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Which opioid works best for day surgery pain? study pits morphine against hydromorphone

NCT ID NCT02223377

Symptom relief Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two common opioids, morphine and hydromorphone, to see which provides better pain relief with less nausea and vomiting after same-day surgeries. About 400 adults undergoing procedures like gallbladder removal or hernia repair will receive one of the two drugs in the recovery room. The goal is to find the most effective option for managing pain while minimizing side effects, helping patients recover faster and more comfortably.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
morphine and hydromorphone
What this could lead to
If one drug proves clearly better, it could become the preferred choice for managing pain after day surgeries, improving patient comfort and recovery speed.
What could go wrong
This is a single study with 402 people, and results may not apply to all surgeries or patients. Both drugs can cause nausea, itching, or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

402 people

The number who actually took part.

Start date

Jan 2015

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ambulatory surgeries producing at least moderate pain-such as cholecystectomy, appendicectomy, ovarian cystectomy, inguinal hernia repair, abdominal wall hernias * ability to communicate in English. Exclusion Criteria: * allergy to M or HM * patient on regular chronic opioid medication * patient uncontrolled systemic disease * severe obesity with a BMI \>35 * significant psychological impairment * history of drug addiction or dependence * any planned regional or nerve block other than local anesthesia infiltration patients with confirmed sleep apnea * emergency surgeries and urological surgeries

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Conditions

The condition(s) this trial relates to.

Pain Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain Post-operative nausea and vomiting

Contacts and locations

Locations

  • Hamilton Health Sciences

    Hamilton, Ontario, L8L 2X2, Canada

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, L8N 4A6, Canada

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