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Mind over muscle: study reveals how pain anticipation alters gait

NCT ID NCT07251387

Knowledge-focused Sponsor: Universite de Picardie Jules Verne Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how the mere expectation of pain can change the way your muscles work together when you walk. Researchers will apply a harmless cream to healthy volunteers and suggest it might cause pain, then measure muscle activity during treadmill walking. The goal is to understand the 'nocebo effect'—where negative expectations cause real physical changes—and how it affects movement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
neutral cream with verbal suggestions of pain
What this could lead to
If successful, this could help understand how the brain's expectation of pain alters movement, potentially informing treatments for chronic pain or fear of movement.
What could go wrong
This is a very small, early-stage study with only 12 healthy participants, so results may not apply to people with actual pain conditions. The intervention is psychological, not a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-35 years old * Healthy participant with no self-reported diagnosed neurological, musculoskeletal, or cardiovascular disorders * Body Mass Index (BMI) \< 30 * Ability to walk unaided for at least 10 minutes without major physical limitations Exclusion Criteria: * Presence of pain at the time of testing * Self-reported diagnosed condition affecting mobility * Known allergy to any component of the study cream * Allergy to EMG electrode adhesives * Inability to stand unassisted for more than 1 minute * Inability to walk/run at the required speed and distance * Weight exceeding 150 kg (due to treadmill limitations) * Recent intake (prior intervention) of: * Analgesics (within 6 hours) * Cigarettes (within 6 hours) * Caffeine (within 2 hours) * Skin lesions at the cream application site * Pregnancy * Failure to understand instructions * Daytime pain reported by participant on day of experimentation

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nocebo effect Pain Pain anticipation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre de Recherche sur le Vieillissement

    RECRUITING

    Sherbrooke, Canada

  • Université de Picardie Jules Verne

    RECRUITING

    Amiens, France

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