PAIN MANAGEMENT

This study tests whether an ultrasound-guided nerve block given before gallbladder surgery can lower the amount of painkillers and anesthesia needed during the operation. It also looks at whether it reduces pain and nausea after surgery. The trial involves 64 adults scheduled for…

This study tests whether a robotic baby seal named PARO can help reduce pain and anxiety in children aged 1 to 7 years when they get an IV. About 120 kids will either receive standard care or standard care plus the robot. Researchers will measure pain using a special scale and al…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests whether giving ketamine during laparoscopic gastric sleeve surgery can lower the chance and severity of shoulder pain after the operation. About 50 adults aged 18-60 with severe obesity will take part. Half will receive ketamine as part of their anesthesia, and t…

This study looks at whether a supervised program of moderate aerobic and resistance exercise is safe and helpful for breast cancer survivors who still have pain after treatment. Ten women who finished cancer therapy at least six months ago will take part. The goal is to see if ex…

This study compares two steroids, dexamethasone and methylprednisolone, to see which one better reduces swelling and pain after surgery for a broken lower jaw. About 72 adults aged 18 to 40 with a recent, isolated jaw fracture will receive one of the two drugs. The goal is to hel…

This study tests whether ThermaCare Knee Heatwraps can reduce knee pain in people with moderate osteoarthritis. About 80 adults aged 19-69 will wear the wraps for 8 hours a day over 7 days. The main goal is to see if pain levels drop after 3 days of treatment, measured using a si…

This study is testing whether using a virtual reality (VR) headset that shows a calming nature video can help reduce pain and anxiety during a first-trimester abortion. About 72 adults will be randomly assigned to receive either standard care or standard care plus the VR headset.…

This study compares two methods of numbing the arm (infraclavicular block) for forearm or hand surgery in 60 obese adults. The goal is to see which approach works faster and provides better pain relief after surgery. Participants will have their pain and satisfaction measured for…

This study is testing a mobile app designed to help cancer survivors who have finished treatment manage their pain and other symptoms. The app provides tools and support to boost confidence in self-care. About 25 participants will use the app for a short time to see if it is easy…

This study tests two different ways of giving pain medicine through a patient-controlled pump after surgery. The goal is to see if a smarter pump that adjusts the dose based on your pain can lower the total amount of opioids needed and reduce side effects. About 1170 adults havin…

This study compares two types of anesthesia—general and regional—for people with Parkinson's disease who need their deep brain stimulator battery replaced. The goal is to see which method provides better pain control and higher patient satisfaction after surgery. About 50 adults …

This study tests whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for opioids and improve pain control after pancreatoduodenectomy (a major pancreatic surgery). About 93 adults scheduled for this surgery will be randomly assigned to receive n…

This study tests whether a special nerve block (parasternal plane block) can better control pain during heart surgery in children aged 6 months to 7 years. The goal is to reduce the need for strong pain medicines and help children recover faster. Sixty children having planned hea…

This study tests whether a combination of two pain medicines given through an IV (tramadol and paracetamol) works better and causes fewer side effects than a standard shot of pethidine for women in early labor. About 140 pregnant women with a single baby at full term will take pa…

This study tests a new pain-relief method for people having lung surgery with small incisions (VATS). It combines two numbing medicines, one long-acting, given as a nerve block before surgery. The goal is to see if it reduces pain and the need for extra painkillers in the first 4…

This study looks at two different ways to program a pain pump that patients control after surgery. The goal is to see if a new method can lower the amount of opioids needed, while still controlling pain well. About 450 adults having various surgeries will take part. The results m…

This study compares two common treatments for De Quervain's tenosynovitis, a painful thumb tendon condition: wearing a static hand-wrist splint versus doing specific exercises. Researchers will measure pain, hand function, strength, and ultrasound changes in 40 adults with recent…

This study tests if taking melatonin before a planned C-section can lower pain and the need for extra painkillers afterward. Sixty women aged 18-40 will receive different doses of melatonin 30 minutes before surgery and be monitored for 24 hours. The goal is to find the best dose…

This study tests whether giving sedation before ultrasound-guided spinal anesthesia can lower the chance of back pain after surgery. Spinal anesthesia is common for lower body surgeries but can cause discomfort or ongoing back pain. Researchers will compare standard methods with …

This study compares two pain relief methods for people having lung surgery with small incisions (VATS). One group gets a single shot of numbing medicine near the ribs, while the other gets that shot plus a continuous drip of numbing medicine through a small tube placed under the …

This study tests whether adding a short course of the steroid methylprednisolone to standard pain treatment can lower pain and reduce the need for opioids after ACL repair. About 90 people aged 13 to 50 having ACL surgery will participate. The goal is to improve pain control whil…

This study is testing an app called PancreasPlus for people with pancreatic cancer. The app helps patients track symptoms, get information, and communicate with their healthcare team from home. Researchers want to see if using the app improves patient engagement and quality of li…

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for seven days, starting before surgery. The goal is to see if it lowers the amount of opioids needed in the first 48 hours after surger…

This study looks at whether combining pain education with therapeutic exercise can reduce pain and improve quality of life in women with endometriosis. Researchers will track how well participants stick with the program and measure changes in pain, negative thoughts about pain, a…

This study looks at whether teaching patients simple breathing exercises before a transplant can help lower their pain and improve how well they recover after surgery. About 60 adults having their first transplant will take part. One group will learn and practice breathing exerci…

This study compares two types of nerve blocks (M-Tapa and TAP block) to control pain after open inguinal hernia repair. About 60 adults will receive one of the blocks before surgery, and their pain scores and satisfaction will be measured 24 hours later. The goal is to see which …

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of strong painkillers (opioids) needed after the operation. About 70 adults with broken jaw or midface bones will be randomly assigned to receive either the numbin…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study looks at two different nerve blocks used to control pain in children after a common hernia surgery. About 65 children aged 1 to 8 will receive either a rectus sheath block or a caudal epidural block. Researchers will measure pain scores, nausea, and how soon kids can m…

This study tests whether a special nerve block, called a transversalis fascia plane block, can help control pain after kidney donation surgery. Half of the 50 participants will receive the nerve block plus standard anesthesia, while the other half will receive only standard anest…

This study tests whether a new, long-acting painkiller (liposomal bupivacaine) combined with a standard painkiller can reduce pain for up to 72 hours after hemorrhoid surgery. About 156 adults aged 18–64 having elective hemorrhoid surgery will take part. The goal is to see if thi…

This study looks at whether the BETY exercise program, which combines physical exercises with emotional and social support, can improve pain and quality of life in people with knee osteoarthritis who have already received a joint injection. About 60 adults with moderate knee oste…

This study tests whether a pain plan that limits opioids can help adults who get hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior hip replacement will be randomly assigned to either the limited-opioid plan or a standard…

This study tests whether a special ultrasound-guided nerve block (called Quadro-Iliac Plane block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 100 adults having a first hip replacement will be randomly assigned to get either the nerve …

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely ease severe pain in people with advanced cancer that doesn't respond to opioids. Fifteen adults with advanced cancer and persistent pain will receive the treatment and …

This study compares breathing exercises to local anesthesia for pain control during joint injections. About 136 adults scheduled for ultrasound-guided joint injections will be randomly assigned to receive either numbing medicine (with fake breathing instructions) or breathing exe…

This study tests two types of nerve blocks to see which one makes it easier for patients to get into position for spinal anesthesia before hip surgery. It will involve 90 adults having hip fracture repair. The goal is to reduce pain and improve comfort during the procedure.

This study looks at whether a low dose of ketorolac, an NSAID painkiller, can safely reduce the need for opiates in critically ill ICU patients. Opiates are effective but can lead to dependence after leaving the hospital. The trial will enroll 30 adults in the ICU who are in pain…

This study tests whether personalized lifestyle coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions or continue their usual care. The goal is to see if coaching improves pain, slee…

This study tests whether a long-acting painkiller (liposomal bupivacaine) plus a standard painkiller works better than the standard painkiller alone for pain after lung surgery. About 100 adults having lung surgery will be enrolled. The goal is to see if the combination reduces t…

This study tests whether adding ketamine to a standard nerve block (called a retroclavicular block) can better control pain during and after upper arm surgery. About 80 adults having arm surgery will receive either the standard block or one with ketamine added. Researchers will m…

This study compares standard pain relief (IV drugs plus wound numbing) to a combination of two nerve blocks (BAP and TAP) in 140 adults having minimally invasive left-sided colorectal surgery. The goal is to see if the nerve blocks lower pain intensity and reduce the need for opi…

This study looks at whether adding a small amount of ketamine to usual pain medicine (like morphine) can better relieve severe pain from sickle cell disease in children and young adults ages 5 to 20. About 120 participants will be randomly assigned to receive either standard pain…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain education, can help women aged 18 to 48 who have migraines. Researchers will measure changes in headache-related disability, pain sensitivity, and quality of life. The goal …

This study compares two types of nerve blocks to manage pain after heart surgery through the breastbone. About 50 adults will receive either one block or a combination of two blocks. The goal is to find which method provides better pain relief and reduces the need for strong pain…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults will be randomly assigned to have music or not during their procedure. Afterward, they will rate their pain on a 0–10 scale. If music helps, it could be a si…

This study tests which combination of pain medicines works best after rotator cuff repair. 130 adults who need shoulder surgery will receive different pain regimens. The goal is to see which approach reduces the need for strong narcotic painkillers while still controlling pain ef…

This study looks at whether a specific nerve block can reduce pain after kidney transplant surgery. 50 adults will receive either the nerve block or standard care. The goal is to lower pain and the need for strong painkillers, helping patients recover faster.

This study compares two pain relief methods used during robotic kidney surgery: a cheaper mix of drugs called R.E.C.K and a more expensive option called Exparel. About 170 adults having robotic kidney removal will be randomly assigned to one of the two treatments. Researchers wil…

This study tests whether adding a common anti-inflammatory drug (dexamethasone) to a standard numbing medicine (bupivacaine) can improve pain control during upper limb vascular surgery. About 80 adults having arm surgery will receive the injection near their collarbone. The goal …

This study tests a quick-dissolving tablet placed under the tongue (sublingual sufentanil) to relieve moderate to severe pain from a single injury in the emergency room. About 300 adults with arm or leg injuries will receive either the new tablet or standard pain treatment. The g…

This study compares two hands-on treatments—kinesiotaping (a special tape) and peloidotherapy (mud packs)—plus home exercises, against exercises alone for people with mild-to-moderate carpal tunnel syndrome. 90 adults will be randomly assigned to one of three groups. The goal is …

This study looks at how metamizole (Optalgin®), a painkiller, changes the levels of blood thinners (apixaban or rivaroxaban) in cancer patients. Researchers will measure drug concentrations at several time points with and without metamizole. The goal is to understand the interact…

This study looks at how pain and the ability to walk change in the first days after a limb amputation. Researchers will review medical records of 150 adults who had an amputation. The goal is to better understand recovery patterns, not to test a new treatment.

This study looks at how common central sensitization (a condition where the nervous system is overly sensitive to pain) is in adults with autism who do not have intellectual disabilities. Researchers will survey 100 participants to measure pain sensitivity and related symptoms. T…

This study aims to understand what sensations can be created by spinal cord stimulation in people with chronic pain. Researchers will adjust stimulation settings to see how sensations change. The goal is to improve pain management by learning how to control these artificial feeli…

This study watches 254 adults after elective surgery to see what factors affect how much pain medicine they need in the recovery room. Researchers will collect data from normal care—no extra treatments or changes. The goal is to find patterns that help doctors personalize pain ma…

This study looks at how patients experience pain checks after planned surgery. Researchers want to know if these checks feel supportive or stressful, and how that affects trust in nurses and willingness to report pain. About 300 adults having elective general surgery will fill ou…

This study looks at how a gentle electrical current applied to specific acupoints (like those used in acupuncture) affects the way the brain handles pain signals. Researchers will measure brain activity in 35 healthy adults before and after the stimulation. The goal is to underst…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …