Scientists investigate if amylin analogue sparks migraines

NCT ID NCT07340788

Not yet recruiting Knowledge-focused Sponsor: Danish Headache Center Source: ClinicalTrials.gov ↗

First seen Jan 20, 2026 · Last updated Jun 08, 2026 · Updated 22 times

Summary

This study looks at whether pramlintide, a drug similar to the hormone amylin, can cause migraine attacks in people who get migraines without aura. Researchers will give 21 participants either pramlintide or a placebo and watch for headaches over 12 hours. The goal is to understand how amylin might play a role in starting migraines.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Rigshospitalet Glostrup

Glostrup Municipality, 2600, Denmark

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

brain disorder central nervous system disorder Headache headache disorder hypnic headache migraine disorder nervous system disorder Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMINO ACIDS, PEPTIDES, AND PROTEINS AMINO ACIDS, PEPTIDES, AND PROTEINS AMINO ACIDS, PEPTIDES, AND PROTEINS AMYLIN AMYLIN BRAIN DISEASES CENTRAL NERVOUS SYSTEM DISEASES HEADACHE HEADACHE HEADACHE DISORDERS HEADACHE DISORDERS HEADACHE DISORDERS, PRIMARY HEADACHE DISORDERS, PRIMARY HORMONES HORMONES HORMONES, HORMONE SUBSTITUTES, AND HORMONE ANTAGONISTS HORMONES, HORMONE SUBSTITUTES, AND HORMONE ANTAGONISTS MIGRAINE DISORDERS NERVOUS SYSTEM DISEASES NEUROLOGIC MANIFESTATIONS PAIN PATHOLOGICAL CONDITIONS, SIGNS AND SYMPTOMS PATHOLOGICAL CONDITIONS, SIGNS AND SYMPTOMS PEPTIDE HORMONES PEPTIDES PRAMLINTIDE PRAMLINTIDE SIGNS AND SYMPTOMS