Can exercise help stroke survivors avoid chronic pain? new study investigates.

NCT ID NCT07327593

Knowledge-focused Sponsor: Neuron, Spain Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a single session of cardiovascular exercise affects pain sensitivity in people who have had a stroke and in healthy individuals. Researchers will measure pain thresholds before and after exercise in 60 participants. The goal is to understand why exercise can temporarily reduce pain and whether this effect is different after a stroke, which could lead to better pain management strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: cardiovascular exercise training
What this could lead to: If successful, this study could help design exercise programs to prevent or reduce chronic pain after stroke.
What could go wrong: This is a small, early-stage observational study with only 60 participants. It does not test a treatment, so results may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Healthy cohort: * Age \> 18 years * No neurological damage * No medical conditions that could affect the test Post-stroke cohort: * Age \> 18 years * Ischemic or hemorrhagic stroke (time since onset \> 3 months) Exclusion Criteria: Healthy cohort: * Any medical condition that could affect the test (respiratory, cardiovascular, metabolic diseases, for example) * Pain in any location, of duration \> 1 week in the 3 months preceding the trial. Post-stroke cohort: * Unable to participate in the test (no possibility of transfer or active pedaling) * Medical contraindication to cardiovascular training for any reason * Inability to follow instructions or communicate sensations during training * Other neurological pathology, cardiac pathology (unstable angina, arrhythmias, aortic or left ventricular problems, myocarditis, pericarditis), pulmonary pathology that affects the test (pulmonary embolisms, pulmonary hypertension, etc.), renal or metabolic problems (severe renal dysfunction, uncontrolled diabetes, etc.), acute infection or fever, neurosurgery within 6 weeks prior to inclusion in the study * Pain in any location, lasting \> 1 week in the 3 months prior to the trial. * Use of beta-blockers, antidepressants, or any medication that may alter heart rate measurements

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Conditions

The condition(s) this trial relates to.

Pain stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exercise induced hypoalgesia Pain Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can exercise help stroke survivors avoid chronic pain? new study investigates.

What the study statuses mean