Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could ketamine replace morphine for kids in pain?

NCT ID NCT06835504

Symptom relief Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketamine hydrochloride and morphine sulphate
What this could lead to
If ketamine works as well as morphine, it could offer a safer, non-opioid option for managing acute pain in children.
What could go wrong
This is a non-inferiority trial, so ketamine might not be as effective as morphine. Side effects from ketamine are also possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,010 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Abdominal pain or isolated long-bone extremity fracture (suspected or proven) 2. Self-reported pain score of ≥ 6/10 3. Requires IV morphine for analgesia as determined by the treating physician Exclusion Criteria: 1. Weight \> 82.4 kg 2. Known allergy/contraindication to morphine or ketamine 3. Antecedent receipt of ketamine related to presenting complaint 4. Inability to use self-report measures of pain or questionnaires 5. Chronic disease associated with pain 6. Chronic pain condition requiring use of opioids as outpatient 7. Hemodynamic instability or critical illness per treating physician 8. Altered mental state (e.g., GCS , 14 or clinical intoxication) 9. Known history of schizophrenia, liver or kidney problems, or osteogenesis imperfecta 10. Concern for open fracture, neurovascular compromise, or compartment syndrome 11. Injuries in addition to the extremity injury (e.g., head, neck, abdomen) 12. Known or reported pregnancy 13. Does not speak English or Spanish 14. Patient previously enrolled in this study 15. Wards of state, foster children, or children in custody

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Abdominal pain are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Abdominal Pain agnosia anxiety disorder bone fracture Depression Emergencies Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal pain Isolated extremity fracture Pain Pediatrics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Arthur M. Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Nemours Children's Hospital

    Wilmington, Delaware, 19803, United States

  • NewYork Presbyterian Morgan Stanley Children's Hospital

    New York, New York, 10032, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • UC Davis Children's Hospital

    Sacramento, California, 95817, United States

  • UPMC Children's Hospital of Pittsburgh

    Pittsburgh, Pennsylvania, 15224, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.