PAIN

This study is tracking how well implanted nerve stimulation devices work for managing chronic pain over the long term. It will follow 4,800 patients who receive these commercially available devices as part of their normal medical care. The goal is to see how effective the treatme…

This study aims to find a better treatment for fibromyalgia, a condition causing widespread pain and fatigue. Researchers will compare the effectiveness and safety of a new drug called crisugabalin against the commonly used medication pregabalin. The trial will involve over 1,100…

This study aims to find out which type of device is better for holding a urinary catheter in place for patients in intensive care: an adhesive patch or an elastic band. Researchers will compare the two to see which one causes fewer skin injuries, less pain, and fewer infections. …

This study is testing whether combining two prescription pain medications (pregabalin and desvenlafaxine) works better than using pregabalin alone for people with fibromyalgia. Researchers want to see if the combination provides stronger pain relief without causing significantly …

This study is testing if a mindfulness training program and regular pain management visits with a doctor can help people who have long-term pain and take opioid painkillers. The goal is to see if these approaches can reduce pain, improve daily life, and lower the risks associated…

This study aims to see if combining two existing medications works better than one alone for managing fibromyalgia pain. It will enroll 750 adults with moderate to severe fibromyalgia who haven't found relief from standard treatments. Researchers will compare pain levels, side ef…

This study is testing if a new combination of two drugs works better for fibromyalgia pain than the current standard drug alone. It will involve 384 adults with moderate to severe fibromyalgia who haven't found enough relief from other non-drug treatments. The goal is to see if t…

This study is testing whether giving extra support and training to case managers helps them better use a structured care plan for veterans. The plan focuses on managing pain and risky substance use, especially for veterans who have recently left military service. Researchers want…

This study compares two medications for treating fibromyalgia, a chronic condition causing widespread pain and fatigue. Researchers want to see if a newer drug called mirogabalin works better or has fewer side effects than the commonly used pregabalin. The trial involves 674 adul…

This study is testing whether a combined PET/MRI scan can accurately locate the source of chronic pain in people who have had joint surgery. Researchers will compare scans from 128 people with persistent pain to scans from people without pain to see if areas of inflammation light…

This study is testing a new augmented reality (AR) system designed to help doctors during MRI-guided needle procedures, like biopsies or injections. The AR system projects a visual guide onto the patient, showing the doctor the best path for the needle. Researchers want to see if…

This study is testing a new way to measure pain in people with fibromyalgia, a condition known for widespread chronic pain. Researchers are using artificial intelligence (AI) to analyze patients' facial expressions and checking saliva for biological markers, hoping to create a mo…

This study aims to improve how chronic pain is detected and treated in people who have survived torture. Researchers will test if adding a simple pain questionnaire to a standard medical exam can dramatically improve pain detection. They will also explore what pain treatments are…

This study is testing if the oral medication venlafaxine can prevent postherpetic neuralgia—the severe, long-lasting nerve pain that sometimes follows a shingles outbreak. It will enroll 832 adults who have developed a shingles rash within the last 30 days and are experiencing mo…

This early study is testing whether oxytocin (a hormone sometimes called the 'love hormone') given as a nasal spray can help reduce pain and make opioid painkillers less appealing. Researchers will give 45 healthy recreational opioid users oxytocin or a placebo spray along with o…

This study is testing whether a therapy called dry needling can help reduce pain and improve daily life for people with long-term low back pain. Researchers will compare three different dry needling session plans in about 42 adults. The main goal is to see if the treatment plan i…

This study is testing if a numbing injection (nerve block) given before nose reshaping surgery can reduce the amount of strong painkillers needed during the operation and help control pain afterward. Researchers will compare 90 patients, with half receiving the nerve block and ha…

This study is testing whether a customized physical therapy plan, based on how many shoulder tendons were repaired, works better than standard therapy for recovery after rotator cuff surgery. Researchers will measure shoulder function, pain levels, and sleep quality in 50 patient…

This small pilot study is testing whether a procedure that freezes the nerves around broken ribs can provide better, longer-lasting pain relief than current standard treatments alone. The study will recruit 24 adults with 3 to 8 broken ribs on one side of their body. Researchers …

This study is testing whether using immersive virtual reality (VR) can help reduce chronic jaw pain, known as Temporomandibular Disorder (TMD). Researchers are comparing real VR to a fake 'sham' VR to see if the distraction and experience can change how the brain processes pain. …

This study is testing if wearing a supportive back brace for four weeks can help people who go to the emergency room for common low back pain. Researchers want to see if the brace reduces pain, improves movement, and decreases the need for painkillers like opioids. They are compa…

This study is testing if using a simple stress ball during cataract surgery can help patients feel less pain and fear, and be more satisfied with their experience. Researchers will compare 60 patients who use a stress ball during surgery to those who do not. The goal is to see if…

This study is testing if a special therapeutic toy doll can help reduce fear, anxiety, and pain for young children getting a shot. Researchers will compare 80 children aged 4-6 who play with the doll before their injection to children who get the shot using the usual clinic routi…

This study is testing a special exercise program called BETY for people with knee osteoarthritis who have recently received a knee injection. The program combines physical exercises with techniques to manage pain, mood, and stress. Researchers want to see if this approach helps r…

This study is testing a new training and support program for nursing home staff to help them better recognize and treat pain in residents who have dementia. The program involves a nurse working with staff for a year to improve pain assessment and management. Researchers will comp…

This study is testing whether a short, audio-recorded mindfulness practice can help reduce pain for patients sitting in an orthopedic clinic waiting room. Researchers will compare the mindfulness audio to standard injury management advice to see which is more effective. The goal …

This study aims to see if a combination of pain education and a tailored exercise program can help reduce pain, improve mood, and enhance quality of life for women with endometriosis. It will involve 32 adult women who have been diagnosed with the condition. Researchers will trac…

This study is testing two new physical therapy approaches for people with chronic shoulder pain from impingement syndrome. It will compare graded motor imagery (a mental practice technique) and task-oriented exercise training against standard physical therapy. The goal is to see …

This study is testing whether a very short, 7-minute mindfulness session can help reduce pain and anxiety for people undergoing specific spinal procedures. Researchers will enroll 80 adults who are having either a kyphoplasty or radiofrequency ablation. The goal is to see if this…

This study aims to find the best way to reduce pain during vitamin B12 injections. Researchers will compare three methods: a plastic device called a ShotBlocker pressed against the skin, using a pre-cooled needle, and using both together. They will measure pain levels and patient…

This study is testing if testosterone replacement therapy can help men who have developed low testosterone from taking long-term opioid pain medication. Researchers want to see if receiving testosterone for six months improves pain levels, energy, sexual function, and overall qua…

This study is testing whether a special, calming way of talking to patients can reduce their fear, stress, and pain during a common heart test called coronary angiography. Over 300 adults scheduled for this elective procedure will be randomly assigned to receive either this 'hypn…

This study is testing whether using immersive virtual reality (VR) games for shoulder exercises is more effective than standard physical therapy for people with frozen shoulder. Researchers will compare two groups of patients over six weeks to see if the VR approach better reduce…

This study aims to find a better way to manage pain after a specific bone-strengthening surgery for cancer patients. It will compare using a standard opioid painkiller alone versus adding a non-opioid medication called toradol. The goal is to see if the combination reduces overal…

This study is testing whether using a virtual reality (VR) headset during a common kidney stone treatment can help reduce patients' pain and anxiety. 72 adult patients receiving shock wave therapy will be randomly assigned to either use VR during the procedure or receive standard…

This early-stage study aims to test the safety and side effects of an experimental pain medication called TT5. Researchers will give increasing doses to healthy volunteers and surgical patients to see how the body handles the drug. The main goal is to determine if TT5 is safe eno…

This study is testing if a handheld squeezable ball called Grasp can help reduce pain and distress for children and teens during needle procedures like blood draws or dental injections. Researchers will compare the experience of kids using the Grasp device, which provides music a…

This study is testing whether a simple, non-drug device can make getting an IUD less painful. Researchers are comparing a handheld electrical nerve stimulator to a placebo device in 86 women during their IUD insertion appointment. The goal is to find a safe, easy way to manage th…

This study aims to help Veterans with chronic pain learn about and use non-medication approaches to manage their pain. Veterans will work with a coach to explore their personal values and goals, then identify pain management strategies that fit their lifestyle. The study focuses …

This small pilot study is testing whether patients can safely and effectively self-administer liquid acetaminophen (Tylenol) for pain after shoulder replacement surgery. Researchers want to see if this approach is practical and acceptable to patients compared to nurses giving pil…

This study is testing if a simple breathing exercise can help people feel less anxious, in less pain, and less nauseous when they undergo an ERCP, a common but uncomfortable medical procedure. About 70 adult patients will be randomly assigned to either learn the 'box breathing' t…

This study is testing whether a common muscle relaxant called baclofen can help reduce the often-severe pain caused by shingles. Researchers want to see if adding baclofen to standard pain treatments provides better relief for 750 adults with recent shingles outbreaks. The main g…

This study is testing whether using virtual reality (VR) headsets during medical imaging procedures can help reduce pain and anxiety in children. Researchers will compare VR use against standard care for 500 children aged 8 and older at Children's Hospital Los Angeles. The goal i…

This study is testing if a special pain education session before exercise helps people with neck pain more than exercise alone. Researchers will compare three groups: one gets education plus exercise, one gets just exercise, and one gets a placebo. They will measure changes in pa…

This small pilot study is testing whether a single, brief mindfulness session before surgery can help people with endometriosis. The goal is to see if learning mindfulness techniques is practical for patients and if it might help them cope with stress and pain after their operati…

This study is testing if playing music during a colonoscopy can help reduce the pain and discomfort many patients feel. Over 1,000 people will be randomly assigned to have their procedure with or without background music. The goal is to see if this simple, low-cost method can mak…

This study is testing whether acupuncture can help manage the chronic pain that often comes with sickle cell disease. Researchers will compare traditional needle acupuncture to a needle-free laser version in about 120 participants. They will also use brain scans and other tests t…

This Yale University study is testing if a very low dose of a prescription cannabis pill (dronabinol) can help people in recovery from opioid addiction. The goal is to see if it can safely reduce their pain sensitivity, ease cravings, and improve mood and thinking. The study invo…

This study is testing whether a physiotherapist-guided online exercise program can help reduce pain and improve movement for people who work from home and experience desk-related discomfort. It involves a 6-week program of twice-weekly video sessions. The goal is to see if this c…

This study is testing if a TENS unit, which uses mild electrical pulses on the skin, can reduce pain during a common outpatient procedure for stress urinary incontinence. 100 women will be randomly assigned to receive either a real TENS device or a placebo device during their pro…

This study is testing a new prenatal education program designed to help first-time mothers. It aims to reduce their fear of childbirth, change unhelpful beliefs about pain, and increase their confidence for a normal delivery. The program is being compared to standard hospital pre…

This study is testing whether a device called the NOVABLOC system can help reduce pain and the need for opioid painkillers after total knee replacement surgery. Researchers will compare the device to a sham (fake) treatment in 120 patients to see if it safely improves pain contro…

This study is testing whether using virtual reality (VR) goggles during heart device implantation can make patients more comfortable. It will involve 150 adults who are awake but numbed for the procedure. Researchers will measure if VR reduces pain and anxiety, and if patients ne…

This study is testing if using a simple stress ball can help reduce pain and anxiety for patients having a chest tube removed after open heart surgery. It will involve 46 patients, with half using the stress ball during the procedure and half receiving only standard care. Researc…

This study is testing a new mobile healthcare team that travels to homes and care facilities to help manage pain in children and young adults (up to age 25) with autism, intellectual disabilities, or multiple disabilities. The team provides specialized pain assessments and create…

This study is testing a new training program for family caregivers to help them manage pain in loved ones with mild to moderate dementia. The program teaches caregivers pain coping skills to coach their family member, aiming to improve pain management and reduce caregiver stress.…

This early-stage study is testing a new oral medication called HRS-6257 for pain relief. Researchers will give the drug to 80 healthy volunteers to check its safety, how the body processes it, and whether food affects its absorption. The main goal is to see what side effects occu…

This study is testing whether a special patch-like device can help reduce pain after a cesarean delivery, with the goal of helping women need less opioid pain medication. Researchers will compare the device to a fake version and to standard pain care in 180 women. The main thing …

This study is testing if watching a calming, educational video can help patients feel less pain and anxiety during a thyroid biopsy. It will involve 68 patients in Turkey, with half watching the video before and during the procedure while the other half receives standard care. Re…

This study is testing whether a special numbing injection given directly into the scalp before brain surgery can better control pain afterwards. Researchers are comparing a combination of two drugs (flurbiprofen and ropivacaine) against standard care in 216 patients. The main goa…

This study is testing a free, 3-month virtual coaching program designed for people waiting for hip or knee replacement surgery. The program aims to help participants stay active, manage pain, and reduce feelings of loneliness while they wait. Researchers want to see if the progra…

This study is testing if wearing a virtual reality headset showing calming scenes can reduce pain and distress for older adults during wound care. Up to 20 residents in a long-term care home will try the VR headsets during their routine wound dressing changes. Researchers will me…

This study is testing a medicated skin patch to relieve the pain caused by shingles (herpes zoster). Researchers want to see if applying the patch directly to the painful area can reduce discomfort and improve sleep and daily life for patients. The goal is to offer a localized tr…

This study is comparing two different pain management plans for children aged 3-17 having tonsil surgery. One plan uses strong opioid painkillers, while the other tries to avoid them by using different medications. The goal is to see if the opioid-free plan controls pain just as …

This study is testing if a therapy app on a phone can help teens and young adults with sickle cell disease manage their chronic pain. It will see if adding one-on-one support from a peer who also has the disease makes the app more helpful. The goal is to reduce pain, lower the ne…

This study is testing if a pill called tulodesvenlafaxine can safely reduce the severe pain caused by shingles. It will involve 750 adults who have had a shingles rash for less than 90 days and are still in significant pain. The goal is to see if this medication, which works on b…

This study is testing if two simple, drug-free methods can help ease the pain of childbirth. Researchers are comparing warm lower-back massage using a cherry pit bag and a partner-assisted warm shower against standard care. They will measure pain levels and overall birth experien…

This study is testing whether listening to live or recorded music before brain surgery can help reduce patients' stress, anxiety, and pain. Researchers will measure changes in vital signs, blood markers, and patient questionnaires in 132 adults. The goal is to see if music is a h…

This study is testing if a small electrical device placed in the mouth can reduce the pain people feel after getting braces tightened. Up to 150 teens and adults getting routine orthodontic treatment will try the device on one side of their mouth and a fake, non-working version o…

This study is testing if a special zinc oxide adhesive device is better than a standard one at holding catheters (thin tubes placed in veins) in place for hospitalized adults. Researchers want to see if it causes fewer problems like skin irritation, pain, or the tube moving out o…

This study aims to find out if the common painkiller paracetamol (acetaminophen) is actually needed for people with chronic cancer pain who are already taking strong opioid medications. About 140 adult patients currently taking both medications will be randomly assigned to either…

This study is testing whether a virtual reality meditation app or relaxing music works better to reduce anxiety and pain during breast biopsies. Researchers will compare these two approaches against standard care in 600 women undergoing the procedure. The goal is to find non-medi…

This pilot study is testing whether patients can manage pain after major orthopedic surgery without opioid painkillers. Researchers will compare two groups: one receiving opioid-free pain medication at discharge and another receiving usual care that includes opioids. The study ai…

This study is testing whether classical massage can help people with chronic muscle pain in their neck and shoulders. Researchers will compare massage alone to massage combined with standard physical therapy exercises. They will measure changes in pain levels, muscle tightness, a…

This study is testing whether training leg reflexes can reduce chronic nerve pain in people with spinal cord injuries. Researchers are recruiting 15 people with this type of pain to participate in about 50 training sessions over 6.5 months. The goal is to see if this specific tra…

This study is testing a new mobile phone app designed to help cancer survivors manage pain and other symptoms after treatment. The app provides educational messages, tips for talking with doctors, and tools for tracking how you feel. Researchers want to see if the app is easy to …

This study is testing if adding a new pain medication called Crisugabalin to standard shingles treatment provides better pain relief. It will involve 750 adults with active shingles and moderate to severe pain. Researchers want to see if this newer drug works better and causes fe…

This study aims to train therapists to provide personalized mental health therapies to cancer patients and their caregivers who are experiencing significant distress, anxiety, depression, or sleep problems. About 100 patients and caregivers in Massachusetts will receive therapy s…

This study is testing if simple, drug-free distraction techniques can make dental visits easier for children. Researchers will see if letting kids use a kaleidoscope or watch cartoons during a numbing injection reduces their pain, fear, and anxiety. The study involves 126 childre…

This study is testing if applying a hot water bag to the abdomen can help people with ileus, a condition where the intestines stop moving. The goal is to see if this simple, non-drug method can reduce their pain and help get their bowels working again. Researchers will compare re…

This study is testing a new, FDA-approved non-opioid pain medication called Suzetrigine (Journavx™) for people having hip replacement surgery. The goal is to see if it can effectively manage post-surgery pain and reduce the need for traditional opioid painkillers, which can have …

This study is testing whether a simple coloring activity can help reduce pain and anxiety for adults waiting to be seen in a hospital emergency department. Researchers will give patients nature-themed or geometric coloring pages and measure changes in their self-reported pain and…

This study is testing whether adding a newer pain medication called mirogabalin to standard shingles treatment provides better pain relief. It will involve 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. Researchers will…

This study is testing whether adding a specific type of physical therapy called 'neural mobilization' (gentle nerve stretching) to standard balance training can better help people with diabetic nerve pain. It will involve 32 participants with type 2 diabetes and neuropathy. The g…

This study is testing whether using a virtual reality (VR) headset during common outpatient urology procedures can help reduce patients' pain and anxiety. It will involve 56 adults undergoing procedures like prostate biopsy, cystoscopy, or circumcision. The goal is to see if this…

This study is testing if using a standard, step-by-step method for giving blood thinner injections can reduce bruising and pain at the injection site for patients with heart disease. It involves 180 patients in Hong Kong who need these injections twice daily. Nurses will be train…

This study is testing a medicated skin patch to relieve the pain caused by shingles (herpes zoster). Researchers want to see if applying the patch directly to the painful area can reduce pain severity and improve sleep and daily life for patients. The goal is to offer a localized…

This study is testing if a medication called desvenlafaxine can help reduce the severe pain caused by shingles. Researchers want to see if it works better than current pain treatments and is safe for patients. The trial will involve 750 adults who have had a shingles rash for les…

This study is testing a specific nerve-blocking technique to see if it can better control pain and improve recovery for people having lower back fusion surgery. Researchers will place a small catheter in the back to deliver numbing medicine before surgery and track participants' …

This study is testing if adding a specific hands-on therapy (Mulligan SNAG) to standard physical therapy works better for chronic low back pain. Researchers will compare it to standard therapy alone and a fake version of the hands-on technique. They are recruiting 30 adults with …

This study aims to test new methods for measuring brain activity to better understand thinking problems in people with chronic pain or depression. Researchers will use brain stimulation and scans while participants complete thinking tasks. The study includes 45 people: 15 healthy…

This research aims to understand why people from different racial backgrounds experience and assess pain differently. The study involves healthy volunteers who will either experience mild pain or observe others in pain, while researchers measure their reactions. The goal is to id…

This study aims to understand how gender identity and hormone levels influence pain sensitivity. Researchers will recruit 120 cisgender and transgender adults to complete pain sensitivity tests, blood draws for hormone analysis, and questionnaires about quality of life and social…

This study aims to understand the connection between how the knee is aligned on an X-ray and a patient's experience of pain, daily function, and fear of movement (kinesiophobia). Researchers will observe 100 adults with knee osteoarthritis, using their recent X-rays and questionn…

This study aims to better understand pain by observing how people with and without pain conditions experience different sensations. Researchers will recruit up to 10,000 participants aged 12 and older to complete questionnaires, medical tests, MRI scans, and sensory experiments i…

This study aims to understand how the brain processes pain and itch sensations. Researchers will work with 30 healthy volunteers over three days, applying different substances to the face and measuring skin sensitivity and blood flow. The goal is to gather basic knowledge about h…

This study aims to understand how low doses of nitrous oxide (laughing gas) affect how the brain processes pain and forms memories. Researchers will use MRI brain scans on 60 healthy volunteers while they perform tasks involving pain and memory, both with and without the gas. The…

This study aims to understand how different areas of the brain communicate when people experience pain. Researchers will use brain scans and mild electrical stimulation on 60 healthy volunteers while applying controlled pressure to create temporary pain. The goal is to gather kno…

This study aims to understand how a person's metabolic health—including markers like insulin resistance and cholesterol—might be connected to pain and a heightened pain response (central sensitization) in women with lipedema. Researchers will observe and measure these factors in …

This study aims to understand how office setup, posture, and work hours relate to neck, shoulder, and back pain among medical secretaries. Researchers will survey 110 hospital secretaries about their workstations, daily routines, and pain levels. The goal is to identify risk fact…

This study aims to understand how smoked and swallowed THC affects people differently based on their age and sex. Researchers will measure how THC influences pain relief, feelings of being 'high', and mental impairment in adults aged 18-65 who already use cannabis. The goal is to…

This study aims to better understand the chronic pain experienced by most people with ADPKD, a genetic kidney disease. Researchers will compare pain sensitivity and quality of life in 150 patients with ADPKD against healthy volunteers using standardized tests and questionnaires. …

This study aims to understand how leg swelling after a total knee replacement affects the settings of a TENS machine, a common device used for pain relief. Researchers will compare the machine's settings on the swollen, operated knee to the patient's other healthy knee and to mea…

This study aims to better understand what causes migraine by investigating the immune system. Researchers will compare levels of specific immune cells and inflammatory signals in women with and without migraine, some of whom also have other autoimmune conditions. The goal is to g…

This study aims to better understand how pain-relieving nerve blocks work for people who donate part of their liver. Researchers will observe 20 liver donors who receive standard nerve blocks after surgery. They will map where the pain relief occurs on the skin and track how much…

This study aims to understand how eating high-fat meals affects inflammation and pain sensitivity in people living with chronic spinal cord injury. Researchers will compare blood markers and pain tests after participants eat different meals. The goal is to learn how body composit…

This study aims to find out if a low-dose buprenorphine skin patch is as good at relieving pain as the common pill oxycodone, but with a lower risk of abuse and addiction. Researchers will test 120 healthy adults who don't use opioids, giving them different doses of the patch, th…

This study aims to understand how smoking high-strength cannabis affects feelings of pleasure and pain tolerance in people who use it regularly. Researchers will test 30 participants by having them smoke different strengths of cannabis, including a fake version, and measure their…

This study aims to build a large database to better understand pain. It will enroll 300 military patients and veterans, collecting their survey answers, blood, and saliva over time. The goal is to gather detailed information to help scientists develop better pain treatments in th…

This study aims to understand how negative feelings like stress, pain, and hunger affect the brain and change the way people make decisions. Researchers will recruit 900 healthy adults and temporarily induce these states using methods like watching videos, solving math problems, …

This study aims to understand if CBD, a non-intoxicating cannabis component, can reduce the negative effects of THC, the main psychoactive compound in cannabis. Researchers will give controlled doses of THC and CBD to 30 regular cannabis users and measure their experiences, pain …

This study aims to understand if the strength and endurance of a person's core muscles are related to their shoulder pain, reaction time, and daily function. Researchers will compare 52 people with a diagnosed rotator cuff shoulder injury to a group of healthy individuals. They w…

This study aims to understand how a temporary, experimental pain affects the way healthy older adults learn and remember new walking patterns. Researchers will use a special split-belt treadmill and a safe, short-term pain stimulus. The goal is to gather basic knowledge about how…

This study aims to better understand how children and teenagers break down common anesthesia and pain medications like ketamine and morphine. Researchers will observe 460 participants under 18 who are already receiving these drugs as part of their standard medical care. By taking…

This study aims to understand how sleep problems, specifically insomnia, develop in the first year after someone is diagnosed with cancer. Researchers will follow 260 patients who had no sleep issues at diagnosis, checking in regularly to track their sleep quality, pain, mood, an…

This study aims to understand how two common anesthesia drugs, ketamine and propofol, affect brain activity related to memory and pain. Researchers will scan the brains of 60 healthy adults using MRI and EEG while they receive the drugs alone and in combination. The goal is to ga…

This is an early safety study testing a new oral medication called SBS-147, which is being developed to treat acute pain. Researchers will give the drug to healthy adults to check for side effects and see how the body processes it. Some participants will receive the actual drug w…

This study aims to understand how psychological factors like expectations and emotions change how we feel pain. Researchers will recruit 500 healthy volunteers to undergo brain scans and simple tests involving mild, brief pain or other sensations. The goal is to map how the brain…

This University of California, Los Angeles study aims to understand how cannabis affects pain relief and addiction potential differently in men versus women. Researchers will recruit 160 adults who regularly use cannabis to test different cannabis strengths and measure pain respo…

This study aims to understand how exercise temporarily reduces pain sensitivity, a phenomenon called exercise-induced hypoalgesia (EIH). Researchers will compare this effect in 60 healthy adults and stroke survivors who are currently pain-free, using the same cycling exercise. Th…

This pilot study aims to understand if quitting smoking for 4 weeks can improve the body's natural pain regulation systems in Native American smokers. Researchers will recruit 150 Native American daily smokers to test whether financial incentives for quitting smoking lead to meas…

This study aims to understand how a common pain and sedation medication (remifentanil) behaves in the bodies of low-weight patients who are critically ill and on breathing machines. Researchers will measure drug levels in the blood and monitor patients' blood pressure and heart r…

This study uses brain scans (fMRI) to understand how a sedative drug called remimazolam affects memory, pain perception, and brain activity in healthy adults. Researchers will compare brain scans taken with and without the drug while participants perform memory tasks and experien…

This study aims to understand if having a more regular sleep schedule improves markers of heart, blood vessel, and metabolic health. Researchers will ask healthy adults and a subgroup with chronic pain to keep a consistent bedtime for 12 weeks. They will measure changes in blood …

This study aims to find the best way to help intensive care unit (ICU) teams consistently use a proven set of care practices known as the ABCDEF bundle. Researchers will test two different support strategies for hospital staff across 12 ICUs, involving about 8,100 critically ill …

This study aims to test whether specific sensory tests and skin biopsies can reliably measure nerve pain caused by cancer treatments like chemotherapy. Researchers will enroll 450 people, including cancer patients with treatment-related pain, those starting treatment, and healthy…

This study uses brain scans to understand how a placebo cream affects pain and anxiety. Healthy volunteers will have heat applied to different body sites while researchers measure brain activity. The goal is to learn how the brain processes pain and how expectations of relief can…

This study aims to measure how much of an experimental pain medication called suzetrigine gets into breast milk. It will involve 12 healthy women who are currently breastfeeding. The goal is to understand how much of the drug a nursing infant might be exposed to and to check for …

This study aims to understand how people experience screening colonoscopies and whether that experience affects their decision to get screened again in the future. Researchers will follow 8,000 adults in Denmark, asking them about pain, discomfort, and their overall experience ri…