CENTRAL NERVOUS SYSTEM DISEASES

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel occlusion stroke will be randomly assigned to receive either…

This early-stage trial tests a specially engineered virus, G207, in children and young adults (ages 3 to 21) whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is …

This study tests whether adding an experimental drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. The trial is for patients whose tumors have certain genetic…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults are being…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that offers a specialize…

This study looks at whether increasing physical activity using a motivational smartphone app can slow down cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease. Researchers will enroll 80 people with iRBD and 50 health…

This study tests whether combining virtual reality (VR) exercises with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who had a stroke at least three months ago. About 100 adults will be assigned to different therapy groups to see which ap…

This study is testing whether virtual reality (VR) and mixed reality (MR) games can help stroke survivors improve arm and hand function. About 45 adults who had a stroke will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the VR/MR approache…

This study tests a non-invasive spinal stimulation technique to help control blood pressure in people who had a spinal cord injury within the past month. Many of these individuals experience dangerous drops in blood pressure when sitting up, causing dizziness and nausea that can …

This study is testing whether a smartphone app can help doctors better understand and treat depression by tracking symptoms every day. About 200 adults with depression will use the app or receive standard care. The goal is to see if the app leads to greater improvement in mood an…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study tests whether a live video call between a neurologist and ambulance paramedics can improve the detection of strokes before reaching the hospital. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps paramedics use stroke s…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical …

This study looks at a blood marker called BD-tau, which may show how much brain injury happens after a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults who had a stroke. The goal is to learn when the marker rises and how long it stays high, whic…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…