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New pain check method aims to cut opioid overuse in ICU

NCT ID NCT07473115

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at a new way to assess pain in intensive care patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to adjust pain medicine more safely. Researchers will compare data from 400 adults to see if the new method reduces opioid use and pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Mechanically ventilated adult patients in the intensive care unit.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Part A * Admission to the intensive care unit * Adults (≥18 years) of all sex and gender * Mechanical ventilation Part B * Admission to the intensive care unit * Adults (≥18 years) of all sex and gender * mechanical ventilation * Continuous opioid therapy * Richmond Agitation Sedation Scale (RASS) ≤ -4 * Presumed duration of mechanical ventilation until the end of observations (until day 3) * Established vascular access suitable for blood sampling independent of study inclusion (arterial line or central venous catheter) Exclusion Criteria: Part A * None Part B * Previous enrolment into the current investigation * Tracheostomy * Chronic opioid use * Regional anaesthesia * Implanted pacemaker device * Allergy to silicone or ECG-electrodes * Ophthalmologic disease (e.g. ocular trauma, glaucoma) or past eye surgery * Fixed pupils * Known or suspected neurologic disease (including hypoxic encephalopathy) * Therapy with atropine or topical mydriatics in previous 24 hours or planned * Therapy with systemic steroids in previous 24 hours or planned * Therapy with neuromuscular blocking agents in previous 24 hours or planned * Stomatitis * Active oral or nasal bleeding

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Conditions

The condition(s) this trial relates to.

agnosia Critical Illness Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Pain Pain management

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital Zurich

    Zurich, Canton of Zurich, 8091, Switzerland

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