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Exercise may be a Drug-Free way to tame migraines

NCT ID NCT06716489

Symptom relief Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a supervised aerobic exercise program, combined with a single session of pain education, can reduce migraine-related disability and improve sensory and muscle function. One hundred women with migraine will either exercise on a treadmill three times a week for 16 weeks or receive standard physical activity advice. The goal is to find a safe, accessible, non-drug treatment for migraine.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
supervised aerobic exercise plus pain neuroscience education
What this could lead to
If it works, this could offer a low-cost, non-drug option to help manage migraine symptoms and reduce headache-related disability.
What could go wrong
This is a small, early-stage trial with only 100 participants. The exercise program is time-intensive (3 times/week for 16 weeks), and results may not apply to all migraine sufferers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 48 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged between 18 and 48 years. * Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD). * Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment. Exclusion Criteria: * Presence of any other type of concurrent headache. * Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others. * Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions. * Premature ovarian failure. * Regular physical exercise in the past year. * Body Mass Index (BMI) above 30.0. * Smokers or individuals using drugs that interfere with sensitivity and cardiac modulation (e.g., beta-blockers). * Abuse of abortive medications.

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Conditions

The condition(s) this trial relates to.

agnosia Headache headache disorder hypnic headache migraine disorder Motor Activity Neck Pain Sensation Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aerobic exercise Headache Headache disorders Headache disorders, primary Headache, migraine Migraine Migraine disease Migraine disorder Migraine disorders, brain Pain management Psychosocial factors Quality of life Sensory disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ribeirão Preto Medical School - University of São Paulo (FMRP-USP)

    RECRUITING

    Ribeirão Preto, São Paulo, 14049-900, Brazil

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