New nerve block could reduce opioid use after knee surgery
NCT ID NCT07629388
First seen Jun 21, 2026 · Last updated Jun 21, 2026
Summary
This trial tests whether a combined nerve block can improve pain relief after total knee replacement while preserving leg strength. 240 adults scheduled for knee surgery will receive either the combined block or a standard saphenous nerve block. Researchers will measure opioid use, pain levels, and how quickly patients can stand and walk after surgery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hôpital privé Dijon Bourgogne
Dijon, 21000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ropivacaine with clonidine and dexamethasone
What this could lead to
If it works, this could offer a better way to manage pain after knee replacement, reducing opioid use and helping patients recover leg strength faster.
What could go wrong
This is a small, early-stage trial comparing two nerve block techniques. The combined block may not provide better pain relief or could cause unexpected side effects. Results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.