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Sleep hormone may ward off Post-Surgery brain fog in seniors

NCT ID NCT03785158

First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 31 times

Summary

This study tested whether giving melatonin, a natural sleep hormone, could prevent delirium (sudden confusion) in older adults after major surgery. About 88 patients aged 65 and older took either melatonin or a placebo before and after their operation. The main goal was to see if a larger study is possible, not yet to prove melatonin works. Results will help design future research.

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Contacts and locations

Locations

  • Hamilton Health Sciences-Juravinski Hospital Location

    Hamilton, Ontario, L8V 1C3, Canada

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, L8N 4A6, Canada

Conditions

Explore the condition pages connected to this study.