Mcmaster University

This study tests a new COVID-19 vaccine that you breathe in as a mist, aiming to boost immunity in the lungs and blood. About 350 healthy adults who have already had three mRNA COVID shots will get either the experimental vaccine or a placebo. Researchers will check safety and im…

This study is a registry that collects information on different blood thinner treatments for people with antiphospholipid syndrome who have had an artery clot in the past year. The goal is to see which treatment works best to prevent future clots and bleeding. About 150 adults wi…

This study looks at whether giving pregnant people half the usual dose of a steroid (Celestone) can prevent serious health problems in babies born early. About 3,254 participants will be randomly assigned to receive either the standard two doses or just one dose. The goal is to s…

This early-stage study tests whether a drug called DNase I is safe and feasible for ICU patients with sepsis. Sepsis is a life-threatening response to infection that can cause organ failure. The trial will enroll 36 adults and monitor how many complete the treatment and how their…

This study looks at how the body adapts to weight loss in teens aged 12-17 with obesity. Participants will either follow a lifestyle program alone for 6 months, then add the drug semaglutide, or start both together. The goal is to see if adding semaglutide helps the body burn ene…

This study tests a new surgical method (AMIC) against the standard microfracture procedure for repairing damaged hip cartilage. Forty adults aged 18-55 with hip pain and cartilage defects will be randomly assigned to one of the two surgeries. Researchers will track pain, hip func…

This study looks at whether surgery or non-surgical care works better for people who have dislocated their shoulder for the first time. Researchers will follow 100 participants aged 14 to 40 for two years to see which approach lowers the chance of the shoulder popping out again a…

This study tests a virtual health coaching program for 160 adults with type 2 diabetes and mental health struggles. Participants get weekly coaching calls, support from a care team, and online tools. The goal is to see if this approach improves quality of life and reduces diabete…

This study tests whether using a phlegm (sputum) test to guide treatment can reduce chronic cough in people with interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either standard care or care guided by spu…

This study tests whether a virtual therapy led by parents can help teens with anorexia nervosa while reducing long wait times for treatment. About 90 families will take part, with parents guiding sessions using online materials and support from a therapist. The goal is to see if …

This study tests a 10-week power training program for people who had a stroke at least 6 months ago. The goal is to see if fast, explosive exercises can improve walking, strength, and balance better than standard slow strength training. Sixty participants will be randomly assigne…

This study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss. 26 adults recently diagnosed with cancer will either receive usual care or extra support from a physiotherapist navigator for 12-18 weeks. The navigat…

This study tests a training program called ABCs that teaches healthcare providers how to have better conversations with patients facing serious illness. About 350 doctors, nurses, and other providers will take online modules and virtual workshops. The goal is to see if the traini…

This small pilot study is testing a new program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education, one-on-one peer support, and help for community healthcare providers. The g…

This study looks at how mucus buildup in the airways affects people with asthma, COPD, and chronic cough. Researchers will use CT scans and breathing tests to compare 240 adults and 50 children with these conditions to healthy volunteers. The goal is to find patterns and markers …

This study is testing a web-based app called IAMABLE that shares rehabilitation strategies for people with chronic conditions like heart disease, muscle or joint problems, and nerve disorders. Researchers will enroll 50 adults aged 45 to 75 across five Canadian cities. Half will …

This study looks at how different types of hormonal birth control affect blood sugar regulation in young, healthy women. Researchers will compare three groups: those not on birth control, those taking birth control pills, and those using an IUD. Participants will drink a sugary b…

This study looks at how to make stroke rehabilitation research more inclusive, especially for women and people with aphasia (trouble speaking or understanding language). Researchers will test a new way of recruiting participants and compare it to the usual method. The goal is to …

This study looks at why some people with asthma don't get better with standard inhalers. Researchers will use MRI and CT scans to see if blocked or narrow airways stop the medicine from reaching the lungs. They will test if oral medications work better for these patients. The goa…

This pilot study explores whether a common food additive (potassium sorbate) affects how much people eat. Twenty adults with obesity will receive either the additive or a placebo, and their food intake over 24 hours will be measured. The goal is to see if this type of study is fe…