CORONARY ARTERY DISEASE

This study compares two ways of preparing a narrowed heart stent before using a drug-coated balloon to reopen it. About 500 adults with in-stent restenosis will be randomly assigned to either aggressive balloon prep (using cutting or scoring balloons) or standard prep. The goal i…

This study tests whether a HUAWEI smartwatch with artificial intelligence can help people who had a heart attack monitor their health during home recovery. About 1,050 adults will either use the AI smartwatch, a regular smartwatch, or standard care for three months. The goal is t…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The program includes digital tools, personalized guidance, and ongoing support. Researchers will compare it…

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus stent in about 2,000 people with coronary artery disease who need a procedure to open blocked heart arteries. The goal is to see if the new stent is as good as the stand…

This study compares two treatments for coronary artery disease: a drug-coated balloon and a drug-eluting stent. It focuses on patients with high bleeding risk who need a simpler approach. The goal is to see which option leads to fewer heart attacks, strokes, or repeat procedures.

This study looks at 654 people with heart failure and a weak heart pump (ejection fraction 40% or less) caused by blocked arteries. Half will get artery-opening stents plus standard heart medications, and the other half will get medications alone. The goal is to see which approac…

This study compares two ways to reroute blood flow around blocked heart arteries during bypass surgery. One method uses only arteries from the chest and arm, while the other uses a mix of artery and leg vein grafts. The goal is to see which approach keeps the new blood vessels op…

This study compares two treatments for blocked small heart arteries: paclitaxel-coated balloons and drug-eluting stents. About 1,380 adults with stable or unstable chest pain will be randomly assigned to one of these options. The goal is to see which works better at preventing he…

This study tests a special balloon that uses shockwaves to break up hard calcium deposits in heart arteries. It will include 200 people with severe blockages. Researchers will check if the treatment is safe and helps keep arteries open.

This study tests two medical devices (Amplatzer Amulet and LAmbre) that close a small pouch in the heart called the left atrial appendage. In people with atrial fibrillation, this pouch can form clots that cause strokes. By sealing it off, the goal is to lower stroke risk and all…

This study looks at 140 adults with coronary heart disease who need non-emergency non-cardiac surgery. Researchers want to see if it's safer and more effective to open blocked heart arteries before or after that surgery. The goal is to reduce major heart problems like heart attac…

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard statin therapy soon after a heart attack can make artery plaques thicker and more stable. About 212 adults who recently had a heart attack and underwent stenting will be randomly as…

This study looks at two approaches for people with high-risk fatty deposits (plaques) in their heart arteries found on a CT scan. One group gets early heart catheterization with possible stenting plus standard medications, while the other gets medications alone. The goal is to se…

This study will test whether using a special ultrasound camera inside the heart's arteries (called IVUS) during a common procedure to open blockages (PCI) can improve outcomes for minority patients with complex coronary artery disease. About 1010 adults who identify as a racial o…

This study looks at 300 people having heart bypass surgery to find the best length of time to take two blood thinners (ticagrelor plus aspirin) after the operation. Participants will take the combination for either 3, 6, or 12 months, then switch to aspirin alone. The goal is to …

This study tests a new temporary heart pump called the Supira System in people with coronary artery disease who need a high-risk procedure to open blocked arteries. About 358 participants will be randomly assigned to receive either the Supira System or an existing pump (Impella).…

This study tests two settings on a temporary heart pump used during a high-risk procedure to open blocked arteries in people with weak hearts. Half of the 50 participants will get an automatic pump setting that adjusts flow as needed, while the other half gets a fixed lower flow.…

This study tests if a drug-coated balloon is as safe and effective as a drug-coated stent for treating large blockages in heart arteries. About 2,492 people with coronary artery disease will be randomly assigned to one of the two treatments. Doctors will use special imaging to gu…

This study compares the safety of the drug flecainide to standard rhythm-control medications (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least …

This trial looks at whether placing a drug-coated stent in a completely blocked heart artery works better than just using medications over at least 10 years. About 840 people with chronic total occlusion will be randomly assigned to one of the two treatments. The main goal is to …

This pilot study checks if it's possible to run a larger trial on low-dose aspirin for people with early, symptom-free coronary artery disease. About 48 adults with signs of artery blockage but no symptoms will be randomly assigned to take aspirin or not. The main goal is to see …

This study compares two methods to prepare severely calcified heart arteries before placing a stent: a shockwave device that breaks up calcium versus standard balloon treatment. It also compares two imaging techniques to guide the procedure. About 3,060 adults with coronary arter…

This study looks at whether taking two blood thinners for just 1 month after a special balloon procedure is as safe and effective as the standard 6-month course. About 1,484 adults with small heart arteries and stable chest pain will be randomly assigned to either 1 or 6 months o…

This study tests whether using a special heart scan (coronary CTA) to guide intensive treatment can reduce major heart problems like heart attacks and strokes compared to standard care. About 15,000 high-risk adults aged 40-75 in rural China will take part. The main goal is to se…

This study compares a new device called Freesolve, a temporary magnesium scaffold that dissolves over time, to a standard permanent metal stent for treating blocked heart arteries. About 1,859 people with coronary artery disease will be enrolled to see if the dissolving scaffold …

This study looks at whether people with atrial fibrillation (AF) and prior heart stents can safely stop taking blood thinners if their heart rhythm stays normal for at least a year after AF ablation. Participants will either continue blood thinners or switch to a single antiplate…

This study tests if a special thinner tube (6-French Glidesheath Slender) can make heart procedures safer and more effective for people with small blood vessels. About 594 adults with coronary artery disease will be randomly assigned to receive the procedure through the wrist usi…

This study tests whether a robotic system can safely and effectively assist doctors during a common heart procedure to open blocked arteries. About 170 adults with coronary artery disease will be randomly assigned to receive the procedure with the robot or by a human alone. The g…

This study tests an experimental drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants will receive either YN001 or a placebo by IV, alongside their usual heart medications. The main goal is to see if YN001 reduces non-calc…

This study looks at people who had a heart attack and received a stent. It compares different combinations of blood thinners and cholesterol drugs to find the safest and most effective way to prevent future heart problems while reducing side effects like bleeding. About 4,400 adu…

This study will follow about 50 adults who received a special drug-coated stent (ABLUMINUS NP) to treat blocked heart arteries. Researchers want to see how safe and effective the stent is in real-world use over 5 years. The main goal is to check if the treated artery stays open a…

This pilot study aims to see if a computer-controlled gas challenge can safely and effectively identify coronary artery disease in healthy adults aged 45 and older. Participants will breathe controlled gas mixtures while their vital signs and symptoms are monitored. The goal is t…

This study will check if two blood markers (MPV and SIRI) can help doctors diagnose and predict how serious a heart attack or unstable angina is. About 300 adults with acute coronary syndrome will have their blood tested within 24 hours of symptoms. The goal is to see if these ma…

This study looks at whether using two types of heart scans together (coronary CTA and CT-FFR) helps doctors make better decisions for people with chest pain who are at moderate risk. About 2,000 participants will be randomly assigned to get either the new scan approach or standar…

This study tests a high-tech digital stethoscope that listens for tiny changes in heart sounds to spot coronary artery disease and valve problems early. Researchers will record heart sounds from 500 adults who are already scheduled for standard heart scans. If successful, this si…

This study will test a new type of CT scanner that uses silicon-based detectors to take clearer pictures of the heart's blood vessels. The goal is to see if this new technology can provide better image quality while using less radiation compared to current standard CT scanners. A…

This study aims to see if a single-lead electrocardiogram (ECG) analyzed by machine learning can screen for heart conditions, diabetes, and chronic kidney disease. Researchers will enroll about 5000 adults who have already had a full medical exam. They will record a 1-minute ECG …

This study tests if a numbing injection near certain neck nerves, given before heart bypass surgery, can prevent a common complication called atrial fibrillation (an irregular heartbeat). About 450 adults having bypass surgery will receive either the nerve block or a placebo. The…

This study tests whether watching a virtual reality simulation of a cardiac catheterization before the procedure can reduce anxiety and improve satisfaction. About 120 adults having their first heart catheterization in Oman will take part. Half will experience the VR simulation, …

This study tests a new care approach for Thai adults aged 60 and older who have had a heart attack and a stent procedure. The program combines in-person education, motivational counseling, and a mobile app (LINE) to support healthy habits and recovery at home. Researchers will me…

This study looks at whether listening to guided meditation audio can lower stress and anxiety in people having open-heart surgery. About 72 adults will either receive the meditation sessions or standard care. Researchers will measure stress hormones, blood sugar, and anxiety leve…

This study tests whether a personalized AI-generated video (featuring a nurse avatar) can improve recovery for 128 adults after coronary artery bypass surgery. Patients will either get standard discharge instructions or the AI video plus standard care. Researchers will measure pa…

This study looks at a small mesh device placed in a heart vein to help people with severe chest pain from advanced coronary artery disease. Researchers will measure blood flow and pain levels in 25 participants over 6 months. The goal is to see if the device improves blood supply…

This study tests a new nursing program designed to help patients and their caregivers adapt after heart bypass surgery. About 40 adults who have had the surgery and are recovering at home will take part. The program focuses on improving physical and emotional well-being, and the …

This study looks at whether 12 virtual health coaching sessions over 16 weeks can improve the health and well-being of people with heart disease, such as heart failure or a recent heart attack. Researchers will compare those who get coaching plus standard care to those who only g…

This study is watching 500 adults in China who have hard, bony-like plaques (calcified nodules) in their heart arteries. Doctors will use special cameras inside the blood vessels to see these plaques in detail and track how patients do over time. The goal is to learn more about t…

This study looks at why coronary artery disease (blockages in heart arteries) gets worse rapidly in some patients. Researchers will compare 34 people with fast-progressing disease to 18 with slow-progressing disease, checking their medical history, lab results, and imaging. The g…

This study compares three common treatments for coronary artery disease—surgery, stents, and medication—to see how each affects kidney function over the long term. Researchers will track 1,700 patients for at least five years, measuring changes in kidney health and rates of new o…

This study looks at 600 people with blocked heart arteries who will receive a drug-coated balloon treatment. Before the procedure, doctors will use a special camera (OCT) to take pictures of the plaque inside the artery. The goal is to see if different plaque types (like fatty, s…

This study will see if an AI program called CaRi-Heart can help doctors make better treatment decisions for people with heart disease. The AI looks at inflammation in the heart arteries using pictures from a regular CT scan, with no extra cost or radiation. Researchers will compa…

This study is a large registry that will follow 5,000 adults with coronary artery disease who receive a treatment using a drug-coated balloon to open blocked heart arteries. The goal is to collect long-term data on how well the balloon works and its safety over time. Participants…

This study looks at whether it is safe and better for patients to eat and drink as usual before an elective heart catheterization. About 2000 adults will be randomly assigned to either fast or not fast before their procedure. Researchers will compare how satisfied patients are an…

This study tests a new tool that helps doctors and cancer survivors decide together on the best heart-protecting medications and heart scans. About 60 adult cancer survivors who have not yet seen a heart specialist will take part. The goal is to see if the tool is easy to use and…

This study compares mild cooling (33-34°C) to normal body temperature (36.5°C) during heart bypass surgery to see which better protects the brain. About 160 adults having elective coronary artery bypass grafting will be randomly assigned to one of the two temperature groups. Rese…

This study tests whether using very low radiation doses combined with special image-enhancing software can produce clear pictures of the heart's arteries. About 50 adults who need a standard heart artery X-ray will have extra low-radiation images taken and compared to the usual m…

This study looks at whether having a team of heart experts discuss treatment decisions in real time during a procedure can improve outcomes for people with diabetes and severe blockages in all three main heart arteries. About 1,350 participants will be randomly assigned to either…

This study will test a new type of CT scanner (photon counting CT) to see if it can better identify and measure different parts of artery plaques in people with heart disease. Researchers will follow 180 adults for up to several years to see if these detailed images can predict s…

This study will observe 1,000 adults in China with severe coronary artery disease who are at high risk for bypass surgery but are undergoing a procedure called PCI to open blocked arteries. Researchers will track their health for one year to see how many survive and how many have…

This early study looks at whether transferring healthy gut bacteria (via a stool transplant) can change the gut microbiome in 30 adults with type 2 diabetes and stable coronary artery disease. Participants get the transplant during a colonoscopy and are monitored for 6 months. Th…

This study tests whether an artificial intelligence (AI) tool can help emergency room doctors better interpret heart CT scans for people with chest pain. About 530 adults at intermediate risk for a heart attack will be randomly assigned to have their scans read with or without AI…

This study looks at how a low dose of colchicine, an anti-inflammatory drug, changes proteins in the blood of people with coronary heart disease who have high inflammation. Researchers will compare blood samples from 176 patients before and after one month of treatment to find ne…

This study looks at 100 adults who had a stroke caused by a large blood clot in the front part of the brain and underwent a procedure to remove it. Researchers will use a special ultrasound (transcranial Doppler) to measure blood flow in the brain after the procedure. The goal is…

This study compares two imaging methods (CT-FFR and QFR) to help doctors decide the best treatment for people with coronary artery disease. About 1,400 adults with narrowed heart arteries will be randomly assigned to one of the two imaging-guided strategies. The goal is to see wh…

This study observes 30 adults in Mexico who are already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans, heart CT scans, and body composition tests to see how the drug affects knee cartilage, heart fat, and overall body health over one y…

This study tests whether sending an electronic letter to people with ischemic heart disease and high cholesterol encourages them to get their cholesterol checked. About 100,000 adults in Denmark will either receive the letter or not, and researchers will track lab tests and docto…

This study will test a computer program designed to help doctors make better decisions when treating patients with high cholesterol and related heart risks. Researchers will compare the program's recommendations to what doctors actually prescribed for 500 patients. The goal is to…

This study will develop an artificial intelligence (AI) tool to help doctors decide the best heart treatment for people who have both immune thrombocytopenia (ITP) and coronary artery disease. Researchers will analyze data from 600 patients to predict the risk of major heart prob…

This study involves 800 elderly patients (70 years or older) with heart artery disease. Researchers will use CT scans, frailty assessments, and blood tests to create a model that predicts the risk of major heart events over two years. The goal is to improve treatment decisions fo…