PAIN MANAGEMENT

This study aims to see if a new computer-controlled numbing device causes less pain and anxiety for children than the standard dental syringe. Researchers will compare the two methods in 28 children, aged 3 to 5, who need a baby tooth pulled. The goal is to find a more comfortabl…

This study aims to see if a local numbing shot reduces pain for women undergoing an outpatient hysteroscopy, a procedure to examine the uterus. Researchers will compare pain levels between patients receiving the numbing medication and those receiving a placebo saline solution. Th…

This study aims to find which of two nerve-blocking techniques works better for pain relief after inguinal hernia repair surgery. Researchers will compare a newer method called the Quadro-iliac Plane Block against a more established Transversus Abdominis Plane Block. The study in…

This study compares three different anesthesia approaches for people having minimally invasive ankle surgery. Researchers want to see which method helps patients wake up faster after surgery, experience less pain and nausea, and go home sooner. The trial will involve 200 adults h…

This study aims to see if using a therapeutic robot shaped like a baby seal, named PARO, can help manage pain and anxiety in young children getting an IV line placed. Researchers will compare standard pain management techniques with and without the PARO robot. They plan to enroll…

This study is testing whether using virtual reality (VR) can help people feel less anxious before knee replacement surgery and manage pain better afterward. Researchers will give 64 patients relaxing VR videos at different times to see if it improves their recovery experience. Th…

This study aims to see if using a special calculator to predict a patient's risk of severe pain can help doctors choose more effective pain medications for common in-office gynecologic procedures. Researchers will compare pain and satisfaction levels between patients whose medica…

This study aims to find a better way to manage pain for people having cervical preparation the day before a second-trimester abortion. Researchers are testing if an injection that combines a numbing medicine (lidocaine) with an anti-inflammatory medicine (ketorolac) around the ce…

This study aims to see if watching videos through virtual reality (VR) glasses can help reduce pain and fear in children getting an IV needle placed. Researchers will compare two different VR videos (an aquarium and a kaleidoscope) against standard care in 150 children aged 7 to …

This study aims to find the best method for numbing the gums before dental injections to reduce pain during cavity treatment. Researchers will compare different topical anesthesia approaches in 204 adults needing fillings for reversible tooth inflammation. Participants will rate …

This study aims to see if giving a local anesthetic block to the abdominal wall before surgery starts is better at reducing the need for strong opioid painkillers during the operation, compared to giving the same block after surgery ends. It will involve 50 adults having robotic …

This study is testing whether a structured nursing communication method can help reduce pain and anxiety for adult outpatients during painful burn dressing changes. It will compare a special communication approach, delivered over three dressing sessions, to standard care. The goa…

This study aims to see if a treatment called photobiomodulation (PBM), which uses low-level laser light, can help reduce pain and improve jaw function in adults with myofascial temporomandibular disorder (TMD). Researchers will compare PBM alone, PBM with jaw exercises, and a pla…

This early-stage study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' is safe and practical to give to adults recovering from major trauma surgery who also have opioid use disorder. Researchers want to see if this one-time dose can help …

This study is testing whether watching a calming nature video through a virtual reality headset can help reduce pain and anxiety for people having a first-trimester abortion procedure. Researchers will compare the experience of 72 patients who receive standard care plus the VR he…

This study is testing if a video-guided mental exercise, called imagined acupuncture, can help control pain after spinal surgery. Researchers want to see if this approach reduces pain, helps patients use fewer opioid painkillers, and recover function faster. They will compare 120…

This study aims to find the best physical therapy approach for working adults with shoulder pain lasting over a month. It will compare three methods: standard therapy, targeted strength exercises, and a combined physical and psychological support program. Researchers will also te…

This study is testing whether botulinum toxin (Botox) injections work better than standard numbing injections for reducing nerve pain that develops after limb injury or amputation. Researchers will compare pain relief over 24 weeks in 100 adults who have had this type of pain for…

This study compares two brief, non-drug psychological techniques to see if they can quickly reduce acute pain in hospitalized adults. 160 patients with recent, significant pain will be randomly assigned to receive one 20-minute bedside session of either mindfulness, guided imager…

This study is testing if virtual reality (VR) can help reduce pain and anxiety during Pap smears, a test for cervical cancer. Researchers will have 60 women either watch a relaxing nature video through a VR headset or receive standard care during the procedure. The goal is to see…

This study aims to find the best nasal spray medication for quickly relieving severe pain in children who come to the emergency room with injuries like broken bones. Researchers will compare two pain-relieving sprays—sufentanil and ketamine—given alongside standard care to see wh…

This study aims to find out which of two common nerve-blocking techniques works better for pain relief after a specific type of abdominal hysterectomy. Researchers will observe 30 patients who receive one of the two pain-blocking injections before surgery. They will carefully mea…

This study is testing a new pain management plan for adults getting hip replacement surgery. It aims to see if using mostly non-opioid medications and techniques can safely reduce the need for strong opioid painkillers after the operation. Researchers will compare pain levels and…

This study is testing whether using anesthesia without opioids during pancreatic surgery can reduce patients' pain and need for opioid painkillers afterward. Researchers will compare two groups of 200 patients to see if the opioid-free method lowers pain and side effects like nau…

This study compares two different nerve-blocking techniques to manage pain after laparoscopic gallbladder removal surgery. Researchers will test which method better reduces pain and decreases the need for opioid painkillers in the first 24 hours after surgery. The study involves …

This study aims to see if a gentle hand and foot massage technique called Su Jok therapy can reduce pain in newborns during a routine heel prick blood test. Researchers will compare pain levels in 66 healthy newborns, with half receiving the massage before the procedure and half …

This study aims to see if personalized lifestyle coaching helps older adults better manage long-term muscle and joint pain. Researchers will compare a group receiving coaching sessions to a group receiving usual care. They will measure changes in pain levels, daily function, stre…

This study is testing a special marker that contains numbing medicine to see if it can reduce pain from light needle pricks on the forearm. Researchers will apply the marker to one spot and compare pain levels to an untreated spot nearby. Twenty adult volunteers will rate their p…

This study will test two simple, drug-free methods to make hormone injections less painful and scary for people with breast cancer. Researchers will compare a plastic device called a ShotBlocker and a tapping technique against standard injections in 99 patients. The goal is to fi…

This study is testing if a local anesthetic (bupivacaine) injected into the chest cavity can better control pain after minimally invasive chest surgery. Researchers will compare two different strengths of the drug against a placebo (saltwater) in 249 patients. The main goal is to…

This study aims to see if adding one of two antioxidant supplements, N-Acetylcysteine (NAC) or Alpha-Lipoic Acid (ALA), to standard pain medication can better manage pain after keyhole appendix removal surgery. Researchers will compare how well each supplement reduces pain intens…

This study is testing whether a single medical device called Medstrom can effectively monitor pain, sedation level, and muscle relaxation during colon cancer surgery. Currently, doctors use multiple separate devices for these measurements, which can be complicated and sometimes g…

This study compares two anesthesia methods for people having major pancreatic surgery. Researchers want to see if using anesthesia without opioids (strong painkillers) works as well as standard anesthesia that includes opioids. They'll measure pain levels and how much opioid medi…

This study is testing if a gentle, non-invasive stimulation of the ear nerve can help manage pain after major abdominal surgery. The goal is to see if this method can reduce the amount of strong opioid painkillers patients need in their first 24 hours of recovery. Researchers wil…

This study will test if using virtual reality (VR) goggles as a distraction can reduce the pain and anxiety patients feel when needles are inserted for their dialysis treatment. It will involve 150 adults on hemodialysis who use a specific type of vascular access. Researchers wil…

This study aims to see if two simple, drug-free methods—watching cartoons and receiving foot reflexology (a type of massage)—can help children feel less pain, nausea, and anxiety after an operation. It will involve 105 children between 4 and 6 years old who are having planned sur…

This study aims to find which of two ultrasound-guided nerve-block techniques works better for pain control after laparoscopic gallbladder removal. Researchers will compare a newer method (recto-intercostal block) against a more established one (transversus abdominis block) in 90…

This study is testing two simple, drug-free methods to make penicillin shots less painful and scary. Researchers will see if applying a cold spray or a device that vibrates and cools the skin helps 90 adults getting an injection. The goal is to find easy ways to improve comfort d…

This study aims to see if listening to music can help reduce pain and anxiety for men undergoing a prostate biopsy, a procedure used to check for cancer. It will compare pain and stress levels in about 78 men who either listen to music or do not during the biopsy. The goal is to …

This study aims to understand how treatment for laryngeal (voice box) cancer affects patients' daily lives over a full year. Researchers will follow 120 patients, asking them to complete questionnaires about their voice, swallowing ability, pain, mood, and overall satisfaction be…

This study aims to understand if common opioid pain medications affect how well immunotherapy works for advanced lung cancer. Researchers will follow 100 patients with significant pain who are receiving both immunotherapy and opioids. The goal is to see if pain levels or the pain…

This study aims to understand how a patient's body temperature during and after lung cancer surgery affects their recovery. Researchers will monitor 144 patients having minimally invasive chest surgery to see if lower temperatures lead to more complications or worse pain. The goa…

This study aims to understand how patients feel about routine pain monitoring after elective surgery. Researchers will survey and interview 300 patients to learn whether they view these checks as supportive or stressful, and how these perceptions affect their trust in nurses, anx…

This study aims to understand if a gentle, low-power laser—a type of non-invasive therapy sometimes used for pain—can affect a person's heart rate and the part of the nervous system that controls it. Researchers will recruit 45 healthy volunteers and monitor their heart signals w…