Mcmaster University

This pilot study looks at whether early surgery or rehabilitation is better for teenagers (ages 12-18) who have dislocated their shoulder for the first time. The goal is to see which approach reduces the chance of the shoulder dislocating again and improves pain and function. Thi…

This study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks, strokes, and blood clots in people who had hip fracture surgery and also suffered a heart injury. About 100 adults aged 45 and older will receive either the drug comb…

This study compares two treatments for young people (ages 10-25) who have dislocated their kneecap for the first time within the past 6 months. Half will receive standard rest and physical therapy, while the other half will have early surgery to repair the ligament. Researchers w…

This study tests a prevention program called Family Check-Up+ for 300 families in Ontario with children aged 2-6 who are at risk for behavior problems. The program offers personalized coaching and support to strengthen family relationships and reduce child emotional and behaviora…

This study tests whether a special routine for bathing, skin care, and exposing babies to food proteins through the environment can prevent food allergies. Researchers will compare this routine to standard care in 64 newborns at risk for allergies. Parents will track their baby's…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults at Hamilton General Hospital will be randomly assigned to either the …

This study tests two common medications (low-dose morphine and pregabalin) and a virtual cough control therapy in 124 adults with chronic cough that hasn't improved with standard treatments. The goal is to see which approach works best to reduce coughing and improve quality of li…

This study tests whether the antibiotic vancomycin can safely improve symptoms of ulcerative colitis in adults who also have a liver condition called primary sclerosing cholangitis. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an option for 4 more wee…

This study looks at whether playing music before and during wound dressing changes can help reduce pain and improve healing for older adults with pressure injuries (bed sores). About 50 residents aged 60 and older from long-term care homes will take part. Some homes will play the…

This study tests whether adding ketamine to standard sedation helps ICU patients on breathing machines. Ketamine treats both pain and anxiety, potentially reducing side effects like confusion and dependence on narcotics. About 54 adults in Canadian ICUs will be randomly assigned …

This pilot study looks at whether adding chiropractic care to regular medical care can help adults with long-term back or neck pain reduce their use of opioid painkillers. The study will involve 24 patients from four community health centers in Canada. The main goal is to see if …

This study tests a new rehabilitation program for people with melanoma, a serious skin cancer. The program includes exercises and support before and after surgery to help patients regain strength and confidence. The study will include 30 adults who are scheduled for surgery after…

This study tests whether a virtual exercise program with a peer buddy helps older adults (60+) who have had cancer become more active and feel better. Participants are split into three groups: one gets a peer plus guidance from exercise pros, one gets peer support only, and one g…

This study tests whether giving a simple educational brochure to sepsis survivors before they leave the ICU is practical and helpful. Researchers will enroll 30 adults with sepsis to see if they can successfully deliver the brochure and follow up with surveys. The goal is to lear…

This study tests a structured program called TransitionED that helps youth aged 16+ with eating disorders move from pediatric to adult healthcare. The program includes planning guides, meetings with a clinician, and peer support. Researchers want to see if the program is practica…

This study tests a new recruitment method called the ORDER toolkit, which uses brochures and videos designed with women patients to encourage more women to join stroke research. Researchers will compare this approach to standard recruitment in 1,600 people with stroke or mini-str…

This study tests a mobile app called PeerOnCall that lets firefighters privately connect with peers for support and access wellness resources. About 2,000 Canadian firefighters will use the app for one year. Researchers want to see if adding weekly reminders and feedback helps mo…

This study looks at how eating salt affects gut health in people with Crohn's disease. Researchers want to see if more salt increases protein breakdown in the gut and worsens inflammation and symptoms. The goal is to improve diet advice and create personalized nutrition plans for…

This early-stage study looks at whether the hormone progesterone changes how muscles build protein after resistance exercise. Twenty healthy women aged 18-30 will take either progesterone pills or a placebo, then do leg exercises. Researchers will take small muscle samples to mea…

This study is a small 'pilot' trial to see if a larger study comparing two standard treatments for mild degenerative cervical myelopathy (a type of spinal cord compression in the neck) is possible. Researchers will enroll 56 adults with mild symptoms and randomly assign them to e…