PAIN MANAGEMENT

This study tests a special way for nurses to talk with adult burn patients during painful dressing changes. The method, based on the COMFORT Communication Model, aims to reduce pain and anxiety by building trust, explaining steps, and supporting patients emotionally. About 62 peo…

This study will test if gentle electrical stimulation to nerves near the uterus can reduce pelvic pain after a procedure to treat uterine fibroids. About 60 women will be randomly assigned to receive the active stimulation, a sham (fake) stimulation, or standard care. The goal is…

This study tests whether a vaginal injection of ketorolac (an anti-inflammatory) plus lidocaine (a numbing agent) can reduce pain when placing osmotic dilators for second-trimester abortion. About 76 adults will receive either the combined injection or a standard numbing injectio…

This study tests whether watching a guided imagery video about acupuncture can reduce pain and the need for painkillers after spinal surgery. 120 adults will watch either an acupuncture imagery video or a general education video daily for a week after their operation. The goal is…

This study looks at whether adding nerve blocks (parasternal and adductor canal blocks) to standard pain medicine can reduce pain and the need for strong painkillers after coronary artery bypass surgery. About 120 adults having planned bypass surgery will be randomly assigned to …

This study compares continuous regional anesthesia (numbing the leg continuously) to standard pain management for people with war-related lower limb injuries. Researchers will measure pain levels and opioid use in 150 adults over 72 hours. The goal is to find a more effective way…

This study tests two quick, drug-free mental techniques—body-scan mindfulness and guided imagery—to see if they can lower acute pain in hospital patients. About 160 adults in Colombia will receive one of these brief sessions or a standard educational talk. Pain levels are measure…

This study compares three types of anesthesia for people having ankle surgery to see which one helps them recover and go home faster. Two hundred adults will be randomly assigned to receive either total intravenous anesthesia, general anesthesia, or spinal anesthesia, all combine…

This study compares two non-drug methods—a small plastic device called ShotBlocker and a gentle skin-tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. About 99 women will be randomly assigned to one of the…

This study tests if Su Jok therapy, a gentle hand massage technique, can reduce pain in newborns during a standard heel prick blood test. About 66 full-term babies will be randomly assigned to receive either the therapy or standard care. Researchers will measure pain using a vali…

This study tests whether using a risk-stratification calculator to choose pain medications for in-office gynecologic procedures (like IUD insertion or biopsy) improves patient pain scores and satisfaction compared to standard care. About 200 adults will be assigned to receive pai…

This study looks at whether watching cartoons and getting foot reflexology can ease nausea, pain, and anxiety in children after surgery. It will include 105 kids aged 4 to 6 who are having planned surgery with general anesthesia. The goal is to find simple, non-drug ways to help …

This study compares three physical therapy approaches for adults aged 20–60 with shoulder pain lasting at least four weeks. Participants are randomly assigned to routine therapy, targeted exercises, or therapy that also addresses emotional factors. The goal is to see which approa…

This study tests whether two common antioxidants, N-Acetylcysteine (NAC) and Alpha-Lipoic Acid (ALA), can help reduce pain and the need for strong painkillers after laparoscopic appendix removal. 180 adults undergoing this surgery will receive either NAC, ALA, or a placebo alongs…

This study tests whether using virtual reality (VR) goggles during needle insertion can reduce pain and anxiety in people on hemodialysis. About 150 adults with end-stage kidney disease will be randomly assigned to receive VR distraction or standard care. The goal is to see if a …

This study compares two injection treatments for nerve pain (neuroma) after limb injury or amputation. One hundred adults with moderate to severe pain will receive either botulinum toxin (Botox) or a local anesthetic. The goal is to see which provides better pain relief at 8 week…

This study tests if adding a new nerve block (BiFeS) to a standard one (adductor canal block) provides better pain relief after meniscopathy knee surgery. About 135 adults aged 18-65 will be enrolled. The goal is to reduce pain and the need for strong painkillers like morphine.

This study tests whether a video game that guides children through breathing exercises can reduce pain, fear, and anxiety during routine blood draws. About 60 children aged 7 to 12 will be randomly assigned to either play the breathing game during the procedure or receive standar…

This study tests whether listening to music during a prostate biopsy can lower pain and anxiety. About 78 men over age 50 with suspected prostate cancer will take part. Half will listen to music during the procedure, the other half will not. The goal is to see if music helps make…

This study will test if watching virtual reality videos can help people feel less anxious before knee replacement surgery and have less pain afterward. About 64 people having knee replacement will be randomly assigned to use VR or not. The goal is to see if VR can improve comfort…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study tests a special marker that contains numbing medicine. When applied to the skin, it may reduce pain from needle pricks. Twenty adults will have the marker applied to their forearm and then receive light pricks every 10 minutes for 40 minutes. The goal is to see how wel…

This study tests whether a local anesthetic (mepivacaine) can reduce pain during an outpatient hysteroscopy, a procedure to look inside the uterus. About 70 women who have never had this procedure will be randomly assigned to receive either the anesthetic or a placebo (salt water…

This study tests two simple, non-drug methods—cold spray and a vibrating Buzzy device—to reduce pain and fear during penicillin injections. About 90 adults will be randomly assigned to one of three groups to see which approach works best. The goal is to improve patient comfort us…

This study compares opioid-free anesthesia to standard opioid anesthesia in 200 adults having laparoscopic pancreatic surgery. The goal is to see if avoiding opioids leads to less pain, nausea, and better recovery after surgery. Participants will be monitored for pain and side ef…

This study tests two ways to numb the belly wall after laparoscopic gallbladder removal. One method uses a single injection to block nerves in the abdominal muscles, while the other targets the side of the abdomen. The goal is to see which provides better pain relief and reduces …

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests whether listening to a short, guided mindfulness recording can help reduce pain in people waiting for orthopedic care. About 300 adults will be randomly assigned to different lengths of mindfulness practice or a control group. The goal is to see if even a brief s…

This study looks at whether using no opioids during pancreatic surgery can control pain just as well as standard opioid anesthesia, while reducing the need for painkillers after surgery. About 200 adults aged 18 to 80 having this surgery will be enrolled. The goal is to see if th…

This study tests a type of anesthesia that uses fewer opioids during spine surgery in people aged 65 and older. The goal is to see if it lowers pain and the need for strong painkillers after surgery. Half the participants will get this opioid-sparing anesthesia, and the other hal…

This study looks at whether watching virtual reality videos (like an aquarium or kaleidoscope) can help children aged 7 to 12 feel less pain and fear when getting an IV. About 150 children having day surgery will be split into three groups: two that watch different VR videos duri…

This study compares two types of ultrasound-guided nerve blocks for pain control after laparoscopic gallbladder removal. Ninety adults scheduled for surgery will receive either a recto-intercostal fascial plane block or a transversus abdominis plane block. The goal is to see whic…

This study tests whether a numbing medicine called bupivacaine, given directly into the chest through a tube, can reduce pain after minimally invasive lung surgery. About 249 adults having lung surgery will receive either a low or high dose of bupivacaine or a placebo. The goal i…

This study compares two ultrasound-guided nerve block techniques—Quadro-iliac Plane Block and Transversus Abdominis Plane Block—for pain control after inguinal hernia repair. About 60 adults aged 18-65 will be enrolled. The goal is to see which method reduces pain and improves re…

This study tests whether watching a calming 360-degree nature video through a VR headset during a Pap smear can lower pain and anxiety. About 60 women will be randomly assigned to either use VR or receive standard care. The goal is to make this important cancer screening more com…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. It compares the device to standard separate monitors in 30 adults aged 18-65. The goal is to see if the single device works just …

This study will test whether a 16-week Pilates program done at home via video calls can improve walking, balance, fatigue, and pain in people with multiple sclerosis (MS). About 50 adults with mild to moderate MS will be assigned to either the Pilates group or a waitlist. Researc…

This study tests if a special light therapy (photobiomodulation) can reduce pain in the jaw and face muscles caused by temporomandibular disorder (TMD). About 140 adults with this condition will receive either light therapy alone, light therapy plus exercises, or a fake light the…

This early-stage trial will test whether a single dose of psilocybin (the active ingredient in magic mushrooms) is safe and practical for adults with opioid use disorder who are recovering from trauma surgery. Seventy participants will receive the drug during their hospital stay …

This study tests different numbing gels and techniques to see which one works best to reduce pain during and after cavity treatment. About 204 healthy adults with tooth decay will be randomly assigned to receive one of the numbing methods before their dental procedure. Participan…

This study tests if a small device that gently stimulates a nerve in the ear can help people use fewer strong painkillers (opioids) after major abdominal surgery. About 108 adults will be randomly assigned to receive either the real stimulation or a fake version. Researchers will…

This study compares a computer-controlled anesthesia device (SleeperOne® 5) with a traditional syringe for numbing children's mouths before tooth extraction. About 28 children aged 3-5 will take part, and their pain, anxiety, and heart rate will be measured. The goal is to see if…

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics for pediatric anesthesia and perioperative medicine. The goal is to create a shared list of top 10 priorities to guide future studies. No treatments are tested—this is …

This study compares two common nerve blocks—TAP and Rectus Sheath Block—for pain relief after hysterectomy. Researchers will map how well each block numbs the surgical incision and measure morphine use. 30 adults undergoing planned hysterectomy will participate. The goal is to id…

This study looks at whether using ChatGPT as a teaching tool can improve how nursing students understand and manage pain. About 156 nursing students will be split into two groups: one using ChatGPT alongside regular bedside training, and the other using only traditional methods. …

This study looks at how low body temperature during lung cancer surgery affects pain and complications afterward. About 144 adults having chest surgery with a tiny camera will have their temperature tracked continuously. The goal is to understand if staying warm during surgery he…

This study looks at whether a gentle, non-invasive laser can change heart rate and the body's automatic nervous system. Researchers will monitor 45 healthy adults aged 20-45 before, during, and after laser treatment. They will also use a numbing gel to test if the effect involves…

This study looks at how well immunotherapy works in people with advanced lung cancer who also have moderate to severe pain and take opioid painkillers. Researchers want to see if the level of pain control or the use of opioids changes how effective the cancer treatment is. About …

This study looks at a new way to assess pain in intensive care unit (ICU) patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to better measure pain and adjust painkillers. The goal is to see if this approach reduc…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change over a year after treatment. Participants fill out questionnaires before treatment and at 3, 6, and 12 months after. The goal is to better understand rec…