Mcmaster University

This study tested whether mepolizumab, a drug that targets certain white blood cells (eosinophils), can reduce airway inflammation in people with COPD who have high levels of these cells. 18 participants received the drug or a placebo for 6 months. The goal was to see if the drug…

This study tested a program to help older adults (70+) who take 5 or more medications reduce their pill burden. The program involved talking with patients about their priorities, a pharmacist review, and a doctor consultation to safely stop or lower doses of medicines. The goal w…

This study looked at 30 adults with severe asthma who did not get better with standard treatments. Researchers wanted to see if dupilumab, a drug that blocks certain immune signals, could reduce signs of the immune system attacking the airways. Participants took dupilumab for 4 m…

This study tested whether using a low-chloride IV fluid (like Ringer's lactate) instead of normal saline could lower the risk of death or kidney damage in people with septic shock. Over 1,100 adults in the ICU took part. The goal was to see if the type of fluid makes a real diffe…

This study tested the drug tezepelumab in 27 adults with moderate-to-severe asthma that was not well controlled by current treatments. The goal was to see if the drug could improve how air moves through the lungs and reduce airway inflammation and mucus plugs. Participants receiv…

This study tested whether giving melatonin, a natural sleep hormone, could prevent delirium (sudden confusion) in older adults after major surgery. About 88 patients aged 65 and older took either melatonin or a placebo before and after their operation. The main goal was to see if…

This study tested whether mepolizumab, a drug that reduces certain immune cells, can lessen chronic cough in people with asthma or a related airway condition. 46 adults with a cough lasting over 8 weeks received the drug, and researchers measured their cough frequency over 14 wee…

This study tested a 9-week online group program called Trauma-Informed Goal Management Training (TI-GMT) to see if it helps people with PTSD improve their thinking skills and reduce symptoms. 33 adults from Ontario took part. The program teaches strategies to manage attention and…

This study tested a smartphone app called Back2Play to help youth recover from concussion. 181 children and teens with a recent concussion used the app to guide their return to school and sports. The goal was to see if the app could reduce symptoms and prevent another concussion …

This study tested whether equine assisted learning (working with horses) can reduce symptoms of trauma in public safety personnel like firefighters, police, and paramedics. 40 participants from Saskatchewan took part in the program. Researchers measured changes in PTSD and other …

This study looked at whether cognitive behavioral therapy (CBT) can help people who had surgery for a broken bone feel less pain over the next year. Over 1,000 adults took part, some getting CBT and others usual care. The goal was to see if CBT lowers the chance of developing lon…

This study looked at how the COVID-19 pandemic impacted children, youth, and families dealing with eating disorders in Canada. Researchers interviewed parents, youth, and healthcare workers to understand their experiences. They also tested virtual parent-led peer support groups t…

This study looked at whether gluten or whole wheat causes stomach issues in people with Irritable Bowel Syndrome (IBS). 29 adults who felt better on a gluten-free diet were given snack bars with either purified gluten, whole wheat (gluten plus other proteins), or a gluten-free pl…

This study looked at why certain foods trigger symptoms in people with Irritable Bowel Syndrome (IBS). Researchers focused on how gut bacteria produce histamine when digesting specific carbohydrates (FODMAPs). Thirty adults with IBS followed a low-FODMAP diet and took special dri…

This study tested whether coaching sessions are practical for young people (ages 16-18) with rheumatic diseases like juvenile arthritis as they move from pediatric to adult rheumatology care. Researchers enrolled 26 participants and measured how many agreed to join, attended sess…

This study looked at two different ways to teach medical residents about recognizing and responding to child maltreatment. 84 residents from Canadian universities took part. The goal was to see if these training methods were acceptable and could be used in a larger future study.

This study analyzed health records from nearly 1 million Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers looked at changes in doctor visits, tests, and treatments before and du…

This study looked at how many women with chronic pain at a pain clinic might have iron deficiency. 81 women answered a questionnaire about symptoms like heavy periods and past iron problems. The goal was to find out how common iron deficiency is and if treating it could help thei…

This study tested whether a transition coach could help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult healthcare. 27 teens took part in a coaching program to build self-management skills. The main goal was to see if …

This study followed 211 older adults who were hospitalized with COVID-19 to see how their ability to move, think, and do daily tasks changed over time. Researchers measured recovery using standard tests of mobility and cognition. The goal is to understand the long-term effects of…

This study tested whether a new training program helps healthcare and social service providers better recognize and respond to intimate partner violence and child maltreatment in veteran families. Forty providers took part, either in a facilitator-led workshop or self-guided onli…

This study looked at whether matching specific exercises to a person's type of low back pain leads to better results. Researchers tested two common exercises—motor control and graded activity—in 425 adults with chronic low back pain. The goal was to see if a simple questionnaire …

This study looked at how heavy drinkers' brains respond when thinking about buying alcohol after seeing pictures of drinks versus non-alcoholic beverages. 72 non-treatment-seeking heavy drinkers had their brains scanned while making hypothetical drink purchase decisions. The goal…

This study looked at how different doses of a ketone supplement affect blood flow to the brain and thinking skills in 20 healthy young adults. Participants drank either a high or low dose of the supplement, and researchers measured brain blood flow and memory. The goal was to lea…