PAIN

This study tested a new set of questions called PainTracker to help doctors guide older adults (65+) who are on long-term opioid therapy toward safer care. The goal was to increase referrals to non-opioid treatments like physical therapy or mental health support, and to reduce ri…

This study tested a behavioral program to help young adult cancer survivors (ages 18-39) with obesity manage their weight and related symptoms like pain, fatigue, and distress. The goal was to reduce their risk of heart disease, a leading cause of death in this group. 38 survivor…

This study tested whether a workplace program to prevent muscle and bone pain is practical and well-liked by workers with physically demanding jobs. 70 workers took part in the program twice a week for eight weeks. Researchers used questionnaires and interviews to see if workers …

This study looked at whether working with a care manager and using an online pain coping program can help people with long-term pain handle their symptoms and daily activities better. Thirty-two adults with chronic pain for at least 3 months and at least one social challenge (lik…

This study tested whether adding electrical-stimulation-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS), a painful condition causing swelling and stiffness. Forty participants received either standard therapy alone or standard …

This small pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program could help older women with knee osteoarthritis. Nineteen women aged 60+ took part in either exercise alone or exercise plus five PNE sessions over 10 weeks.…

This study tested if using a stress ball and listening to music during a colonoscopy can help reduce pain and anxiety. 100 adults having the procedure without sedation took part. Half used the stress ball and music, while the other half received standard care. The results showed …

This study looked at whether aromatherapy (lavender oil massage) and reflexology (targeted foot pressure) could reduce pain and improve sleep in 90 children with cerebral palsy, aged 6 to 12. Children were split into three groups: aromatherapy, reflexology, or no extra care. The …

This early-stage study tested a new drug called HRS-2129 in 23 healthy adults to see if it is safe and how the body processes it. Researchers also measured how the drug affects the ability to feel cold and heat pain. The study is complete, but results are not yet available.

This study tested whether low-level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health during the early phase of braces treatment. 108 adults aged 18-30 received either LLLT on their front teeth or no laser at each visit over 6 months. Researche…

This study tested if kinesiologic taping (a special elastic tape placed on the knee) can reduce pain, improve movement, and lessen fear of moving in people with knee rheumatoid arthritis. Thirty adults aged 45-60 were split into two groups: one got the real tape, the other got a …

This study looked at 132 adults getting vitamin B12 shots to see if using a ShotBlocker device, a cold needle, or both together could lower pain and boost satisfaction. Participants rated their pain and satisfaction after the injection. The goal is to find simple ways to make rou…

This study looked at whether pressing on a specific point (GB30) before getting a shot can lower pain, reduce fear, and boost satisfaction. 68 adults who needed a painkiller injection took part. Half got acupressure before the shot, and half got standard care. The results showed …

This study tested whether wearing virtual reality glasses during chest tube removal after open heart surgery can lower pain and keep heart rate and blood pressure stable. 82 adults on their second or third day after surgery took part. The goal was to see if a simple, drug-free di…

This study looked at whether playing digital games or watching cartoons can help children aged 5 to 10 feel less pain, fear, and anxiety while getting stitches in the emergency room. A total of 90 children were split into three groups: one played a game, one watched cartoons, and…

This study tested whether Voltaren Gel, a topical pain reliever, can help people with knee osteoarthritis move more and feel better in daily life. About 196 adults aged 40 to 85 used the gel as directed for three weeks while wearing an activity tracker. The goal was to see if it …

This study tested whether a virtual reality program that uses biofeedback (like heart rate monitoring) could help children and teenagers aged 12-18 manage pain after surgery. 93 participants used the program before and after their operation. The goal was to see if the approach wa…

This study tested whether guided breathing exercises (4-7-8 breathing and diaphragmatic breathing) can help reduce pain, anxiety, and improve comfort during the needle insertion for hemodialysis. 90 adult kidney patients on dialysis were randomly assigned to one of two breathing …

This study tested whether a computer program called PAINRelieveIt could help hospice patients with cancer and their caregivers better manage pain. About 250 patient-caregiver pairs took part, with some using the program and others receiving usual care. The goal was to see if the …

This study tested whether applying cold to sore joints can reduce pain and improve daily life in people with rheumatoid arthritis. Researchers enrolled 90 adults who had RA for at least 6 months and were experiencing pain. The goal was to see if this simple, low-cost, non-drug me…

This study tested whether giving montelukast before surgery reduces pain and the need for strong painkillers in children aged 3-8 having their tonsils removed. Half the children received montelukast and half a placebo. Researchers tracked pain scores, opioid use, and calls or vis…

This study tested if a doctor's calming and encouraging words during a colonoscopy (done without sedation) can help reduce pain and anxiety. 102 adults took part, with half receiving positive verbal suggestions and the other half receiving standard care. The goal was to see if th…

This study tested whether numbing sprays (lidocaine or benzocaine) can reduce pain and improve satisfaction when inserting needles into the arm access site of people on hemodialysis. Sixty adults were randomly assigned to receive one of the two numbing sprays or a placebo spray r…

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors took part in sessions and surveys. The goal was to see if the program was practical and helpful, with follow-ups at 3 months to check smoking status and pain levels.

This study tested whether regular phone calls from a nurse could help people with fibromyalgia manage their pain and stay active. 44 adults were split into two groups: one received three nurse phone calls with education, the other got usual care. After two months, the researchers…

This study tested whether a cooling spray called Num can lower the pain women feel from the numbing injection (paracervical block) given before certain gynecologic procedures. 98 adults took part, rating their pain on a simple 0-to-100 scale. The goal was to see if the spray make…

This study tested whether watching a nature-themed virtual reality video during coronary angiography (a heart procedure) could lower pain and anxiety. 90 adults who had never had the procedure before took part. One group used VR while the other received standard care. The goal wa…

This study looked at whether giving children aged 4-6 a liquid hourglass or a spiky ball toy during a blood draw can reduce their pain, fear, and anxiety. 120 children were randomly assigned to use one of the toys or receive standard care. The goal was to see if these simple dist…

This study tested whether gabapentin or clonidine is better at reducing pain after spinal surgery. 90 adults aged 18-60 having one or two-level lumbar laminectomy took part. Pain was measured using a standard 0-10 scale, and anxiety was also tracked. The results help doctors choo…

This study looked at whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. 70 women were randomly assigned to either use VR or receive standard care. Pain and anxiety levels were measured right after the procedure. The goal is to find a simple, …

This study looked at the safety of ropivacaine, a numbing medicine, when used for a nerve block during circumcision in over 2000 boys up to age 16. The main goal was to see if it caused any rare but serious side effects like tissue death (necrosis) of the penis head. The results …

This study looked at whether a drug called dexmedetomidine is safer than morphine for sedating newborns with brain injury who are undergoing cooling therapy. Fifty infants were enrolled to compare side effects and drug levels. The goal is to find a pain management option that cau…

This study looked at whether doing progressive relaxation exercises—like tensing and relaxing muscles—can help people with a slipped disc in their lower back. 96 adults were split into two groups: one got standard care, the other added supervised relaxation sessions three times a…

This study looked at whether a 50% oxygen and 50% nitrous oxide (laughing gas) mixture can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, catheter placements, or stitch removal. Researchers observed 100 children and measured pain using …

This study tested whether giving children stickers during an IV insertion can lower their pain and anxiety. 72 kids aged 5-10 took part. The idea is that a simple, fun distraction might help them cope better with the procedure.

This study tested whether certain health and wellness products can help reduce pain in adults. About 1,000 people took either a product or a placebo (a dummy pill) without knowing which they got. Researchers measured changes in pain, anxiety, and sleep over time to see if the pro…

This study looked at whether using breathing exercises and squeezing a stress ball during dressing changes can help burn patients feel less pain and anxiety. 210 adults with burns covering 15% or less of their body took part. The goal was to see if these simple techniques could m…

This study tested whether applying a gel called PuraBond to the surgical wound after mouth or throat surgery can reduce pain and complications. 73 adults having surgery for abnormal growths or cancer were randomly assigned to receive the gel or not. Researchers measured pain leve…

This study looked at ways to reduce pain in women who had severe perineal tears during childbirth. 67 women were given either a placebo, a low dose of ketamine plus morphine, or morphine alone. The goal was to see which option worked best for pain one week after delivery.

This study tested a new medicine called MR-107A-02 to see if it can safely reduce pain after hernia repair surgery. About 579 adults took part, comparing the new drug to a placebo (fake pill) and an active painkiller. The goal was to measure pain intensity and the need for extra …

This study tested whether Korean hand acupuncture (manupuncture) can reduce pain in women with endometriosis. 74 women were randomly assigned to receive either real acupuncture or a placebo treatment. The goal was to see if this gentle, non-drug approach could help manage pain th…

This study looked at whether using virtual reality glasses or music during burn dressing changes can lower pain, anxiety, and fear of pain. 120 adults with burns on less than 15% of their body took part. Researchers measured their pain and anxiety levels using simple scales to se…

This study looked at whether taking high doses of vitamin B6 can change how healthy adults feel pain. Researchers tested 43 people using heat and mild electric shocks to measure pain thresholds and tolerance. The goal was to see if vitamin B6 could help people withstand pain long…

This study tested whether a medicine called Intravenous Immunoglobulin (IVIG) is safe and works to shorten painful episodes (crises) in people with sickle cell disease. About 300 people aged 6 to 65 took part. The goal was to see if IVIG could reduce how long the pain lasts and t…

This study looked at whether adding strain counterstrain therapy—a gentle, hands-on technique—to standard care can reduce pain, fatigue, and improve quality of life in women with fibromyalgia. 105 women were split into three groups: one received standard care, another added the t…

This study looked at 304 children aged 2 to 17 who came to the emergency room with a broken arm or leg bone and needed strong pain medicine. Researchers wanted to see if giving paracetamol (acetaminophen) and/or ibuprofen along with morphine worked better than morphine alone. The…

This study tested whether reflexology (a type of foot massage) can reduce pain felt during episiotomy repair—the stitching of a cut made during vaginal birth. 80 women who gave birth vaginally were split into two groups: one received reflexology, the other standard care. Research…

This study looked at 120 full-term newborns to see if holding them in different positions (on their back, side, or stomach) during a routine heel prick blood test could lower their pain and improve comfort. Researchers measured pain scores, heart rate, and oxygen levels before, d…

This study looked at whether cannabis oil extracts (with different levels of THC and CBD) can help cancer patients manage pain, nausea, anxiety, and sleep problems better than a placebo. About 91 adults with cancer took part, each trying several oil types in a blinded, crossover …

This study tested two different ultrasound-guided nerve blocks to control pain in 20 women having mastectomy. The goal was to see if a newer, more side-lying block (proximal intercostal) is easier to perform and safer than the standard paravertebral block. Researchers measured ho…

This study tested a special anesthesia and pain management plan for 70 older adults (age 60+) having heart surgery. The goal was to see if it could lower confusion after surgery, keep blood pressure stable, and reduce pain and opioid use. Researchers measured blood markers of bra…

This study tested a long-lasting painkiller called liposomal bupivacaine (Exparel) in 19 people having hernia repair surgery. The goal was to see if it improves pain control and patient satisfaction after the operation. Researchers measured how satisfied patients were with their …

This study looked at whether shining a special light (photobiomodulation) on tears from childbirth can reduce pain and help healing. 183 women who had a vaginal birth with a cut or tear were offered the light treatment along with standard care. Researchers compared their pain and…

This study compared two types of nerve blocks for pain control in 100 people with hip fractures. The goal was to see which block better preserves leg muscle strength while still easing pain. Results help doctors choose the best option for recovery.

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble readjusting to civilian life. The workshop taught practical skills like managing emotions, solving problems, and focusing attention. The goal was to help Veterans feel more connected to their…

This study tested a program that combines mind-body skills (like deep breathing and relaxation) with a Fitbit activity tracker to help people with long-term pain. 82 adults with chronic pain took part in weekly sessions and wore the device. The goal was to see if the program was …

This study compared adding Mulligan SNAG (a type of hands-on therapy) to standard physiotherapy for people with long-term low back pain. Thirty adults with pain lasting at least 6 months were randomly assigned to receive either SNAG plus physiotherapy, physiotherapy alone, or a f…

This study looked at whether listening to music can help reduce pain and anxiety in people who just had coronary artery bypass surgery. Sixty adults who were having the surgery took part. The goal was to see if music therapy, a non-drug method, could improve their recovery experi…

This study looked at whether doing exercises at work or at home works better for office workers with low back pain. 57 adults aged 25-40 who sit for long hours took part. Researchers measured pain, daily function, and quality of life to see which approach helps more.

This study tested whether acupressure, a technique where pressure is applied to specific points on the body, can help reduce pain and anxiety in people undergoing a bladder test called urodynamics. 68 adults were randomly assigned to receive either acupressure or standard care. R…

This study tested whether a simple hypnosis technique called the 'magic glove' can prevent pain in children aged 7 to 14 during propofol injection, compared to the standard numbing medicine lidocaine. One hundred children scheduled for surgery took part. The goal was to see which…

This study tested whether two people—a hospice patient and their caregiver—could use virtual reality (VR) together to experience calming nature scenes. The goal was to see if this shared experience could help reduce pain, anxiety, and fear of death. 26 English-speaking hospice pa…

This study tested whether hypnosis or virtual reality (VR) can better reduce pain during repeated medical procedures like wound dressing changes. Fifty-two patients who experienced significant pain despite usual painkillers took part. Each patient tried both methods at different …

This study tested whether applying Emla cream (a numbing cream) before a routine pneumococcal vaccination reduces pain in 3-month-old babies. 72 healthy infants were randomly assigned to receive either Emla cream or a placebo cream. Pain was measured using a standard scale (FLACC…

This study tested whether a non-visual audio biofeedback device (like NOICE or Quest 3) can help people feel less pain and anxiety during a cold pain task. 42 healthy adults participated, rating their pain and anxiety after using the device or nothing. The goal was to see if soun…

This study looked at whether sleeping at least an hour more each night for a week can help college students handle pain better. 36 healthy students wore sleep and heart monitors and took pain tests before and after the extra sleep. The goal was to see if more sleep raises pain to…

This study tested a short form of cognitive behavioral therapy (CBT) for veterans with long-term muscle or bone pain. 184 veterans received either six 30-minute therapy sessions plus usual care, or usual care alone. The goal was to see if the therapy helped them do daily activiti…

This study looked at whether nursing care based on Kolcaba's Comfort Theory can reduce pain and improve comfort in healthy, full-term newborns right after a vaginal birth. Sixty babies were included. Researchers measured pain, comfort, crying, and vital signs. The goal was to see…

This study tested a cooling spray (vapocoolant) to see if it reduces pain when getting an IV in the emergency department. 300 adults who needed an IV were randomly given either the cooling spray or sterile water before the needle. The main goal was to measure pain scores on a 0-1…

This study tested whether giving patients a brief lesson about mindfulness before a short meditation session helps them feel less pain while waiting at an orthopedic clinic. Over 600 adults took part, and researchers measured changes in how unpleasant and intense their pain felt.…

This study looked at whether giving ketamine through a nebulizer (a machine that turns liquid into a mist you breathe in) can help children aged 7 to 17 with acute pain in the emergency department. Researchers compared three different doses to see which one reduced pain the most …

This study looked at whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in adults having an ERCP procedure. 70 participants were split into two groups: one did box breathing plus standard care, the other had standard care alone. Th…

This study tested whether placing a hot water bag on the belly can reduce pain and help the bowels start moving again in people with ileus (a bowel blockage). Sixty adults with a certain type of ileus took part. Researchers measured pain levels before and after using the hot wate…

This study tested a single injection of a long-acting painkiller (SDE) to manage pain after hemorrhoid removal surgery. 221 adults received either the drug or a placebo, and their pain levels were tracked for 48 hours. The goal was to see if the injection safely reduces pain and …

This study tested whether a special injection of multiple drugs around the knee can better control pain after total knee replacement compared to standard painkillers like opioids and NSAIDs. 80 adults with end-stage knee arthritis were enrolled. The goal was to see if the injecti…

This study compared two pain management approaches for 62 children having tonsil surgery. One group received standard opioid pain medicine, while the other got a non-opioid combination. The goal was to see if the non-opioid plan controls pain just as well, with fewer side effects…

This study looked at whether Reiki, a gentle hands-on therapy, can help elderly nursing home residents feel less pain, less tired, and sleep better. Sixty people aged 50 and older with chronic pain took part. Researchers measured sleep quality, fatigue, and pain levels before and…

This study looked at whether classical massage can reduce pain and improve daily life in people with myofascial pain syndrome, a condition causing muscle knots and radiating pain. Sixty adults aged 30-50 with persistent neck and arm pain took part. Researchers compared massage al…

This study looked at whether adding ketamine to a standard nerve block (external oblique intercostal plane block) could better control pain after open chest surgery (thoracotomy). Fifty adults scheduled for this surgery took part. The main goal was to see how long it took before …

This study tested a phone-based counseling program for veterans with chronic pain who were at risk for substance misuse. Over 1,100 veterans took part, receiving brief advice and referrals to pain management services. The goal was to reduce pain and risky substance use through su…

This study tested whether a mobile app with guided imagery therapy could help children aged 7 to 12 with ongoing stomach pain. Four children used the app for 8 weeks, listening to 10-15 minute sessions most days. The goal was to see if the app could reduce pain frequency and inte…

This study looked at whether giving testosterone to women over 60 with chronic back pain, low testosterone, and long-term opioid use could improve their pain and quality of life. 36 women received either testosterone or a placebo. The goal was to see if testosterone helps with pa…

This study tested a smartphone-based prayer program called PUSH (Pray Until Something Happens) to help adults with sickle cell disease reduce stress and pain. Forty participants who reported pain and used opioids were included. The goal was to see if adding prayer to standard car…

This study tested whether smelling lemongrass essential oil during a tooth extraction can lower pain, anxiety, and stress. Twenty-one people aged 12 to 25 had two premolars removed on different sides—one side with aromatherapy, the other without. Researchers measured pain, anxiet…

This study tested whether using virtual reality (VR) during femoral sheath removal after coronary angiography can lower pain, anxiety, and changes in vital signs. One hundred adults were randomly assigned to either wear VR goggles or receive standard care during the procedure. Th…

This study tested a special injection technique (ventrogluteal) in 90 children aged 6-12 to see if it hurts less than the usual method. Kids who got the new technique reported lower pain scores and had a slower pulse rate after the shot. The findings suggest this simple change ca…

This study looked at whether reflexology (a type of foot massage) can reduce pain, improve sleep, and stabilize vital signs in people who have had a stroke. 70 stroke patients were split into two groups: one received 12 reflexology sessions over six weeks plus usual care, while t…

This study tested whether platelet-rich plasma (PRP) injections work better than steroid shots for shoulder arthritis pain in 50 adults aged 18 to 70. Participants received one type of injection and reported changes in pain, movement, and quality of life over time. The goal was t…

This study looked at whether adding pregabalin or gabapentin to usual opioid painkillers can reduce the amount of opioids needed by people with orthopedic injuries. About 109 adult trauma patients took part. The goal was to see if these add-on drugs help control pain while loweri…

This study tested whether chewing gum and using hot compresses after gynecologic cancer surgery can reduce pain, help the bowels work sooner, and improve overall comfort. 84 women who had minimally invasive surgery took part. The goal was to see if these simple, drug-free methods…

This study looked at whether using different amounts of a numbing medicine in a back muscle injection (erector spinae plane block) can reduce pain and the need for strong painkillers after a hysterectomy. 80 adults having the surgery took part. The goal was to find the best volum…

This study tested a telerehabilitation program for people with knee osteoarthritis. 118 adults aged 50+ with mild to moderate knee arthritis took part. The program used online sessions to guide exercises and monitor pain, stiffness, and physical function. The goal was to see if r…

This study tested a pain relief method called paravertebral block for people having chest surgery (thoracotomy) who cannot have the usual epidural pain relief. The surgeon placed a small tube near the spine during surgery to deliver numbing medicine for 48 hours. The goal was to …

This study tested whether acupuncture can help reduce pain in people with long COVID. 93 adults with ongoing pain after a COVID infection were randomly assigned to receive either 8 acupuncture sessions or their usual care. Over 5 months, participants completed online surveys abou…

This study tested whether foot reflexology, a type of focused foot massage, could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part. One group received 10 sessions of foot reflexology over 5 weeks, while th…

This study tested whether using an ultrasonic surgical device (piezosurgery) instead of a traditional rotary drill can reduce pain, swelling, and jaw stiffness after removing impacted wisdom teeth. Twenty-two healthy adults each had one wisdom tooth removed with the ultrasonic to…

This study tested whether spraying a cold mist on the skin before a blood-thinner shot (low molecular weight heparin) can reduce pain and bruising in people recovering from orthopedic surgery. 101 adults took part. The goal was to see if this simple, drug-free method works better…

This study looked at whether kinesiological taping (a special tape placed on the skin) or foot massage can reduce pain, tiredness, and mood problems in women who had a cesarean delivery. About 97 new mothers were split into three groups: one got taping, one got foot massage, and …

This study tested whether using virtual reality (VR) during wound dressing changes can reduce pain and improve sleep in adults with moderate to severe burns. Sixty patients with burns covering 25-60% of their body took part. The results showed that VR helped lower pain during the…

This study tested whether a 10% lidocaine spray reduces pain when inserting an IV catheter. Forty women each received four IV insertions—two with the spray and two without—on different arm locations. They rated their pain on a 0-10 scale. The goal was to see if the spray made the…

This study looked at whether a guided relaxation program on a tablet could help adults with sickle cell disease manage pain and stress while in the hospital. Forty-six participants used the program to listen to calming audio-visual recordings. The goal was to see if this simple, …

This study tested whether a PECS nerve block, given before surgery, could lower the amount of opioids needed and improve pain control in women undergoing breast cancer surgery. Seventy women took part, and the approach aimed to reduce pain and increase satisfaction. The results h…

This study tested a special training program to help people with advanced cancer manage pain and keep doing daily activities. 211 patients took part, learning skills to cope with pain and find meaning despite their illness. The program focused on improving quality of life and red…

This study looked at whether guided strength training and stretching, along with a home exercise plan, is better than just a home exercise plan alone for reducing pain in dental students. Sixteen second-year dental students took part. The goal was to see if these exercises could …

This study tested whether using virtual reality (VR) during heart device implantation (like pacemakers or defibrillators) can lower patients' anxiety and pain. 100 adults were randomly assigned to receive VR or standard care during the procedure. Researchers measured anxiety leve…

This study tested whether using virtual reality (VR) goggles before a stomach scope procedure could help children aged 6 to 15 feel less anxious, have less pain, and recover faster. 66 first-time patients were randomly assigned to either use VR or receive standard care. The VR gr…

This study looked at whether listening to slow-tempo music for seven days could help older adults in the intensive care unit (ICU) avoid delirium—a state of confusion that can lead to longer hospital stays and memory problems. Researchers enrolled 160 patients aged 50 and older w…

This study tested two small devices—Coolsense (cold only) and Buzzy (cold plus vibration)—to see if they reduce pain and anxiety in children aged 6–12 with type 1 diabetes during insulin injections. 90 children were split into three groups: one used Coolsense, one used Buzzy, and…

This study tested whether applying a medical glue (cyanoacrylate) or a concentrated growth factor gel to the roof of the mouth after gum graft surgery helps the wound heal faster and reduces pain. Sixty healthy adults who needed a gum graft participated. The results will show if …

This study tested whether inhaling lavender essential oil can reduce anxiety and pain in people with moderate to severe pain. 68 participants either breathed in lavender oil or a placebo for 30 minutes. Researchers measured changes in anxiety and pain levels using standard questi…

This study tested whether a sugar-free sweet-tasting solution applied before a dental injection could reduce pain in children aged 6-12. Fifty-four kids received either the sweet solution or plain water before local anesthesia. Pain was measured using child-reported and observer-…

This study tested whether a mother's scent and a knitted octopus toy can reduce pain in newborns with birth asphyxia who are receiving therapeutic hypothermia. Forty-five full-term infants in the NICU were randomly assigned to receive these comforting items. Pain levels were meas…

This study tested a special way of talking called 'hypnotic communication' to help men feel less anxious and have less pain during a prostate biopsy. About 100 men took part, and half received this calming talk from a trained nurse while the other half got standard care. The goal…

This study tested whether a brief behavioral program called Acceptance and Commitment Therapy (ACT) could help at-risk veterans avoid persistent pain and disability after total knee replacement. About 400 veterans scheduled for knee surgery were randomly assigned to receive eithe…

This study tested whether using virtual reality (VR) during a knee pain treatment called genicular nerve radiofrequency ablation could reduce pain and improve patient satisfaction. Forty adults who were already scheduled for the procedure took part. The results showed that VR hel…

This study looked at whether live music played in the ICU can help critically ill patients feel less pain, anxiety, and stress. Over 100 patients, along with their families and hospital staff, took part. Researchers measured changes in pain, anxiety, and relaxation using simple r…

This study looked at whether one radiation treatment works as well as two for reducing pain from cancer that has spread to the bones. 102 adults with bone metastases and pain were randomly assigned to receive either a single dose or two doses of radiation. The main goal was to se…

This study looked at whether adding gentle spinal mobilization to a home exercise program could reduce neck pain and improve physical fitness in recreational tennis players. Thirty adults with mechanical neck pain took part. Half did only exercises at home, while the other half a…

This study tested whether watching virtual reality during a blood draw could help school-age children feel less pain, anxiety, and emotional distress. 86 children participated, and researchers measured their pain, anxiety, and emotional behavior using simple scales. The goal was …

This study tested two methods to block nerves in the upper arm during surgery: the usual blind injection versus an ultrasound-guided approach. The goal was to see which better prevents pain from the tourniquet used during the procedure. 140 adults having upper arm surgery took pa…

This study tested several non-drug methods to reduce pain from shots in 120 preschool children aged 4 to 6. Methods included a vibrating bee-shaped device (Buzzy), a plastic tool with bumps (ShotBlocker), a palm stimulator, and a skin tap technique. The goal was to find which wor…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain and mood to see if the device helped.

This study tested two simple, non-drug methods to help children aged 6 to 9 feel less pain and anxiety during their first dental visit. One group played with toy dental tools before the procedure, another used virtual reality glasses, and a third group had standard care. Research…

This study looked at whether structured play activities can lower anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in recreational play alongside regular care. Anxiety levels were measured before and after the play se…

This study tested a gas called Kalinox (a mix of nitrous oxide and oxygen) to see if it helps reduce pain during short medical procedures in adults with cancer, such as spinal taps or bone biopsies. About 200 patients took part, and the study compared Kalinox to standard pain rel…

This study looked at whether listening to music during a bladder test (called urodynamic testing) can make the experience less painful and embarrassing. The test involves placing a small tube and can be uncomfortable. 90 adults took part, with some listening to music and others n…

This study tested whether injecting a steroid (triamcinolone acetonide) along with a numbing drug (ropivacaine) into the surgical wound before closing it can reduce pain and the need for strong painkillers after major spinal surgery. 118 adults having spinal surgery took part. Th…

This study tested a program called DAPPER for African American women aged 50 and older who had pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study measured changes in pain intensity and d…

This study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) could lower patients' anxiety and pain. 144 adults scheduled for the injection were split into two groups: one listened to slow music, the other had no music. Researcher…

This study tested whether ozone therapy can reduce pain and tissue thickness in women with lipedema, a condition that causes painful fat buildup. 45 women received either local or systemic ozone treatments. The goal was to see if ozone's anti-inflammatory effects could ease sympt…

This study looked at whether showing children aged 7 to 12 a short educational video before a bone marrow aspiration and biopsy can lower their anxiety, fear, and pain, and increase their satisfaction. Sixty children having the procedure for the first time took part. The goal was…

This study tested whether injecting a numbing medicine (ropivacaine) into the nose during sinus surgery can reduce pain afterward. 184 adults having endoscopic sinus surgery took part. The goal was to see if this simple step could improve recovery and lower the need for other pai…

This study tested whether listening to nature sounds while getting up and moving after laparoscopic gallbladder surgery helps lower anxiety, pain, and stress. 70 adults who had their first gallbladder removal surgery took part. Researchers measured anxiety and pain using simple 0…

This study tested a personalized internet-based program called WebTIPS to help children ages 1-12 feel less anxious before and after surgery. Over 1,200 parent-child pairs took part, with some using WebTIPS and others receiving standard online information. The goal was to see if …

This study tested two types of nerve blocks (TFP and TAP) to see which one works better for pain after robotic-assisted prostate removal. 108 men who were in good health before surgery took part. The goal was to find out which block reduces pain, cuts the need for extra pain medi…

This study looked at whether the 4-7-8 breathing technique (breathe in for 4 seconds, hold for 7, out for 8) can help reduce pain, nausea, and vomiting after bariatric surgery. Sixty adults who had weight-loss surgery were split into two groups: one practiced the breathing techni…

This study looked at whether watching parrots, fish, or turtles could reduce pain and anxiety in patients receiving palliative care when they had a needle inserted into a port catheter. 120 adults took part. Researchers measured pain and anxiety levels before and after the animal…

This study tested a new medicine called MR-107A-02 to see if it can safely relieve pain after bunionectomy (foot surgery). About 410 adults took part. The goal was to measure how well the drug reduces pain and whether it can cut down the need for stronger opioid painkillers.

This study tested a new medicine called LEVI-04 to see if it can reduce pain in people with knee osteoarthritis. About 518 adults with knee pain took either the drug or a placebo. The main goal was to measure pain changes using standard pain scales. The trial is complete, and res…

This study tested a team-based care program for 516 people with stage III or IV cancer. The program aimed to help them stay mobile, reduce pain, and improve quality of life. Researchers found that the program helped maintain physical function and eased pain over six months.

This study tested whether a Bridge device can reduce pain and the need for opioid painkillers after rotator cuff surgery. 42 adults having outpatient surgery received the device along with standard anesthesia. Researchers tracked pain scores and opioid use for a week after surger…

This study tested a non-invasive device called ANI that measures heart rate patterns to assess comfort in 20 non-communicating patients receiving end-of-life palliative care. The goal was to see if the ANI could reliably detect pain or stress during routine care, compared to a st…

This study tested a pain-relief method for people recovering from chest surgery (thoracotomy) who cannot have standard epidural pain control. A small tube placed in the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All patients also …

This study tested two simple tools—a ShotBlocker and a vibration pen—to see if they could reduce pain in babies during routine vaccinations. 96 healthy infants aged 2-6 months were randomly assigned to use one of the tools or receive the shot as usual. Pain was measured using a s…

This study looked at whether a diabetes education program plus a cinnamon supplement could help adults with type 2 diabetes who have nerve pain in their feet. 62 people took part, with half receiving the education and cinnamon, and the other half acting as a comparison group. Res…

This study tested whether virtual reality (VR) exercises can help people with frozen shoulder (adhesive capsulitis) feel less pain, move better, and improve their quality of life. Thirty-six adults aged 18 to 65 with frozen shoulder took part. Researchers measured pain, shoulder …

This study tested whether live parrots, robotic parrots, or pictures of parrots could reduce pain during blood draws in 240 adults with chronic illnesses. Participants were randomly assigned to one of the three therapies, and their pain levels were measured before and during the …

This study looked at whether certain health and wellness products can help reduce pain. Over 2,000 adults in the U.S. who wanted less pain took either an active product or a placebo without knowing which. The main goal was to see if the products reduced how much pain interfered w…

This study tested whether relaxation exercises and virtual reality (VR) can reduce pain, jaw stiffness, anxiety, and sleep problems after wisdom tooth surgery. 36 adults who had their lower wisdom teeth removed tried these non-drug methods. The goal was to see if these simple tec…

This study tested five different devices for giving numbing shots in the roof of the mouth during tooth extractions. 200 healthy adults took part to see which method caused the least pain and fear. The goal is to find the most comfortable way to deliver dental anesthesia.

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with hand paralysis and pain. The goal was to see if the device could better improve …

This study tested non-drug methods to reduce nerve pain in the feet and legs of people with HIV. 196 adults with HIV and long-term nerve pain took part. The goal was to see if these approaches could lower pain and improve daily life.

This study tested how easy and useful the MeTime MS app is for adults with multiple sclerosis who have fatigue and chronic pain. Ten participants used the app to guide them through either a relaxing or stimulating acupressure routine at home. After six weeks, researchers intervie…

This study tested whether hot compresses with black seed or ginger essential oils can reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee pain applied the oils daily for 7 days. The goal was to see if these natural oils offer ext…

This study tested a nasal spray containing two pain medicines (sufentanil and ketamine) for children aged 1 to 17 with moderate to severe pain in the emergency room. The goal was to see if the spray is safe, tolerable, and works well for pain relief. 155 children took part, and r…

This study looked at whether manual therapy (hands-on treatment) or home exercises could reduce pain and improve jaw movement in people with bruxism (teeth grinding). Thirty young adults with bruxism were split into two groups: one did exercises at home for 8 weeks, the other rec…

This study looked at whether massage therapy after open heart surgery can reduce pain, improve sleep quality, and lower stress hormone levels. 96 adults who had elective open heart surgery took part. Some received back massages, while others received standard care. Researchers me…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical for adults with opioid use disorder and chronic pain. 63 participants were enrolled to see if they would stick with the program. The goal was to explore if this app…

This study tested whether wearing virtual reality (VR) glasses during a kidney stone treatment called ESWL can lower patients' pain, anxiety, and improve comfort. Seventy adults having ESWL for the first time took part. Researchers measured pain, anxiety, and comfort levels using…

This study looked at whether aromatherapy (using essential oils) can help reduce pain for women during labor. 94 first-time mothers with a single baby and no major complications were randomly assigned to receive either aromatherapy along with standard pain control or standard pai…

This study looked at whether adding medical marijuana to a 24-week support program helps adults with long-term pain reduce their opioid painkiller dose and improve pain. 87 people on high-dose opioids took part. The goal was to see if marijuana could make it easier to lower opioi…

This study tested whether a lidocaine spray applied to the cervix can reduce pain during intrauterine device (IUD) insertion. 90 women aged 18-45 who wanted an IUD took part. The goal was to see if this simple spray makes the routine procedure more comfortable.

This study tested a smartphone app called e-PainSupport for people receiving home hospice care. The app helps patients and their caregivers report pain to nurses and learn about pain management. The goal was to see if using the app could reduce how much pain patients feel. 88 pat…

This study tested whether listening to music during wound care can help people with venous leg ulcers feel less pain and anxiety. 97 patients were split into three groups: one listened to Turkish instrumental music, another to Western music without lyrics, and a third had standar…

This study looked at whether special sponges placed in the tooth socket after extraction can stop bleeding faster and help the wound heal better. Thirty adults who had a tooth pulled were given these sponges, and researchers measured bleeding time, pain, swelling, and gum color c…

This study tested whether a fixed-dose combination of acetaminophen and naproxen sodium reduces pain better than a placebo after bunionectomy (foot surgery). 143 adults took multiple doses over 48 hours and rated their pain intensity. The goal was to see if the combo pill provide…

This study tested whether using virtual reality glasses or listening to white noise can reduce pain and anxiety during a common medical procedure: inserting an IV. 76 adults were randomly assigned to one of three groups: VR, white noise, or standard care. Right after the IV was p…

This study tested a standardized care program for 70 adults who had back surgery in Erbil, Iraq. The program aimed to reduce pain, improve daily function, and increase patient knowledge. Researchers measured pain and disability before and 8 weeks after surgery to see if the progr…

This study looked at whether a special heart monitor (called ANI) can predict how a patient will react when a breathing tube is placed. Researchers gave a small electrical pulse to mimic pain and then checked if the heart's response matched the patient's movement or blood pressur…

This study looked at how experimental knee pain changes the way healthy people walk. 34 adults received two knee injections—one that caused temporary pain and one that did not. Researchers used motion-capture cameras and pain sensitivity tests to see how walking patterns changed …

This study surveyed 186 adults with sickle cell disease (SCD) in the U.S. to learn how the COVID-19 pandemic impacted their stress, anxiety, pain, sleep, and healthcare use. Participants completed online questionnaires about their medical history, mental and physical health, and …

This study looked at how information about what matters to older Veterans with chronic pain—like their home life and daily challenges—can help doctors provide better care. Researchers talked to 230 Veterans aged 65 and older, their caregivers, and clinicians to develop a computer…

This study followed 392 adults who had planned surgeries to map their pain levels over the first 7 days after the operation. Researchers wanted to see if different pain patterns could help predict who might develop long-term chronic pain 3 months later. The goal is to better unde…

This study tested three different doses of gentle, painless neck movements (mechanical vagus nerve stimulation) in 128 healthy adults to see how they affect heart rate, balance, pain sensitivity, and digestion. Researchers measured heart rate, balance, and pain responses before a…

This study looked at how a low dose of the anesthetic sevoflurane, combined with short-term pain, affects memory and automatic body responses in healthy adults. Researchers used brain scans to see which parts of the brain are involved. The study involved 42 participants over two …

This study tested whether a vibrating device can distract from the pain of a needle prick. 200 healthy adults received light pinpricks with and without the device. Researchers measured pain levels and anxiety to see if the vibration helps. The goal is to find a simple way to ease…

This study looked at 100 women with painful periods to find out how much pain relief is enough to make a real difference in their daily lives. Researchers measured pain and symptoms using standard questionnaires. The goal is to help future studies focus on changes that actually m…

This study looked at 110 breast cancer patients to see if arm swelling (lymphedema) is linked to a specific type of muscle pain called myofascial pain syndrome. Researchers checked for tender spots in the muscles and measured pain levels. The goal was to understand how these cond…

This study looked at how puberty changes pain sensitivity in healthy teens aged 9 to 16. Researchers measured pain from heat and cold, and checked hormone levels to see if they are linked to pain. The goal was to understand why some teens might develop chronic pain as they grow.

This study looked at whether a heart-rate-based index (called ANI) can help measure pain in 17 children with cerebral palsy. The children were monitored during painful procedures like injections and physical therapy. The goal was to see if this method could be a reliable way to a…

This study looked at 21 preterm infants to see if a skin sensor could measure pain during a procedure called LISA, which helps babies breathe. The sensor was compared to a standard pain scale used by nurses. The goal is to better understand which babies need pain medicine, so tre…

This study looked back at medical records of 126 people who had total knee replacement surgery and received nerve blocks for pain. The goal was to compare different nerve block methods to see which one works best for pain relief, how often nerve injury happens, and whether chroni…

This study looked at 100 adults with sacroiliac joint pain to find out which patient traits predict better results from a steroid injection. Researchers measured pain and disability before and after the injection. The goal was to help doctors choose the right patients for this tr…

This study tested a brief, computer-based program that gives personalized feedback to adults with chronic pain who drink heavily and take prescription opioids. The goal was to see if the program could increase knowledge about the risks of mixing alcohol and opioids, boost motivat…

This study tested a device called VerTouch against standard methods (feeling for landmarks or using ultrasound) to find the best spot for spinal injections in 86 adults. The goal was to see if VerTouch reduces how many times the needle needs to be adjusted. Results will help doct…

This study looked at whether treating obstructive sleep apnea (OSA) can also reduce pain and problems in the jaw and face (temporomandibular disorders, or TMD). Researchers examined 40 adults with OSA before they started any treatment and again after at least 18 months of therapy…

This study looked at whether pain in the jaw joint (temporomandibular joint) is linked to pelvic pain in adults. Researchers also explored how psychological factors and pain sensitivity might play a role. A total of 133 adults with chronic pain completed questionnaires about thei…

This study looked at how safe a numbing medicine (ropivacaine) is when used in a specific nerve block for chest surgery. 20 adults having robotic or video-assisted chest surgery took part. Researchers measured medicine levels in the blood and checked pain scores to understand ris…

This study looked at 110 medical secretaries to see how their desk setup, posture, and work habits relate to muscle and joint pain. Participants filled out surveys about their work environment and any aches they had. The goal was to find links between poor ergonomics and pain in …

This study worked with 100 torture survivors to better diagnose chronic pain. Researchers tested if adding a simple pain questionnaire could catch pain that standard methods miss. They also interviewed survivors about pain treatments and tested if a digital program could help tra…

This study compared women with and without fibromyalgia to see if they had different levels of chronic pelvic pain and pelvic floor problems. Researchers used pain scales and questionnaires to measure pain and its impact on daily life. The goal was to better understand how these …

This study tested a single dose of a new experimental drug called SBS-1000 in 48 healthy adults. The main goal was to check for side effects and see how the drug moves through the body. This is an early safety study, so it does not test if the drug actually relieves pain.

This study used a special brain imaging technique called near-infrared spectroscopy to measure blood flow changes in the brain when people under general anesthesia experienced pain or heard sounds. The goal was to understand how the brain processes these signals while asleep. 44 …

This study looked at 151 people with shingles to find out who might develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information to build a prediction model. The goal is to help doctors identify high-risk patients early and tailo…

This study looked at whether higher estrogen levels make propofol injection more painful in women. Researchers compared IVF patients with high estrogen to those with normal levels. The goal is to better understand how hormones affect pain and improve patient comfort during anesth…

This study looked at whether a personalized meal plan with more omega-3 fatty acids (found in fish) could help breast cancer survivors manage symptoms like fatigue, pain, depression, and sleep problems. About 98 women who had finished treatment for early-stage breast cancer took …

This study examined whether a person's body mass index (BMI) influences how well a nerve block controls pain after surgery for a slipped disc in the lower back. Researchers measured pain levels in 75 adults at different times after surgery. The goal was to see if higher BMI leads…

This study tested whether a full-scale trial is possible for a new approach to manage recurrent pain in children with severe neurologic impairment. 54 children and their parents participated, with some receiving the PQ-ResPOND intervention (a web-based survey system plus a pallia…

This study tested whether playing an active virtual reality game (where you move) or watching a passive VR video changes how much heat or pressure pain healthy adults can tolerate. 265 participants tried both types of VR. The goal was to see which approach raises pain thresholds …

This study looked at how watching someone else experience pain can actually reduce your own pain. Researchers used brain scans to understand the brain activity behind this 'observational learning' effect. 211 healthy adults participated, and the goal was to map the brain areas in…

This study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used exams, imaging, and surveys to track pain, inflammation, and joint changes. The goal was to learn how the disease progresses and what factors predict outcomes, not to test a new treatment.

This study tested a quick, one-minute checklist to identify women at high risk for severe pain after gynecologic day surgery. Researchers followed 487 women and checked if the tool could accurately predict who would have severe pain at home. The goal is to help doctors give bette…

This study looked at 679 adults to find out which factors make a colonoscopy without sedation more painful. The goal was to create a tool that helps doctors predict pain before the procedure, so they can take steps to reduce it. The research did not test any new treatment, but in…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers observed 50 children to see if the monitor's readings matched behavioral pain scales. The goal was to find a reliable …

This study tested two devices that measure pain in children aged 1 to 12 during surgery. The goal was to see how well they detect pain signals. Fifty children took part, and the results help doctors choose better pain monitors for young patients.

This study tested whether changes in pupil size can reliably measure acute pain. Researchers gave short, painful heat pulses to 20 adults with hip or knee arthritis and measured how their pupils reacted. The goal was to see if pupil response could be a trustworthy, objective pain…

This study looked at how broken sleep changes the way healthy adults feel pain and move their shoulders and knees. Thirty participants had their sleep disrupted on purpose, then received painful injections to measure their pain responses. The goal was to understand if poor sleep …

This study examined how genetic differences in the CYP2D6 enzyme influence pain relief from oxycodone in 100 elderly patients undergoing lung cancer surgery. The goal was to tailor pain management to each patient's genetic profile, reducing side effects and improving pain control…

This pilot study tested a program called STEPPT to see if it could reduce differences in how often Hispanic and non-Hispanic White patients with back or neck pain are referred to and attend physical therapy. 144 adults from a community health clinic took part. Researchers measure…

This study involved 200 Albanian adults with back pain to test whether translated pain and disability questionnaires are accurate and reliable. Participants filled out several standard forms, like the Roland-Morris and Oswestry Disability Index, in Albanian. The goal was to make …