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New pain drug TT5 enters first human tests – could it ease Post-Surgery pain?

NCT ID NCT06789861

Symptom relief Sponsor: Tafalgie Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug, TT5, for pain relief. It involves 94 healthy adults and surgical patients to check safety and how the drug moves through the body. Participants receive either TT5 or a placebo, and researchers monitor side effects and vital signs. The goal is to find safe doses for future studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 94 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Main inclusion criteria for Parts A and B: * Non-smoker for the confinement period of the study. * Medically healthy and without clinically significant abnormalities. * Negative screen for alcohol and drugs of abuse. * No history of psychiatric disorders. * Female participants of non-childbearing potential must be post-menopausal or surgically sterile at least 3 months prior to dosing. * Sexually active females of childbearing potential and non-sterile males must be willing to use an acceptable contraceptive method throughout the study. * Able to understand the study procedures and provide signed informed consent to participate in the study in English. Main exclusion criteria for Parts A and B: * History of clinically significant asthma, anaphylaxis, major medical, psychiatric illness or surgery. * Acute or chronic clinically relevant systemic disease or disorder. * Renal insufficiency * History of drug or alcohol consumption abuse. * Drinking excessive amounts of tea, coffee, chocolate and/or beverage containing caffeine. * Have used any investigational drug or participated in any clinical trial within 4 weeks prior to screening. * Unable to refrain from strenuous exercise. * Participant who has received blood or plasma derivatives, who had a surgery or who has given blood within 4 weeks prior to the screening visit or has planned to give blood or sperm within the 90 days following the study. * Pregnant or lactating female participant.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cmax & PARC

    RECRUITING

    Adelaide, South Australia, 5000, Australia

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