PAIN

This study compares a new device called Freesolve, a temporary magnesium scaffold that dissolves over time, to a standard permanent metal stent for treating blocked heart arteries. About 1,859 people with coronary artery disease will be enrolled to see if the dissolving scaffold …

This study looks at whether adding core-strengthening exercises to a hip and knee workout program can help reduce pain and improve knee alignment in women with patellofemoral pain syndrome (knee pain around the kneecap). 36 women aged 19-35 with knee pain lasting over 6 weeks wil…

This study tests if giving pain medicine before egg retrieval can reduce pain during the procedure. About 177 women having IVF will be randomly assigned to receive indomethacin, paracetamol, or a placebo. Pain levels will be measured right after the procedure and for several days…

This study looks at whether listening to music and chewing gum can help women feel less pain and anxiety while getting stitches for an episiotomy (a cut made during childbirth). About 60 first-time mothers will be involved. The goal is to see if these simple, drug-free methods im…

This study looks at whether adding alprazolam (a medicine for anxiety) to standard ibuprofen can better manage pain after a root canal. About 110 adults with tooth pain will be split into two groups: one gets ibuprofen alone, the other gets ibuprofen plus alprazolam. They will ra…

This study tests a telephone-based program to help 220 veterans who smoke and have chronic pain quit smoking. The program uses interactive voice response (IVR) technology to deliver counseling and support. Researchers will measure how many participants stay smoke-free for 6 to 12…

This study looks at whether a mobile app that plays guided imagery sessions can reduce chronic belly pain in children aged 7 to 12 with functional abdominal pain disorders. Participants listen to 10-15 minute sessions five days a week for eight weeks, alongside their usual care. …

This study compares two nerve block techniques for pain after breast cancer surgery (mastectomy). One block is placed under a chest muscle, the other combines both under and over the muscle. Researchers want to see which method better reduces pain and the need for opioid painkill…

This study will test whether a specific acupuncture method called Jin's Three-Needle technique, combined with electroacupuncture, can reduce pain and improve neck movement in people with cervical spondylosis (a common cause of chronic neck pain). About 104 adults aged 18 to 70 wi…

This study explores a new way to treat cervical radiculopathy (nerve pain in the neck and arm) by gently moving the nerves in the opposite, pain-free arm. It is for people who cannot tolerate direct treatment on their painful side due to sensitivity or fear. Forty adults will rec…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study looks at two simple, drug-free ways to help cancer patients feel less pain during a bone marrow biopsy: fake coughing or squeezing a stress ball. About 80 adults who have had cancer for at least 3 months will try one of these methods during the procedure. The goal is t…

This pilot study will test whether banana leaves can be used as a primary dressing for partial-thickness burns (second-degree burns). About 30 adults with small burns will receive banana leaf dressings, and their pain, healing time, and need for painkillers will be compared to pa…

This study tests a smartphone app called I-STAMP designed to help people with advanced cancer manage their pain and keep track of their medications. About 73 participants will use the app and then rate how easy it is to use and how helpful they find it. The goal is to see if the …

This study looks at whether playing a guessing game can lower fear, pain, and bad feelings in children aged 6 to 12 when they get blood drawn. About 70 kids will take part, and researchers will measure their pain, fear, and emotions using special scales. The goal is to find a sim…

This study compares two injection treatments for nerve pain (neuroma) after limb injury or amputation. One hundred adults with moderate to severe pain will receive either botulinum toxin (Botox) or a local anesthetic. The goal is to see which provides better pain relief at 8 week…

This study looks at whether listening to music after a planned cesarean section can help reduce pain, anxiety, and improve the bond between mother and baby. About 70 first-time mothers will take part. Researchers will measure pain, anxiety levels, and mother-infant attachment usi…

This study tests whether listening to music can help reduce pain and stress during the non-surgical realignment of a broken wrist. 192 adults will be randomly assigned to hear their preferred music, a therapist-chosen playlist, or standard care. Pain levels and vital signs will b…

This study tests whether using virtual reality (VR) or a combination of VR and hypnosis can help women feel less pain and anxiety during a diagnostic hysteroscopy, a common procedure to look inside the uterus. 45 adult patients will be randomly assigned to standard care, VR, or h…

This study tests whether a single dose of (2R,6R)-HNK, a drug related to ketamine, can safely reduce short-term pain in healthy adults aged 18 to 60. Participants will receive either the drug, a placebo, or no treatment, and will undergo pain tests and brain scans. The goal is to…

This study tests if adding a common steroid (dexamethasone) to a numbing nerve block can prevent severe "rebound pain" after hand surgery. About 60 adults will be randomly assigned to receive either the steroid or a placebo with their nerve block. Researchers will track how many …

This study tests whether listening to a short, guided mindfulness recording can help reduce pain in people waiting for orthopedic care. About 300 adults will be randomly assigned to different lengths of mindfulness practice or a control group. The goal is to see if even a brief s…

This study looks at two simple, drug-free methods—Helfer Skin Tap (gentle tapping near the injection site) and vibration—to see if they can lower pain and fear in children aged 5-10 getting a shot in the emergency department. About 186 children will be randomly assigned to one of…

This study compares three types of injections—glucocorticoid, ozone, and 5% dextrose—for relieving pain in people with mild to moderate carpal tunnel syndrome. Researchers will measure nerve function and pain levels in 105 adults aged 18 to 65 who have not responded to other trea…

This study tests whether a gel made from propolis (a bee product) can reduce tooth sensitivity after professional whitening. Sixty-six adults will receive either propolis gel, a standard desensitizing gel, or a placebo before bleaching. Their pain and tooth color will be tracked …

This study looks at whether adding diphenhydramine (an antihistamine) to standard pain and anxiety medication can reduce pain during a first-trimester abortion. About 98 adults will receive either diphenhydramine or a placebo alongside usual sedation. The goal is to see if this s…

This study tests whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that sometimes lasts for months after the operation. About 100 adults having planned heart surgery will be randomly assigned to receive either ketamine or a placebo during …

This study tests whether listening to positive self-affirmation recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two participants will be split into two groups, with one group listening to the affirmations daily. The goal …

This study tests whether a 4-week program combining exercise with ergonomic training can reduce pain, improve sleep quality, and lower anxiety in nursing students. Sixty students will be randomly assigned to either the program or their usual classes. The goal is to see if adding …

This study compares two ultrasound-guided nerve blocks (TFP and ESP) for pain relief after cesarean section. Sixty women having a planned C-section will receive one of the two blocks, and researchers will measure their pain scores and how much opioid pain medicine they need. The …

This study looks at whether using a stress ball or getting a gentle hand massage during eye surgery can help lower anxiety, pain, and improve vital signs like heart rate and blood pressure. About 174 adults having eye surgery while awake will be split into three groups: hand mass…

This study tests a program called AIMSS-CARE, which combines exercise, education, symptom tracking, and follow-up, to help breast cancer patients in Ethiopia manage joint and muscle pain caused by aromatase inhibitors. 88 women will be randomly assigned to either the program or u…

This study tests whether a nasal spray of ketorolac (an anti-inflammatory) or ketamine (a pain reliever) works better to reduce pain before a finger nerve block in the emergency room. About 64 adults with finger injuries will receive one of the two sprays, and their pain levels, …

This study looks at whether a virtual reality (VR) mindfulness experience can improve well-being and reduce anxiety in adults staying in the hospital. About 42 patients will try VR and also receive standard care, so each person serves as their own comparison. The goal is to see i…

This study tests whether shining a special light on the skin before inserting a copper IUD can lower the pain women feel during the procedure. The trial will involve 72 women, with half getting real light therapy and half getting a fake treatment. If it works, this simple, drug-f…

This study looks at whether listening to music or using virtual reality can reduce pain, anxiety, and fear in children aged 6-12 with leukemia when they receive care for painful mouth sores caused by chemotherapy. About 45 children will be randomly assigned to a music group, a VR…

This study tests whether adding tizanidine to the standard drug pregabalin provides better pain relief for people with fibromyalgia, a condition causing widespread pain and fatigue. About 164 adults with daily pain will receive either the combo or pregabalin alone for 12 weeks. T…

This study tests if a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will either receive the gas or a placebo mask alongside standard numbing medication. Participants will rate …

This study looks at whether taking 200 mg of CBD daily for 12 weeks can reduce inflammation, ease pain, improve sleep, and boost quality of life in Brazilian Jiu-Jitsu athletes. About 100 athletes aged 18-40 who train at least 3 times a week will participate. Half will get CBD an…

This study looks at whether listening to calming music during a nail biopsy can lower pain and anxiety. About 30 adults having the procedure will be randomly chosen to either hear a playlist or get standard care. Afterward, they will rate their pain, anxiety, and satisfaction to …

This study tests whether a gentle electrical nerve stimulation (based on wrist-ankle acupuncture) plus a standard painkiller can reduce pain and nausea during egg retrieval for IVF. Sixty women aged 21-42 will be randomly assigned to receive either the real stimulation or a sham …

This study tests whether giving patients a lidocaine drip during and after major non-cardiac surgery helps them recover faster. About 2,290 adults having elective surgery will be randomly assigned to receive either lidocaine or a placebo. The goal is to see if lidocaine shortens …

This study compares two types of dental sealers used during root canal treatment to see which one causes less pain afterward. About 118 adults with painful tooth nerve inflammation will be randomly assigned to receive either a tricalcium silicate-based sealer or a resin-based sea…

This study tests whether a 15-minute live music therapy session can lower pain in newborns with hypoxic-ischemic encephalopathy (HIE) who are receiving cooling therapy. Twenty-two babies in the NICU will either get standard care or standard care plus music after routine nursing p…

This study tests whether a personalized AI-generated video (featuring a nurse avatar) can improve recovery for 128 adults after coronary artery bypass surgery. Patients will either get standard discharge instructions or the AI video plus standard care. Researchers will measure pa…

This study compares two types of virtual reality—an interactive puzzle game versus calming scenery—to see which better reduces pain and anxiety during common in-office ENT procedures like sinus surgery or vocal cord injections. About 132 adults will wear a VR headset during their…

This study tests whether injecting a patient's own fat into long-lasting wounds can reduce pain better than standard wound care alone. Researchers will enroll 62 adults with chronic wounds (like diabetic or burn wounds) that have lasted over 3 months. Pain levels will be tracked …

This study tests if electroacupuncture (a type of acupuncture with mild electric pulses) can reduce a group of common symptoms—pain, tiredness, sleep trouble, anxiety, depression, and brain fog—in breast cancer survivors. About 228 women who have finished active cancer treatment …

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises as effectively as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving standard in-person sessions, the other …

This study looks at whether craniosacral therapy, a gentle hands-on technique, can help reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers will either receive the therapy or be in …

This study looks at whether using virtual reality goggles or a vibrating Buzzy device can lower pain, fear, and anxiety in children aged 7 to 10 during a skin prick test for allergies. About 111 children will be randomly placed into one of three groups: VR, Buzzy, or standard car…

This study tests whether watching a liquid-gel or sand hourglass during blood collection can lower pain, fear, and anxiety in children aged 5 to 10. About 120 kids will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, drug-free way …

This study tests whether rinsing the surgical area with a mix of ketamine and standard pain reliever (bupivacaine) reduces pain after gallbladder removal. Sixty adults having laparoscopic cholecystectomy will be randomly assigned to receive either the standard rinse or the ketami…

This study looks at whether a 6-week virtual reality (VR) program is a practical and acceptable way to teach people with chronic pain about their condition. Fifty adults with chronic pain will use a VR tool called Reality Health™ to learn about pain science, coping strategies, an…

This study compares ketamine to morphine for treating sudden, severe pain in children visiting the emergency department. About 1,010 children with belly pain or a broken arm or leg will receive one of the two medicines. The goal is to see if ketamine works just as well as morphin…

This study tests a web-based program designed to help people with advanced cancer manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. About 40 patients and their partners will use the program to track symptoms and get person…

This study tests whether low-level laser therapy can reduce perineal pain and improve wound healing in women who had a vaginal birth with tearing. About 206 new mothers will receive either real laser treatment or a fake (sham) treatment shortly after delivery. Researchers will me…

This study will test whether a virtual reality (VR) mindfulness program can help patients feel less anxious and experience less pain during minimally invasive vascular surgery done under local anesthesia. About 160 adults will be randomly assigned to either receive the VR mindful…

This study tests a program called SPARK for adults aged 50 and older who have ongoing pain, depressive symptoms, and trouble moving around. Participants will receive 8 nurse visits at home to learn ways to cope with pain and improve mood. The goal is to see if this approach reduc…

This study tests whether a special bone cement (made with bioactive glass) combined with ultrasound can safely stabilize bones and reduce pain in people with advanced cancer that has spread to the pelvis. Only 8 participants will receive the treatment alongside standard care, and…

This study compares a computer-controlled anesthesia device (SleeperOne® 5) with a traditional syringe for numbing children's mouths before tooth extraction. About 28 children aged 3-5 will take part, and their pain, anxiety, and heart rate will be measured. The goal is to see if…

This study aims to create a new pain assessment scale, called EDEX, specifically for extremely premature infants born before 27 weeks. These babies show pain differently than older preemies, and current tools may not work well. Researchers will compare the new scale with an exist…

This study looks at how the fear of pain affects the way your muscles work together when you walk. Researchers will use a special cream to create a brief pain experience in one group, then give them a harmless cream they think is painful. A second group gets only the harmless cre…

This early-stage study looks at how a drug called efavirenz changes the way a new pain medicine (suzetrigine) moves through the body. It involves 18 healthy adults and does not aim to treat any condition. The main goal is to measure drug levels and check for side effects when bot…

This study looks at how the way your feet press on the ground might be linked to where and how much pain you feel. Researchers will measure foot pressure in 53 healthy young adults aged 18-35 while they stand and walk, and ask about their pain levels. The goal is to understand if…

This study looks at whether a drug called pramlintide, which mimics a natural body chemical (amylin), can cause migraine attacks in people who get migraines without aura. About 21 adults with a history of migraine without aura will receive either pramlintide or a placebo, and res…

This study looks at 130 adults having nose surgery to see if two common steroids (methylprednisolone and dexamethasone) change how quickly a drug called sugammadex reverses muscle relaxants. It also checks pain and nausea after surgery. The goal is to help doctors choose the best…

This study looks at how the brain's opioid system influences placebo effects on both physical pain and the pain of social rejection. Sixty adults who recently went through an unwanted breakup will receive either a drug that blocks opioids (naloxone) or a saltwater spray, and then…

This study looks at how self-compassion and self-efficacy (belief in your own abilities) relate to body awareness, pain, and healthy lifestyle habits in adults aged 65 and older. Researchers will ask 150 older adults to fill out online questionnaires. The goal is to better unders…

This study aims to translate the COMFORTneo pain assessment tool, originally developed in Dutch, into French for use with newborns. Researchers will work with 50 healthcare professionals from French hospitals to ensure the translated version is accurate and easy to understand. Th…

This study follows 150 adults with severe arm or leg injuries who needed a tourniquet to stop bleeding. Researchers will track how long the tourniquet was used and check for pain, nerve pain, and recovery over 6 months. The goal is to see if longer tourniquet use increases the ch…

This study looks at whether a phenomenon called 'offset analgesia'—where pain relief happens after a brief intense heat—can also occur with cold pain. Researchers will test how placebo and nocebo effects influence pain and itch sensations in 30 healthy adults. The goal is to bett…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury (TBI) within the last 14 days. Researchers will track their pain for 6 months to find out who develops long-term chronic pain and why. The goal is to create a tool that can predict chro…

This study looks at how seeing someone else benefit from treatment, along with your own past experiences, can strengthen the placebo effect—where you feel better even without active medicine. 120 healthy adults will be split into groups to test these effects on pain and unpleasan…

This study looks at how adding dexamethasone (a steroid) to a nerve block for shoulder surgery changes the amount of pain medicine (bupivacaine) in the blood. Researchers will compare giving the steroid through the nerve block versus through an IV. Forty adults having shoulder su…

This study looks at blood samples from 90 people: 30 healthy, 30 with diabetes but no nerve pain, and 30 with diabetic nerve pain. Researchers will analyze the blood to find markers that could help diagnose nerve damage earlier. The goal is to better understand the disease and fi…

This study looks at whether pramlintide, a substance similar to a natural hormone, can cause migraine-like headaches in people who have had persistent headaches for at least a year after a mild traumatic brain injury. About 21 adults aged 18 to 65 will receive either pramlintide …

This study looks at whether a natural brain chemical called adrenomedullin can cause migraine attacks in people who already get migraines. Researchers will give the chemical to 26 adults with migraine without aura, after they have taken a preventive migraine drug (erenumab). The …

This study looks at a new way to assess pain in intensive care unit (ICU) patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to better measure pain and adjust painkillers. The goal is to see if this approach reduc…