Which sealer hurts less? new trial tests root canal pain relief
NCT ID NCT07388368
First seen Jun 26, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This study compares two types of dental sealers used after root canal treatment to see which causes less pain. About 118 adults with painful tooth inflammation will receive either a tricalcium silicate sealer or a resin-based sealer. Pain levels will be measured at 24 hours, 72 hours, and 7 days after treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- tricalcium silicate sealer (CeraSeal) and resin-based sealer (Endoplus)
- What this could lead to
- If one sealer works better, it could mean less pain after root canal treatment for people with pulpitis.
- What could go wrong
- This is a small, early-stage trial with only 118 people, so results may not apply to everyone. Pain is subjective and hard to measure precisely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 118 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2026
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * • Patients of age group 18 to 60 years * Healthy patients with ASA class 1 and 2 * Patients of both genders * Teeth diagnosed as symptomatic irreversible pulpitis * Single as well as multirooted teeth Exclusion Criteria: * Teeth with calcified or previously treated canals * Immunocompromised or mentally handicapped patients * Pregnant or lactating mothers * Teeth with periodontal probing depths of 5 mm or more * Cracked or un restorable teeth * Teeth where root canal instrumentation could not reach within 2 mm of the radiographic apex
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Armed Force Institute of Dentistry
RECRUITINGRawalpindi, Punjab Province, 46000, Pakistan
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