arteries. About 150 participants will get the stent and be followed for up to 5 years. The goal is to see if the stent is safe and effective at keeping the artery …

This study tests whether the drug colchicine can prevent atrial fibrillation (a type of irregular heartbeat) in people recovering from heart bypass surgery. Researchers will compare 70 patients who receive colchicine plus a special surgical technique with 70 patients who receive …

This study tests whether a moderate-dose statin combined with ezetimibe works as well as a high-dose statin alone in stabilizing fatty plaques in heart arteries. About 408 adults with coronary artery disease will receive one of the two treatments for 52 weeks. The goal is to see …

This study compares a newer, gentler heart-lung machine (MiECC) to the standard machine used during heart surgery. The goal is to see if the newer machine reduces serious complications like heart attack, stroke, or kidney injury. About 1,300 adults having planned coronary bypass …

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow or change the buildup of fatty plaque in the heart arteries. It includes 200 adults aged 40-75 with high genetic risk for heart disease but no symptoms. Participants get a…

This study tests a special balloon coated with a drug (sirolimus) to open up small blood vessels in the heart that are narrowed by coronary artery disease. About 1,600 adults with chest pain or silent ischemia will be randomly assigned to receive this balloon or standard treatmen…

This study compares two blood-thinning medications, prasugrel and ticagrelor, when taken alone (without aspirin) by people with heart disease who have had a stent placed at least 90 days earlier. The goal is to see if one is better at preventing blood clots. The study will involv…

This study tests a new, very thin stent coated with a drug (sirolimus) in 500 heart disease patients who also take blood thinners. These patients have a high risk of bleeding when they need a stent. The new stent may allow for a shorter course of antiplatelet drugs, potentially r…

This study tests whether an inhaled medication called Aroxxen® can reduce heart muscle damage in people undergoing a common procedure to open blocked heart arteries (stent placement). About 180 adults with coronary artery disease will receive either Aroxxen® inhalation or standar…

This study tests whether a stronger blood thinner (prasugrel) combined with aspirin works better than the standard combination of clopidogrel and aspirin for people with coronary artery disease who need complex stents. About 3,500 adults will be randomly assigned to one of the tw…

This study tests a special balloon coated with medicine to treat narrowed small arteries in the heart. About 960 adults with coronary artery disease will receive either this balloon or standard treatment. The goal is to see if the balloon is safe and effective at keeping arteries…

This study tests whether using a special algorithm to decide how long patients take two blood thinners after a heart stent procedure leads to better outcomes than the usual one-size-fits-all approach. About 2,788 adults who have received a drug-coated stent will be enrolled. The …

This study compares two treatments for coronary artery disease: a drug-coated balloon (DCB) and a drug-eluting stent (DES). Researchers will measure how much the artery narrows again after treatment using ultrasound. About 256 adults with blocked heart arteries will take part to …

This study is for people who have chest pain (angina) but no major blockages in their heart arteries. It tests whether a special diagnostic procedure during heart catheterization can help doctors choose the right medications to reduce pain and improve quality of life. About 1,500…

This study compares two strategies to reduce bleeding risk in people who take two blood thinners after having a stent placed in their heart. The goal is to see if lowering the dose of one drug works as well as switching to a different drug. About 78 adults who have had a stent wi…

This study tests a new type of heart stent that slowly dissolves over time. It is designed for people with long blockages in their coronary arteries. The goal is to see if the stent is safe and works well to keep arteries open and reduce heart problems over one year. About 100 pa…

This study tests whether adding YN001 to standard cholesterol-lowering therapy can reduce plaque in heart arteries. About 24 adults with coronary atherosclerosis and at least one blocked artery will receive YN001 intravenously. The main goal is to see changes in plaque volume and…

This study compares two diabetes drugs, semaglutide and dapagliflozin, against the standard treatment metformin in 300 adults with pre-diabetes and coronary artery disease. The goal is to see if these drugs can slow or reverse the buildup of fatty plaque in the heart arteries ove…

This study compares two approaches for people with chronic coronary syndrome (narrowed heart arteries). One group gets a special CT scan to guide procedures like stents, while the other gets only medications. The goal is to see which strategy better prevents heart attacks, death,…

This study compares two ways to open completely blocked heart arteries: a drug-coated balloon and a drug-coated stent. About 200 adults with chronic total occlusion will be randomly assigned to one treatment. The goal is to see which method keeps the artery open longer and reduce…

This study tests a pharmacy-led program to help low-income patients with chronic conditions like diabetes and heart disease take their medications after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to help with follow-up care. …

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to standard treatment can prevent major heart problems like heart attacks, strokes, or death in people with high-risk coronary plaques seen on CT scans. About 3,600 adults with at least one s…

This study compares a new dissolvable heart stent (Firesorb) to a standard metal stent in 2,000 people with coronary artery disease. The dissolvable stent is designed to support the artery temporarily and then disappear, potentially reducing long-term risks. The goal is to see if…

This study looks at 600 women with blocked heart arteries to compare two treatments: stenting (a small tube placed through a wrist or groin incision) and bypass surgery (open-heart surgery using blood vessels from elsewhere in the body). The goal is to see which approach leads to…

This study is testing a special stent (a small mesh tube) coated with a drug called sirolimus to treat coronary artery disease. The stent is placed in blocked heart arteries to keep them open and prevent future heart problems. Researchers will follow 10,000 patients to see how sa…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study tests a special balloon coated with medicine to treat narrowed heart arteries. It is for people with previous stent blockages or small artery disease. About 1205 adults will receive the balloon treatment to see if it safely improves blood flow and reduces the need for …

This study is checking if a medical device called Essential Pro is safe and works as intended for people with narrowed or blocked heart arteries. About 100 patients who already received the device as part of their routine care will be followed. Researchers will track heart-relate…

This study tests whether a comprehensive treatment plan can reduce serious heart events in people with rapidly-progressive coronary artery disease driven by inflammation. Researchers will compare each participant's outcomes before and after treatment. The study enrolls 39 adults …

This study is checking how well two new stents (Synergy XD and Synergy Megatron) work in everyday medical practice for people with coronary artery disease. About 2000 adults getting these stents will be followed to see if they have fewer heart attacks, need repeat procedures, or …

This study looks at two ways to deliver cardiac rehabilitation—a program of exercise, education, and counseling for people with heart conditions. One method is in-person at a clinic, the other is done remotely via telehealth. The goal is to see if both approaches are equally effe…

This study tests whether a drug-coated balloon works better than a drug-eluting stent for treating complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two procedures. The main goal is to see which approach red…

This study tests whether using sound waves (lithotripsy) to crack hard calcium deposits in heart arteries helps place stents better than standard methods like high-pressure balloons. About 666 adults with severe artery calcification will be randomly assigned to receive either sho…

This study tests a drug called meplazumab in 18 adults with coronary artery disease (narrowed heart arteries). The drug targets inflammation in artery plaques, which may help slow disease progression. Participants receive the drug or a placebo for several months, and doctors use …

This study tests whether a daily arm-cuff treatment (remote ischemic conditioning) plus mindfulness exercises can lower the risk of heart attacks, heart failure, and chest pain in 2,000 adults with coronary artery disease that wasn't fully fixed. Participants must have at least o…

This study tests whether treating fatty heart plaques with a drug-coated balloon reduces their danger more than standard medications alone. About 400 adults with acute coronary syndrome will be randomly assigned to receive either the balloon treatment or no extra treatment during…

This study tests whether a home monitoring program using text messages and a smartphone app can help people with coronary artery disease manage their health after a stent procedure. 200 participants will either receive standard care or the digital program, which includes remote b…

This study looks at whether berberine, a natural compound, can help blood thinners work better in people who have had a heart stent. About 64 adults who are already taking aspirin and clopidogrel will receive different doses of berberine or no extra treatment for up to 13 weeks. …

This study compares a new AI-driven method (MPFFR) against the standard invasive FFR test to decide if and where to place stents in blocked heart arteries. About 2,100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see i…

This study tests a temporary heart pump (iVAC 2L) in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps keep blood flowing during the procedure, which may reduce the chance of death, heart attack, or stroke. The goal is to see if the dev…

This study tests whether giving elderly patients with kidney disease a personalized amount of fluids, guided by a lung water monitor, can prevent acute kidney injury after a heart imaging procedure called coronary angiography. About 320 participants aged 60 and older with chronic…

This study tests whether ziltivekimab, a drug that reduces inflammation, can improve artery health in people who recently had a heart attack. About 332 participants will receive either ziltivekimab or a placebo, along with standard care, for 15 months. Special imaging will measur…

This study tests whether a drug called indobufen works better and causes fewer side effects than aspirin in people over 65 who have had a heart attack or unstable angina and received a stent. About 2,800 participants will take either indobufen plus ticagrelor or aspirin plus tica…

This study tests a new stomach acid-reducing drug (tegoprazan) against a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners. The goal is to see if the new drug is as good at preventing serious stomach problems like bleeding and ulcers. Participants t…

This study compares two ways to treat hardened calcium deposits in heart arteries. One method uses a tiny drill plus shockwaves, the other uses shockwaves alone. The goal is to see which approach allows for better stent placement. About 120 adults with severe coronary artery dise…

This study tests whether a lower dose of the blood thinner ticagrelor works better than the standard clopidogrel in stable heart disease patients who are at high risk for a heart attack during a stent procedure. About 50 adults will be enrolled and their blood's ability to clot w…

This study tests if drug-coated balloons work as well as drug-eluting stents for treating blocked heart arteries at branch points. About 321 adults with coronary artery disease will be randomly assigned to one of three treatments. The goal is to see which approach keeps arteries …

This study compares two heart bypass surgery techniques in women: using one artery (single arterial grafting) versus multiple arteries (multiple arterial grafting) to reroute blood around blocked heart vessels. The goal is to see which method leads to fewer heart problems, stroke…

This study looks at 2000 people with chest pain and non-high risk blockages in their heart arteries found on a CT scan. It compares two next steps: an invasive procedure (like placing a stent) versus a non-invasive approach (like medication and monitoring). The goal is to see whi…

This study tests whether giving the blood thinner cangrelor during a minimally invasive heart bypass (MIDCAB) is safe and helps prevent dangerous blood clots. About 30 adults with coronary artery disease will receive cangrelor through an IV during surgery, and their outcomes will…

This study tests whether the drug clopidogrel can prevent major heart problems and strokes in people who have early, non-blocking plaque in their heart arteries. About 11,000 adults aged 40 and older with plaque found on scans but no current symptoms will take either clopidogrel …

This study looks at using a paclitaxel-coated balloon to open up small heart arteries in people with coronary artery disease who also have a high risk of bleeding. The goal is to see if this treatment works well and allows patients to safely stop taking blood thinners after just …

This study looks at how well and how safely scaffold implants work in people with coronary artery disease. Over 1,100 adults who need at least one scaffold will be followed for at least a year. The goal is to track heart-related events like heart attack or the need for repeat pro…

This study compares two ways to treat long, spread-out blockages in heart arteries. One method uses a dissolving scaffold and drug-coated balloons, while the other uses permanent metal stents. The goal is to see if the newer approach works as well at keeping arteries open after 1…

This study tests two strategies for deciding which narrowed heart arteries to treat with stents. One strategy uses a special camera to look at the plaque buildup and decide based on how much and how dangerous it looks. The other uses a pressure wire to measure blood flow and deci…

This study compares two types of drug-coated stents (small mesh tubes placed in heart arteries) in 2,100 people who have had a heart attack or unstable chest pain. The goal is to see which stent better prevents heart-related death, heart attacks, or the need for repeat procedures…

This study tests whether using a special device (orbital atherectomy) to grind down calcium deposits before placing a stent is better than the standard balloon method. About 200 adults with hardened heart arteries will be randomly assigned to one of the two approaches. The goal i…

This study looks at two common ways to restore blood flow to the heart in 600 minority patients with blocked arteries. One method uses a small tube (stent) inserted through the wrist or groin, while the other is open-heart bypass surgery using blood vessels from the chest or leg.…

This study tests two methods to fix heart stents that haven't opened fully. About 80 adults with narrowed stents will get either a special balloon or a shockwave device. The goal is to see which approach opens the stent better, improving blood flow and reducing the need for repea…

This study looks for the best type and dose of a single blood thinner (P2Y12 inhibitor) for people who have had a heart stent placed. About 355 participants will try different doses to find the sweet spot that prevents blood clots without causing dangerous bleeding. The goal is t…

This registry tracks the safety and performance of resorbable magnesium scaffolds in people with coronary artery disease. It follows standard treatment guidelines and includes over 1,100 participants in real-world settings. The main goal is to see how often heart-related problems…

This study is testing a new type of heart stent, called XIENCE Skypoint, against other stents used to open blocked arteries. About 2,000 adults with coronary artery disease will receive the new stent and be followed for a year to see if it prevents death, heart attacks, or the ne…

This study looks at two treatments for coronary artery disease in large blood vessels (≥3.5 mm): a drug-coated balloon and a drug-eluting stent. About 94 adults with heart disease will be randomly assigned to one treatment. The main goal is to see how well the treated artery can …

This study compares two imaging methods for guiding treatment of hardened coronary arteries. About 700 adults with heart disease will either receive CT-guided or standard ultrasound-guided care during stent placement. The goal is to see if the CT approach improves stent expansion…

This study tests whether adding Yiyang Huoluo Decoction, a Chinese herbal medicine, to standard heart treatments can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. About 30 people aged 50-75 will be randomly assigned to r…

This study tests if a new, easier-to-use pressure microcatheter works as well as the standard pressure wire for guiding treatment of narrowed heart arteries. About 2500 adults with stable coronary artery disease or recent non-emergency heart attack will be randomly assigned to on…

This study looks at 600 people who had a major heart attack and have other blockages that are not severe enough to need immediate treatment. Some of these blockages are unstable and could cause another heart attack. The trial compares two approaches: placing stents in these unsta…

This study looks at two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed. One approach switches patients from a strong blood thinner to a milder one while keeping aspirin. The other stops aspirin and keeps the strong blood thinner a…

This study looks at how well a drug-coated balloon works over time for people with coronary artery disease. Researchers will track 1,500 patients to see if the balloon helps prevent heart attacks, death, or the need for repeat procedures. The goal is to understand the treatment's…

This study tests whether colchicine, a safe anti-inflammatory drug used for centuries, can reduce the risk of heart attack, stroke, or death in 700 heart disease patients undergoing major surgery. Participants take colchicine or a placebo before and after their operation. The goa…

This study tests whether a personalized blood-thinning plan (shorter dual therapy followed by one drug alone) is safer and just as effective as the standard approach for people with coronary artery disease who have received a stent guided by imaging. About 3,944 adults will be fo…

This pilot study tests whether the diabetes drug canagliflozin can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. About 16 participants will receive either the drug or a placebo for 6 months. The main goal is to see changes …

This study follows over 2,000 patients with coronary artery disease who received a device called Sequent Please Neo during routine care. Researchers want to confirm the device is safe and works well by tracking major heart problems like heart attacks or the need for repeat proced…

This study is testing a drug called regadenoson in children who need a heart stress test. The drug helps doctors see how well blood flows to the heart. The goal is to check the drug's safety and how the body processes it in different age groups, from infants to teenagers.

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. About 4,300 people having planned, non-emergency bypass will be randomly assigned to one of the two methods. The goal is to see if multiple grafts lower the chan…

This study looks at whether a 12-week cardiovascular rehabilitation program (exercise training three times a week) can improve artery health and reduce inflammation in adults aged 40-70 with coronary artery disease. Researchers will measure artery thickness, blood vessel function…

This study compares two techniques used during heart stent placement for left main coronary artery disease: one guided by standard angiography and another using a pressure wire (FFR). About 960 adults with significant left main artery blockage will be enrolled. The goal is to see…

This study compares two types of drug-coated balloons (Selution with sirolimus vs. SeQuent Please Neo with paclitaxel) to treat narrowed heart arteries in medium-small vessels. About 140 adults with stable angina or stabilized acute coronary syndrome will be enrolled. The main go…

This study looks at whether SGLT2 inhibitors (a type of diabetes drug) can prevent acute kidney injury caused by contrast dye used during heart procedures like angiography or stenting. Researchers will analyze data from 4,000 patients to compare kidney function before and after t…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time, compared to a permanent metal stent. The goal is to see if the dissolvable stent is safe and works as well for people with blocked heart arteries. About 1,859 adults with coronary arte…

This study tests a new balloon device that delivers the drug sirolimus to treat re-narrowed heart arteries (in-stent restenosis). It compares this balloon to an existing one that uses paclitaxel. About 740 adults with one re-narrowed artery will be randomly assigned to receive on…

This study is following 50,000 people with coronary artery disease who receive drug-eluting stents during routine care. The goal is to see how well these stents work and how safe they are in everyday practice. Researchers will track major heart problems like death, heart attack, …

This study looks at two ways to treat hardened calcium deposits (calcified nodules) in heart arteries after using sound waves to break them up. About 128 adults with coronary artery disease will be randomly assigned to get either a drug-coated balloon or a drug-coated stent. The …

This study is testing a medical device that uses gentle sound waves to break up hard calcium deposits inside heart arteries. The goal is to safely open severely hardened arteries so a stent can be placed more effectively. The study will enroll about 335 adults in the US with seve…

This study tests whether using an AI program to analyze CT scans of heart arteries can help doctors make more accurate diagnoses and treatment plans for people with suspected heart disease. About 1000 participants will be randomly assigned to either get this AI-guided care or sta…

This study tests a new computer program that helps doctors diagnose blocked heart arteries from CT scans more accurately. Researchers will look at past scans from 1,000 patients to see if the software can reduce the need for invasive tests like angiograms. The goal is to make dia…

This study is testing whether certain proteins in the blood can tell if a person has significant blockages in their heart arteries. About 1,000 adults with suspected coronary artery disease will have their blood tested and compared to results from a heart CT scan. If successful, …

This study tests a new type of MRI that looks at how the heart uses energy. It aims to help doctors decide which patients with heart disease will benefit most from bypass surgery. About 30 adults with coronary artery disease and healthy volunteers will get this special scan. The …

This study compares two non-invasive tests for coronary heart disease: a CT scan of the heart arteries versus a heart ultrasound combined with a neck artery ultrasound. The goal is to see which approach better detects both minor and severe blockages, helping doctors choose the ri…

This study looks at whether a non-invasive CT scan (FFR CT) can accurately measure blood flow in the heart's arteries, compared to the standard invasive test. Researchers will review data from 500 adults with suspected coronary artery disease to see how well the CT scan works acr…

This study tests a new imaging agent called [15-O]-H2O, given through an IV, to see if it can accurately detect coronary artery disease using a PET scan. About 215 adults with suspected heart disease will receive the agent at rest and during stress. The goal is to confirm how wel…

This study tests whether artificial intelligence can find early signs of coronary artery disease on regular chest CT scans that don't use contrast dye. Researchers will analyze scans from about 1,600 adults to see if the AI can predict dangerous plaque and blockages. If successfu…

This study tests a new imaging method called µQFR to see how well it can detect blocked blood flow in side branches of heart arteries after a single stent is placed. About 290 adults with complex coronary artery disease will be enrolled. The goal is to see if this non-invasive ap…

This study tests a new 3D imaging method called 3DStent to see if it can detect when a heart stent is not fully expanded after placement. About 200 adults with coronary artery disease who need a stent will be enrolled. The goal is to compare 3DStent results with standard ultrasou…

This study tests whether artificial intelligence can automatically analyze ultrasound videos to detect coronary artery disease. Researchers will enroll 1,500 people with suspected heart disease who are already scheduled for a coronary angiogram. The goal is to see if AI can provi…

This study tests whether an artificial intelligence (AI) tool can help doctors spot calcium buildup in the heart arteries from chest CT scans done for other reasons. The goal is to start or increase cholesterol-lowering medicine in people aged 40–75 who have no prior heart diseas…

This study looks at whether a tailored plan can prevent coronary artery disease in people who survived cancer. It includes 748 adults aged 40-70 who had chemotherapy or radiation more than 5 years ago. Participants get heart risk checks and, if needed, a CT scan to guide preventi…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury. About 242 adults having elective bypass surgery will receive either the supplements or a placebo. The goal is to see if this simple approach can protect kidney fu…

This study tests whether giving a numbing medicine (ropivacaine) through chest tubes placed after heart surgery helps patients recover better and feel less pain. About 116 adults having planned heart surgery will receive either the medicine or a placebo. The main goal is to see i…

This study tests whether opening blocked heart arteries with stents can improve quality of life for people with a type of heart failure called HFpEF. 350 participants will be randomly assigned to receive either a real stent or a placebo procedure, and neither they nor their docto…

This study looks at 570 people with chronic coronary syndrome (ongoing heart artery disease causing chest pain). It compares two approaches: immediate heart catheterization plus medication optimization versus medication alone. The goal is to see which strategy better relieves ang…

This study looks at whether using a high-tech camera called OCT during heart stent placement can help people with stable angina take blood thinners for a shorter time. Normally, patients take these drugs for 6-12 months to prevent clots, but longer use raises bleeding risk. The s…

This study tests two breathing exercises—segmental breathing and active cycle breathing—against standard care in 99 adults recovering from open heart surgery. The goal is to see which technique better reduces shortness of breath and improves oxygen levels, heart rate, and blood p…

This study tests whether watching a short educational video can lower anxiety in adults waiting for a heart procedure called PCI. About 144 participants will either watch the video or receive usual care. Anxiety levels are measured before and after using a standard questionnaire.

This study tests a device called Bioboosti that uses pulsed electromagnetic waves to see if it can improve blood flow to the heart in people with coronary artery disease. About 120 adults who have heart ischemia and cannot have standard procedures like stents or bypass will recei…

This study looks at whether telling people their genetic risk for heart disease (called a polygenic risk score) helps them lower their cholesterol and improve their heart health over one year. About 500 adults aged 30-75 who are not on cholesterol medication will be randomly assi…

This study reviews medical records of 5,000 adults who had heart surgery at UC Davis Medical Center. Researchers want to find out which factors influence recovery and survival after surgery. The goal is to use this information to improve care and outcomes for future heart surgery…

This study will follow about 20,000 people with coronary artery disease who had a procedure to open blocked heart arteries using a special measurement called FFR. The goal is to see how well the treated arteries hold up over 2 years by tracking heart-related events like heart att…

This study follows 1500 adults who are scheduled for heart surgery or a less invasive valve procedure. Researchers want to learn what factors predict major heart problems like stroke, heart failure, or death after the procedure. Participants will be monitored for several years to…

This study is looking at 180 non-diabetic adults with early coronary artery disease to see if a simple blood test called the triglyceride-glucose (TyG) index can help predict the severity of artery blockages. Participants will have their TyG index measured and compared to their a…

This study follows 30,000 people diagnosed with various forms of coronary artery disease to see how different risk factors affect their long-term health. Researchers will track deaths from any cause and from heart-related problems. The goal is to better understand what influences…

This study enrolls 600 people – both heart disease patients who have had a stent procedure and healthcare providers – to understand how they rank the seriousness of different health events like heart attack, stroke, or bleeding. The goal is to improve how clinical trials measure …

This study follows 25,000 adults with multivessel coronary artery disease to see how different treatments—medication, bypass surgery, or stents—affect their long-term health. Researchers track major events like death, heart attack, stroke, and repeat procedures. The goal is to un…

This study looks at how aging inside our cells may make heart disease worse. Researchers will measure DNA damage and other aging markers in 300 people with different types of chest pain or heart attacks. The goal is to find new ways to predict and treat dangerous plaque buildup i…

This study is observing 10,000 people with a severe blockage in the left main coronary artery to see how different treatments—medication, stents, or bypass surgery—work in everyday medical practice. Researchers will track deaths, heart attacks, and other major events over the lon…

This study compares two methods to reopen completely blocked heart arteries in people with coronary artery disease. About 74 participants will be randomly assigned to one of two techniques to see which is faster, safer, and less stressful for doctors. The goal is to find the best…

This study tests whether having patients fill out online surveys about their quality of life and heart symptoms before a doctor visit helps improve communication and care. About 200 adults with known or suspected coronary artery disease and their cardiologists will take part. The…

This study reexamines 1,400 adults originally part of a large Swedish health study to identify risk factors for heart, lung, and liver diseases. Participants undergo advanced imaging, blood tests, and questionnaires. The goal is to better understand how conditions like coronary a…

This study looks at 1300 adults who had a heart procedure (PCI) and are at high risk for bleeding. Researchers will use artificial intelligence to find which blood-thinning medicines work best and for how long to prevent heart attacks and strokes while avoiding dangerous bleeds. …

This study watches how drug-coated balloons change blood vessels in people with coronary artery disease. Researchers will use CT scans to measure blood flow and plaque before and after the procedure. The goal is to see how these changes relate to patient outcomes. About 165 adult…

This study is for people with a type of heart disease linked to inflammation. Researchers want to learn about the symptoms, treatments, and health outcomes of 120 participants. The goal is to better understand this condition, not to test a new treatment.

This study will test a new, faster CT scanner to see if it can better detect risky plaque in heart arteries and measure blood flow. About 500 adults with known or suspected heart disease will get a special CT scan, and results will be compared with standard tests like angiograms …

This study looks at tiny structures inside heart cells called mitochondria, which help produce energy. Researchers want to see if problems with these structures are linked to worse heart failure outcomes. About 45 to 60 people with heart failure and blocked arteries will give sma…

This study looks at why some ICU patients bleed longer after a tube is removed from their leg artery following heart procedures. Researchers will track 157 adults to find factors that affect bleeding and the required 6-hour flat bed rest. The goal is to create a tool that predict…

This study looks at a technique where blood left in the heart-lung machine after bypass surgery is returned to the patient during the procedure. Researchers want to see if this simple step lowers the need for donated blood transfusions in the first day after surgery. The study in…

This study looks at whether a special score that combines genetics and patient information can identify people with stable coronary artery disease who are at higher risk for a heart attack or heart injury during a planned stent procedure. About 500 adults will be enrolled and fol…

This study looks at why some people tolerate ventricular tachycardia (a fast, abnormal heart rhythm) better than others. Researchers will measure blood pressure and blood flow in the heart arteries of 70 people already scheduled for a heart catheter procedure. They want to see if…

This study surveys 600 people—including heart disease patients and their healthcare providers—to understand their preferences between two treatments for blocked arteries: permanent metal stents (DES) or drug-coated balloons (DCB) that leave no metal behind. The goal is to find ou…

This study follows 1,200 people with coronary artery disease who are joining a cardiac rehab program. Researchers will collect detailed health data, including fitness tests, activity trackers, and long-term heart monitoring, to understand what helps patients stick with healthy ch…

This study tests an online decision aid called "My Heart Care and CKD" for people with both chronic kidney disease and heart disease. The tool helps patients and doctors understand the risks and benefits of heart procedures like angiograms or surgery, which can be riskier for kid…

This study follows 80 adults who had coronary artery bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare lab tests, heart and lung function, and imaging between those who get pneumonia and…

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who need a valve replacement. One method is the usual invasive X-ray, and the other uses non-invasive risk management. The goal is to see which approach leads to better health a…

This study aims to understand why some fatty buildups in heart arteries are dangerous while others are not. Researchers will use a special camera inside the arteries and analyze blood cells to find clues. The study involves 350 adults with or without significant artery narrowing.…

This study tests a new device that collects blood samples directly from the coronary arteries of 300 people with established coronary artery disease. The goal is to measure specific molecules linked to artery blockages, which could help doctors develop more personalized treatment…

This study aims to understand why some people with coronary artery disease get worse quickly due to inflammation. Researchers will compare 20 patients with inflammation-linked rapid disease to 10 patients with standard disease. They will look at medical history, lab tests, and im…

This study looks at how accurately a CT scan can measure the amount of plaque (fatty buildup) in the heart arteries compared to a more invasive ultrasound method. It involves 250 adults with stable coronary artery disease who already need a heart catheterization. The goal is to s…

This study looks at four different treadmill tests to see which one best measures how much oxygen the body uses during exercise in people with coronary artery disease. Researchers want to know if the best test differs between women and men. The goal is to improve exercise testing…

This study tests whether doing several heart tests (like a CT scan, ultrasound, and blood flow scan) all in one day is faster and cheaper than the usual step-by-step approach for people with possible coronary artery disease. About 500 patients from Swedish primary care centers wi…

This study looks at four simple physical tests—like timed walking and standing up from a chair—to see which one best measures how well patients recover after coronary artery bypass surgery. Researchers will test 150 adults aged 30-50 on the third and fifth day after surgery. The …

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of 140 people with mild blockages. Participants get either statins or a placebo for 3 months, and advanced CT scans track plaque changes. The goal is to understand who…

This study looks at whether singing, alone or in a group, is a practical activity for older adults with coronary artery disease. Researchers want to see if people will stick with it and if it might help lower heart disease risk. The study involves 32 participants and focuses on h…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study looks at whether tiny plastic particles (microplastics and nanoplastics) are present in the blood of people with chronic heart disease. Researchers will collect blood samples from 120 patients during a routine heart catheter procedure and analyze the samples for plasti…

This study looks at how calcium buildup in artery walls affects the healing of a heart stent after one month. Researchers will use a special camera to compare stent struts over calcium deposits to those without calcium. The goal is to understand if calcium slows down the covering…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study is a registry that will follow up to 100,000 people who have received or will receive a Medtronic medical device. It aims to collect real-world information on how safe and effective these devices are over time. Participants are not given any new treatment; instead, the…

This study is testing a new type of MRI scan that looks at how the heart uses energy, to see if it can help doctors understand heart muscle health better than current methods. Researchers will compare this new scan with standard PET and SPECT scans in 15 people—6 healthy voluntee…

This study looks at whether using a tiny camera inside the heart's arteries during stent placement can prevent future heart attacks, repeat procedures, or death. Over 11,000 adults with complex coronary artery disease will be tracked to see if this imaging approach works better t…

This study looks at whether telling people they have a high genetic risk for heart disease helps them improve their heart health over one year. About 200 adults aged 40 to 75 who have a high genetic risk but no current heart disease will take part. Half will learn their genetic r…

This study looks at whether a special heart scan (coronary CT angiography) is better than standard follow-up care for high-risk patients who have had a stent placed to open blocked arteries. About 3,500 adults aged 19 and older with complex heart conditions will be enrolled. The …

This study tests whether customizing medications based on a person's specific type of heart microcirculation problem can improve quality of life better than standard care. About 180 people with chest pain but no major artery blockages will be randomly assigned to either personali…

This study follows 4,000 people with coronary artery disease who have had special imaging of their heart arteries. Researchers want to see if the images can predict serious heart events like heart attack or death. No new treatment is given; the goal is to learn how well imaging c…

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This pilot study is testing whether wearable devices like smartwatches can be useful for tracking the health of people recovering from a serious illness that required intensive care. Researchers want to see if patients find these devices easy to use and helpful over a 6-month per…