CORONARY ARTERY DISEASE

This study aims to find out if newer diabetes medications (semaglutide or dapagliflozin) are better than the standard drug metformin at slowing or reversing the buildup of fatty plaque in the heart's arteries. It will involve 300 adults who have both diagnosed coronary artery dis…

This study aims to find the best way to monitor high-risk patients who have had a stent placed to open a blocked heart artery. It will compare using regular coronary CT angiography (a detailed heart scan) against standard guideline-based follow-up care. The goal is to see if the …

This study is testing how safely a specific drug-coated heart stent (Onyx) can be expanded wider than its normal size. Researchers will enroll 30 adults with coronary artery disease who need a stent placed in a tapered blood vessel. They will use a special high-resolution camera …

This study is testing whether adding a specific Chinese herbal formula, called Yiyang Huoluo Decoction, to standard heart medications is safe and more effective for treating coronary artery disease and hardening of the arteries in adults aged 50-75. Researchers will compare two g…

This study compares two different techniques doctors use to reopen completely blocked heart arteries. Researchers will measure which method works better, is safer, and causes less stress for both patients and doctors. The study includes 74 patients with difficult blockages and wi…

This study is testing if a newer, smaller heart-lung machine causes fewer serious problems after heart surgery compared to the standard machine. It will involve 1,300 patients having planned heart bypass or valve replacement surgery at hospitals around the world. The main goal is…

This study is testing whether a 12-week supervised exercise program can improve artery health and reduce inflammation in people with coronary artery disease. Researchers will compare 28 patients doing exercise training three times weekly against 22 healthy volunteers. They'll mea…

This study is testing a comprehensive treatment plan for a specific, aggressive type of coronary artery disease believed to be driven by inflammation. It will enroll about 39 patients who have this condition and compare their health outcomes before and after starting the new trea…

This study compares two common cholesterol-lowering approaches to see which better stabilizes dangerous plaque buildup in heart arteries. It will follow 408 adults with coronary artery disease for one year, using advanced heart imaging to measure changes in plaque. The goal is to…

This study compares two approaches to reduce bleeding risk in people who have received heart stents. Researchers want to see which medication strategy works better: switching to a milder blood thinner while keeping aspirin, or dropping aspirin while keeping the stronger blood thi…

This study is testing whether a non-invasive device that uses pulsed electromagnetic waves can improve blood flow to the heart in people with coronary artery disease. The 120 participants will use the device at home daily for 12 weeks while researchers measure changes in heart bl…

This study compares two procedures for treating blockages where heart arteries split into branches. Researchers are testing whether a drug-coated balloon works as well as or better than the standard drug-coated stent. The study will enroll 321 patients with coronary artery diseas…

This study is testing whether a new drug called ziltivekimab can help stabilize the fatty plaques in heart arteries after someone has a heart attack. About 332 participants who recently had a heart attack will be randomly assigned to receive either the new drug or a placebo injec…

This study is testing whether adding a PCSK9 inhibitor drug to standard cholesterol-lowering therapy is better at preventing serious heart and stroke events in people with high-risk plaque in their heart arteries. The plaque is identified using a special, non-invasive CT scan. Re…

This study is testing if a newer stomach acid medicine (tegoprazan) works as well as a standard one (rabeprazole) to prevent serious stomach problems in heart patients. The patients are at high risk because they take long-term blood-thinning medications. Over 3,300 participants w…

This study compares two approaches for treating hard calcium deposits in heart arteries before placing a stent. Researchers are testing whether using a rotational drill plus shockwave therapy works better than shockwave therapy alone for certain types of calcium. The trial involv…

This study compares two common procedures for treating severely clogged heart arteries in people whose hearts pump weakly. Researchers will follow 754 patients for about 5 years to see whether open-heart bypass surgery or less-invasive artery stenting leads to fewer deaths, strok…

This study is testing a new type of heart stent that dissolves over time against the standard permanent metal stent. It aims to see if the dissolving stent is at least as safe and effective for opening blocked heart arteries. The trial will enroll 2000 adults with coronary artery…

This study is observing how well a special balloon coated with medicine works to open small, blocked heart arteries in real-world patients. It also aims to see if a shorter course of blood-thinning medication (just 7 days) is safe for patients who have a high risk of bleeding. Th…

This study is testing the safety and effectiveness of a new, longer version of a drug-coated stent designed to open severely blocked heart arteries. It will involve 150 adults with coronary artery disease who have a single, long blockage in a native heart artery. Participants wil…

This study is testing if customizing heart medication based on a person's specific test results works better than standard care at improving chest pain and quality of life. It will involve about 180 adults who have chest pain and reduced blood flow to the heart, but whose main he…

This study is testing whether a special balloon coated with medicine (called SELUTION SLR) works as well as or better than standard drug-coated stents for treating new blockages in small heart arteries. About 960 patients with coronary artery disease will be randomly assigned to …

This study aims to find out if a telehealth (remote) cardiac rehabilitation program works as well as the traditional in-person version. It will enroll over 500 adults with various heart conditions who are eligible for rehab. Researchers will compare how much participants improve …

This study aims to find out whether using a special CT scan to guide heart procedures works better than medication alone for people with chronic chest pain. Researchers will compare two approaches: one group gets procedures based on CT scan results, while the other group receives…

This study compares two procedures for treating complex blockages where heart arteries split. Researchers want to see if using a special drug-coated balloon on one branch, along with a stent in the main artery, works as well as the current approach of placing stents in both branc…

This study aims to find out if using two arteries instead of one during heart bypass surgery leads to better long-term results for women. It will enroll 2,300 women undergoing their first bypass surgery and randomly assign them to receive either the single or double artery techni…

This study is looking at whether a specific technique used during heart surgery can reduce patients' need for blood transfusions afterward. The technique involves returning the patient's own blood left in the heart-lung machine at the end of surgery. Researchers will observe 130 …

This study is testing if using a special shockwave device to break up hard calcium deposits in heart arteries before placing a stent is better than other preparation methods. It will involve about 666 adults with severely hardened heart arteries. The main goal is to see if this a…

This study is testing a new antibody drug called meplazumab to see if it can reduce inflammation and fatty plaque buildup in the arteries of people with coronary artery disease. It will involve 18 patients who will receive either the drug or a placebo. Researchers will use heart …

This study aims to find out which of two common drug-coated heart stents works better and is safer for people who have just had a serious heart event. It will involve 2,100 patients who have had a heart attack or unstable angina and need a stent to open a blocked artery. Research…

This study is testing the safety and performance of a new, longer version of a dissolvable heart stent called Freesolve. The stent is placed in blocked heart arteries to improve blood flow, slowly releases a medicine to prevent re-narrowing, and is designed to dissolve over time.…

This study is testing if using a special device to grind away hardened calcium in a heart artery branch works better than the standard method before placing a stent. Researchers will compare the two approaches in 200 patients with coronary artery disease to see which one leads to…

This study is tracking how well dissolvable magnesium stents work in everyday medical practice for people with clogged heart arteries. It will follow over 1,100 patients for one year to see if the stent area needs repeat treatment or causes serious heart problems. The goal is to …

This study compares two methods to reopen arteries that have been completely blocked for months. Researchers want to see if using a drug-coated balloon is as good as or better than implanting a permanent drug-coated stent. The study will enroll 200 adults with this specific type …

This study is testing a new drug-coated balloon to treat two types of blockages in heart arteries. It will compare the balloon to another device for blockages that return inside old stents, and to historical data for new blockages in small arteries. About 1,200 participants will …

This large study aims to improve outcomes for people with severe coronary artery disease who need a stent procedure. It will test if routinely using a special camera inside the heart's arteries to guide stent placement leads to fewer future heart attacks, repeat procedures, and d…

This international study is testing whether using just one blood-thinning medication is as safe and effective as using two after a specific type of heart artery procedure. It focuses on patients aged 75 and older or those at high risk for bleeding. The goal is to find the best ba…

This study compares two blood-thinning medications (prasugrel and ticagrelor) when used alone in patients with coronary artery disease who have had a stent placed. Researchers want to see if one drug works as well as the other at preventing dangerous blood clots while potentially…

This study is testing a new surgical technique for placing stents (tiny mesh tubes) in complex, branching heart arteries. The goal is to see if this 'Double Kissing Nano-Culotte' method leads to fewer complications like heart attacks or the need for repeat procedures compared to …

This study is monitoring the real-world safety and performance of a specific heart stent (Ultimaster Nagomi™) designed to treat long blockages in coronary arteries. It will follow over 1,000 patients who receive this stent as part of their standard care to see how well it works a…

This study is testing if using a tiny, high-definition camera inside the heart's arteries during a stent procedure can lead to better results. If the camera shows the stent is perfectly placed, doctors hope patients can safely take a strong blood-thinning medication for just one …

This study aims to find the best way to fix a heart stent that has re-narrowed because it didn't fully expand during the original procedure. Researchers will compare a newer method using sound waves (intravascular lithotripsy) against the standard method of using high-pressure ba…

This study is testing whether treating dangerous, fat-filled plaques in heart arteries with a special drug-coated balloon is better than using standard heart medications alone. It involves 400 adults who have recently had a type of heart attack. Researchers will compare how much …

This study aims to see how well two newer heart stents (Synergy XD and Synergy Megatron) work and how safe they are compared to other drug-coated stents already in use. It will follow 2,000 adults with clogged heart arteries in their normal medical care. The main goal is to track…

This study is testing a new type of heart stent in patients with coronary artery disease who need a stent but are already taking long-term blood thinners. These patients are at high risk for serious bleeding. The new stent is designed to release medication and dissolve over time,…

This study aims to find the best way to guide stent placement for patients with a serious blockage in their main heart artery. It will compare using standard imaging (angiography) against a more detailed pressure measurement (FFR) to decide where to put the stents. About 960 pati…

This study is testing if a special heart scan (called a PET scan) can help doctors decide the best treatment for people with ongoing chest pain from heart disease. It will compare two approaches: sending patients for a heart procedure right away versus first trying to optimize th…

This study aims to find the safest and most effective blood-thinning drug combination for people over 65 who receive a heart stent after a heart attack or severe chest pain. It will compare a newer drug (indobufen) with the standard drug (aspirin), both taken with a second medica…

This study is testing a temporary heart pump called the iVAC 2L to see if it can help patients survive and recover better from high-risk stent procedures. The pump is inserted through a leg artery and helps the heart pump blood during the delicate surgery. Researchers will follow…

This study compares two different drug-coated balloons used to open narrowed heart arteries in medium-small vessels. Researchers want to see which balloon (Selution with sirolimus or SeQuent Please Neo with paclitaxel) keeps arteries open better one year after the procedure. Abou…

This study aims to see how well the XIENCE Skypoint stent works compared to other drug-coated stents for people with coronary artery disease. It will follow 2,000 patients in real-world medical practice for one year after their procedure. The main goal is to see which stents lead…

This study is testing a new medical device designed to treat severely hardened and narrowed heart arteries. The device uses sound wave technology (intravascular lithotripsy) to break up hard calcium deposits inside the artery before a stent is placed. Researchers aim to see if th…

This study is comparing two procedures for treating blocked heart arteries. It is testing a drug-coated balloon that inflates to open the artery and then is removed, against the standard drug-coated metal stent that stays in place permanently. The goal is to see if the balloon me…

This study aims to find out which of two common procedures is better for restoring blood flow to the heart in women with blocked arteries. It compares open-heart bypass surgery to a less invasive procedure where a small mesh tube (stent) is placed. Researchers will follow 600 wom…

This study aims to find out if a newer blood-thinning drug (prasugrel) works better and is as safe as a standard one (clopidogrel) when taken with aspirin after a heart stent procedure for complex blockages. It will involve 3,500 adults who are having a planned, non-emergency ste…

This study is monitoring the long-term safety and performance of the Sequent Please Neo heart stent in over 2,000 real-world patients. It aims to confirm the device remains safe and effective for treating blocked heart arteries in everyday clinical practice. The main goal is to t…

This study compares two common procedures for restoring blood flow to the heart in minority patients with coronary artery disease. One is minimally invasive stenting; the other is open-heart bypass surgery. Researchers will track participants for up to 10 years to see which proce…

This study is testing a special balloon coated with a drug called sirolimus to see if it's safe and effective for treating narrowed small arteries in the heart. About 1,605 adults with coronary artery disease will be randomly assigned to receive either this new balloon treatment …

This study is comparing two common treatments for clogged heart arteries: a drug-coated balloon that inflates and is removed, and a drug-coated stent that stays in place. Researchers want to see which one helps the artery work better 8 months after the procedure. About 94 people …

This study is testing a new balloon treatment for people whose previously placed heart stents have become reblocked. It compares a new sirolimus-coated balloon to an existing paclitaxel-coated balloon to see if they work equally well at keeping the artery open. About 740 particip…

This study is testing a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time. It is being compared to a standard, permanent metal drug-coated stent (Xience) in 1,859 patients with blocked heart arteries. The main goal is to see if the disso…

This study is for people who have had a major heart attack and have other weak, fatty buildups (plaques) in their heart arteries that haven't yet caused a blockage. It compares two approaches: implanting a tiny mesh tube (stent) into these risky plaques plus giving strong heart m…

This study is observing 1,500 patients who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how safe and effective this treatment is in everyday medical practice over the long term. Researchers will track whether patients have major heart-r…

This study is testing if an experimental drug called YN001, given by IV infusion, can safely reduce the amount of plaque that builds up inside heart arteries. It will involve 24 adults in Australia who have coronary artery disease and are already taking a standard cholesterol-low…

This study tests a new support program for low-income patients with chronic diseases like diabetes and heart problems after they leave the hospital. It provides free medications, delivers them to the bedside and then to the home, and offers a coach to help with follow-up care. Re…

This study aims to see if a newer blood-thinning drug (low-dose ticagrelor) works better than the standard drug (clopidogrel) for a specific group of patients. It focuses on 50 people with stable heart disease who are getting a stent placed and who have a high score on a special …

This study is testing if using a personalized risk calculator helps doctors decide the best length of time for patients to take two blood-thinning drugs after getting a heart stent. It will compare this calculator-guided approach to the current standard where doctors decide based…

This study is testing if a personalized care plan based on a detailed AI analysis of a heart scan is better than standard care for people with chest pain suspected to be from heart disease. It aims to improve diagnosis accuracy, better control cholesterol, and reduce unnecessary …

This study is testing a special balloon coated with medicine to open up heart arteries that are 100% blocked. The goal is to see if this balloon treatment works well and is safe, potentially avoiding the need for a permanent metal stent. Researchers will follow 30 patients with t…

This study is testing if adding a natural compound called berberine to standard blood-thinning medications (aspirin and clopidogrel) can better prevent dangerous blood clots in patients who have had a heart stent placed. It will involve about 64 patients who are 8 to 40 weeks pas…

This study is testing whether a remote monitoring program can help people better manage their health after a heart procedure like a stent placement. 200 patients will be split into two groups: one gets standard care, and the other gets devices to track their health at home along …

This study compares two procedures for treating severely hardened heart arteries. After using sound waves to break up the hard calcium deposits, doctors will test whether using a drug-coated balloon works as well as or better than a traditional drug-coated stent at keeping the ar…

This large study aims to evaluate how well drug-coated stents work and how safe they are in everyday medical practice for patients with blocked heart arteries. It will follow 50,000 patients who receive these stents as part of their standard care. The main goal is to track seriou…

This study is monitoring the Essential Pro device, which is already approved and used to treat blocked heart arteries. Researchers are following 100 patients who receive the device as part of their standard care to confirm it remains safe and works as intended over time. The goal…

This study compares two common heart scan methods to see which better detects clogged arteries and prevents heart attacks. Researchers will follow 2,000 patients with suspected heart disease for five years, randomly assigning them to either a CT scan or a stress ultrasound with n…

This study is testing whether artificial intelligence (AI) can help doctors detect coronary artery disease by analyzing heart ultrasound videos. It aims to create a faster, more automated tool to screen for blocked heart arteries, which could reduce the need for more invasive tes…

This study is testing whether a new type of CT scanner, called a Photon Counting Detector CT, can give doctors clearer and more useful pictures of the heart's arteries. Researchers will compare images from this new scanner to standard heart scans in 450 patients with suspected co…

This study compares two medical devices used to guide heart stent placement. Researchers want to see if a newer, easier-to-use pressure microcatheter works as well as the standard pressure wire for measuring blockages and optimizing stent procedures. The trial will enroll 2,500 a…

This study is testing a new precision medicine tool called the ABCD-GENE score. It aims to identify which patients with stable heart disease are at higher risk of heart muscle damage during a planned stent placement procedure. Researchers will enroll 500 patients to see if this s…

This study is testing a new type of MRI scan to see if it can better identify which patients with severe heart disease will benefit most from bypass surgery. Researchers will compare scans from 30 patients before and after surgery to scans from healthy people. The goal is to impr…

This study aims to see if using a special heart CT scan to plan a procedure is as good as or better than the current standard method, which uses an ultrasound probe inside the artery. Researchers will compare the two approaches in 700 patients with hardened, clogged heart arterie…

This study is comparing two ways to check for possible coronary artery disease in people visiting their primary care doctor with chest symptoms. One group gets a new 'package' of three heart scans all done in one day. The other group gets the standard step-by-step tests. Research…

This study is testing a new 3D imaging tool called 3DStent to see if it works as well as the current standard (ultrasound) for checking if a heart stent is properly expanded during a procedure. It will involve 200 patients who are already scheduled to have a stent placed with ult…

This study is testing a new type of PET scan that uses a special tracer called [15-O]-H2O to see if it can better identify blocked heart arteries. About 215 adults with suspected heart disease will get the scan once while resting and once after receiving a stress medication. The …

This study is testing a new, high-resolution CT scanner to see if it can better identify dangerous, unstable plaque in heart arteries and assess blood flow problems without invasive procedures. It will enroll 500 adults with suspected or known heart disease or type 2 diabetes. Th…

This study aims to find the best next step for patients with chest pain who have a moderate blockage in their heart arteries found on a CT scan. It will compare two approaches: going directly to an invasive procedure (angiogram) versus trying more non-invasive tests first. The go…

This study is testing whether artificial intelligence (AI) can find early signs of coronary artery disease (a leading cause of heart attacks) on standard, non-contrast chest CT scans. Researchers are using data from over 1,600 patients who had both a routine chest CT and a specia…

This study is testing a computer-based tool called µQFR that analyzes standard heart scan images. The goal is to see if it can accurately tell when a smaller side-branch artery is still blocked enough to need treatment after a main artery has received a stent. Researchers will en…

This study aims to see if measuring a specific protein in the blood (troponin) can accurately identify patients who do NOT have significant blockages in their heart arteries. It will enroll 1,000 people who are scheduled for a heart scan due to suspected heart disease. The goal i…

This study is testing if a drug called colchicine, combined with a small surgical opening in the heart's lining, can prevent a common irregular heartbeat (atrial fibrillation) after coronary bypass surgery. Researchers will compare 70 patients receiving this new approach to 70 pa…

This study is testing if telling doctors about hidden heart artery calcium, found by AI in old chest CT scans, leads them to start or increase preventive medications. It involves 1,500 adults aged 40-75 who have had a chest CT in the last 3 years but no prior heart disease. The g…

This large study is testing whether the blood thinner clopidogrel can prevent first-time heart attacks, strokes, or death in people who have early signs of heart artery plaque but no symptoms. It will enroll over 11,000 adults aged 40+ to see if the benefits of preventing major e…

This study looks at whether a common class of diabetes drugs, called SGLT2 inhibitors (flozins), can help prevent kidney injury caused by the contrast dye used during heart imaging and procedures. Researchers are reviewing the medical records of 4,000 patients who had these heart…

This study is testing whether two common medications—a cholesterol-lowering statin and an anti-inflammatory drug called colchicine—can slow down the buildup of early, hidden plaque in the arteries of people at high genetic risk for heart disease. It involves 200 adults aged 40-75…

This study tests whether personalized fluid therapy guided by lung water monitoring can prevent kidney damage in elderly patients with existing kidney problems who undergo coronary angiography. Researchers will compare two groups: one receiving standard care and one receiving flu…

This study is testing if a safe, old anti-inflammatory drug called colchicine can prevent serious heart complications after major surgery. It will involve 700 veterans with a history of heart disease who are having surgery. Participants will take either colchicine or a placebo pi…

This study is testing a personalized screening and management plan designed to prevent coronary artery disease in cancer survivors. It will enroll about 750 people aged 40-70 who finished chemotherapy or radiotherapy over five years ago. The plan uses scans and health reviews to …

This study is testing whether two over-the-counter supplements, CoQ10 and Glutathione, can prevent kidney injury in patients undergoing elective heart bypass surgery. About 242 participants will receive either the supplements or a placebo starting the day before surgery and conti…

This study is testing if a local anesthetic (ropivacaine) delivered directly into the chest cavity through drainage tubes can improve recovery and reduce pain after major heart surgery. It compares this method against a placebo in 116 patients. The goal is to see if this targeted…

This study aims to see how accurately a non-invasive CT scan can measure the amount of plaque in heart arteries compared to a more detailed ultrasound done during a procedure. It will involve 250 people with stable coronary artery disease who are already scheduled for a standard …

This study aims to find out if telling people their genetic risk score for coronary artery disease motivates them to improve their heart health. Researchers will enroll 500 adults aged 30-75 who are not on cholesterol medication. Half will get their genetic risk results right awa…

This study aims to see if detailed pictures taken inside heart arteries can help doctors better predict which patients might have future heart problems, like heart attacks or needing another procedure, after they receive a stent. Researchers will follow 4,000 patients with corona…

This study aims to understand what factors influence recovery and survival rates after major heart and vascular surgeries. Researchers will analyze the medical records of 5,000 past patients to look for patterns related to medications, age, and other health conditions. The goal i…

This study aims to use artificial intelligence (AI) to analyze data from 1,300 heart patients who are at high risk of serious bleeding after receiving a stent (PCI). The goal is to identify which patients are most at risk and to figure out the safest and most effective type and d…

This study aims to test and validate new, detailed heart scanning methods. Researchers will scan healthy volunteers and people with various heart conditions while their hearts are under mild stress, such as from light exercise or receiving extra fluids. The goal is to better unde…

This study is testing a new way to combine three different types of heart scans to better understand the health of heart muscle in people with severe heart disease. It will enroll 15 people, including 9 patients scheduled for bypass surgery and 6 healthy volunteers. The goal is t…

This study aims to observe and compare how patients with serious left main coronary artery disease fare over the long term with different treatments. Researchers will follow 10,000 patients across Asia-Pacific to see which approach—medication, stents, or bypass surgery—works best…

This study aims to better understand a specific type of coronary artery disease (CAD) that is linked to chronic inflammation, often affects younger women, and doesn't respond well to standard heart treatments. Researchers will observe 120 patients with this condition over two yea…

This study is testing whether wearable devices like smartwatches and smart scales are practical and helpful for people recovering from a serious hospital stay in the Intensive Care Unit (ICU). Researchers want to see if tracking health data at home can help patients and doctors b…

This study aims to see if telling people they have a high genetic risk for heart disease motivates them to improve their heart health. Researchers will follow 200 middle-aged adults with no current heart disease for one year. Half will be told their genetic risk score right away,…

This study aims to find out if different treadmill exercise tests work better for men versus women with coronary artery disease. Researchers will compare four different exercise protocols to see which one helps participants reach their highest oxygen use during exercise. The stud…

This study aims to understand why heart disease develops differently in women and men, focusing on the roles of hormones and inflammation. Researchers will collect blood samples and survey 6000 patients with chest pain to analyze hormone levels and inflammatory markers. The goal …

This study aims to understand if calcium buildup in heart arteries affects how well a stent heals in the first month after placement. Researchers will enroll 40 patients with coronary artery disease who are getting a specific stent. They will use a special imaging scan to compare…

This study aims to understand if getting pneumonia in the hospital after heart bypass surgery leads to worse heart and lung health over the following year. Researchers will observe 80 patients who have had the surgery, comparing those who develop pneumonia to those who do not. Th…

This study aims to understand what factors affect how long patients need to lie flat and have pressure applied after a tube used in heart procedures is removed from their leg artery. Researchers will observe 157 ICU patients to identify which patient characteristics or conditions…

This study aims to understand what heart patients and their doctors prefer when treating clogged arteries: a permanent metal stent or a drug-coated balloon that leaves no implant. Researchers will survey 600 people, including patients who have had these procedures and the healthc…

This study aims to understand if a simple blood test, called the TyG index, can help predict the severity of heart artery blockages in younger patients who have heart disease but not diabetes. Researchers will enroll 180 participants to see if this test result is linked to how ma…

This study follows 20,000 patients who've had a common heart artery procedure to understand what happens over the next two years. Researchers will track heart-related problems, medication use, and how artery plaque changes over time. The goal is to learn which patients do well lo…

This study aims to understand if problems with tiny energy-producing parts inside heart cells, called mitochondria, are linked to how heart failure progresses. Researchers will enroll 45-60 patients with heart failure who are scheduled for heart bypass surgery. They will take sma…

This study aims to better understand a specific, fast-progressing type of heart disease linked to inflammation. Researchers will compare 20 patients with this inflammation-linked disease to 10 patients with the more common type of heart disease. They will look at medical historie…

This study aims to understand what factors influence survival and heart-related deaths in people with coronary artery disease. Researchers will follow 30,000 patients with various forms of heart artery disease over time. The goal is to identify which risk factors are most strongl…

This study aims to determine which of four simple physical tests best measures recovery progress after heart bypass surgery. Researchers will compare walking tests and strength tests in 150 patients on days 3 and 5 after their operation. The goal is to help doctors design better …

This study aims to understand how taking many different medications affects the health of older adults living with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will follow 2,000 participants aged 65 and older for two years, asking them to co…

This is a large follow-up study to understand how different factors in the body are connected. Researchers are re-examining 1,400 people in Stockholm to see if things like gum health, sleep patterns, and body inflammation are linked to future risks of heart, lung, and liver disea…

This study aims to learn how a specific balloon treatment for clogged heart arteries changes the artery itself over time. Researchers will use detailed heart scans taken before the treatment and again two years later in about 165 patients. By comparing these scans, they hope to u…

This study aims to understand if tiny plastic particles in our environment get into the bloodstream and affect heart health. Researchers will measure the amount of microplastics in the blood of 120 people with chronic heart disease who are already scheduled for heart scans and pr…

This study aims to understand how heart disease patients and their doctors rank the importance of different health problems that can occur after a stent procedure. Researchers will ask 600 participants—including patients who had the procedure and their healthcare providers—to com…

This registry tracks how well Medtronic medical devices work in real-world use for conditions like heart rhythm problems, neurological disorders, and urinary issues. It will follow 100,000 patients who receive eligible Medtronic products to monitor safety and effectiveness over t…

This study is creating a large registry to track the long-term health of people with multiple blocked heart arteries. Researchers will follow 25,000 patients to see how they fare over time after receiving different treatments like medication, bypass surgery, or stents. The goal i…

This study aims to understand if a short, 3-month course of high-dose cholesterol medication (statin) can change the fatty buildup (plaque) in heart arteries, as seen on special heart scans. Researchers will follow 140 patients with chest pain but no prior statin use for 24 month…

This study aims to better understand how different types of plaque in heart arteries develop and lead to heart attacks. Researchers will examine 350 patients with coronary artery disease using special imaging cameras inside blood vessels. The goal is to link specific plaque featu…